Collated Gene Ontology terms

Biological process: protein tyrosine kinase activity(2019) protein serine/threonine kinase activity(2024) protein kinase activity(2024) ATP binding(2024)

Molecular function: small ncRNA-mediated heterochromatin formation2015, 2024 negative regulation of RNA catabolic process2023, 2024 RNA processing2024 mRNA stabilization2022, 2024 RNA splicing2020, 2024 DNA damage response2020, 2024 positive regulation of RNA export from nucleus2019, 2024 mitotic cell cycle2020, 2024 mRNA processing2024 cell division2024
RNA-mediated gene silencing2012, 2024 protein phosphorylation2024 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing2023 ncRNA-mediated post-transcriptional gene silencing2011 mRNA splicing, via spliceosome2010

Cellular component: nucleus2009, 2012, 2020, 2024 nuclear speck2019, 2020, 2024 nucleolus2019, 2024 nucleoplasm2019, 2020, 2024 catalytic step 2 spliceosome2010, 2024 spliceosomal complex2021 membrane2024 cytoplasm2023

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 11/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 35/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
W1PM14_AMBTC
EnsemblPlants»
0.0
AMTR_s00024p00121650 Protein kinase domain-containing protein Amborella trichopoda
TI:13333 None
 
G1KQ07_ANOCA
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Anolis carolinensis
TI:28377 None
   
A0A1S4H4P1_ANOGA
EnsemblMetazoa»
0.0
Protein NRDE2 homolog Anopheles gambiae
TI:7165 None
 
F4J6D7_ARATH
TAIR»
0.0
At3g17712 Protein NRDE2 homolog Arabidopsis thaliana
TI:3702 None
 
Q9LSH4_ARATH
TAIR»
0.0
At3g17740 At3g17740/MIG5_3 At3g17740 (Uncharacterized
protein At3g17740/MIG5_3)		 Arabidopsis thaliana
TI:3702 None
 
Q4WLJ0_ASPFU
EnsemblFungi»
0.0
AFUA_6G13360 NRDE-2, necessary for
RNA interference-domain-containing protein		 Aspergillus fumigatus
TI:746128 None
 
F4P9P8_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_91264 Suppressor of forked domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
A0A3Q1NNB2_BOVIN
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Bos taurus
TI:9913 None
   
I1IEQ2_BRADI
EnsemblPlants»
0.0
100822966 Suppressor of forked domain-containing protein Brachypodium distachyon
TI:15368 None
 
A0A9J7LVD7_BRAFL
CTD»
0.0
LOC118425103 Nuclear exosome regulator NRDE2-like Branchiostoma floridae
TI:7739 None
   
M4E0E1_BRACM
EnsemblPlants»
0.0
Suppressor of forked domain-containing protein Brassica campestris
TI:3711 None
   
H8WH80_CAEBR
WormBase»
0.0
nrde-2 Protein CBR-NRDE-2 Caenorhabditis briggsae
TI:6238 None
 
NRDE2_CAEEL
WormBase»
3.9
nrde-2 Nuclear exosome regulator NRDE2
(Nuclear RNAi defective-2 protein)		 Caenorhabditis elegans
TI:6239 None
 
A0A8I3NQK7_CANLF
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Canis lupus
TI:9612 None
   
A0A2G2ZN18_CAPAN
EnsemblPlants»
0.0
T459_11784 Uncharacterized protein Capsicum annuum
TI:4072 None
 
A0A2G3A0U8_CAPAN
EnsemblPlants»
0.0
T459_09927 Protein NRDE2 homolog Capsicum annuum
TI:4072 None
 
A0A2K3D0Z2_CHLRE
EnsemblPlants»
0.0
CHLRE_13g589650v5 Suppressor of forked domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
F6QKB5_CIOIN
Ensembl»
0.0
LOC100177099 Protein NRDE2 homolog Ciona intestinalis
TI:7719 None
 
A0A067DUY2_CITSI
Ensembl»
0.0
CISIN_1g001167mg Protein NRDE2 homolog Citrus sinensis
TI:2711 None
 
Q5K7T3_CRYNJ
EnsemblFungi»
0.0
CNM01360 DUF1740-domain-containing protein Cryptococcus neoformans
TI:5207 None
 
A0A0A0LVY4_CUCSA
EnsemblPlants»
0.0
Csa_1G043050 Protein NRDE2 homolog Cucumis sativus
TI:3659 None
 
E7F365_DANRE
ZFIN»
1.0
nrde2 NRDE-2, necessary for RNA
interference, domain-containing (Protein NRDE2 homolog)		 Danio rerio
TI:7955 None
 
E9H5W0_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_308050 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F0ZZ12_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_99413 Suppressor of forked domain-containing protein Dictyostelium purpureum
TI:5786 None
 
NRDE2_DICDI
dictyBase»
1.5
nrde2 Nuclear exosome regulator
NRDE2 (Protein NRDE2 homolog)		 Dictyostelium discoideum
TI:44689 None
 
Q9VXW9_DROME
FlyBase»
2.0
Dmel\CG5877 Uncharacterized protein, isoform A
(Uncharacterized protein, isoform D)		 Drosophila melanogaster
TI:7227 None
 
Q5B1X4_EMENI
EnsemblFungi»
0.0
ANIA_05456 DUF1740-domain-containing protein Emericella nidulans
TI:162425 None
 
A0A022Q2P1_ERYGU
EnsemblFungi»
0.0
MIMGU_mgv1a000564mg Protein NRDE2 homolog Erythranthe guttata
TI:4155 None
 
M3WEV8_FELCA
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Felis catus
TI:9685 None
 
A0A8V0Z1Z2_CHICK
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Gallus gallus
TI:9031 None
   
I1L3Z9_SOYBN
EnsemblPlants»
0.0
100812285 Suppressor of forked domain-containing protein Glycine max
TI:3847 None
 
I1MQN2_SOYBN
EnsemblPlants»
0.0
100786596 Suppressor of forked domain-containing protein Glycine max
TI:3847 None
 
G3R0F7_GORGO
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Gorilla gorilla
TI:9593 None
 
A0A1U8HTU0_GOSHI
Ensembl»
0.0
LOC107887131 Protein NRDE2 homolog isoform X1 Gossypium hirsutum
TI:3635 None
   
A0A1U8JS35_GOSHI
Ensembl»
0.0
LOC107908438 Protein NRDE2 homolog isoform X1 Gossypium hirsutum
TI:3635 None
   
A0A251VKK6_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr01g0002621 HanXRQr2_Chr14g0625691 SiRNA-mediated silencing protein NRDE-2 Helianthus annuus
TI:4232 None
 
T1FVA9_HELRO
EnsemblMetazoa»
0.0
20212755 Suppressor of forked domain-containing protein Helobdella robusta
TI:6412 None
 
NRDE2_HUMAN
Ensembl»
5.0
NRDE2 Nuclear exosome regulator
NRDE2 (Protein NRDE2 homolog)		 Homo sapiens
TI:9606 None
 
F2DY98_HORVV
EnsemblPlants»
0.0
Predicted protein Hordeum vulgare
TI:4513 None
 
B7P6Q4_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW001175 Uncharacterized protein Ixodes scapularis
TI:6945 None
 
A0A2I4GZ24_JUGRE
EnsemblPlants»
0.0
LOC109012102 Nuclear exosome regulator NRDE2 Juglans regia
TI:51240 None
 
A0A6P9EQM4_JUGRE
EnsemblPlants»
0.0
LOC118348493 Nuclear exosome regulator NRDE2-like Juglans regia
TI:51240 None
   
A0A1Y1HKF9_KLENI
EnsemblPlants»
0.0
KFL_000240040 Uncharacterized protein Klebsormidium nitens
TI:105231 None
 
W5MRK8_LEPOC
Ensembl»
0.0
NRDE-2, necessary for
RNA interference, domain containing		 Lepisosteus oculatus
TI:7918 None
 
F7CR99_MACMU
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Macaca mulatta
TI:9544 None
   
A0A2C9VLL0_MANES
EnsemblPlants»
0.0
MANES_06G000900 Protein NRDE2 homolog Manihot esculenta
TI:3983 None
 
A0A2R6W2R1_MARPO
EnsemblPlants»
0.0
MARPO_0172s0015 Suppressor of forked domain-containing protein Marchantia polymorpha
TI:3197 None
 
G7JP36_MEDTR
EnsemblPlants»
0.0
11415298 Putative siRNA-mediated silencing protein NRDE-2 Medicago truncatula
TI:3880 None
 
G7KIG9_MEDTR
EnsemblPlants»
0.0
MTR_6g072640 Uncharacterized protein Medicago truncatula
TI:3880 None
 
G7KJ52_MEDTR
EnsemblPlants»
0.0
MTR_6g074610 Uncharacterized protein Medicago truncatula
TI:3880 None
 
F7CXT9_MONDO
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Monodelphis domestica
TI:13616 None
   
A9UTC3_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_23417 Uncharacterized protein Monosiga brevicollis
TI:81824 None
 
NRDE2_MOUSE
Ensembl»
2.5
Nrde2 Nuclear exosome regulator
NRDE2 (Protein NRDE2 homolog)		 Mus musculus
TI:10090 None
 
A0A804KRA5_MUSAM
EnsemblPlants»
0.0
Protein NRDE2 homolog Musa acuminata
TI:4641 None
   
A0A1U8B5Q7_NELNU
EnsemblBacteria»
0.0
LOC104611077 Protein NRDE2 homolog Nelumbo nucifera
TI:4432 None
   
A7RZP5_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g241809 Protein NRDE2 homolog Nematostella vectensis
TI:45351 None
 
Q7RYK9_NEUCR
EnsemblFungi»
0.0
NCU00120 DUF1740-domain-containing protein Neurospora crassa
TI:5141 None
 
A0A1S3ZC07_TOBAC
EnsemblFungi»
0.0
LOC107785207 Protein NRDE2 homolog isoform X1 Nicotiana tabacum
TI:4097 None
   
A0A1S3ZHR1_TOBAC
EnsemblFungi»
0.0
LOC107786802 Protein NRDE2 homolog Nicotiana tabacum
TI:4097 None
   
A0A6I8PAN7_ORNAN
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Ornithorhynchus anatinus
TI:9258 None
   
Q6ZHF3_ORYSJ
EnsemblPlants»
0.0
Os02g0772500 Os02g0772500 protein Oryza sativa
TI:4530 None
 
H2MTT5_ORYLA
Ensembl»
0.0
nrde2 NRDE-2, necessary for
RNA interference, domain containing		 Oryzias latipes
TI:8090 None
   
H2R982_PANTR
Ensembl»
0.0
NRDE2 Chromosome 14 open reading frame 102
(NRDE-2, necessary for RNA interference, domain containing)		 Pan troglodytes
TI:9598 None
 
A0DU55_PARTE
EnsemblProtists»
0.0
GSPATT00020243001 Chromosome undetermined scaffold_64,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None
 
A0A7I4EHU7_PHYPA
EnsemblPlants»
0.0
Suppressor of forked domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A2K1XHD6_POPTR
EnsemblPlants»
0.0
POPTR_015G033300 Suppressor of forked domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A2A6B923_PRIPA
EnsemblMetazoa»
0.0
WBGene00098731 Golgi apparatus membrane protein TVP23 homolog Pristionchus pacificus
TI:54126 None
 
A0A251PD18_PRUPE
EnsemblPlants»
0.0
PRUPE_5G239800 Suppressor of forked domain-containing protein Prunus persica
TI:3760 None
 
E3KBE5_PUCGT
EnsemblFungi»
0.0
PGTG_07907 DUF1740-domain-containing protein Puccinia graminis
TI:5297 None
 
A0A8I6AG13_RAT
RGD»
3.5
Nrde2 NRDE-2, necessary for
RNA interference, domain containing		 Rattus norvegicus
TI:10116 None
   
B9SNW2_RICCO
EnsemblBacteria»
0.0
RCOM_0582330 Protein NRDE2 homolog Ricinus communis
TI:3988 None
 
B6K0D8_SCHJY
EnsemblFungi»
0.0
SJAG_01331 DuF1740 family protein Schizosaccharomyces japonicus
TI:4897 None
 
NRDE2_SCHPO
PomBase»
1.8
SPBC20F10.05 Protein NRDE2 homolog Schizosaccharomyces pombe
TI:4896 None
 
A7F4M7_SCLS1
EnsemblFungi»
0.0
SS1G_12552 DUF1740-domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
D8R9W7_SELML
EnsemblPlants»
0.0
SELMODRAFT_88336 Suppressor of forked domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8SEJ0_SELML
EnsemblPlants»
0.0
SELMODRAFT_179031 Suppressor of forked domain-containing protein Selaginella moellendorffii
TI:88036 None
 
K3YPF1_SETIT
EnsemblPlants»
0.0
101761529 Suppressor of forked domain-containing protein Setaria italica
TI:4555 None
 
A0A3Q7FN71_SOLLC
EnsemblPlants»
0.0
101265113 Suppressor of forked domain-containing protein Solanum lycopersicum
TI:4081 None
   
C5XTI0_SORBI
EnsemblPlants»
0.0
SORBI_3004G314000 Protein NRDE2 homolog Sorghum bicolor
TI:4558 None
 
A0A7M7PUR5_STRPU
EnsemblMetazoa»
0.0
Protein NRDE2 homolog Strongylocentrotus purpuratus
TI:7668 None
   
F1SDA5_PIG
Ensembl»
0.0
NRDE2 NRDE-2, necessary for
RNA interference, domain containing		 Sus scrofa
TI:9823 None
   
A0A061FXE1_THECC
EnsemblPlants»
0.0
TCM_013315 UPF0614 protein C14orf102, putative isoform 1 Theobroma cacao
TI:3641 None
 
D6W9C7_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_00974 Protein NRDE2 homolog-like Protein Tribolium castaneum
TI:7070 None
 
B3S6G4_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_30197 Suppressor of forked domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A3B6NV53_WHEAT
EnsemblPlants»
0.0
CFC21_084633 Protein NRDE2 homolog Triticum aestivum
TI:4565 None
 
A0A3B6PSJ8_WHEAT
EnsemblPlants»
0.0
CFC21_089414 Protein NRDE2 homolog Triticum aestivum
TI:4565 None
 
A0A3B6QLR8_WHEAT
EnsemblPlants»
0.0
Protein NRDE2 homolog Triticum aestivum
TI:4565 None
   
F6HW74_VITVI
EnsemblPlants»
0.0
VIT_17s0119g00310 Protein NRDE2-like Vitis vinifera
TI:29760 None
 
F6HW75_VITVI
EnsemblPlants»
0.0
VIT_17s0119g00330 Protein NRDE2-like Vitis vinifera
TI:29760 None
 
A0A6I8PV13_XENTR
Xenbase»
0.0
nrde2 NRDE-2, necessary for RNA interference, domain
containing (Nuclear exosome regulator NRDE2 isoform X1)		 Xenopus tropicalis
TI:8364 None
   
Q6IRN3_XENLA
Xenbase»
0.0
nrde2.L MGC83828 protein (NRDE-2, necessary for
RNA interference, domain containing L homeolog)		 Xenopus laevis
TI:8355 None
 
Q6C750_YARLI
EnsemblFungi»
0.0
YALI0_E03762g YALI0E03762p Yarrowia lipolytica
TI:4952 None
 
A0A804PNU6_MAIZE
EnsemblPlants»
0.0
Protein NRDE2 Zea mays
TI:4577 None
   
A0A0K9PN27_ZOSMR
EnsemblPlants»
0.0
ZOSMA_20G00900 Protein NRDE2 homolog Zostera marina
TI:29655 None