Collated Gene Ontology terms

Biological process:

Molecular function: late endosome to vacuole transport via multivesicular body sorting pathway2013, 2017, 2024, 2025 protein transport2025 protein targeting to vacuole2018

Cellular component: membrane2025 fungal-type vacuole membrane2009, 2013, 2017, 2018, 2025 endoplasmic reticulum2010, 2025 Vps55/Vps68 complex2013, 2017, 2025 cytoplasm2003, 2018, 2025 neuronal cell body2018, 2025 glial cell projection2018, 2025 endosome2024, 2025 endoplasmic reticulum membrane2025 Golgi membrane2025
nuclear lumen2018, 2025 mitochondrion2018, 2025 vacuolar membrane2025 plasma membrane2007 ciliary plasm2018 Golgi apparatus2009

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 3/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A2I2Y4W8_GORGO
Ensembl»
0.0
Transmembrane protein 50B Gorilla gorilla
TI:9593 None
 
A0A2I3T9G9_PANTR
Ensembl»
0.0
Uncharacterized protein Pan troglodytes
TI:9598 None
 
A0A3B3I7D5_ORYLA
Ensembl»
0.0
Transmembrane protein 50A Oryzias latipes
TI:8090 None
   
A0A3Q7ISR1_SOLLC
EnsemblPlants»
0.0
Uncharacterized protein Solanum lycopersicum
TI:4081 None
   
A0A3Q7ISU8_SOLLC
EnsemblPlants»
0.0
Transmembrane protein 50 homolog Solanum lycopersicum
TI:4081 None
   
A0A7M7RFK3_STRPU
EnsemblMetazoa»
0.0
Transmembrane protein 50A Strongylocentrotus purpuratus
TI:7668 None
   
H3GZB6_PHYRM
EnsemblProtists»
0.0
Transmembrane protein 50A Phytophthora ramorum
TI:164328 None
 
K3YZF6_SETIT
EnsemblPlants»
0.0
Transmembrane protein 50A Setaria italica
TI:4555 None
 
W5M467_LEPOC
Ensembl»
0.0
Transmembrane protein 50A Lepisosteus oculatus
TI:7918 None
 
W5M958_LEPOC
Ensembl»
0.0
Transmembrane protein 50B Lepisosteus oculatus
TI:7918 None
 
B7FGM3_MEDTR
EnsemblPlants»
0.0
11416140 Transmembrane protein 50A, putative Medicago truncatula
TI:3880 None
 
Q7Q7C9_ANOGA
EnsemblMetazoa»
0.0
1276082 AGAP005380-PA Anopheles gambiae
TI:7165 None
 
T1ELW5_HELRO
EnsemblMetazoa»
0.0
20197565 Transmembrane protein 50A Helobdella robusta
TI:6412 None
 
T1G2S4_HELRO
EnsemblMetazoa»
0.0
20215372 Transmembrane protein 50A Helobdella robusta
TI:6412 None
 
Q4WDH4_ASPFU
TubercuList»
0.0
AFUA_6G04760 UPF0220 domain protein Aspergillus fumigatus
TI:746128 None
 
Q75AT9_EREGS
euHCVdb»
0.0
AGOS_ADL169W ADL169Wp Eremothecium gossypii
TI:33169 None
 
W1NNU9_AMBTC
euHCVdb»
0.0
AMTR_s00173p00054160 Transmembrane protein 50A Amborella trichopoda
TI:13333 None
 
Q5AYT6_EMENI
TubercuList»
0.0
ANIA_06544 UPF0220 domain
protein (AFU_orthologue AFUA_6G04760)		 Emericella nidulans
TI:162425 None
 
D6WTE5_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_09639 Transmembrane protein 50B-like Protein Tribolium castaneum
TI:7070 None
 
D6WU96_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_09723 Transmembrane protein 50B-like Protein Tribolium castaneum
TI:7070 None
 
Q949Z8_ARATH
TAIR»
0.5
At1g36980 Transmembrane 50A-like protein Arabidopsis thaliana
TI:3702 None
 
F4P8J1_BATDJ
neXtProt»
0.0
BATDEDRAFT_26562 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
M4FH08_BRACM
EnsemblPlants»
0.0
BRAPAZ1V2_A05P27950.2 Transmembrane protein 50A Brassica campestris
TI:3711 None
 
A0A078ID31_BRANA
neXtProt»
0.0
BnaA05g36340D (rape) hypothetical
protein (BnaA05g36340D protein)		 Brassica napus
TI:3708 None
 
A0A1D8PPU3_CANAL
CGD»
0.0
CAALFM_C602180WA orf19.10962 Vacuolar protein sorting-associated protein 68 Candida albicans
TI:5476 None
 
A8WVX5_CAEBR
WormBase»
0.0
CBG03988 CBG_03988 Protein CBG03988 Caenorhabditis briggsae
TI:6238 None
 
Q9N2X7_CAEEL
WormBase»
0.5
CELE_Y74C10AL.2 Y74C10AL.2 Transmembrane protein 50A Caenorhabditis elegans
TI:6239 None
 
A0A2K3E7J6_CHLRE
euHCVdb»
0.0
CHLRE_01g042950v5 Transmembrane protein 50A Chlamydomonas reinhardtii
TI:3055 None
 
A8J7F0_CHLRE
euHCVdb»
0.0
CHLRE_03g159300v5 Transmembrane protein 50A Chlamydomonas reinhardtii
TI:3055 None
 
A0A067GZQ4_CITSI
euHCVdb»
0.0
CISIN_1g032718mg Transmembrane protein 50A Citrus sinensis
TI:2711 None
 
Q5KMY1_CRYD1
TubercuList»
0.0
CNB00090 Protein-vacuolar targeting-related
protein, putative		 Cryptococcus deneoformans
TI:40410 None
 
A0A0A0KQ70_CUCSA
euHCVdb»
0.0
Csa_5G387940 Transmembrane protein 50A Cucumis sativus
TI:3659 None
 
F0Z776_DICPU
TubercuList»
0.0
DICPUDRAFT_52137 Transmembrane protein Dictyostelium purpureum
TI:5786 None
 
Q9VZE2_DROME
FlyBase»
0.5
Dmel\CG15012 GEO04055p1 (GH03029p) Drosophila melanogaster
TI:7227 None
 
A0A804KA29_MUSAM
EnsemblPlants»
0.0
GSMUA_84670.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A251TWB3_HELAN
neXtProt»
0.0
HannXRQ_Chr09g0260151 HanXRQr2_Chr09g0392121 Transmembrane protein 50A Helianthus annuus
TI:4232 None
 
B7PV12_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW007616 Membrane protein, putative Ixodes scapularis
TI:6945 None
 
A0A7U2I2B9_PHANO
TubercuList»
0.0
JI435_016990 Uncharacterized protein Phaeosphaeria nodorum
TI:13684 None
 
A0A1Y1I667_KLENI
euHCVdb»
0.0
KFL_001980240 Transmembrane protein 50A Klebsormidium nitens
TI:105231 None
 
Q4Q856_LEIMA
TubercuList»
0.0
LMJF_28_2095 Transmembrane protein Leishmania major
TI:5664 None
 
Q4Q7V5_LEIMA
TubercuList»
0.0
LMJF_30_0040 Transmembrane protein Leishmania major
TI:5664 None
 
H2XWZ6_CIOIN
Ensembl»
0.0
LOC100183691 Transmembrane protein 50B-like Ciona intestinalis
TI:7719 None
   
B6SZ92_MAIZE
EnsemblPlants»
0.0
LOC100281814 Transmembrane protein 50A Zea mays
TI:4577 None
 
B6TFT3_MAIZE
EnsemblPlants»
0.0
LOC100285861 Salt tolerant protein Zea mays
TI:4577 None
 
C6T022_SOYBN
EnsemblPlants»
0.0
LOC100306592 Transmembrane protein 50A Glycine max
TI:3847 None
 
K7KM93_SOYBN
EnsemblPlants»
0.0
LOC100820532 Transmembrane protein 50A Glycine max
TI:3847 None
 
I1IAR1_BRADI
EnsemblPlants»
0.0
LOC100829218 Salt tolerant protein Brachypodium distachyon
TI:15368 None
 
I1IQN2_BRADI
EnsemblPlants»
0.0
LOC100840360 Salt tolerant protein Brachypodium distachyon
TI:15368 None
 
K3ZXX0_SETIT
EnsemblPlants»
0.0
LOC101784378 Salt tolerant protein Setaria italica
TI:4555 None
 
M1CNS7_SOLTU
EnsemblPlants»
0.0
LOC102589977 Transmembrane protein 50a Solanum tuberosum
TI:4113 None
   
A0A1U7Z329_NELNU
neXtProt»
0.0
LOC104588728 Transmembrane protein 50 homolog Nelumbo nucifera
TI:4432 None
   
A0A1U8BKE7_NELNU
euHCVdb»
0.0
LOC104612066 Transmembrane protein 50 homolog isoform X1 Nelumbo nucifera
TI:4432 None
   
A0A1S3ZYV0_TOBAC
euHCVdb»
0.0
LOC107791890 Transmembrane protein 50 homolog Nicotiana tabacum
TI:4097 None
   
A0A1U8JUP0_GOSHI
euHCVdb»
0.0
LOC107910589 Transmembrane protein 50 homolog Gossypium hirsutum
TI:3635 None
   
A0A1U8KL11_GOSHI
euHCVdb»
0.0
LOC107916793 Transmembrane protein 50 homolog isoform X1 Gossypium hirsutum
TI:3635 None
   
A0A1U8L0P3_GOSHI
euHCVdb»
0.0
LOC107922594 Transmembrane protein 50 homolog Gossypium hirsutum
TI:3635 None
   
A0A1U8LFP0_GOSHI
euHCVdb»
0.0
LOC107925944 Transmembrane protein 50 homolog Gossypium hirsutum
TI:3635 None
   
A0A1U8NT21_GOSHI
euHCVdb»
0.0
LOC107951435 Transmembrane protein 50 homolog Gossypium hirsutum
TI:3635 None
   
A0A2I4GBG7_JUGRE
euHCVdb»
0.0
LOC109006422 Transmembrane protein 50A Juglans regia
TI:51240 None
   
A0A9R0JU52_SPIOL
euHCVdb»
0.0
LOC110786907 Transmembrane protein 50A Spinacia oleracea
TI:3562 None
   
A0A2K1L3B2_PHYPA
EnsemblPlants»
0.0
LOC112277454 Transmembrane protein 50A Physcomitrium patens
TI:3218 None
 
A9SYX8_PHYPA
EnsemblPlants»
0.0
LOC112279010 Transmembrane protein 50A Physcomitrium patens
TI:3218 None
 
C3XVY6_BRAFL
neXtProt»
0.0
LOC118422973 Transmembrane protein 50B-like isoform X2 Branchiostoma floridae
TI:7739 None
 
Q1XA87_WHEAT
EnsemblPlants»
0.0
LOC123103943 Salt tolerant protein Triticum aestivum
TI:4565 None
 
F2E4A8_HORVV
EnsemblPlants»
0.0
LOC123398559 Predicted protein Hordeum vulgare
TI:4513 None
 
A0A9R1VTI7_LACSA
neXtProt»
0.0
LSAT_V11C400209410 Transmembrane protein 50A Lactuca sativa
TI:4236 None
 
A0A2C9U158_MANES
euHCVdb»
0.0
MANES_18G073000v8 Transmembrane protein 50 homolog Manihot esculenta
TI:3983 None
 
A0A2R6XRI4_MARPO
euHCVdb»
0.0
MARPO_0004s0020 Transmembrane protein 50A Marchantia polymorpha
TI:3197 None
 
A9V7D3_MONBE
neXtProt»
0.0
MONBRDRAFT_28158 Uncharacterized protein Monosiga brevicollis
TI:81824 None
 
Q1K7E1_NEUCR
TubercuList»
0.0
NCU04188 UPF0220 domain-containing protein Neurospora crassa
TI:5141 None
 
A7S086_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g241936 Transmembrane protein 50A Nematostella vectensis
TI:45351 None
 
Q6YTI5_ORYSJ
euHCVdb»
0.0
Os02g0566900 Os02g0566900 protein (cDNA
clone:J023003M06, full insert sequence)		 Oryza sativa
TI:4530 None
 
Q67UZ7_ORYSJ
euHCVdb»
0.0
Os09g0453000 Os09g0453000 protein (cDNA
clone:J013132I06, full insert sequence)		 Oryza sativa
TI:4530 None
 
E3K6U8_PUCGT
TubercuList»
0.0
PGTG_05272 Uncharacterized protein Puccinia graminis
TI:5297 None
 
B9GUG4_POPTR
euHCVdb»
0.0
POPTR_002G089300 Transmembrane protein 50A Populus trichocarpa
TI:3694 None
 
A0A3N7EYQ8_POPTR
neXtProt»
0.0
POPTR_005G171901 Transmembrane protein 50A Populus trichocarpa
TI:3694 None
 
M5Y077_PRUPE
euHCVdb»
0.0
PRUPE_1G506000 Transmembrane protein 50 homolog Prunus persica
TI:3760 None
 
B9RJB7_RICCO
euHCVdb»
0.0
RCOM_1032880 Transmembrane protein 50A, putative Ricinus communis
TI:3988 None
 
D8RG45_SELML
neXtProt»
0.0
SELMODRAFT_234744 SELMODRAFT_410867 Transmembrane protein 50A Selaginella moellendorffii
TI:88036 None
 
C5X284_SORBI
euHCVdb»
0.0
SORBI_3002G222900 Salt tolerant protein Sorghum bicolor
TI:4558 None
 
C5XVK5_SORBI
euHCVdb»
0.0
SORBI_3004G186000 Salt tolerant protein Sorghum bicolor
TI:4558 None
 
A7ETT4_SCLS1
TubercuList»
0.0
SS1G_08741 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None
 
A0A1U8GFF3_CAPAN
euHCVdb»
0.0
T459_12019 Transmembrane protein 50 homolog Capsicum annuum
TI:4072 None
 
A0A061FHN0_THECC
euHCVdb»
0.0
TCM_035011 Uncharacterized protein isoform 1 Theobroma cacao
TI:3641 None
 
A0A251T7L4_HELAN
euHCVdb»
0.0
TM50A Putative transmembrane protein 50A Helianthus annuus
TI:4232 None
 
A0A1D5P292_CHICK
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Gallus gallus
TI:9031 None
   
A0A287ALM5_PIG
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Sus scrofa
TI:9823 None
   
A0A3B3I2R5_ORYLA
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Oryzias latipes
TI:8090 None
   
A0A5F8HDH0_MONDO
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Monodelphis domestica
TI:13616 None
   
A0A8I3P1C9_CANLF
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Canis lupus
TI:9612 None
   
A0ABI8AD76_FELCA
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Felis catus
TI:9685 None
   
F6SWE6_ORNAN
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Ornithorhynchus anatinus
TI:9258 None
   
F6YUA2_HORSE
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Equus caballus
TI:9796 None
   
F7FZH5_MACMU
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Macaca mulatta
TI:9544 None
 
G3R938_GORGO
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Gorilla gorilla
TI:9593 None
 
H9GK41_ANOCA
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Anolis carolinensis
TI:28377 None
   
Q17QR3_BOVIN
Ensembl»
0.0
TMEM50A Transmembrane protein 50A Bos taurus
TI:9913 None
 
TM50A_HUMAN
Ensembl»
0.5
TMEM50A Transmembrane protein 50A
(Small membrane protein 1)		 Homo sapiens
TI:9606 None
 
A0A1L1RX69_CHICK
Ensembl»
0.5
TMEM50B Transmembrane protein 50B Gallus gallus
TI:9031 None
   
A0A4X1U1L0_PIG
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Sus scrofa
TI:9823 None
 
A0A6I8PPT4_ORNAN
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Ornithorhynchus anatinus
TI:9258 None
   
A0ABI7YZ60_FELCA
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Felis catus
TI:9685 None
   
E2RRK3_CANLF
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Canis lupus
TI:9612 None
   
F6V201_MONDO
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Monodelphis domestica
TI:13616 None
   
F6VXN2_HORSE
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Equus caballus
TI:9796 None
   
G1KCM1_ANOCA
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Anolis carolinensis
TI:28377 None
   
G2HFA3_PANTR
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Pan troglodytes
TI:9598 None
 
G3SKJ8_GORGO
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Gorilla gorilla
TI:9593 None
 
H9FZH2_MACMU
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Macaca mulatta
TI:9544 None
 
TM50B_BOVIN
Ensembl»
0.0
TMEM50B Transmembrane protein 50B Bos taurus
TI:9913 None
 
TM50B_HUMAN
Ensembl»
0.5
TMEM50B Transmembrane protein 50B
(HCV p7-trans-regulated protein 3)		 Homo sapiens
TI:9606 None
 
B3RS80_TRIAD
CTD»
0.0
TRIADDRAFT_54503 Transmembrane protein 50A Trichoplax adhaerens
TI:10228 None
 
A2ER91_TRIV3
TubercuList»
0.0
TVAG_226570 Transmembrane protein Trichomonas vaginalis
TI:5722 None
 
A2DCX4_TRIV3
TubercuList»
0.0
TVAG_237740 Putative membrane protein Trichomonas vaginalis
TI:5722 None
 
Q384E3_TRYB2
TubercuList»
0.0
Tb11.01.0590 Uncharacterized protein Trypanosoma brucei
TI:5691 None
 
A0A8J8XSG2_RAT
RGD»
0.0
Tmem50a Transmembrane protein 50A Rattus norvegicus
TI:10116 None
   
TM50A_MOUSE
Ensembl»
0.5
Tmem50a Transmembrane protein 50A
(Small membrane protein 1)		 Mus musculus
TI:10090 None
 
A6JLG6_RAT
RGD»
0.0
Tmem50b Transmembrane protein 50B Rattus norvegicus
TI:10116 None
 
TM50B_MOUSE
Ensembl»
0.5
Tmem50b Transmembrane protein 50B Mus musculus
TI:10090 None
 
E0CRD0_VITVI
neXtProt»
0.0
VIT_18s0001g04010 Transmembrane protein 50-like Vitis vinifera
TI:29760 None
 
VPS68_YEAST
SGD»
2.4
VPS68 Vacuolar protein sorting-associated protein 68 Saccharomyces cerevisiae
TI:4932 None
 
A0A454XKI6_PRIPA
EnsemblMetazoa»
0.0
WBGene00109521 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
H3FE63_PRIPA
EnsemblMetazoa»
0.0
WBGene00110098 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A454XVQ7_PRIPA
EnsemblMetazoa»
0.0
WBGene00274117 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
Q6C8B9_YARLI
TubercuList»
0.0
YALI0_D20944g YALI0D20944p Yarrowia lipolytica
TI:4952 None
 
A0A0K9Q5E1_ZOSMR
euHCVdb»
0.0
ZOSMA_102G00160 Putative Transmembrane protein 50a Zostera marina
TI:29655 None
 
A0A0K9P634_ZOSMR
euHCVdb»
0.0
ZOSMA_3G01490 Putative Transmembrane protein 50a Zostera marina
TI:29655 None
 
YGW2_SCHPO
PomBase»
0.5
pi063 SPBC8D2.02c UPF0220 protein C8D2.02c Schizosaccharomyces pombe
TI:4896 None
 
TMM50_DICDI
dictyBase»
0.5
tmem50 Transmembrane protein 50 homolog Dictyostelium discoideum
TI:44689 None
 
A4QNG8_XENTR
Xenbase»
0.0
tmem50a LOC100125157 protein (Transmembrane protein 50A) Xenopus tropicalis
TI:8364 None
 
Q803R8_DANRE
ZFIN»
0.5
tmem50a Tmem50a protein (Transmembrane protein 50A) Danio rerio
TI:7955 None
 
A0A8J0UF66_XENLA
Xenbase»
0.0
tmem50a.L Transmembrane protein 50A isoform X1 Xenopus laevis
TI:8355 None
   
Q4V7Y9_XENLA
Xenbase»
0.0
tmem50a.S MGC114915 protein (Transmembrane
protein 50A S homeolog)		 Xenopus laevis
TI:8355 None
 
Q28G39_XENTR
Xenbase»
0.0
tmem50b Transmembrane protein 50B
(Transmembrane protein 50b; C21orf4)		 Xenopus tropicalis
TI:8364 None
 
Q7T0Y8_XENLA
Xenbase»
0.0
tmem50b.L MGC68857 protein (Transmembrane
protein 50B L homeolog)		 Xenopus laevis
TI:8355 None
 
A0A1L8H596_XENLA
Xenbase»
0.0
tmem50b.S Transmembrane protein 50B Xenopus laevis
TI:8355 None
   
B6K4F5_SCHJY
TubercuList»
0.0
vps68 Vacuolar sorting protein Vps68 Schizosaccharomyces japonicus
TI:4897 None