Standard knownness: 18.1; Custom knownness: None; Num. species: 98; Orthology database: Panther19.0; Protein members: 334
Molecular function:
ERAD pathway2004, 2006, 2012, 2013, 2014, 2015, 2023, 2024, 2025
endoplasmic reticulum unfolded protein response2004, 2006, 2012, 2013, 2019, 2023, 2025
response to stress2025
cellular response to stress2025
proteolysis involved in protein catabolic process2025
proteasomal protein catabolic process2025
retrograde protein transport, ER to cytosol2004, 2006, 2013, 2014, 2015, 2025
negative regulation of retrograde protein transport, ER to cytosol2015, 2025
protein N-linked glycosylation2012, 2025
response to unfolded protein2012, 2025
protein destabilization2014, 2025
positive regulation of cell population proliferation2005, 2006, 2025
positive regulation of cell growth2005, 2006, 2025
positive regulation of protein ubiquitination2015, 2025
cellular response to misfolded protein2023, 2025
proteasome-mediated ubiquitin-dependent protein catabolic process2018, 2025
protein transport2025
ubiquitin-dependent protein catabolic process2025
response to misfolded protein2009, 2025
endocytosis2004, 2025
regulation of retrograde protein transport, ER to cytosol2019, 2023
regulation of cell cycle process2009
proteolysis2025
protein quality control for misfolded or incompletely synthesized proteins2004
cellular response to unfolded protein2012
IRE1-mediated unfolded protein response2018
translation2025
suckling behavior2013
secretion by cell2011
response to endoplasmic reticulum stress2014
regulation of transcription by RNA polymerase II2011
protein folding2025
positive regulation of apoptotic process2014
misfolded protein transport2014
hyphal growth2011
establishment of protein localization2004
defense response to bacterium2012
Cellular component:
endoplasmic reticulum membrane2004, 2006, 2012, 2013, 2014, 2016, 2022, 2025
endoplasmic reticulum2006, 2009, 2012, 2018, 2023, 2025
membrane2012, 2014, 2025
early endosome2011, 2012, 2025
late endosome2012, 2025
Golgi apparatus2013, 2024, 2025
perinuclear region of cytoplasm2013, 2025
Golgi membrane2013, 2025
Derlin-1-VIMP complex2015, 2025
Derlin-1 retrotranslocation complex2015, 2025
endoplasmic reticulum quality control compartment2020, 2025
cytoplasm2017, 2018, 2025
perinuclear endoplasmic reticulum2011, 2025
endosome2009, 2025
nucleoplasm2017, 2025
cytosol2019, 2025
apicoplast2009
ATPase complex2025
rough endoplasmic reticulum2025
ribosome2025
ribonucleoprotein complex2025
plasma membrane2019
cytosolic ribosome2025
ciliary plasm2017
chloroplast2018
Hrd1p ubiquitin ligase complex2016
Hrd1p ubiquitin ligase ERAD-L complex2013
| Chordates: | 22/21 | ![]() |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 3/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 13/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 3/3 | |
| Excavates: | 4/4 | |
| Harosa: | 4/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 40/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 |
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