Collated Gene Ontology terms

Biological process: ribosome binding(2008, 2023) serine-type endopeptidase activity(2023) hydrolase activity(2023)

Molecular function: signal peptide processing2001, 2009, 2014, 2020, 2022, 2023 protein targeting to ER2006, 2009, 2017, 2023 virion assembly2019 viral protein processing2019 proteolysis2002

Cellular component: signal peptidase complex2002, 2009, 2014, 2019, 2020, 2022, 2023 endoplasmic reticulum membrane2002, 2004, 2009, 2013, 2020, 2022, 2023 endoplasmic reticulum2016, 2021, 2023 membrane2023

Phylogenetic distribution

Chordates: 19/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 35/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Knownness history

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2 4 6 8 10 Knownness

Proteins

UniProt ID
Organism DB»
Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
W1NX74_AMBTC
EnsemblPlants»
0.0
AMTR_s00092p00156160 Microsomal signal peptidase 12 kDa subunit Amborella trichopoda
TI:13333 None
 
W1PPK2_AMBTC
EnsemblPlants»
0.0
AMTR_s00013p00227820 Signal peptidase complex subunit 1 Amborella trichopoda
TI:13333 None
 
G1KGM1_ANOCA
Ensembl»
0.0
SPCS1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Anolis carolinensis
TI:28377 None
   
Q7QAD1_ANOGA
EnsemblMetazoa»
0.0
1274446 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Anopheles gambiae
TI:7165 None
 
Q84MC9_ARATH
TAIR»
0.0
At4g40042 At4g40042 (Microsomal signal peptidase
12 kDa subunit (SPC12))
Arabidopsis thaliana
TI:3702 None
 
SPCS1_ARATH
TAIR»
0.0
At2g22425 Signal peptidase complex subunit 1 (Microsomal signal
peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Arabidopsis thaliana
TI:3702 None
 
SPC1_ASHGO
EnsemblFungi»
0.0
SPC1 Signal peptidase complex subunit 1 Ashbya gossypii
TI:33169 None
 
Q4WTR2_ASPFU
EnsemblFungi»
0.0
AFUA_5G05800 Microsomal signal peptidase Spc12, putative Aspergillus fumigatus
TI:746128 None
 
F4NUZ4_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_84776 Microsomal signal peptidase 12 kDa subunit Batrachochytrium dendrobatidis
TI:109871 None
 
A0A3Q1MLX7_BOVIN
Ensembl»
0.0
SPCS1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Bos taurus
TI:9913 None
   
G3MWQ7_BOVIN
Ensembl»
0.0
LOC781197 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Bos taurus
TI:9913 None
   
SPCS1_BOVIN
CTD»
0.0
SPCS1 Signal peptidase complex subunit 1 (Microsomal signal
peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Bos taurus
TI:9913 None
 
I1IIK6_BRADI
EnsemblPlants»
0.0
100844194 Signal peptidase complex subunit 1 Brachypodium distachyon
TI:15368 None
 
C3YRN3_BRAFL
CTD»
0.0
LOC118430573 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Branchiostoma floridae
TI:7739 None
 
A0A078FL92_BRANA
EnsemblPlants»
0.0
BnaA09g42640D (rape) hypothetical
protein (BnaA09g42640D protein)
Brassica napus
TI:3708 None
 
A8WZL7_CAEBR
WormBase»
0.0
CBG05330 CBG_05330 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Caenorhabditis briggsae
TI:6238 None
 
SPCS1_CAEBR
WormBase»
0.0
spcs-1 Signal peptidase complex subunit 1 (Microsomal signal
peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Caenorhabditis briggsae
TI:6238 None
 
SPCS1_CAEEL
WormBase»
1.0
spcs-1 Signal peptidase complex subunit 1 (Microsomal signal
peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Caenorhabditis elegans
TI:6239 None
 
SPCS1_CANLF
Ensembl»
0.0
SPCS1 Signal peptidase complex subunit 1 (Microsomal signal
peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Canis lupus
TI:9612 None
 
A0A1U8GH31_CAPAN
EnsemblPlants»
0.0
T459_11116 Putative signal peptidase complex subunit 1 Capsicum annuum
TI:4072 None
 
A0A067H2H9_CITSI
Ensembl»
0.0
CISIN_1g034532mg Signal peptidase complex subunit 1 Citrus sinensis
TI:2711 None
 
A0A0S2LII0_CRYNJ
EnsemblFungi»
0.0
CNB02665 Signal peptidase complex subunit 1 Cryptococcus neoformans
TI:5207 None
 
A0A0A0KS09_CUCSA
EnsemblPlants»
0.0
Csa_5G589960 Signal peptidase complex subunit 1 Cucumis sativus
TI:3659 None
 
Q499B2_DANRE
ZFIN»
1.0
fa97f07 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Danio rerio
TI:7955 None
 
E9HAP9_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_309157 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Daphnia pulex
TI:6669 None
 
F0ZFQ6_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_24005 Microsomal signal peptidase 12 kDa subunit Dictyostelium purpureum
TI:5786 None
 
SPCS1_DICDI
dictyBase»
1.0
spcs1 Signal peptidase complex subunit 1 Dictyostelium discoideum
TI:44689 None
 
SPCS1_DROME
FlyBase»
1.0
Spase12 Signal peptidase complex subunit 1 (Microsomal signal
peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Drosophila melanogaster
TI:7227 None
 
C8V9I6_EMENI
EnsemblFungi»
0.0
ANIA_11133 Microsomal signal peptidase
Spc12, putative (AFU_orthologue AFUA_5G05800)
Emericella nidulans
TI:162425 None
 
B1N3M1_ENTH1
EnsemblProtists»
0.0
EHI_193470 EHI_200720 Uncharacterized protein Entamoeba histolytica
TI:5759 None
 
A0A022QF79_ERYGU
Ensembl»
0.0
MIMGU_mgv1a017099mg Signal peptidase complex subunit 1 Erythranthe guttata
TI:4155 None
 
A0A022RT54_ERYGU
Ensembl»
0.0
MIMGU_mgv1a017104mg Signal peptidase complex subunit 1 Erythranthe guttata
TI:4155 None
 
A0A059D8V0_EUCGR
EnsemblPlants»
0.0
EUGRSUZ_B03484 Microsomal signal peptidase 12 kDa subunit Eucalyptus grandis
TI:71139 None
 
M3WUM5_FELCA
Ensembl»
0.0
SPCS1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Felis catus
TI:9685 None
 
A0A8V1A741_CHICK
Ensembl»
0.0
Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Gallus gallus
TI:9031 None
   
A8BSQ8_GIAIC
EnsemblProtists»
0.0
GL50803_003154 GL50803_3154 Microsomal signal peptidase
12 kDa subunit (SPC12)
Giardia intestinalis
TI:5741 None
 
A0A0R0F1J8_SOYBN
EnsemblPlants»
0.0
GLYMA_18G192200 Signal peptidase complex subunit 1 Glycine max
TI:3847 None
 
I1K3L2_SOYBN
EnsemblPlants»
0.0
100797100 Signal peptidase complex subunit 1 Glycine max
TI:3847 None
 
I1KS11_SOYBN
EnsemblPlants»
0.0
100526911 Signal peptidase complex subunit 1 Glycine max
TI:3847 None
 
I1LN93_SOYBN
EnsemblPlants»
0.0
100801319 Signal peptidase complex subunit 1 Glycine max
TI:3847 None
 
I1MYG5_SOYBN
EnsemblPlants»
0.0
100777545 Signal peptidase complex subunit 1 Glycine max
TI:3847 None
 
G3RSY2_GORGO
Ensembl»
0.0
Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Gorilla gorilla
TI:9593 None
 
A0A1U8KGH6_GOSHI
Ensembl»
0.0
LOC107916724 Probable signal peptidase complex subunit 1 Gossypium hirsutum
TI:3635 None
   
A0A1U8KUR2_GOSHI
Ensembl»
0.0
LOC107920887 Probable signal peptidase complex subunit 1 Gossypium hirsutum
TI:3635 None
   
A0A1U8NAB7_GOSHI
Ensembl»
0.0
LOC107946272 Probable signal peptidase complex subunit 1 Gossypium hirsutum
TI:3635 None
   
A0A251U1L5_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr08g0207731 Putative microsomal signal
peptidase 12kDa subunit
Helianthus annuus
TI:4232 None
 
T1EHJ5_HELRO
EnsemblMetazoa»
0.0
20196045 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Helobdella robusta
TI:6412 None
 
SPCS1_HUMAN
Ensembl»
4.3
SPCS1 Signal peptidase complex subunit 1 (Microsomal signal
peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Homo sapiens
TI:9606 None
 
A0A8I7B654_HORVV
EnsemblPlants»
0.0
Signal peptidase complex subunit 1 Hordeum vulgare
TI:4513 None
   
B7PTZ5_IXOSC
EnsemblMetazoa»
0.0
8031326 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Ixodes scapularis
TI:6945 None
 
A0A2I4FYJ1_JUGRE
EnsemblPlants»
0.0
LOC109003154 Probable signal peptidase complex subunit 1 Juglans regia
TI:51240 None
   
A0A2I4FYK1_JUGRE
EnsemblPlants»
0.0
LOC109003160 Probable signal peptidase complex
subunit 1 isoform X1
Juglans regia
TI:51240 None
   
A0A1Y1IER9_KLENI
EnsemblPlants»
0.0
KFL_004330090 Microsomal signal peptidase complex subunit Klebsormidium nitens
TI:105231 None
 
W5MWY6_LEPOC
Ensembl»
0.0
Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Lepisosteus oculatus
TI:7918 None
 
F7H6U6_MACMU
Ensembl»
0.0
SPCS1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Macaca mulatta
TI:9544 None
   
A0A2C9UN26_MANES
EnsemblPlants»
0.0
MANES_13G018500 Uncharacterized protein Manihot esculenta
TI:3983 None
 
A0A2C9USN6_MANES
EnsemblPlants»
0.0
MANES_12G012800 Signal peptidase complex subunit 1 Manihot esculenta
TI:3983 None
 
A0A2R6X291_MARPO
EnsemblPlants»
0.0
MARPO_0041s0086 Signal peptidase complex subunit 1 Marchantia polymorpha
TI:3197 None
 
A0A072TSU0_MEDTR
EnsemblPlants»
0.0
MTR_8g080380 Microsomal signal peptidase 12 kDa protein Medicago truncatula
TI:3880 None
 
G7JC07_MEDTR
EnsemblPlants»
0.0
11437567 Microsomal signal peptidase 12 kDa protein Medicago truncatula
TI:3880 None
 
F6SRE0_MONDO
Ensembl»
0.0
SPCS1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Monodelphis domestica
TI:13616 None
   
A9UPP6_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_13509 Microsomal signal peptidase 12 kDa subunit Monosiga brevicollis
TI:81824 None
 
SPCS1_MOUSE
Ensembl»
3.3
Spcs1 Signal peptidase complex subunit 1 (Microsomal signal
peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Mus musculus
TI:10090 None
 
A0A804HR65_MUSAM
EnsemblPlants»
0.0
GSMUA_290850.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A804ID66_MUSAM
EnsemblPlants»
0.0
103978445 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A804KBX4_MUSAM
EnsemblPlants»
0.0
GSMUA_89630.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A1U8Q0J6_NELNU
EnsemblBacteria»
0.0
LOC104591701 Probable signal peptidase complex subunit 1 Nelumbo nucifera
TI:4432 None
 
A0A1U8Q180_NELNU
EnsemblBacteria»
0.0
LOC104592912 Probable signal peptidase complex subunit 1 Nelumbo nucifera
TI:4432 None
 
A7SCR5_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g169043 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Nematostella vectensis
TI:45351 None
 
A7UWR4_NEUCR
EnsemblFungi»
0.0
NCU11313 Microsomal signal peptidase Spc12 Neurospora crassa
TI:5141 None
 
A0A1S3Y830_TOBAC
EnsemblFungi»
0.0
LOC107773555 Probable signal peptidase complex subunit 1 Nicotiana tabacum
TI:4097 None
   
A0A1S3ZL26_TOBAC
EnsemblFungi»
0.0
LOC107787855 Probable signal peptidase complex subunit 1 Nicotiana tabacum
TI:4097 None
   
A0A1S3ZLE2_TOBAC
EnsemblFungi»
0.0
LOC107788042 Probable signal peptidase complex
subunit 1 isoform X1
Nicotiana tabacum
TI:4097 None
   
A0A6I8N580_ORNAN
Ensembl»
0.0
Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Ornithorhynchus anatinus
TI:9258 None
   
A0A0P0Y9Q3_ORYSJ
EnsemblPlants»
0.0
Os12g0438900 Os12g0438900 protein Oryza sativa
TI:4530 None
 
H2MMS4_ORYLA
Ensembl»
0.0
spcs1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Oryzias latipes
TI:8090 None
   
A0A2J8P873_PANTR
Ensembl»
0.0
SPCS1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Pan troglodytes
TI:9598 None
 
A0BDT6_PARTE
EnsemblProtists»
0.0
GSPATT00027733001 Chromosome undetermined scaffold_101,
whole genome shotgun sequence
Paramecium tetraurelia
TI:5888 None
 
A0DCS0_PARTE
EnsemblProtists»
0.0
GSPATT00015696001 Chromosome undetermined scaffold_46,
whole genome shotgun sequence
Paramecium tetraurelia
TI:5888 None
 
Q0UGL0_PHANO
EnsemblFungi»
0.0
SNOG_09104 Microsomal signal peptidase 12 kDa subunit Phaeosphaeria nodorum
TI:13684 None
 
A0A2K1JZ06_PHYPA
EnsemblPlants»
0.0
PHYPA_013881 Microsomal signal peptidase 12 kDa subunit Physcomitrium patens
TI:3218 None
 
A0A2K1KN47_PHYPA
EnsemblPlants»
0.0
PHYPA_006098 Signal peptidase complex subunit 1 Physcomitrium patens
TI:3218 None
 
A0A2K1KST0_PHYPA
EnsemblPlants»
0.0
PHYPA_003811 Microsomal signal peptidase 12 kDa subunit Physcomitrium patens
TI:3218 None
 
A9STZ8_PHYPA
EnsemblPlants»
0.0
PHYPA_016616 Uncharacterized protein Physcomitrium patens
TI:3218 None
 
A9TMQ7_PHYPA
EnsemblPlants»
0.0
PHYPA_005579 Uncharacterized protein Physcomitrium patens
TI:3218 None
 
Q8ILC7_PLAF7
EnsemblProtists»
0.0
PF3D7_1433600 Signal peptidase complex subunit
SPC1, putative (EC 3.4.21.89)
Plasmodium falciparum
TI:5833 None
 
B9HKY8_POPTR
EnsemblPlants»
0.0
POPTR_008G175800 Microsomal signal peptidase 12 kDa subunit Populus trichocarpa
TI:3694 None
 
U5G3S5_POPTR
EnsemblPlants»
0.0
POPTR_010G059300 Signal peptidase complex subunit 1 Populus trichocarpa
TI:3694 None
 
A0A2A6BKF0_PRIPA
EnsemblMetazoa»
0.0
WBGene00274431 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Pristionchus pacificus
TI:54126 None
 
A0A251R203_PRUPE
EnsemblPlants»
0.0
PRUPE_1G228300 Microsomal signal peptidase 12 kDa subunit Prunus persica
TI:3760 None
 
E3K8I9_PUCGT
EnsemblFungi»
0.0
PGTG_06473 Microsomal signal peptidase 12 kDa subunit Puccinia graminis
TI:5297 None
 
D3ZFK5_RAT
RGD»
3.0
Spcs1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Rattus norvegicus
TI:10116 None
   
B9RMF9_RICCO
EnsemblBacteria»
0.0
RCOM_1080710 Signal peptidase complex subunit, putative Ricinus communis
TI:3988 None
 
SPC1_YEAST
SGD»
4.8
SPC1 Signal peptidase complex subunit 1
(Microsomal signal peptidase subunit 1)
Saccharomyces cerevisiae
TI:4932 None
 
SPC1_SCHPO
PomBase»
2.0
spc1 Signal peptidase complex subunit 1 Schizosaccharomyces pombe
TI:4896 None
 
A7E404_SCLS1
EnsemblFungi»
0.0
SS1G_00026 Microsomal signal peptidase 12kDa subunit Sclerotinia sclerotiorum
TI:5180 None
 
D8QRB3_SELML
EnsemblPlants»
0.0
SELMODRAFT_77762 Signal peptidase complex subunit 1 Selaginella moellendorffii
TI:88036 None
 
D8RJI8_SELML
EnsemblPlants»
0.0
SELMODRAFT_95228 Signal peptidase complex subunit 1 Selaginella moellendorffii
TI:88036 None
 
D8RRJ0_SELML
EnsemblPlants»
0.0
SELMODRAFT_99869 Microsomal signal peptidase 12 kDa subunit Selaginella moellendorffii
TI:88036 None
 
D8SC59_SELML
EnsemblPlants»
0.0
SELMODRAFT_113427 Signal peptidase complex subunit 1 Selaginella moellendorffii
TI:88036 None
 
A0A0Q3VE93_SETIT
EnsemblPlants»
0.0
Signal peptidase complex subunit 1 Setaria italica
TI:4555 None
 
A0A3Q7FCZ0_SOLLC
EnsemblPlants»
0.0
Signal peptidase complex subunit 1 Solanum lycopersicum
TI:4081 None
   
C5WQG8_SORBI
EnsemblPlants»
0.0
SORBI_3001G148700 Signal peptidase complex subunit 1 Sorghum bicolor
TI:4558 None
 
A0A7M7LT29_STRPU
EnsemblMetazoa»
0.0
Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Strongylocentrotus purpuratus
TI:7668 None
   
A0A5S6G9F8_PIG
Ensembl»
0.0
SPCS1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Sus scrofa
TI:9823 None
   
SPCS1_PIG
CTD»
0.0
SPCS1 Signal peptidase complex subunit 1 (Microsomal signal
peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Sus scrofa
TI:9823 None
 
B8C1V5_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_34186 Microsomal signal peptidase 12 kDa subunit Thalassiosira pseudonana
TI:35128 None
 
A0A061E5H7_THECC
EnsemblPlants»
0.0
TCM_008867 Microsomal signal peptidase
12 kDa subunit (SPC12)
Theobroma cacao
TI:3641 None
 
D6WSR1_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_10137 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Tribolium castaneum
TI:7070 None
 
B3S097_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_57735 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Trichoplax adhaerens
TI:10228 None
 
A0A3B6GYD4_WHEAT
EnsemblPlants»
0.0
CFC21_048677 Signal peptidase complex subunit 1 Triticum aestivum
TI:4565 None
 
W5CV46_WHEAT
EnsemblPlants»
0.0
CFC21_036844 CFC21_042823 CFC21_042825 TRAES_3BF117700040CFD_c1 Signal peptidase complex subunit 1 Triticum aestivum
TI:4565 None
 
A0A0D1E4R5_USTMA
EnsemblFungi»
0.0
UMAG_12166 Microsomal signal peptidase 12 kDa subunit Ustilago maydis
TI:5270 None
 
D7TAV5_VITVI
EnsemblPlants»
0.0
VIT_01s0010g03360 Signal peptidase complex subunit 1 Vitis vinifera
TI:29760 None
 
A9ULB3_XENTR
Xenbase»
0.0
spcs1 Signal peptidase complex subunit 1
(Microsomal signal peptidase 12 kDa subunit)
Xenopus tropicalis
TI:8364 None
 
B5RSM2_YARLI
EnsemblFungi»
0.0
YALI0_F26156g YALI0F26156p Yarrowia lipolytica
TI:4952 None
 
A0A804P9F2_MAIZE
EnsemblPlants»
0.0
Signal peptidase complex subunit 1 Zea mays
TI:4577 None
   
B6SJA3_MAIZE
EnsemblPlants»
0.0
100280989 Signal peptidase complex subunit 1 Zea mays
TI:4577 None
 
A0A0K9PVC8_ZOSMR
EnsemblPlants»
0.0
ZOSMA_156G00470 Putative Signal peptidase complex subunit Zostera marina
TI:29655 None