Collated Gene Ontology terms

Biological process: signal recognition particle binding(2020, 2023, 2025) serine-type endopeptidase activity(2024, 2025) protein-containing complex binding(2020, 2025) MHC class I protein binding(2006, 2025) ATPase binding(2015, 2021, 2025) ubiquitin-specific protease binding(2015, 2025) ubiquitin protein ligase binding(2015, 2025) protease binding(2014, 2025) identical protein binding(2019, 2025) hydrolase activity(2025)
peptidase activity2025 structural constituent of ribosome2025 signaling receptor activity2004 protein folding chaperone2023 misfolded protein binding2014

Molecular function: ERAD pathway2004, 2006, 2012, 2013, 2014, 2015, 2023, 2024, 2025 endoplasmic reticulum unfolded protein response2004, 2006, 2012, 2013, 2019, 2023, 2025 response to stress2025 cellular response to stress2025 proteolysis involved in protein catabolic process2025 proteasomal protein catabolic process2025 retrograde protein transport, ER to cytosol2004, 2006, 2013, 2014, 2015, 2025 negative regulation of retrograde protein transport, ER to cytosol2015, 2025 protein N-linked glycosylation2012, 2025 response to unfolded protein2012, 2025
protein destabilization2014, 2025 positive regulation of cell population proliferation2005, 2006, 2025 positive regulation of cell growth2005, 2006, 2025 positive regulation of protein ubiquitination2015, 2025 cellular response to misfolded protein2023, 2025 proteasome-mediated ubiquitin-dependent protein catabolic process2018, 2025 protein transport2025 ubiquitin-dependent protein catabolic process2025 response to misfolded protein2009, 2025 endocytosis2004, 2025 regulation of retrograde protein transport, ER to cytosol2019, 2023 regulation of cell cycle process2009 proteolysis2025 protein quality control for misfolded or incompletely synthesized proteins2004 cellular response to unfolded protein2012 IRE1-mediated unfolded protein response2018 translation2025 suckling behavior2013 secretion by cell2011 response to endoplasmic reticulum stress2014 regulation of transcription by RNA polymerase II2011 protein folding2025 positive regulation of apoptotic process2014 misfolded protein transport2014 hyphal growth2011 establishment of protein localization2004 defense response to bacterium2012

Cellular component: endoplasmic reticulum membrane2004, 2006, 2012, 2013, 2014, 2016, 2022, 2025 endoplasmic reticulum2006, 2009, 2012, 2018, 2023, 2025 membrane2012, 2014, 2025 early endosome2011, 2012, 2025 late endosome2012, 2025 Golgi apparatus2013, 2024, 2025 perinuclear region of cytoplasm2013, 2025 Golgi membrane2013, 2025 Derlin-1-VIMP complex2015, 2025 Derlin-1 retrotranslocation complex2015, 2025
endoplasmic reticulum quality control compartment2020, 2025 cytoplasm2017, 2018, 2025 perinuclear endoplasmic reticulum2011, 2025 endosome2009, 2025 nucleoplasm2017, 2025 cytosol2019, 2025 apicoplast2009 ATPase complex2025 rough endoplasmic reticulum2025 ribosome2025 ribonucleoprotein complex2025 plasma membrane2019 cytosolic ribosome2025 ciliary plasm2017 chloroplast2018 Hrd1p ubiquitin ligase complex2016 Hrd1p ubiquitin ligase ERAD-L complex2013

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 13/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 4/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 40/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 5 10 15 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
DERL1_MOUSE
Ensembl»
14.1
Derl1 Derlin-1 (Degradation in endoplasmic reticulum
protein 1) (Der1-like protein 1)		 Mus musculus
TI:10090 None
 
DER21_ARATH
TAIR»
1.5
DER2.1 Derlin-2.1 (AtDerlin2-1) Arabidopsis thaliana
TI:3702 None
 
DERL2_HUMAN
Ensembl»
8.5
DERL2 Derlin-2 (Degradation in endoplasmic reticulum protein
2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)		 Homo sapiens
TI:9606 None
 
DERL2_MOUSE
Ensembl»
10.1
Derl2 Derlin-2 (Degradation in endoplasmic reticulum
protein 2) (Der1-like protein 2) (F-LANa)		 Mus musculus
TI:10090 None
 
DERL3_HUMAN
Ensembl»
8.4
DERL3 Derlin-3 (Degradation in endoplasmic reticulum
protein 3) (DERtrin-3) (Der1-like protein 3)		 Homo sapiens
TI:9606 None
 
RBL15_ARATH
TAIR»
1.5
RBL15 Rhomboid-like protein 15 (AtRBL15) (EC 3.4.21.-) Arabidopsis thaliana
TI:3702 None
 
DER1_YEAST
SGD»
6.9
DER1 Degradation in the
endoplasmic reticulum protein 1		 Saccharomyces cerevisiae
TI:4932 None
 
DER22_ARATH
TAIR»
1.5
DER2.2 Derlin-2.2 (AtDerlin2-2) Arabidopsis thaliana
TI:3702 None
 
DERL3_MOUSE
Ensembl»
6.0
Derl3 Derlin-3 (Degradation in endoplasmic reticulum protein
3) (Der1-like protein 3) (Protein IZP6)		 Mus musculus
TI:10090 None
 
RHBD2_HUMAN
Ensembl»
1.5
RHBDD2 Rhomboid domain-containing protein 2 Homo sapiens
TI:9606 None
 
RHBD2_MOUSE
Ensembl»
0.5
Rhbdd2 Rhomboid domain-containing protein
2 (Rhomboid-like protein 7)		 Mus musculus
TI:10090 None
 
DERL1_ARATH
TAIR»
1.5
DER1 Derlin-1 (AtDerlin1-1) Arabidopsis thaliana
TI:3702 None
 
DERL1_HUMAN
Ensembl»
18.1
DERL1 Derlin-1 (Degradation in endoplasmic reticulum
protein 1) (DERtrin-1) (Der1-like protein 1)		 Homo sapiens
TI:9606 None
 
DFM1_YEAST
SGD»
5.5
DFM1 DER1-like family member protein 1 Saccharomyces cerevisiae
TI:4932 None
 
Q4VBS8_DANRE
ZFIN»
1.5
derl2 Derlin Danio rerio
TI:7955 None
 
DERL1_DROME
FlyBase»
4.6
Der-1 Derlin-1 (DER1-like protein 1) Drosophila melanogaster
TI:7227 None
 
DERL2_CAEEL
WormBase»
5.0
der-2 Derlin-2 (DER1-like protein 2) (cDerlin-2) Caenorhabditis elegans
TI:6239 None
 
Q9VEU2_DROME
FlyBase»
3.3
Der-2 Derlin Drosophila melanogaster
TI:7227 None
 
DERL1_CAEEL
WormBase»
4.1
cup-2 Derlin-1 (Coelomocyte uptake defective protein
2) (DER1-like protein 1) (cDerlin-1)		 Caenorhabditis elegans
TI:6239 None
 
DERL1_DICDI
dictyBase»
2.5
derl1 Probable derlin-1 homolog Dictyostelium discoideum
TI:44689 None
 
DERL2_DICDI
dictyBase»
2.5
derl2 Probable derlin-2 homolog Dictyostelium discoideum
TI:44689 None
 
F1Q4W3_DANRE
ZFIN»
1.5
derl1 Derlin Danio rerio
TI:7955 None
 
F1R121_DANRE
ZFIN»
1.5
derl3 Derlin Danio rerio
TI:7955 None
 
Q5ZMF9_CHICK
Ensembl»
3.5
DERL1 Derlin Gallus gallus
TI:9031 None
 
YFFH_SCHPO
PomBase»
1.5
SPAC1687.17c Uncharacterized derlin-like protein C1687.17c Schizosaccharomyces pombe
TI:4896 None
 
YGR8_SCHPO
PomBase»
1.5
SPBC365.08c Uncharacterized derlin-like protein C365.08c Schizosaccharomyces pombe
TI:4896 None
 
A0A1D5PW06_CHICK
Ensembl»
0.0
DERL2 Derlin Gallus gallus
TI:9031 None
   
A0A8I6AMH0_RAT
RGD»
1.5
Derl2 Derlin Rattus norvegicus
TI:10116 None
   
A0ABK0LU34_RAT
RGD»
8.5
LOC120094610 Derlin Rattus norvegicus
TI:10116 None
   
D3ZQG3_RAT
RGD»
0.5
Rhbdd2 Rhomboid domain containing 2 Rattus norvegicus
TI:10116 None
   
F6RIR9_CHICK
Ensembl»
1.5
DERL3 Derlin Gallus gallus
TI:9031 None
   
G3V8X2_RAT
RGD»
3.0
Derl3 Derlin Rattus norvegicus
TI:10116 None