Cluster UKP00724
- PRE-MRNA-SPLICING FACTOR ISY1
Standard knownness: 3.4; Custom knownness: None; Num. species: 93; Orthology database: Panther18.0; Protein members: 113
Collated Gene Ontology terms
Biological process:
first spliceosomal transesterification activity(2009, 2023)
RNA binding(2014, 2015)
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(2023)
metal ion binding(2023)
dioxygenase activity(2023)
Molecular function: generation of catalytic spliceosome for second transesterification step2009, 2017, 2023 mRNA 3'-splice site recognition2009, 2017, 2023 mRNA splicing, via spliceosome2006, 2010, 2011, 2019, 2023 mRNA processing2023 RNA splicing2023 regulation of primary miRNA processing2019, 2022 ribosomal large subunit biogenesis2021 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 mRNA cis splicing, via spliceosome2005 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021
Cellular component:
nucleus2009, 2017, 2019, 2023
catalytic step 2 spliceosome2010, 2011, 2017, 2023
Prp19 complex2009, 2013, 2014, 2017, 2023
post-mRNA release spliceosomal complex2009, 2016, 2017, 2023
post-spliceosomal complex2009, 2017, 2023
U2-type catalytic step 1 spliceosome2009, 2019, 2023
spliceosomal complex2006, 2014, 2023
cytoplasm2023
U2-type post-mRNA release spliceosomal complex2016, 2023
U2-type catalytic step 2 spliceosome2009, 2023
cytosol2009, 2019
precatalytic spliceosome2010
nucleoplasm2015
Phylogenetic distribution
| Chordates: | 21/21 |  |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 2/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 15/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 3/3 | |
| Excavates: | 2/4 | |
| Harosa: | 4/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 37/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 |
Proteins
| UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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A0A3Q7HF18_SOLLC EnsemblPlants» |
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Pre-mRNA-splicing factor ISY1 homolog |
Solanum lycopersicum TI:4081 None |
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A0A453YQY0_ANOGA EnsemblMetazoa» |
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Uncharacterized protein |
Anopheles gambiae TI:7165 None |
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A0A7M7HH27_STRPU EnsemblMetazoa» |
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Pre-mRNA-splicing factor ISY1 homolog |
Strongylocentrotus purpuratus TI:7668 None |
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A0A804MWF5_MAIZE EnsemblPlants» |
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Uncharacterized protein |
Zea mays TI:4577 None |
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A0A804N8X1_MAIZE EnsemblPlants» |
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Uncharacterized protein |
Zea mays TI:4577 None |
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A0A804PRT0_MAIZE EnsemblPlants» |
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Uncharacterized protein |
Zea mays TI:4577 None |
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A0A804RGB8_MAIZE EnsemblPlants» |
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Uncharacterized protein |
Zea mays TI:4577 None |
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A0A8I6Y822_HORVV EnsemblPlants» |
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Pre-mRNA-splicing factor ISY1 |
Hordeum vulgare TI:4513 None |
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A0A8I6YGC5_HORVV EnsemblPlants» |
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Pre-mRNA-splicing factor ISY1 |
Hordeum vulgare TI:4513 None |
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A0A8I6YR32_HORVV EnsemblPlants» |
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Pre-mRNA-splicing factor ISY1 |
Hordeum vulgare TI:4513 None |
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F2D0F3_HORVV EnsemblPlants» |
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Predicted protein |
Hordeum vulgare TI:4513 None |
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F6Q4Z2_CIOIN Ensembl» |
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ISY1 splicing factor homolog |
Ciona intestinalis TI:7719 None |
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H3GPB1_PHYRM EnsemblProtists» |
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Pre-mRNA-splicing factor ISY1 |
Phytophthora ramorum TI:164328 None |
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W5N9D3_LEPOC Ensembl» |
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ISY1 splicing factor homolog |
Lepisosteus oculatus TI:7918 None |
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B6T8I4_MAIZE EnsemblPlants» |
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100282530 | Pre-mRNA-splicing factor ISY1 |
Zea mays TI:4577 None |
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K7M5I4_SOYBN EnsemblPlants» |
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100813312 | Uncharacterized protein |
Glycine max TI:3847 None |
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I1IBB5_BRADI EnsemblPlants» |
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100837197 | Pre-mRNA-splicing factor ISY1 |
Brachypodium distachyon TI:15368 None |
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K3YUC5_SETIT EnsemblPlants» |
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101755311 | Pre-mRNA-splicing factor ISY1 |
Setaria italica TI:4555 None |
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M1A9U9_SOLTU EnsemblPlants» |
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102585139 | Pre-mRNA-splicing factor isy-1 |
Solanum tuberosum TI:4113 None |
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G7K4N4_MEDTR EnsemblPlants» |
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11437391 | Pre-mRNA-splicing factor ISY1 (Putative isy1-like splicing) |
Medicago truncatula TI:3880 None |
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T1FRZ6_HELRO EnsemblMetazoa» |
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20211593 | Pre-mRNA-splicing factor ISY1 homolog |
Helobdella robusta TI:6412 None |
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B7P3U9_IXOSC EnsemblMetazoa» |
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8024201 | Pre-mRNA-splicing factor ISY1 homolog |
Ixodes scapularis TI:6945 None |
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U5D3Q1_AMBTC EnsemblPlants» |
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AMTR_s00030p00067450 | Pre-mRNA-splicing factor ISY1 homolog |
Amborella trichopoda TI:13333 None |
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W1PB82_AMBTC EnsemblPlants» |
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AMTR_s00146p00098380 | Pre-mRNA-splicing factor ISY1 homolog |
Amborella trichopoda TI:13333 None |
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D6WZG2_TRICA EnsemblMetazoa» |
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AUGUSTUS-3.0.2_12663 | Pre-mRNA-splicing factor ISY1 homolog-like Protein |
Tribolium castaneum TI:7070 None |
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Q9LS97_ARATH TAIR» |
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At3g18790 At3g18790/MVE11_17 | AT3G18790 protein (AT3g18790/MVE11_17) (Pre-mRNA-splicing factor ISY1-like protein) (Uncharacterized protein At3g18790/MVE11_17) |
Arabidopsis thaliana TI:3702 None |
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F4NX73_BATDJ EnsemblBacteria» |
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BATDEDRAFT_9482 | Isy1-like splicing factor |
Batrachochytrium dendrobatidis TI:109871 None |
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A0A078FZW5_BRANA EnsemblPlants» |
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BnaA01g26490D | (rape) hypothetical protein (BnaA01g26490D protein) |
Brassica napus TI:3708 None |
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A0A3B6ES31_WHEAT EnsemblPlants» |
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CFC21_038647 | Pre-mRNA-splicing factor ISY1 |
Triticum aestivum TI:4565 None |
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A0A080YUU8_WHEAT EnsemblPlants» |
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CFC21_045104 TRAES_3BF066000070CFD_c1 | Pre-mRNA-splicing factor ISY1 |
Triticum aestivum TI:4565 None |
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A0A3B6NRB2_WHEAT EnsemblPlants» |
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CFC21_083574 | Pre-mRNA-splicing factor ISY1 |
Triticum aestivum TI:4565 None |
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A0A341X041_WHEAT EnsemblPlants» |
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CFC21_088320 CFC21_088322 CFC21_092743 | Pre-mRNA-splicing factor ISY1 |
Triticum aestivum TI:4565 None |
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A8IC04_CHLRE EnsemblPlants» |
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CHLRE_10g427150v5 | Pre-mRNA-splicing factor ISY1 |
Chlamydomonas reinhardtii TI:3055 None |
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A0A067D5R4_CITSI Ensembl» |
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CISIN_1g022187mg | Pre-mRNA-splicing factor ISY1-like protein |
Citrus sinensis TI:2711 None |
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A0A0A0KBN6_CUCSA EnsemblPlants» |
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Csa_7G431430 | Pre-mRNA-splicing factor ISY1 homolog |
Cucumis sativus TI:3659 None |
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F0ZA89_DICPU EnsemblProtists» |
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DICPUDRAFT_52847 | Pre-mRNA-splicing factor ISY1 |
Dictyostelium purpureum TI:5786 None |
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Q9VHV6_DROME FlyBase» |
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Dmel\CG9667 | RE31520p (Uncharacterized protein, isoform A) |
Drosophila melanogaster TI:7227 None |
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C4LVU3_ENTH1 EnsemblProtists» |
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EHI_187260 | Cell cycle control protein cwf12, putative |
Entamoeba histolytica TI:5759 None |
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E9G232_DAPPU EnsemblMetazoa» |
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EOG090X09UC | EOG090X09UC |
Daphnia pulex TI:6669 None |
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A0A059CKB1_EUCGR EnsemblPlants» |
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EUGRSUZ_C00068 | Pre-mRNA-splicing factor ISY1 homolog |
Eucalyptus grandis TI:71139 None |
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A0A0R0JL42_SOYBN EnsemblPlants» |
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GLYMA_06G234100 | Uncharacterized protein |
Glycine max TI:3847 None |
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K7LDA5_SOYBN EnsemblPlants» |
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GLYMA_09G114600 | Uncharacterized protein |
Glycine max TI:3847 None |
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A0A804KJX0_MUSAM EnsemblPlants» |
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GSMUA_233950.1 | (wild Malaysian banana) hypothetical protein |
Musa acuminata TI:4641 None |
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A0DUH5_PARTE EnsemblProtists» |
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GSPATT00020364001 | Chromosome undetermined scaffold_64, whole genome shotgun sequence |
Paramecium tetraurelia TI:5888 None |
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A0A0N4SUM8_MOUSE Ensembl» |
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Gm45140 | Predicted gene 45140 |
Mus musculus TI:10090 None |
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A0A251VCQ9_HELAN EnsemblPlants» |
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HannXRQ_Chr03g0092051 HanXRQr2_Chr03g0135951 | Pre-mRNA-splicing factor Isy1, helix hairpin bin domain superfamily |
Helianthus annuus TI:4232 None |
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A0A2I2ZEJ9_GORGO Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Gorilla gorilla TI:9593 None |
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A0A5G2RDZ4_PIG Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Sus scrofa TI:9823 None |
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A0A803STY9_ANOCA Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Anolis carolinensis TI:28377 None |
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E1BMC8_BOVIN Ensembl» |
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ISY1 | ISY1 splicing factor homolog (S. cerevisiae) |
Bos taurus TI:9913 None |
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F1P220_CHICK Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Gallus gallus TI:9031 None |
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F1PV40_CANLF Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Canis lupus TI:9612 None |
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F6PPC1_MACMU Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Macaca mulatta TI:9544 None |
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F6S829_ORNAN Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Ornithorhynchus anatinus TI:9258 None |
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F7AEY3_HORSE Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Equus caballus TI:9796 None |
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F7CDJ5_MONDO Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Monodelphis domestica TI:13616 None |
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H2QNB8_PANTR Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Pan troglodytes TI:9598 None |
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ISY1_ASHGO EnsemblFungi» |
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ISY1 | Pre-mRNA-splicing factor ISY1 |
Ashbya gossypii TI:33169 None |
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ISY1_CANAL EnsemblFungi» |
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ISY1 | Pre-mRNA-splicing factor ISY1 |
Candida albicans TI:5476 None |
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ISY1_CRYNJ EnsemblFungi» |
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ISY1 | Pre-mRNA-splicing factor ISY1 |
Cryptococcus neoformans TI:5207 None |
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ISY1_HUMAN Ensembl» |
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ISY1 | Pre-mRNA-splicing factor ISY1 homolog |
Homo sapiens TI:9606 None |
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ISY1_USTMA EnsemblFungi» |
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ISY1 | Pre-mRNA-splicing factor ISY1 |
Ustilago maydis TI:5270 None |
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ISY1_YARLI EnsemblFungi» |
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ISY1 | Pre-mRNA-splicing factor ISY1 |
Yarrowia lipolytica TI:4952 None |
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ISY1_YEAST SGD» |
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ISY1 | Pre-mRNA-splicing factor ISY1 (Interactor of SYF1) (PRP19-associated complex protein 30) |
Saccharomyces cerevisiae TI:4932 None |
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M3W9Z6_FELCA Ensembl» |
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ISY1 | ISY1 splicing factor homolog |
Felis catus TI:9685 None |
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ISY1_MOUSE Ensembl» |
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Isy1 | Pre-mRNA-splicing factor ISY1 homolog |
Mus musculus TI:10090 None |
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ISY1_RAT RGD» |
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Isy1 | Pre-mRNA-splicing factor ISY1 homolog |
Rattus norvegicus TI:10116 None |
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A0A0U9HIS0_KLENI EnsemblPlants» |
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KFL_000570070 | Pre-mRNA-splicing factor ISY1 |
Klebsormidium nitens TI:105231 None |
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Q4QIU3_LEIMA EnsemblProtists» |
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LMJF_07_0020 | Uncharacterized protein |
Leishmania major TI:5664 None |
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A0A1U8A7A9_NELNU EnsemblBacteria» |
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LOC104599888 | Pre-mRNA-splicing factor ISY1 homolog |
Nelumbo nucifera TI:4432 None |
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A0A1S4BWJ9_TOBAC EnsemblFungi» |
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LOC107812596 | Pre-mRNA-splicing factor ISY1 homolog |
Nicotiana tabacum TI:4097 None |
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A0A1S4BZM8_TOBAC EnsemblFungi» |
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LOC107813591 | Pre-mRNA-splicing factor ISY1 homolog |
Nicotiana tabacum TI:4097 None |
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A0A1U8NSK7_GOSHI Ensembl» |
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LOC107950582 | Pre-mRNA-splicing factor ISY1 homolog |
Gossypium hirsutum TI:3635 None |
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A0A2I4E9K1_JUGRE EnsemblPlants» |
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LOC109015181 | Pre-mRNA-splicing factor ISY1 homolog |
Juglans regia TI:51240 None |
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A0A9J7MS86_BRAFL CTD» |
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LOC118416748 | Pre-mRNA-splicing factor ISY1 homolog |
Branchiostoma floridae TI:7739 None |
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A0A2C9WI68_MANES EnsemblPlants» |
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MANES_01G056600 | Pre-mRNA-splicing factor ISY1 homolog |
Manihot esculenta TI:3983 None |
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A0A2R6XAU1_MARPO EnsemblPlants» |
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MARPO_0026s0083 | Uncharacterized protein |
Marchantia polymorpha TI:3197 None |
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A0A022QA51_ERYGU Ensembl» |
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MIMGU_mgv1a010859mg | Pre-mRNA-splicing factor ISY1 homolog |
Erythranthe guttata TI:4155 None |
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A9UYQ4_MONBE EnsemblProtists» |
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MONBRDRAFT_32310 | Pre-mRNA-splicing factor ISY1 |
Monosiga brevicollis TI:81824 None |
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A7RT52_NEMVE EnsemblMetazoa» |
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NEMVEDRAFT_v1g162359 | Pre-mRNA-splicing factor ISY1 homolog |
Nematostella vectensis TI:45351 None |
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Q6K5F4_ORYSJ EnsemblPlants» |
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Os02g0602500 | Os02g0602500 protein (cDNA clone:002-107-H03, full insert sequence) |
Oryza sativa TI:4530 None |
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Q8IKB8_PLAF7 EnsemblProtists» |
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PF3D7_1472000 | Pre-mRNA-splicing factor ISY1, putative |
Plasmodium falciparum TI:5833 None |
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A9T3A6_PHYPA EnsemblPlants» |
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PHYPA_017403 | Uncharacterized protein |
Physcomitrium patens TI:3218 None |
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A0A2K1X3Y3_POPTR EnsemblPlants» |
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POPTR_017G060200 | Pre-mRNA-splicing factor ISY1 homolog |
Populus trichocarpa TI:3694 None |
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A0A251NYP5_PRUPE EnsemblPlants» |
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PRUPE_6G322400 | Uncharacterized protein |
Prunus persica TI:3760 None |
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M5XCY2_PRUPE EnsemblPlants» |
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PRUPE_7G048200 | Pre-mRNA-splicing factor ISY1 homolog |
Prunus persica TI:3760 None |
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B9S3Q1_RICCO EnsemblBacteria» |
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RCOM_1553780 | Pre-mRNA-splicing factor isy-1, putative |
Ricinus communis TI:3988 None |
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D8RME8_SELML EnsemblPlants» |
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SELMODRAFT_231910 | Uncharacterized protein |
Selaginella moellendorffii TI:88036 None |
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D8SLI1_SELML EnsemblPlants» |
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SELMODRAFT_423378 | Uncharacterized protein |
Selaginella moellendorffii TI:88036 None |
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B6K025_SCHJY EnsemblFungi» |
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SJAG_01214 | Complexed with Cdc5 protein Cwf12 |
Schizosaccharomyces japonicus TI:4897 None |
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Q0TVT2_PHANO EnsemblFungi» |
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SNOG_16410 | Pre-mRNA-splicing factor ISY1 |
Phaeosphaeria nodorum TI:13684 None |
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C5XX61_SORBI EnsemblPlants» |
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SORBI_3004G206300 | Uncharacterized protein |
Sorghum bicolor TI:4558 None |
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A7EE12_SCLS1 EnsemblFungi» |
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SS1G_03552 | Pre-mRNA-splicing factor isy1 |
Sclerotinia sclerotiorum TI:5180 None |
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A0A2G2ZIJ0_CAPAN EnsemblPlants» |
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T459_14842 | Pre-mRNA-splicing factor ISY1-like protein |
Capsicum annuum TI:4072 None |
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A0A2G2YCI0_CAPAN EnsemblPlants» |
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T459_26950 | Pre-mRNA-splicing factor ISY1-like protein |
Capsicum annuum TI:4072 None |
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A0A061DJ91_THECC EnsemblPlants» |
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TCM_001356 | Pre-mRNA-splicing factor isy-1 |
Theobroma cacao TI:3641 None |
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B5YMB0_THAPS EnsemblProtists» |
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THAPS_6727 | Uncharacterized protein |
Thalassiosira pseudonana TI:35128 None |
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B3RV12_TRIAD EnsemblMetazoa» |
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TRIADDRAFT_23391 | Pre-mRNA-splicing factor ISY1 homolog |
Trichoplax adhaerens TI:10228 None |
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Q581Y9_TRYB2 VEuPathDB» |
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Tb08.26N11.390 | Uncharacterized protein |
Trypanosoma brucei TI:5691 None |
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A5AII6_VITVI EnsemblPlants» |
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VIT_04s0044g00540 | Pre-mRNA-splicing factor ISY1-like |
Vitis vinifera TI:29760 None |
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A0A0K9PXZ1_ZOSMR EnsemblPlants» |
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ZOSMA_140G00270 | Pre-mRNA-splicing factor ISY1-like protein |
Zostera marina TI:29655 None |
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A0A0K9NV93_ZOSMR EnsemblPlants» |
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ZOSMA_57G00010 | Pre-mRNA-splicing factor ISY1-like protein |
Zostera marina TI:29655 None |
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A0A0K9NTR4_ZOSMR EnsemblPlants» |
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ZOSMA_621G00060 | Pre-mRNA-splicing factor ISY1-like protein |
Zostera marina TI:29655 None |
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ISY1_SCHPO PomBase» |
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cwf12 | Pre-mRNA-splicing factor cwf12 (Complexed with cdc5 protein 12) |
Schizosaccharomyces pombe TI:4896 None |
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A8Y4S2_CAEBR WormBase» |
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isy-1 | Protein CBG23070 |
Caenorhabditis briggsae TI:6238 None |
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ISY1_CAEEL WormBase» |
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isy-1 | Protein isy-1 |
Caenorhabditis elegans TI:6239 None |
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H2MDG0_ORYLA Ensembl» |
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isy1 | ISY1 splicing factor homolog |
Oryzias latipes TI:8090 None |
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ISY1_ASPFU EnsemblFungi» |
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isy1 | Pre-mRNA-splicing factor isy1 |
Aspergillus fumigatus TI:746128 None |
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ISY1_DICDI dictyBase» |
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isy1 | Pre-mRNA-splicing factor ISY1 homolog |
Dictyostelium discoideum TI:44689 None |
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ISY1_EMENI EnsemblFungi» |
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isy1 | Pre-mRNA-splicing factor isy1 |
Emericella nidulans TI:162425 None |
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Q6P811_XENTR Xenbase» |
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isy1 | ISY1 splicing factor homolog |
Xenopus tropicalis TI:8364 None |
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ISY1_NEUCR EnsemblFungi» |
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msp-7 | Pre-mRNA-splicing factor isy1 (mRNA-splicing protein 7) |
Neurospora crassa TI:5141 None |
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A4FUN5_DANRE ZFIN» |
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rab43 | ISY1-splicing factor homolog (Pre-mRNA-splicing factor ISY1 homolog) (Rab43 protein) |
Danio rerio TI:7955 None |
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