Collated Gene Ontology terms

Biological process: cysteine-type deubiquitinase activity(2011, 2014, 2017, 2025) peptidase activity(2025) hydrolase activity(2025) deubiquitinase activity(2025) nucleotide binding(2025)

Molecular function: protein deubiquitination2011, 2025 proteolysis2025 membrane organization2025 membrane biogenesis2025 endocytosis2025 cranial skeletal system development2017 cell motility2025 central nervous system morphogenesis2010

Cellular component: cytosol2016, 2024, 2025 cytoplasm2025 plasma membrane2025 nucleus2018 membrane2014

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A3Q2HQB8_HORSE
Ensembl»
0.0
Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Equus caballus
TI:9796 None
   
A0A7M7NS88_STRPU
EnsemblMetazoa»
0.0
Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A804JAK5_MUSAM
EnsemblPlants»
0.0
ubiquitinyl hydrolase 1 (EC 3.4.19.12) Musa acuminata
TI:4641 None
   
H3GTW7_PHYRM
EnsemblProtists»
0.0
ubiquitinyl hydrolase 1 (EC 3.4.19.12) Phytophthora ramorum
TI:164328 None
 
M4DPD0_BRACM
EnsemblPlants»
0.0
ubiquitinyl hydrolase 1 (EC 3.4.19.12) Brassica campestris
TI:3711 None
   
M4FFW6_BRACM
EnsemblPlants»
0.0
ubiquitinyl hydrolase 1 (EC 3.4.19.12) Brassica campestris
TI:3711 None
   
W5N0M2_LEPOC
Ensembl»
0.0
Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Lepisosteus oculatus
TI:7918 None
 
G7K6B3_MEDTR
EnsemblPlants»
0.0
11413475 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Medicago truncatula
TI:3880 None
 
Q7Q9I0_ANOGA
EnsemblMetazoa»
0.0
1274934 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Anopheles gambiae
TI:7165 None
 
T1FYS9_HELRO
EnsemblMetazoa»
0.0
20213977 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Helobdella robusta
TI:6412 None
 
B7P7H9_IXOSC
EnsemblMetazoa»
0.0
8025771 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Ixodes scapularis
TI:6945 None
 
W1PR61_AMBTC
neXtProt»
0.0
AMTR_s00029p00222940 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Amborella trichopoda
TI:13333 None
 
D6X2A7_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_12435 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Tribolium castaneum
TI:7070 None
 
JOSL_ARATH
TAIR»
0.5
At2g29640 Josephin-like protein (EC 3.4.19.12) Arabidopsis thaliana
TI:3702 None
 
A0A078IN55_BRANA
neXtProt»
0.0
BnaA04g28510D ubiquitinyl hydrolase 1 (EC 3.4.19.12) Brassica napus
TI:3708 None
 
A0A078I6E5_BRANA
neXtProt»
0.0
BnaA05g12400D ubiquitinyl hydrolase 1 (EC 3.4.19.12) Brassica napus
TI:3708 None
 
A0A2K3DVG9_CHLRE
neXtProt»
0.0
CHLRE_03g146707v5 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Chlamydomonas reinhardtii
TI:3055 None
 
A0A067FHK4_CITSI
neXtProt»
0.0
CISIN_1g030121mg ubiquitinyl hydrolase 1 (EC 3.4.19.12) Citrus sinensis
TI:2711 None
 
A0A0A0KBN9_CUCSA
neXtProt»
0.0
Csa_6G187930 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Cucumis sativus
TI:3659 None
 
Q55DI9_DICDI
dictyBase»
0.5
DDB_G0269646 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Dictyostelium discoideum
TI:44689 None
 
F0ZVQ6_DICPU
TubercuList»
0.0
DICPUDRAFT_89426 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Dictyostelium purpureum
TI:5786 None
 
E9GLH3_DAPPU
neXtProt»
0.0
EOG090X0HOM ubiquitinyl hydrolase 1 (EC 3.4.19.12) Daphnia pulex
TI:6669 None
 
A0CQD9_PARTE
neXtProt»
0.0
GSPATT00009354001 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Paramecium tetraurelia
TI:5888 None
 
A0DAK4_PARTE
neXtProt»
0.0
GSPATT00014978001 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Paramecium tetraurelia
TI:5888 None
 
A0BSG9_PARTE
neXtProt»
0.0
GSPATT00031718001 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Paramecium tetraurelia
TI:5888 None
 
A0A9K3DVH5_HELAN
neXtProt»
0.0
HanXRQr2_Chr16g0766971 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Helianthus annuus
TI:4232 None
 
A0A1D5P643_CHICK
Ensembl»
0.5
JOSD1 Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Gallus gallus
TI:9031 None
   
A0A3B3H4W8_ORYLA
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Oryzias latipes
TI:8090 None
   
A0A4X1VR79_PIG
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Sus scrofa
TI:9823 None
 
A0A803TYG5_ANOCA
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Anolis carolinensis
TI:28377 None
   
A0A8I3S3G9_CANLF
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Canis lupus
TI:9612 None
   
A0A9L0S3J7_HORSE
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Equus caballus
TI:9796 None
   
A0ABI7YJ70_FELCA
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Felis catus
TI:9685 None
   
F6RDU7_MONDO
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Monodelphis domestica
TI:13616 None
   
F6T9U8_ORNAN
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Ornithorhynchus anatinus
TI:9258 None
   
G3QI57_GORGO
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Gorilla gorilla
TI:9593 None
 
G7N3V7_MACMU
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Macaca mulatta
TI:9544 None
 
H2QLP0_PANTR
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Pan troglodytes
TI:9598 None
 
JOS1_BOVIN
Ensembl»
0.0
JOSD1 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Bos taurus
TI:9913 None
 
JOS1_HUMAN
Ensembl»
2.3
JOSD1 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Homo sapiens
TI:9606 None
 
A0A2I2ZD86_GORGO
Ensembl»
0.0
JOSD2 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Gorilla gorilla
TI:9593 None
 
A0A2I3RRF5_PANTR
Ensembl»
0.0
JOSD2 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Pan troglodytes
TI:9598 None
 
A0A3Q2I2Y7_HORSE
Ensembl»
0.0
JOSD2 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Equus caballus
TI:9796 None
   
A0A6I8NUT6_ORNAN
Ensembl»
0.0
JOSD2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A8I3S288_CANLF
Ensembl»
0.0
JOSD2 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Canis lupus
TI:9612 None
   
A0AAA9T863_BOVIN
Ensembl»
0.0
JOSD2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Bos taurus
TI:9913 None
   
A0ABI8ALS4_FELCA
Ensembl»
0.0
JOSD2 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Felis catus
TI:9685 None
   
F1RH21_PIG
Ensembl»
0.0
JOSD2 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Sus scrofa
TI:9823 None
   
H2M703_ORYLA
Ensembl»
0.0
JOSD2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Oryzias latipes
TI:8090 None
   
H9FN04_MACMU
Ensembl»
0.0
JOSD2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Macaca mulatta
TI:9544 None
 
JOS2_HUMAN
Ensembl»
3.9
JOSD2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Homo sapiens
TI:9606 None
 
JOSL_DROME
FlyBase»
1.0
Josd Josephin-like protein (EC 3.4.19.12) Drosophila melanogaster
TI:7227 None
 
JOS1_MOUSE
Ensembl»
5.3
Josd1 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Mus musculus
TI:10090 None
 
JOS1_RAT
RGD»
3.5
Josd1 Josephin-1 (EC 3.4.19.12)
(Josephin domain-containing protein 1)		 Rattus norvegicus
TI:10116 None
 
D4AD44_RAT
RGD»
2.0
Josd2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Rattus norvegicus
TI:10116 None
   
JOS2_MOUSE
Ensembl»
3.1
Josd2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Mus musculus
TI:10090 None
 
A0A1Y1HLC5_KLENI
neXtProt»
0.0
KFL_000180550 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Klebsormidium nitens
TI:105231 None
 
A0A804LHL6_MAIZE
EnsemblPlants»
0.0
LOC100282423 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Zea mays
TI:4577 None
   
K7KA59_SOYBN
EnsemblPlants»
0.0
LOC100800726 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Glycine max
TI:3847 None
 
K7M807_SOYBN
EnsemblPlants»
0.0
LOC100814201 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Glycine max
TI:3847 None
 
I1H757_BRADI
EnsemblPlants»
0.0
LOC100846139 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Brachypodium distachyon
TI:15368 None
 
F6VV86_CIOIN
Ensembl»
0.0
LOC101242901 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Ciona intestinalis
TI:7719 None
   
A0A3Q7I2G7_SOLLC
EnsemblPlants»
0.0
LOC101267342 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Solanum lycopersicum
TI:4081 None
   
K4AFD6_SETIT
EnsemblPlants»
0.0
LOC101779065 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Setaria italica
TI:4555 None
 
M1BVG4_SOLTU
EnsemblPlants»
0.0
LOC102598337 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Solanum tuberosum
TI:4113 None
   
A0A1U7ZWI8_NELNU
neXtProt»
0.0
LOC104596979 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Nelumbo nucifera
TI:4432 None
   
A0A1S3WZJ8_TOBAC
neXtProt»
0.0
LOC107759602 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Nicotiana tabacum
TI:4097 None
   
A0A1S3YDT0_TOBAC
neXtProt»
0.0
LOC107775198 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Nicotiana tabacum
TI:4097 None
   
A0A1U8JLE6_GOSHI
neXtProt»
0.0
LOC107906607 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Gossypium hirsutum
TI:3635 None
   
A0A1U8PHK7_GOSHI
neXtProt»
0.0
LOC107959176 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Gossypium hirsutum
TI:3635 None
   
A0A2I4DE76_JUGRE
neXtProt»
0.0
LOC108979256 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Juglans regia
TI:51240 None
   
A0A9R0JAH3_SPIOL
neXtProt»
0.0
LOC110803049 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Spinacia oleracea
TI:3562 None
   
A0A2K1JM96_PHYPA
EnsemblPlants»
0.0
LOC112290550 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Physcomitrium patens
TI:3218 None
 
A0A9J7M729_BRAFL
euHCVdb»
0.0
LOC118429589 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Branchiostoma floridae
TI:7739 None
   
A0A3B6HU20_WHEAT
EnsemblPlants»
0.0
LOC123085377 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Triticum aestivum
TI:4565 None
   
W5EJX2_WHEAT
EnsemblPlants»
0.0
LOC123097968 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Triticum aestivum
TI:4565 None
   
F2DWP6_HORVV
EnsemblPlants»
0.0
LOC123449075 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Hordeum vulgare
TI:4513 None
 
Q10NM7_ORYSJ
neXtProt»
0.0
LOC_Os03g15850 Os03g0265200 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Oryza sativa
TI:4530 None
 
A0A9R1XCM0_LACSA
neXtProt»
0.0
LSAT_V11C500291560 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Lactuca sativa
TI:4236 None
 
A0A9R1WTL7_LACSA
neXtProt»
0.0
LSAT_V11C900497940 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Lactuca sativa
TI:4236 None
 
A0A2C9WD59_MANES
neXtProt»
0.0
MANES_02G121500v8 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Manihot esculenta
TI:3983 None
 
A0A2R6XAG6_MARPO
neXtProt»
0.0
MARPO_0026s0005 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Marchantia polymorpha
TI:3197 None
 
A0A022S024_ERYGU
neXtProt»
0.0
MIMGU_mgv1a017948mg ubiquitinyl hydrolase 1 (EC 3.4.19.12) Erythranthe guttata
TI:4155 None
 
A9URE1_MONBE
neXtProt»
0.0
MONBRDRAFT_31347 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Monosiga brevicollis
TI:81824 None
 
A7SDY8_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g114706 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Nematostella vectensis
TI:45351 None
 
Q8IIP4_PLAF7
TubercuList»
0.0
PF3D7_1111900 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Plasmodium falciparum
TI:5833 None
 
A0A2K2C3A1_POPTR
neXtProt»
0.0
POPTR_001G249400 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Populus trichocarpa
TI:3694 None
 
B9HP66_POPTR
neXtProt»
0.0
POPTR_009G043000v4 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Populus trichocarpa
TI:3694 None
 
M5WK40_PRUPE
neXtProt»
0.0
PRUPE_6G060500 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Prunus persica
TI:3760 None
 
B9SHY7_RICCO
neXtProt»
0.0
RCOM_0611500 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Ricinus communis
TI:3988 None
 
D8SI32_SELML
neXtProt»
0.0
SELMODRAFT_117430 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Selaginella moellendorffii
TI:88036 None
 
D8R3E3_SELML
neXtProt»
0.0
SELMODRAFT_84199 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Selaginella moellendorffii
TI:88036 None
 
C5WQ53_SORBI
neXtProt»
0.0
SORBI_3001G427200 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Sorghum bicolor
TI:4558 None
 
A0A2G3ALX5_CAPAN
neXtProt»
0.0
T459_03111 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Capsicum annuum
TI:4072 None
 
A0A061GWC4_THECC
neXtProt»
0.0
TCM_041657 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Theobroma cacao
TI:3641 None
 
B8C3F4_THAPS
neXtProt»
0.0
THAPSDRAFT_5624 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Thalassiosira pseudonana
TI:35128 None
 
B3RPS8_TRIAD
CTD»
0.0
TRIADDRAFT_21661 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Trichoplax adhaerens
TI:10228 None
 
D7SK18_VITVI
neXtProt»
0.0
VIT_06s0004g06160 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Vitis vinifera
TI:29760 None
 
A0A8R1V2P2_PRIPA
EnsemblMetazoa»
0.0
WBGene00304633 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Pristionchus pacificus
TI:54126 None
   
A0A0K9PR60_ZOSMR
neXtProt»
0.0
ZOSMA_195G00060 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Zostera marina
TI:29655 None
 
A8WMS1_CAEBR
WormBase»
0.0
josd-1 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Caenorhabditis briggsae
TI:6238 None
 
Q8IAA2_CAEEL
WormBase»
0.5
josd-1 ubiquitinyl hydrolase 1 (EC 3.4.19.12) Caenorhabditis elegans
TI:6239 None
 
B2GUF1_XENTR
Xenbase»
0.0
josd1 Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Xenopus tropicalis
TI:8364 None
 
Q08C38_DANRE
ZFIN»
1.3
josd1 Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Danio rerio
TI:7955 None
 
Q2TAT8_XENLA
Xenbase»
0.0
josd1.L Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Xenopus laevis
TI:8355 None
 
A0A1L8GH08_XENLA
Xenbase»
0.0
josd1.S Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein
1) (Josephin domain-containing protein 2) (Josephin-2)		 Xenopus laevis
TI:8355 None
   
A0A8M1PE46_DANRE
ZFIN»
1.6
josd2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Danio rerio
TI:7955 None
   
G1KLS4_ANOCA
Ensembl»
0.0
josd2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Anolis carolinensis
TI:28377 None
   
Q28GQ6_XENTR
Xenbase»
0.0
josd2 Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Xenopus tropicalis
TI:8364 None
 
Q5EAV9_XENLA
Xenbase»
0.0
josd2.L Josephin-2 (EC 3.4.19.12)
(Josephin domain-containing protein 2)		 Xenopus laevis
TI:8355 None