Collated Gene Ontology terms

Biological process: transcription coregulator activity(2007, 2025) ubiquitin protein ligase activity(2014, 2025) transcription coactivator activity(2007) TFIIH-class transcription factor complex binding(2020)

Molecular function: regulation of transcription by RNA polymerase II2007, 2020, 2025 DNA-templated transcription2025 protein ubiquitination2014, 2025 positive regulation of transcription initiation by RNA polymerase II2024, 2025 positive regulation of transcription elongation by RNA polymerase II2024, 2025 RNA polymerase II preinitiation complex assembly2024, 2025 visual behavior2025 transcription by RNA polymerase II2008 positive regulation of DNA-templated transcription2024 auditory behavior2025

Cellular component: mediator complex2005, 2009, 2012, 2023, 2025 nucleus2011, 2018, 2024, 2025 ubiquitin ligase complex2014, 2025 core mediator complex2015, 2025 nucleoplasm2010, 2013

Phylogenetic distribution

Chordates: 19/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 4/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
MED11_MOUSE
Ensembl»
2.8
Med11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Mus musculus
TI:10090 None
 
MED11_DROME
FlyBase»
4.2
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11) (dMED21)		 Drosophila melanogaster
TI:7227 None
 
MED11_HUMAN
Ensembl»
1.8
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Homo sapiens
TI:9606 None
 
A0A0G2K2A7_RAT
RGD»
1.6
Med11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Rattus norvegicus
TI:10116 None
   
MED11_DICDI
dictyBase»
1.0
med11 Putative mediator of RNA polymerase II transcription
subunit 11 (Putative mediator complex subunit 11)		 Dictyostelium discoideum
TI:44689 None
 
MED11_ARATH
TAIR»
0.0
MED11 Mediator of RNA polymerase
II transcription subunit 11		 Arabidopsis thaliana
TI:3702 None
 
MED11_DANRE
ZFIN»
1.6
med11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Danio rerio
TI:7955 None
 
A0A022R2N4_ERYGU
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Erythranthe guttata
TI:4155 None
 
A0A061FQD7_THECC
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Theobroma cacao
TI:3641 None
 
A0A061FXJ7_THECC
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Theobroma cacao
TI:3641 None
 
A0A061GG64_THECC
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Theobroma cacao
TI:3641 None
 
A0A067GSU8_CITSI
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Citrus sinensis
TI:2711 None
 
A0A078GT42_BRANA
euHCVdb»
0.0
BnaCnng05620D Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Brassica napus
TI:3708 None
 
A0A078HI85_BRANA
euHCVdb»
0.0
BnaA05g33870D Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Brassica napus
TI:3708 None
 
A0A078IJ04_BRANA
euHCVdb»
0.0
BnaC05g48810D Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Brassica napus
TI:3708 None
 
A0A0A0L450_CUCSA
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Cucumis sativus
TI:3659 None
 
A0A0K9Q613_ZOSMR
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Zostera marina
TI:29655 None
 
A0A1D5RCJ7_MACMU
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Macaca mulatta
TI:9544 None
   
A0A1S3XZ45_TOBAC
euHCVdb»
0.0
LOC107770332 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Nicotiana tabacum
TI:4097 None
   
A0A1S3Y8Z7_TOBAC
euHCVdb»
0.0
LOC107773720 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Nicotiana tabacum
TI:4097 None
   
A0A1S3ZCE3_TOBAC
euHCVdb»
0.0
LOC107785314 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Nicotiana tabacum
TI:4097 None
   
A0A1S3ZN14_TOBAC
euHCVdb»
0.0
LOC107788739 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Nicotiana tabacum
TI:4097 None
   
A0A1S4HDK1_ANOGA
EnsemblMetazoa»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Anopheles gambiae
TI:7165 None
 
A0A1U7ZB21_NELNU
euHCVdb»
0.0
LOC104592276 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Nelumbo nucifera
TI:4432 None
   
A0A1U8AI64_NELNU
euHCVdb»
0.0
LOC104600523 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Nelumbo nucifera
TI:4432 None
   
A0A1U8GL63_CAPAN
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Capsicum annuum
TI:4072 None
 
A0A1U8JSQ4_GOSHI
euHCVdb»
0.0
LOC107910070 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Gossypium hirsutum
TI:3635 None
   
A0A1U8PR25_GOSHI
euHCVdb»
0.0
LOC107961942 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Gossypium hirsutum
TI:3635 None
   
A0A1Y1HXZ1_KLENI
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Klebsormidium nitens
TI:105231 None
 
A0A251S6P7_HELAN
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Helianthus annuus
TI:4232 None
 
A0A251UK73_HELAN
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Helianthus annuus
TI:4232 None
 
A0A2A6CQM7_PRIPA
EnsemblMetazoa»
0.0
WBGene00204338 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Pristionchus pacificus
TI:54126 None
   
A0A2C9U966_MANES
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Manihot esculenta
TI:3983 None
 
A0A2I4F7W3_JUGRE
euHCVdb»
0.0
LOC108996340 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Juglans regia
TI:51240 None
   
A0A2K2AMX6_POPTR
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Populus trichocarpa
TI:3694 None
 
A0A2R6XHX6_MARPO
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Marchantia polymorpha
TI:3197 None
 
A0A3B3HGV7_ORYLA
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Oryzias latipes
TI:8090 None
   
A0A3B6NQ16_WHEAT
EnsemblPlants»
0.0
LOC123127215 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Triticum aestivum
TI:4565 None
   
A0A3B6PM27_WHEAT
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Triticum aestivum
TI:4565 None
   
A0A3B6QDA1_WHEAT
EnsemblPlants»
0.0
LOC123144298 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Triticum aestivum
TI:4565 None
   
A0A3B6RLY1_WHEAT
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Triticum aestivum
TI:4565 None
   
A0A3B6TX70_WHEAT
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Triticum aestivum
TI:4565 None
   
A0A3P5ZDV9_BRACM
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Brassica campestris
TI:3711 None
   
A0A4X1UXV1_PIG
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Sus scrofa
TI:9823 None
   
A0A5F5PLU4_HORSE
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Equus caballus
TI:9796 None
   
A0A5F8GLL5_MONDO
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Monodelphis domestica
TI:13616 None
   
A0A6I8N8Y1_ORNAN
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7I3ZZY2_PHYPA
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Physcomitrium patens
TI:3218 None
 
A0A7M7NQ44_STRPU
EnsemblMetazoa»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A804HSW9_MUSAM
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Musa acuminata
TI:4641 None
 
A0A804LDR2_MAIZE
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Zea mays
TI:4577 None
   
A0A804P3Q6_MAIZE
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Zea mays
TI:4577 None
   
A0A9J7M240_BRAFL
euHCVdb»
0.0
LOC118427383 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Branchiostoma floridae
TI:7739 None
   
A0A9R0KDL5_SPIOL
euHCVdb»
0.0
LOC110805682 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Spinacia oleracea
TI:3562 None
   
A0A9R1X2J3_LACSA
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Lactuca sativa
TI:4236 None
 
A7EPY8_SCLS1
TubercuList»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Sclerotinia sclerotiorum
TI:5180 None
 
A7RKV3_NEMVE
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Nematostella vectensis
TI:45351 None
 
A9SS72_PHYPA
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Physcomitrium patens
TI:3218 None
 
B3RPT2_TRIAD
CTD»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Trichoplax adhaerens
TI:10228 None
 
B7PMU4_IXOSC
EnsemblMetazoa»
0.0
8053355 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Ixodes scapularis
TI:6945 None
 
B9RXD4_RICCO
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Ricinus communis
TI:3988 None
 
C0PM57_MAIZE
EnsemblPlants»
0.0
LOC100277150 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Zea mays
TI:4577 None
 
C5XX18_SORBI
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Sorghum bicolor
TI:4558 None
 
C5XX20_SORBI
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Sorghum bicolor
TI:4558 None
 
D6WLX0_TRICA
CTD»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Tribolium castaneum
TI:7070 None
 
D7SIR5_VITVI
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Vitis vinifera
TI:29760 None
 
D8S989_SELML
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Selaginella moellendorffii
TI:88036 None
 
D8SVN5_SELML
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Selaginella moellendorffii
TI:88036 None
 
E9H7V7_DAPPU
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Daphnia pulex
TI:6669 None
 
F0ZZW9_DICPU
TubercuList»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Dictyostelium purpureum
TI:5786 None
 
F1MG57_BOVIN
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Bos taurus
TI:9913 None
   
G3QRU5_GORGO
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Gorilla gorilla
TI:9593 None
 
G7I5W9_MEDTR
EnsemblPlants»
0.0
11414265 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Medicago truncatula
TI:3880 None
 
G7LCE6_MEDTR
EnsemblPlants»
0.0
11413700 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Medicago truncatula
TI:3880 None
 
H2QBY2_PANTR
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Pan troglodytes
TI:9598 None
 
H3GWW0_PHYRM
EnsemblProtists»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Phytophthora ramorum
TI:164328 None
 
I1HY54_BRADI
EnsemblPlants»
0.0
LOC100831854 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Brachypodium distachyon
TI:15368 None
 
I1JP91_SOYBN
EnsemblPlants»
0.0
LOC100792126 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Glycine max
TI:3847 None
 
K3YWB2_SETIT
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Setaria italica
TI:4555 None
 
M1C635_SOLTU
EnsemblPlants»
0.0
LOC102599143 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Solanum tuberosum
TI:4113 None
   
M4FDE8_BRACM
EnsemblPlants»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Brassica campestris
TI:3711 None
   
M5VN18_PRUPE
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Prunus persica
TI:3760 None
 
M5VNY5_PRUPE
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Prunus persica
TI:3760 None
 
MED11_BOVIN
CTD»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Bos taurus
TI:9913 None
 
MED11_CAEBR
WormBase»
0.0
mdt-11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Caenorhabditis briggsae
TI:6238 None
 
MED11_CAEEL
WormBase»
0.0
mdt-11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Caenorhabditis elegans
TI:6239 None
 
MED11_XENLA
Xenbase»
0.0
med11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Xenopus laevis
TI:8355 None
 
MED11_XENTR
Xenbase»
0.0
med11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Xenopus tropicalis
TI:8364 None
 
Q1K7L9_NEUCR
TubercuList»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Neurospora crassa
TI:5141 None
 
Q5BGN9_EMENI
TubercuList»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Emericella nidulans
TI:162425 None
 
Q6C590_YARLI
TubercuList»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Yarrowia lipolytica
TI:4952 None
 
Q6YUV3_ORYSJ
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Oryza sativa
TI:4530 None
 
T1FZH4_HELRO
EnsemblMetazoa»
0.0
20214222 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Helobdella robusta
TI:6412 None
 
W1P6Z7_AMBTC
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Amborella trichopoda
TI:13333 None
 
W1PYC6_AMBTC
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Amborella trichopoda
TI:13333 None
 
W5N6D7_LEPOC
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Lepisosteus oculatus
TI:7918 None
 
A0A2K3D2L1_CHLRE
neXtProt»
0.0
CHLRE_12g511250v5 Mediator of RNA polymerase
II transcription subunit 11		 Chlamydomonas reinhardtii
TI:3055 None
 
A0A8I3NQ28_CANLF
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Canis lupus
TI:9612 None
   
A0A9K3IW81_HELAN
euHCVdb»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Helianthus annuus
TI:4232 None
 
A0ABI7Z4Z7_FELCA
Ensembl»
0.0
MED11 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Felis catus
TI:9685 None
   
I1N9W7_SOYBN
EnsemblPlants»
0.0
LOC100306257 Mediator of RNA polymerase II transcription
subunit 11 (Mediator complex subunit 11)		 Glycine max
TI:3847 None