Collated Gene Ontology terms

Biological process: first spliceosomal transesterification activity(2009, 2023) RNA binding(2014, 2015) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(2023) metal ion binding(2023) dioxygenase activity(2023)

Molecular function: generation of catalytic spliceosome for second transesterification step2009, 2017, 2023 mRNA 3'-splice site recognition2009, 2017, 2023 mRNA splicing, via spliceosome2006, 2010, 2011, 2019, 2023 mRNA processing2023 RNA splicing2023 regulation of primary miRNA processing2019, 2022 ribosomal large subunit biogenesis2021 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 mRNA cis splicing, via spliceosome2005 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021

Cellular component: nucleus2009, 2017, 2019, 2023 catalytic step 2 spliceosome2010, 2011, 2017, 2023 Prp19 complex2009, 2013, 2014, 2017, 2023 post-mRNA release spliceosomal complex2009, 2016, 2017, 2023 post-spliceosomal complex2009, 2017, 2023 U2-type catalytic step 1 spliceosome2009, 2019, 2023 spliceosomal complex2006, 2014, 2023 cytoplasm2023 U2-type post-mRNA release spliceosomal complex2016, 2023 U2-type catalytic step 2 spliceosome2009, 2023
cytosol2009, 2019 precatalytic spliceosome2010 nucleoplasm2015

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2 4 6 8 10 Knownness

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
Q9LS97_ARATH
TAIR»
0.0
At3g18790 At3g18790/MVE11_17 AT3G18790 protein (AT3g18790/MVE11_17) (Pre-mRNA-splicing factor
ISY1-like protein) (Uncharacterized protein At3g18790/MVE11_17)		 Arabidopsis thaliana
TI:3702 None
 
Q9VHV6_DROME
FlyBase»
2.5
Dmel\CG9667 RE31520p (Uncharacterized protein, isoform A) Drosophila melanogaster
TI:7227 None
 
A0A0N4SUM8_MOUSE
Ensembl»
0.0
Gm45140 Predicted gene 45140 Mus musculus
TI:10090 None
   
F1P220_CHICK
Ensembl»
1.0
ISY1 ISY1 splicing factor homolog Gallus gallus
TI:9031 None
   
ISY1_HUMAN
Ensembl»
3.3
ISY1 Pre-mRNA-splicing factor ISY1 homolog Homo sapiens
TI:9606 None
 
ISY1_YEAST
SGD»
3.4
ISY1 Pre-mRNA-splicing factor ISY1 (Interactor of
SYF1) (PRP19-associated complex protein 30)		 Saccharomyces cerevisiae
TI:4932 None
 
ISY1_MOUSE
Ensembl»
1.5
Isy1 Pre-mRNA-splicing factor ISY1 homolog Mus musculus
TI:10090 None
 
ISY1_RAT
RGD»
2.0
Isy1 Pre-mRNA-splicing factor ISY1 homolog Rattus norvegicus
TI:10116 None
 
ISY1_SCHPO
PomBase»
1.5
cwf12 Pre-mRNA-splicing factor cwf12 (Complexed
with cdc5 protein 12)		 Schizosaccharomyces pombe
TI:4896 None
 
ISY1_CAEEL
WormBase»
1.8
isy-1 Protein isy-1 Caenorhabditis elegans
TI:6239 None
 
ISY1_DICDI
dictyBase»
1.5
isy1 Pre-mRNA-splicing factor ISY1 homolog Dictyostelium discoideum
TI:44689 None
 
A4FUN5_DANRE
ZFIN»
1.0
rab43 ISY1-splicing factor homolog (Pre-mRNA-splicing
factor ISY1 homolog) (Rab43 protein)		 Danio rerio
TI:7955 None