Collated Gene Ontology terms

Biological process: nuclease activity(2025) hydrolase activity(2025)

Molecular function: mRNA processing2013, 2025 RNA splicing2005, 2025 mRNA splicing, via spliceosome2010, 2019, 2025 dendrite development2025 spindle assembly2024 protein catabolic process2024 ovarian follicle development2024 oogenesis2024 oocyte development2024 learning or memory2025
dentate gyrus development2025 dendritic spine organization2025 dendrite morphogenesis2025 alternative mRNA splicing, via spliceosome2024 mRNA cis splicing, via spliceosome2024 innate immune response2025 immune system process2025 defense response to fungus2007 defense response to bacterium2007 defense response2025 RNA splicing, via transesterification reactions2005

Cellular component: Prp19 complex2012, 2014, 2024, 2025 nucleus2007, 2009, 2018, 2019, 2025 spliceosomal complex2006, 2014, 2025 catalytic step 2 spliceosome2010, 2017, 2025 U2-type catalytic step 2 spliceosome2018, 2019, 2025 DNA replication factor A complex2014, 2025 nuclear speck2024, 2025 precatalytic spliceosome2010, 2025 post-mRNA release spliceosomal complex2016, 2025 nucleolus2021, 2025
post-spliceosomal complex2025 U2-type catalytic step 1 spliceosome2025 nucleoplasm2014 cytosol2019 centrosome2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 12/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
SPF27_MOUSE
Ensembl»
11.2
Bcas2 Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2
homolog) (DNA amplified in mammary carcinoma 1 protein)		 Mus musculus
TI:10090 None
 
B5DFM8_RAT
RGD»
6.0
Bcas2 Pre-mRNA-splicing factor SPF27 Rattus norvegicus
TI:10116 None
   
SPF27_HUMAN
Ensembl»
3.2
BCAS2 Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified
in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)		 Homo sapiens
TI:9606 None
 
SPF27_ARATH
TAIR»
1.6
MOS4 Pre-mRNA-splicing factor SPF27 homolog (Modifier of
SNC1 member 4) (Protein BCAS2 homolog)		 Arabidopsis thaliana
TI:3702 None
 
A0A803TJK0_ANOCA
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Anolis carolinensis
TI:28377 None
   
A0A8I3PM73_CANLF
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Canis lupus
TI:9612 None
   
A0A8V1A7U7_CHICK
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Gallus gallus
TI:9031 None
   
F6R986_MONDO
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Monodelphis domestica
TI:13616 None
   
F7FQ59_ORNAN
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Ornithorhynchus anatinus
TI:9258 None
   
H2PZQ5_PANTR
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Pan troglodytes
TI:9598 None
 
I2CYF2_MACMU
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Macaca mulatta
TI:9544 None
 
I6L631_PIG
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Sus scrofa
TI:9823 None
 
Q5E9D4_BOVIN
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Bos taurus
TI:9913 None
 
Q9VAY6_DROME
FlyBase»
1.8
BCAS2 Pre-mRNA-splicing factor SPF27 Drosophila melanogaster
TI:7227 None
 
SPF27_SCHPO
PomBase»
0.8
cwf7 Pre-mRNA-splicing factor cwf7 (Complexed with
cdc5 protein 7) (Splicing factor 27)		 Schizosaccharomyces pombe
TI:4896 None
 
A0A1S3XDB9_TOBAC
euHCVdb»
0.0
LOC107763847 Pre-mRNA-splicing factor SPF27 homolog Nicotiana tabacum
TI:4097 None
   
A0A1S3ZAD6_TOBAC
euHCVdb»
0.0
LOC107784675 Pre-mRNA-splicing factor SPF27 homolog Nicotiana tabacum
TI:4097 None
   
A0A1S4DAR2_TOBAC
euHCVdb»
0.0
LOC107827641 Pre-mRNA-splicing factor SPF27 homolog Nicotiana tabacum
TI:4097 None
   
A0A1U8J6I2_GOSHI
euHCVdb»
0.0
LOC107902058 Pre-mRNA-splicing factor SPF27
homolog isoform X1		 Gossypium hirsutum
TI:3635 None
   
A0A1U8PSE8_GOSHI
neXtProt»
0.0
LOC107962288 Pre-mRNA-splicing factor SPF27
homolog isoform X1		 Gossypium hirsutum
TI:3635 None
   
A0A9R0K491_SPIOL
euHCVdb»
0.0
LOC110797176 Pre-mRNA-splicing factor SPF27 homolog Spinacia oleracea
TI:3562 None
   
Q5HZR0_XENLA
Xenbase»
0.0
bcas2.L Pre-mRNA-splicing factor SPF27 Xenopus laevis
TI:8355 None
 
SPF27_DANRE
ZFIN»
0.5
bcas2 Pre-mRNA-splicing factor SPF27
(Protein BCAS2 homolog)		 Danio rerio
TI:7955 None
 
SPF27_XENTR
Xenbase»
0.0
bcas2 Pre-mRNA-splicing factor SPF27
(Protein BCAS2 homolog)		 Xenopus tropicalis
TI:8364 None
 
A0A2A6CQJ0_PRIPA
EnsemblMetazoa»
0.0
WBGene00114977 Pre-mRNA-splicing factor SPF27 Pristionchus pacificus
TI:54126 None
   
SPF27_DICDI
dictyBase»
0.0
spf27 Pre-mRNA-splicing factor spf27 Dictyostelium discoideum
TI:44689 None
 
A0A022QJ86_ERYGU
neXtProt»
0.0
MIMGU_mgv1a012413mg Pre-mRNA-splicing factor SPF27 Erythranthe guttata
TI:4155 None
 
A0A061G890_THECC
euHCVdb»
0.0
TCM_027148 Modifier of snc1,4 isoform 1 Theobroma cacao
TI:3641 None
 
A0A067F653_CITSI
euHCVdb»
0.0
CISIN_1g025332mg Pre-mRNA-splicing factor SPF27 Citrus sinensis
TI:2711 None
 
A0A078GGD0_BRANA
euHCVdb»
0.0
BnaC05g35230D BnaC05g35230D protein Brassica napus
TI:3708 None
 
A0A0A0LQG2_CUCSA
euHCVdb»
0.0
Csa_1G042680 Pre-mRNA-splicing factor SPF27 homolog Cucumis sativus
TI:3659 None
 
A0A0K9PQB6_ZOSMR
euHCVdb»
0.0
ZOSMA_187G00240 Pre-mRNA-splicing factor SPF27-like protein Zostera marina
TI:29655 None
 
A0A0K9PXB4_ZOSMR
neXtProt»
0.0
ZOSMA_145G00110 Pre-mRNA-splicing factor SPF27-like protein Zostera marina
TI:29655 None
 
A0A0Q3PBZ5_SETIT
EnsemblPlants»
0.0
BCAS2 protein Setaria italica
TI:4555 None
 
A0A0R0KAQ6_SOYBN
EnsemblPlants»
0.0
LOC100783349 Pre-mRNA-splicing factor SPF27 homolog Glycine max
TI:3847 None
 
A0A1U8AL10_NELNU
euHCVdb»
0.0
LOC104604144 Pre-mRNA-splicing factor SPF27 homolog Nelumbo nucifera
TI:4432 None
   
A0A1Y1I6E7_KLENI
euHCVdb»
0.0
KFL_002950060 BCAS2 Klebsormidium nitens
TI:105231 None
 
A0A251JE54_MANES
euHCVdb»
0.0
MANES_14G168500 Pre-mRNA-splicing factor SPF27 homolog Manihot esculenta
TI:3983 None
 
A0A2G3A341_CAPAN
euHCVdb»
0.0
T459_10748 Pre-mRNA-splicing factor SPF27 -like protein Capsicum annuum
TI:4072 None
 
A0A2I3RUL2_PANTR
Ensembl»
0.0
Uncharacterized protein Pan troglodytes
TI:9598 None
 
A0A2I4HMY7_JUGRE
euHCVdb»
0.0
LOC109019629 Pre-mRNA-splicing factor SPF27 homolog Juglans regia
TI:51240 None
   
A0A2K3CNP4_CHLRE
neXtProt»
0.0
CHLRE_17g697350v5 Pre-mRNA-splicing factor SPF27 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6WCD7_MARPO
euHCVdb»
0.0
MARPO_0110s0002 Pre-mRNA-splicing factor SPF27 Marchantia polymorpha
TI:3197 None
 
A0A3B3I523_ORYLA
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Oryzias latipes
TI:8090 None
   
A0A3B6EEK3_WHEAT
EnsemblPlants»
0.0
LOC123061036 Pre-mRNA-splicing factor SPF27 homolog Triticum aestivum
TI:4565 None
   
A0A3B6GQ02_WHEAT
EnsemblPlants»
0.0
LOC123078109 Pre-mRNA-splicing factor SPF27 homolog Triticum aestivum
TI:4565 None
   
A0A3Q7FST2_SOLLC
EnsemblPlants»
0.0
Pre-mRNA-splicing factor SPF27 homolog Solanum lycopersicum
TI:4081 None
   
A0A679L8Q6_CAEEL
WormBase»
0.0
CELE_T12A2.21 T12A2.21 Uncharacterized protein Caenorhabditis elegans
TI:6239 None
 
A0A6I8PH76_ORNAN
Ensembl»
0.0
Pre-mRNA-splicing factor SPF27 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7RBM7_STRPU
EnsemblMetazoa»
0.0
Pre-mRNA-splicing factor SPF27 Strongylocentrotus purpuratus
TI:7668 None
   
A0A804IDU1_MUSAM
EnsemblPlants»
0.0
GSMUA_199200.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A9J7NC39_BRAFL
neXtProt»
0.0
LOC118430479 Pre-mRNA-splicing factor SPF27 Branchiostoma floridae
TI:7739 None
   
A0A9K3JJH7_HELAN
neXtProt»
0.0
HanXRQr2_Chr03g0134591 Pre-mRNA-splicing factor SPF27 Helianthus annuus
TI:4232 None
 
A0A9R1W7V4_LACSA
neXtProt»
0.0
LSAT_V11C300147400 Pre-mRNA-splicing factor SPF27 homolog Lactuca sativa
TI:4236 None
 
A0C1P1_PARTE
euHCVdb»
0.0
GSPATT00034185001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None
 
A0CBI1_PARTE
neXtProt»
0.0
GSPATT00036931001 Pre-mRNA splicing factor component
Cdc5p/Cef1 C-terminal domain-containing protein		 Paramecium tetraurelia
TI:5888 None
 
A7EYX1_SCLS1
TubercuList»
0.0
SS1G_10537 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None
 
A7S9N3_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g168072 Pre-mRNA-splicing factor SPF27 Nematostella vectensis
TI:45351 None
 
A7SA14_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g110465 Pre-mRNA-splicing factor SPF27 Nematostella vectensis
TI:45351 None
 
A8XR24_CAEBR
WormBase»
0.0
CBG17493 CBG_17493 Protein CBG17493 Caenorhabditis briggsae
TI:6238 None
 
A8XR28_CAEBR
WormBase»
0.0
CBG17488 CBG_17488 Pre-mRNA-splicing factor SPF27 Caenorhabditis briggsae
TI:6238 None
 
A9SH09_PHYPA
EnsemblPlants»
0.0
LOC112286407 Pre-mRNA-splicing factor SPF27 Physcomitrium patens
TI:3218 None
 
A9V6D8_MONBE
neXtProt»
0.0
MONBRDRAFT_33609 Pre-mRNA-splicing factor SPF27 Monosiga brevicollis
TI:81824 None
 
B3RT44_TRIAD
CTD»
0.0
TRIADDRAFT_50080 Pre-mRNA-splicing factor SPF27 Trichoplax adhaerens
TI:10228 None
 
B8C711_THAPS
neXtProt»
0.0
THAPSDRAFT_23777 Uncharacterized protein Thalassiosira pseudonana
TI:35128 None
 
B9IE93_POPTR
euHCVdb»
0.0
POPTR_015G041800 Pre-mRNA-splicing factor SPF27 homolog Populus trichocarpa
TI:3694 None
 
B9SU94_RICCO
euHCVdb»
0.0
RCOM_0572020 Breast carcinoma amplified sequence, putative Ricinus communis
TI:3988 None
 
C0PJK8_MAIZE
EnsemblPlants»
0.0
LOC100284614 Pre-mRNA-splicing factor SPF27-like protein Zea mays
TI:4577 None
 
C5XGI1_SORBI
euHCVdb»
0.0
SORBI_3003G122000 Pre-mRNA-splicing factor SPF27 Sorghum bicolor
TI:4558 None
 
C6KSY5_PLAF7
TubercuList»
0.0
PF3D7_0614400 Pre-mRNA-splicing factor CWF7, putative Plasmodium falciparum
TI:5833 None
 
D6WKN2_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_10444 Pre-mRNA-splicing factor SPF27 Tribolium castaneum
TI:7070 None
 
D7SJ70_VITVI
euHCVdb»
0.0
VIT_17s0000g02840 Pre-mRNA-splicing factor SPF27-like Vitis vinifera
TI:29760 None
 
D8SVE5_SELML
euHCVdb»
0.0
SELMODRAFT_183070 Pre-mRNA-splicing factor SPF27 Selaginella moellendorffii
TI:88036 None
 
D8T0R6_SELML
euHCVdb»
0.0
SELMODRAFT_129290 Pre-mRNA-splicing factor SPF27 Selaginella moellendorffii
TI:88036 None
 
E3JR11_PUCGT
TubercuList»
0.0
PGTG_00129 Breast carcinoma amplified sequence 2 Puccinia graminis
TI:5297 None
 
F0Z9L4_DICPU
TubercuList»
0.0
DICPUDRAFT_86122 Pre-mRNA-splicing factor SPF27 Dictyostelium purpureum
TI:5786 None
 
F2DKT5_HORVV
EnsemblPlants»
0.0
LOC123443459 Predicted protein Hordeum vulgare
TI:4513 None
 
F4P5S2_BATDJ
neXtProt»
0.0
BATDEDRAFT_89766 Pre-mRNA-splicing factor SPF27 Batrachochytrium dendrobatidis
TI:109871 None
 
F6YWI2_CIOIN
Ensembl»
0.0
LOC100182504 Pre-mRNA-splicing factor SPF27 Ciona intestinalis
TI:7719 None
   
G3SIP8_GORGO
Ensembl»
0.0
Uncharacterized protein Gorilla gorilla
TI:9593 None
 
G7LD93_MEDTR
EnsemblPlants»
0.0
11414393 Breast carcinoma amplified sequence protein,
putative (Putative pre-mRNA-splicing factor SPF27)		 Medicago truncatula
TI:3880 None
 
H3H1I5_PHYRM
EnsemblProtists»
0.0
Pre-mRNA-splicing factor SPF27 Phytophthora ramorum
TI:164328 None
 
I1HE83_BRADI
EnsemblPlants»
0.0
LOC100836755 Pre-mRNA-splicing factor SPF27 Brachypodium distachyon
TI:15368 None
 
I1KQH7_SOYBN
EnsemblPlants»
0.0
LOC100777152 Pre-mRNA-splicing factor SPF27 homolog Glycine max
TI:3847 None
 
M1A475_SOLTU
EnsemblPlants»
0.0
LOC102605698 Pre-mRNA-splicing factor SPF27 homolog Solanum tuberosum
TI:4113 None
   
M4DXQ1_BRACM
EnsemblPlants»
0.0
Pre-mRNA-splicing factor SPF27 homolog Brassica campestris
TI:3711 None
   
M4E0J1_BRACM
EnsemblPlants»
0.0
Pre-mRNA-splicing factor SPF27 homolog Brassica campestris
TI:3711 None
   
M5WV86_PRUPE
euHCVdb»
0.0
PRUPE_5G229800 Pre-mRNA-splicing factor SPF27 homolog Prunus persica
TI:3760 None
 
Q1K864_NEUCR
TubercuList»
0.0
NCU01167 BCAS2 family protein Neurospora crassa
TI:5141 None
 
Q22417_CAEEL
WormBase»
0.0
bcas-2 Pre-mRNA-splicing factor SPF27 Caenorhabditis elegans
TI:6239 None
 
Q4WJC5_ASPFU
TubercuList»
0.0
AFUA_1G06460 BCAS2 family protein Aspergillus fumigatus
TI:746128 None
 
Q5B5D6_EMENI
TubercuList»
0.0
ANIA_04244 BCAS2 family
protein (AFU_orthologue AFUA_1G06460)		 Emericella nidulans
TI:162425 None
 
Q5KF64_CRYD1
TubercuList»
0.0
CNF02850 Pre-mRNA-splicing factor SPF27 Cryptococcus deneoformans
TI:40410 None
 
Q6CBS4_YARLI
TubercuList»
0.0
YALI0_C16005g YALI0C16005p Yarrowia lipolytica
TI:4952 None
 
Q7QBT8_ANOGA
EnsemblMetazoa»
0.0
1273664 Pre-mRNA-splicing factor SPF27 Anopheles gambiae
TI:7165 None
 
T1FNX5_HELRO
EnsemblMetazoa»
0.0
20210522 Pre-mRNA-splicing factor SPF27 Helobdella robusta
TI:6412 None
 
W1NNH4_AMBTC
euHCVdb»
0.0
AMTR_s00119p00125710 Pre-mRNA-splicing factor SPF27 Amborella trichopoda
TI:13333 None
 
W5MWS8_LEPOC
Ensembl»
0.0
Pre-mRNA-splicing factor SPF27 Lepisosteus oculatus
TI:7918 None
 
A0A078GJ39_BRANA
euHCVdb»
0.0
BnaC05g32870D BnaC05g32870D protein Brassica napus
TI:3708 None
 
A0A0K9NRJ3_ZOSMR
euHCVdb»
0.0
ZOSMA_69G01030 Uncharacterized protein Zostera marina
TI:29655 None
 
A0A0Q3V624_SETIT
EnsemblPlants»
0.0
Pre-mRNA-splicing factor SPF27 Setaria italica
TI:4555 None
 
A0A251VD28_HELAN
euHCVdb»
0.0
MOS4 Putative modifier of snc1,4 Helianthus annuus
TI:4232 None
 
A0A7U2F5G5_PHANO
TubercuList»
0.0
JI435_017200 Pre-mRNA-splicing factor SPF27 Phaeosphaeria nodorum
TI:13684 None
 
A0A9R1FIU9_WHEAT
EnsemblPlants»
0.0
LOC123069627 Pre-mRNA-splicing factor SPF27 Triticum aestivum
TI:4565 None
 
A0ABI7Y6P6_FELCA
Ensembl»
0.0
BCAS2 Pre-mRNA-splicing factor SPF27 Felis catus
TI:9685 None
   
B6K4Z6_SCHJY
TubercuList»
0.0
cwf7 Splicing factor Cwf7 Schizosaccharomyces japonicus
TI:4897 None
 
B7PNH7_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW006520 Pre-mRNA-splicing factor SPF27 Ixodes scapularis
TI:6945 None
 
G3RWN0_GORGO
Ensembl»
0.0
Pre-mRNA-splicing factor SPF27 Gorilla gorilla
TI:9593 None