Standard knownness: 4.8; Custom knownness: None; Num. species: 87; Orthology database: Panther19.0; Protein members: 121
Molecular function: signal peptide processing2013, 2014, 2020, 2022, 2024 protein targeting to ER2013, 2017, 2024 virion assembly2019 viral protein processing2019 proteolysis2002
Cellular component: signal peptidase complex2002, 2014, 2019, 2020, 2022, 2023, 2024 endoplasmic reticulum membrane2002, 2004, 2009, 2013, 2020, 2022, 2024 endoplasmic reticulum2018, 2021, 2024 membrane2024
Chordates: | 20/21 | ![]() |
Echinoderms: | 0/0 | |
Hemichordates: | 1/1 | |
Annelids: | 1/1 | |
Molluscs: | 0/0 | |
Bryozoans: | 0/0 | |
Platyhelminthes: | 0/0 | |
Rotifers: | 0/0 | |
Nematodes: | 3/3 | |
Arthropods: | 5/5 | |
Tardigrades: | 0/0 | |
Placozoa: | 1/1 | |
Cnidaria: | 1/1 | |
Porifera: | 0/0 | |
Choanoflagellates+: | 12/1 | |
Dikarya: | 0/14 | |
Fungi (other): | 0/1 | |
Protozoa: | 3/3 | |
Excavates: | 2/4 | |
Harosa: | 3/4 | |
Hacrobia: | 0/0 | |
Plants: | 35/39 | |
Archea: | 0/8 | |
Bacteria: | 0/35 |
Click here to switch to the previous version of the database.
UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
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W1NX74_AMBTC EnsemblPlants» |
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AMTR_s00092p00156160 | Microsomal signal peptidase 12 kDa subunit |
Amborella trichopoda TI:13333 None |
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W1PPK2_AMBTC EnsemblPlants» |
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AMTR_s00013p00227820 | Signal peptidase complex subunit 1 |
Amborella trichopoda TI:13333 None |
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G1KGM1_ANOCA Ensembl» |
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Anolis carolinensis TI:28377 None |
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Q7QAD1_ANOGA EnsemblMetazoa» |
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1274446 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Anopheles gambiae TI:7165 None |
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Q84MC9_ARATH TAIR» |
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At4g40042 | At4g40042 (Microsomal signal peptidase 12 kDa subunit (SPC12)) |
Arabidopsis thaliana TI:3702 None |
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SPCS1_ARATH TAIR» |
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At2g22425 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) |
Arabidopsis thaliana TI:3702 None |
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SPC1_ASHGO EnsemblFungi» |
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SPC1 | Signal peptidase complex subunit 1 |
Ashbya gossypii TI:33169 None |
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Q4WTR2_ASPFU EnsemblFungi» |
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AFUA_5G05800 | Microsomal signal peptidase Spc12, putative |
Aspergillus fumigatus TI:746128 None |
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F4NUZ4_BATDJ EnsemblBacteria» |
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BATDEDRAFT_84776 | Microsomal signal peptidase 12 kDa subunit |
Batrachochytrium dendrobatidis TI:109871 None |
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A0A3Q1MLX7_BOVIN Ensembl» |
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Bos taurus TI:9913 None |
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G3MWQ7_BOVIN Ensembl» |
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LOC781197 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Bos taurus TI:9913 None |
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SPCS1_BOVIN CTD» |
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) |
Bos taurus TI:9913 None |
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I1IIK6_BRADI EnsemblPlants» |
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100844194 | Signal peptidase complex subunit 1 |
Brachypodium distachyon TI:15368 None |
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C3YRN3_BRAFL CTD» |
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LOC118430573 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Branchiostoma floridae TI:7739 None |
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A0A078FL92_BRANA EnsemblPlants» |
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BnaA09g42640D | (rape) hypothetical protein (BnaA09g42640D protein) |
Brassica napus TI:3708 None |
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A0A3P5Z0X4_BRACM EnsemblPlants» |
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BRAA01T00094Z BRAPAZ1V2_A01P01050.2 | Signal peptidase complex subunit 1 |
Brassica campestris TI:3711 None |
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M4FBQ9_BRACM EnsemblPlants» |
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Signal peptidase complex subunit 1 |
Brassica campestris TI:3711 None |
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A8WZL7_CAEBR WormBase» |
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CBG05330 CBG_05330 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Caenorhabditis briggsae TI:6238 None |
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SPCS1_CAEBR WormBase» |
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spcs-1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) |
Caenorhabditis briggsae TI:6238 None |
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SPCS1_CAEEL WormBase» |
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spcs-1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) |
Caenorhabditis elegans TI:6239 None |
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SPCS1_CANLF Ensembl» |
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) |
Canis lupus TI:9612 None |
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A0A1U8GH31_CAPAN EnsemblPlants» |
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T459_11116 | Putative signal peptidase complex subunit 1 |
Capsicum annuum TI:4072 None |
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A0A067H2H9_CITSI Ensembl» |
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CISIN_1g034532mg | Signal peptidase complex subunit 1 |
Citrus sinensis TI:2711 None |
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A0A0S2LII0_CRYNJ EnsemblFungi» |
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CNB02665 | Signal peptidase complex subunit 1 |
Cryptococcus neoformans TI:5207 None |
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A0A0A0KS09_CUCSA EnsemblPlants» |
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Csa_5G589960 | Signal peptidase complex subunit 1 |
Cucumis sativus TI:3659 None |
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Q499B2_DANRE ZFIN» |
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fa97f07 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Danio rerio TI:7955 None |
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E9HAP9_DAPPU EnsemblMetazoa» |
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DAPPUDRAFT_309157 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Daphnia pulex TI:6669 None |
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F0ZFQ6_DICPU EnsemblProtists» |
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DICPUDRAFT_24005 | Microsomal signal peptidase 12 kDa subunit |
Dictyostelium purpureum TI:5786 None |
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SPCS1_DICDI dictyBase» |
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spcs1 | Signal peptidase complex subunit 1 |
Dictyostelium discoideum TI:44689 None |
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SPCS1_DROME FlyBase» |
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Spase12 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) |
Drosophila melanogaster TI:7227 None |
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C8V9I6_EMENI EnsemblFungi» |
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ANIA_11133 | Microsomal signal peptidase Spc12, putative (AFU_orthologue AFUA_5G05800) |
Emericella nidulans TI:162425 None |
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B1N3M1_ENTH1 EnsemblProtists» |
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EHI_193470 EHI_200720 | Uncharacterized protein |
Entamoeba histolytica TI:5759 None |
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A0A022QF79_ERYGU EnsemblFungi» |
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MIMGU_mgv1a017099mg | Signal peptidase complex subunit 1 |
Erythranthe guttata TI:4155 None |
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A0A022RT54_ERYGU EnsemblFungi» |
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MIMGU_mgv1a017104mg | Signal peptidase complex subunit 1 |
Erythranthe guttata TI:4155 None |
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M3WUM5_FELCA Ensembl» |
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Felis catus TI:9685 None |
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A0A8V1A741_CHICK Ensembl» |
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Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Gallus gallus TI:9031 None |
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A8BSQ8_GIAIC EnsemblProtists» |
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GL50803_003154 GL50803_3154 | Microsomal signal peptidase 12 kDa subunit (SPC12) |
Giardia intestinalis TI:5741 None |
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A0A0R0F1J8_SOYBN EnsemblPlants» |
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GLYMA_18G192200 | Signal peptidase complex subunit 1 |
Glycine max TI:3847 None |
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I1K3L2_SOYBN EnsemblPlants» |
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100797100 | Signal peptidase complex subunit 1 |
Glycine max TI:3847 None |
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I1KS11_SOYBN EnsemblPlants» |
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100526911 | Signal peptidase complex subunit 1 |
Glycine max TI:3847 None |
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I1LN93_SOYBN EnsemblPlants» |
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100801319 | Signal peptidase complex subunit 1 |
Glycine max TI:3847 None |
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I1MYG5_SOYBN EnsemblPlants» |
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100777545 | Signal peptidase complex subunit 1 |
Glycine max TI:3847 None |
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G3RSY2_GORGO Ensembl» |
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Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Gorilla gorilla TI:9593 None |
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A0A1U8KGH6_GOSHI Ensembl» |
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LOC107916724 | Probable signal peptidase complex subunit 1 |
Gossypium hirsutum TI:3635 None |
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A0A1U8KUR2_GOSHI Ensembl» |
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LOC107920887 | Probable signal peptidase complex subunit 1 |
Gossypium hirsutum TI:3635 None |
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A0A1U8NAB7_GOSHI Ensembl» |
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LOC107946272 | Probable signal peptidase complex subunit 1 |
Gossypium hirsutum TI:3635 None |
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A0A251U1L5_HELAN EnsemblPlants» |
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HannXRQ_Chr08g0207731 | Putative microsomal signal peptidase 12kDa subunit |
Helianthus annuus TI:4232 None |
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T1EHJ5_HELRO EnsemblMetazoa» |
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20196045 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Helobdella robusta TI:6412 None |
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SPCS1_HUMAN Ensembl» |
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) |
Homo sapiens TI:9606 None |
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A0A8I7B654_HORVV EnsemblPlants» |
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Signal peptidase complex subunit 1 |
Hordeum vulgare TI:4513 None |
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B7PTZ5_IXOSC EnsemblMetazoa» |
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8031326 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Ixodes scapularis TI:6945 None |
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A0A2I4FYJ1_JUGRE EnsemblPlants» |
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LOC109003154 | Probable signal peptidase complex subunit 1 |
Juglans regia TI:51240 None |
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A0A2I4FYK1_JUGRE EnsemblPlants» |
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LOC109003160 | Probable signal peptidase complex subunit 1 isoform X1 |
Juglans regia TI:51240 None |
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A0A1Y1IER9_KLENI EnsemblPlants» |
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KFL_004330090 | Microsomal signal peptidase complex subunit |
Klebsormidium nitens TI:105231 None |
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W5MWY6_LEPOC Ensembl» |
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Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Lepisosteus oculatus TI:7918 None |
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F7H6U6_MACMU Ensembl» |
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Macaca mulatta TI:9544 None |
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A0A2C9UN26_MANES EnsemblPlants» |
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MANES_13G018500 | Uncharacterized protein |
Manihot esculenta TI:3983 None |
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A0A2C9USN6_MANES EnsemblPlants» |
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MANES_12G012800 | Signal peptidase complex subunit 1 |
Manihot esculenta TI:3983 None |
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A0A2R6X291_MARPO EnsemblPlants» |
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MARPO_0041s0086 | Signal peptidase complex subunit 1 |
Marchantia polymorpha TI:3197 None |
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A0A072TSU0_MEDTR EnsemblPlants» |
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MTR_8g080380 | Microsomal signal peptidase 12 kDa protein |
Medicago truncatula TI:3880 None |
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G7JC07_MEDTR EnsemblPlants» |
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11437567 | Microsomal signal peptidase 12 kDa protein |
Medicago truncatula TI:3880 None |
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F6SRE0_MONDO Ensembl» |
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Monodelphis domestica TI:13616 None |
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A9UPP6_MONBE EnsemblProtists» |
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MONBRDRAFT_13509 | Microsomal signal peptidase 12 kDa subunit |
Monosiga brevicollis TI:81824 None |
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SPCS1_MOUSE Ensembl» |
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Spcs1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) |
Mus musculus TI:10090 None |
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A0A804HR65_MUSAM EnsemblPlants» |
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GSMUA_290850.1 | (wild Malaysian banana) hypothetical protein |
Musa acuminata TI:4641 None |
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A0A804ID66_MUSAM EnsemblPlants» |
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103978445 | (wild Malaysian banana) hypothetical protein |
Musa acuminata TI:4641 None |
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A0A804KBX4_MUSAM EnsemblPlants» |
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GSMUA_89630.1 | (wild Malaysian banana) hypothetical protein |
Musa acuminata TI:4641 None |
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A0A1U8Q0J6_NELNU EnsemblBacteria» |
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LOC104591701 | Probable signal peptidase complex subunit 1 |
Nelumbo nucifera TI:4432 None |
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A0A1U8Q180_NELNU EnsemblBacteria» |
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LOC104592912 | Probable signal peptidase complex subunit 1 |
Nelumbo nucifera TI:4432 None |
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A7SCR5_NEMVE EnsemblMetazoa» |
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NEMVEDRAFT_v1g169043 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Nematostella vectensis TI:45351 None |
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A7UWR4_NEUCR EnsemblFungi» |
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NCU11313 | Microsomal signal peptidase Spc12 |
Neurospora crassa TI:5141 None |
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A0A1S3Y830_TOBAC EnsemblFungi» |
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LOC107773555 | Probable signal peptidase complex subunit 1 |
Nicotiana tabacum TI:4097 None |
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A0A1S3ZL26_TOBAC EnsemblFungi» |
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LOC107787855 | Probable signal peptidase complex subunit 1 |
Nicotiana tabacum TI:4097 None |
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A0A1S3ZLE2_TOBAC EnsemblFungi» |
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LOC107788042 | Probable signal peptidase complex subunit 1 isoform X1 |
Nicotiana tabacum TI:4097 None |
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A0A6I8N580_ORNAN Ensembl» |
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Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Ornithorhynchus anatinus TI:9258 None |
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A0A0P0Y9Q3_ORYSJ EnsemblPlants» |
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Os12g0438900 | Os12g0438900 protein |
Oryza sativa TI:4530 None |
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H2MMS4_ORYLA Ensembl» |
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spcs1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Oryzias latipes TI:8090 None |
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A0A2J8P873_PANTR Ensembl» |
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Pan troglodytes TI:9598 None |
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A0BDT6_PARTE EnsemblProtists» |
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GSPATT00027733001 | Chromosome undetermined scaffold_101, whole genome shotgun sequence |
Paramecium tetraurelia TI:5888 None |
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A0DCS0_PARTE EnsemblProtists» |
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GSPATT00015696001 | Chromosome undetermined scaffold_46, whole genome shotgun sequence |
Paramecium tetraurelia TI:5888 None |
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A0A2K1JZ06_PHYPA EnsemblPlants» |
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PHYPA_013881 | Microsomal signal peptidase 12 kDa subunit |
Physcomitrium patens TI:3218 None |
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A0A2K1KN47_PHYPA EnsemblPlants» |
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PHYPA_006098 | Signal peptidase complex subunit 1 |
Physcomitrium patens TI:3218 None |
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A0A2K1KST0_PHYPA EnsemblPlants» |
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PHYPA_003811 | Microsomal signal peptidase 12 kDa subunit |
Physcomitrium patens TI:3218 None |
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A9STZ8_PHYPA EnsemblPlants» |
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PHYPA_016616 | Uncharacterized protein |
Physcomitrium patens TI:3218 None |
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A9TMQ7_PHYPA EnsemblPlants» |
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PHYPA_005579 | Uncharacterized protein |
Physcomitrium patens TI:3218 None |
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Q8ILC7_PLAF7 EnsemblProtists» |
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PF3D7_1433600 | Signal peptidase complex subunit SPC1, putative (EC 3.4.21.89) |
Plasmodium falciparum TI:5833 None |
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B9HKY8_POPTR EnsemblPlants» |
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POPTR_008G175800 | Microsomal signal peptidase 12 kDa subunit |
Populus trichocarpa TI:3694 None |
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U5G3S5_POPTR EnsemblPlants» |
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POPTR_010G059300 | Signal peptidase complex subunit 1 |
Populus trichocarpa TI:3694 None |
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A0A2A6BKF0_PRIPA EnsemblMetazoa» |
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WBGene00274431 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Pristionchus pacificus TI:54126 None |
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A0A251R1Y2_PRUPE EnsemblPlants» |
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PRUPE_1G228300 | Signal peptidase complex subunit 1 |
Prunus persica TI:3760 None |
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E3K8I9_PUCGT EnsemblFungi» |
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PGTG_06473 | Microsomal signal peptidase 12 kDa subunit |
Puccinia graminis TI:5297 None |
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D3ZFK5_RAT RGD» |
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Spcs1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Rattus norvegicus TI:10116 None |
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B9RMF9_RICCO EnsemblBacteria» |
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RCOM_1080710 | Signal peptidase complex subunit, putative |
Ricinus communis TI:3988 None |
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SPC1_YEAST SGD» |
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SPC1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase subunit 1) |
Saccharomyces cerevisiae TI:4932 None |
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SPC1_SCHPO PomBase» |
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spc1 | Signal peptidase complex subunit 1 |
Schizosaccharomyces pombe TI:4896 None |
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A7E404_SCLS1 EnsemblFungi» |
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SS1G_00026 | Microsomal signal peptidase 12kDa subunit |
Sclerotinia sclerotiorum TI:5180 None |
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D8QRB3_SELML EnsemblPlants» |
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SELMODRAFT_77762 | Signal peptidase complex subunit 1 |
Selaginella moellendorffii TI:88036 None |
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D8RJI8_SELML EnsemblPlants» |
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SELMODRAFT_95228 | Signal peptidase complex subunit 1 |
Selaginella moellendorffii TI:88036 None |
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D8RRJ0_SELML EnsemblPlants» |
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SELMODRAFT_99869 | Microsomal signal peptidase 12 kDa subunit |
Selaginella moellendorffii TI:88036 None |
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D8SC59_SELML EnsemblPlants» |
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SELMODRAFT_113427 | Signal peptidase complex subunit 1 |
Selaginella moellendorffii TI:88036 None |
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A0A0Q3VE93_SETIT EnsemblPlants» |
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Signal peptidase complex subunit 1 |
Setaria italica TI:4555 None |
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A0A3Q7FCZ0_SOLLC EnsemblPlants» |
|
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Signal peptidase complex subunit 1 |
Solanum lycopersicum TI:4081 None |
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C5WQG8_SORBI EnsemblPlants» |
|
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SORBI_3001G148700 | Signal peptidase complex subunit 1 |
Sorghum bicolor TI:4558 None |
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|||||
A0A7M7LT29_STRPU EnsemblMetazoa» |
|
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Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Strongylocentrotus purpuratus TI:7668 None |
|
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|||||||
A0A5S6G9F8_PIG Ensembl» |
|
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SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Sus scrofa TI:9823 None |
|
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||||||
SPCS1_PIG CTD» |
|
|
SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) |
Sus scrofa TI:9823 None |
|
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|||||
B8C1V5_THAPS EnsemblProtists» |
|
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THAPSDRAFT_34186 | Microsomal signal peptidase 12 kDa subunit |
Thalassiosira pseudonana TI:35128 None |
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A0A061E5H7_THECC EnsemblPlants» |
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TCM_008867 | Microsomal signal peptidase 12 kDa subunit (SPC12) |
Theobroma cacao TI:3641 None |
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D6WSR1_TRICA EnsemblMetazoa» |
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AUGUSTUS-3.0.2_10137 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Tribolium castaneum TI:7070 None |
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A2FMN5_TRIV3 VEuPathDB» |
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TVAG_177430 | Signal peptidase complex subunit 1 |
Trichomonas vaginalis TI:5722 None |
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B3S097_TRIAD EnsemblMetazoa» |
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TRIADDRAFT_57735 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Trichoplax adhaerens TI:10228 None |
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A0A3B6GYD4_WHEAT EnsemblPlants» |
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CFC21_048677 | Signal peptidase complex subunit 1 |
Triticum aestivum TI:4565 None |
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W5CV46_WHEAT EnsemblPlants» |
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CFC21_036844 CFC21_042823 CFC21_042825 TRAES_3BF117700040CFD_c1 | Signal peptidase complex subunit 1 |
Triticum aestivum TI:4565 None |
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D7TAV5_VITVI EnsemblPlants» |
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VIT_01s0010g03360 | Signal peptidase complex subunit 1 |
Vitis vinifera TI:29760 None |
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A0A8J0QFB1_XENLA Xenbase» |
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spcs1.L | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Xenopus laevis TI:8355 None |
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A0A8J1KKJ3_XENLA Xenbase» |
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LOC108704392 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Xenopus laevis TI:8355 None |
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A9ULB3_XENTR Xenbase» |
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spcs1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) |
Xenopus tropicalis TI:8364 None |
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B5RSM2_YARLI EnsemblFungi» |
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YALI0_F26156g | YALI0F26156p |
Yarrowia lipolytica TI:4952 None |
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A0A804P9F2_MAIZE EnsemblPlants» |
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Signal peptidase complex subunit 1 |
Zea mays TI:4577 None |
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B6SJA3_MAIZE EnsemblPlants» |
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100280989 | Signal peptidase complex subunit 1 |
Zea mays TI:4577 None |
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A0A0K9PVC8_ZOSMR EnsemblPlants» |
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ZOSMA_156G00470 | Putative Signal peptidase complex subunit |
Zostera marina TI:29655 None |
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