Collated Gene Ontology terms

Biological process: peptidase activity(2007, 2008, 2013, 2016, 2021, 2025) serine-type endopeptidase activity(2021, 2025) signal peptidase activity(2025) hydrolase activity(2025) protein phosphatase inhibitor activity(2025) zinc ion binding(2025) serine hydrolase activity(2021) nucleic acid binding(2025) enzyme binding(2025)

Molecular function: signal peptide processing2007, 2013, 2016, 2021, 2024, 2025 proteolysis2025 protein targeting to ER2013, 2025 regulation of signal transduction2025 response to virus2023 IRE1-mediated unfolded protein response2018

Cellular component: signal peptidase complex2007, 2014, 2016, 2019, 2021, 2025 membrane2025 endoplasmic reticulum membrane2009, 2013, 2024, 2025 endomembrane system2014, 2025 endoplasmic reticulum2009, 2011, 2013, 2016, 2017, 2021, 2025 plasma membrane2021, 2025 chloroplast2018 serine-type endopeptidase complex2025 plant-type vacuole2021 nuclear envelope2025
membrane protein complex2025 cytoplasm2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 4/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 7/8 
Bacteria: 2/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
O97066_DROME
FlyBase»
3.1
twr Signal peptidase complex catalytic
subunit SEC11 (EC 3.4.21.89)		 Drosophila melanogaster
TI:7227 None
 
SEC11_YEAST
SGD»
4.8
SEC11 Signal peptidase complex catalytic subunit SEC11 (EC
3.4.21.89) (Secretory protein 11) (Signal peptidase I)		 Saccharomyces cerevisiae
TI:4932 None
 
SC11A_HUMAN
Ensembl»
4.4
SEC11A Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase
18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18)		 Homo sapiens
TI:9606 None
 
SC11A_MOUSE
Ensembl»
3.0
Sec11a Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18
kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) (Sid 2895)		 Mus musculus
TI:10090 None
 
SC11A_RAT
RGD»
3.0
Sec11a Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase
18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18)		 Rattus norvegicus
TI:10116 None
 
SC11C_MOUSE
Ensembl»
3.0
Sec11c Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21
kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21)		 Mus musculus
TI:10090 None
 
SC11C_RAT
RGD»
3.0
Sec11c Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21
kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21)		 Rattus norvegicus
TI:10116 None
 
SC11C_HUMAN
Ensembl»
2.6
SEC11C Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21
kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21)		 Homo sapiens
TI:9606 None
 
Q9SSR2_ARATH
TAIR»
1.0
At1g52600 Signal peptidase complex catalytic subunit SEC11 (EC
3.4.21.89) (Signal peptidase complex catalytic subunit sec11)		 Arabidopsis thaliana
TI:3702 None
 
Q9LW08_ARATH
TAIR»
1.0
At3g15710 signal peptidase I (EC 3.4.21.89) Arabidopsis thaliana
TI:3702 None
 
SEC11_DICDI
dictyBase»
2.0
sec11 Signal peptidase complex catalytic
subunit sec11 (EC 3.4.21.89)		 Dictyostelium discoideum
TI:44689 None
 
Q9N3D0_CAEEL
WormBase»
1.5
sec-11 Signal peptidase complex catalytic
subunit SEC11 (EC 3.4.21.89)		 Caenorhabditis elegans
TI:6239 None
 
SEC11_SCHPO
PomBase»
1.5
sec11 Signal peptidase complex catalytic
subunit sec11 (EC 3.4.21.89)		 Schizosaccharomyces pombe
TI:4896 None
 
A0A8V0YDP0_CHICK
Ensembl»
1.0
SEC11C Signal peptidase complex catalytic
subunit SEC11 (EC 3.4.21.89)		 Gallus gallus
TI:9031 None
   
Q6DGR3_DANRE
ZFIN»
1.0
sec11a Signal peptidase complex catalytic
subunit SEC11 (EC 3.4.21.89)		 Danio rerio
TI:7955 None
 
SC11B_HUMAN
AG»
1.0
SEC11B Putative signal peptidase complex catalytic subunit SEC11B
(EC 3.4.21.89) (SEC11 homolog B) (SEC11-like protein 2)		 Homo sapiens
TI:9606 None
 
Q5ZMQ3_CHICK
Ensembl»
0.0
SEC11A Signal peptidase complex catalytic
subunit SEC11 (EC 3.4.21.89)		 Gallus gallus
TI:9031 None