Collated Gene Ontology terms

Biological process: protein phosphatase regulator activity(2011, 2013, 2017, 2025) protein-macromolecule adaptor activity(2011, 2025)

Molecular function: regulation of double-strand break repair via homologous recombination2011, 2025 regulation of double-strand break repair2024, 2025 negative regulation of DNA damage checkpoint2013, 2017 mRNA processing2025 hematopoietic progenitor cell differentiation2014 RNA splicing2025 protein modification process2003 negative regulation of smoothened signaling pathway2017 negative regulation of peptidoglycan recognition protein signaling pathway2022 mitotic cell cycle2008
meiotic recombination checkpoint signaling2024

Cellular component: protein phosphatase 4 complex2007, 2011, 2012, 2013, 2014, 2021, 2025 nucleus2011, 2012, 2013, 2017, 2018, 2020, 2025 cytoplasm2012, 2013, 2017, 2025 nucleoplasm2015, 2024, 2025 chromatin2024, 2025 cytosol2017, 2025 centrosome2003, 2025 chromosome, centromeric region2015

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 13/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
PP4R2_HUMAN
Ensembl»
4.6
PPP4R2 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Homo sapiens
TI:9606 None
 
G3QZA9_GORGO
Ensembl»
0.0
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Gorilla gorilla
TI:9593 None
 
PP4R2_DROME
FlyBase»
2.9
PPP4R2r Serine/threonine-protein phosphatase 4 regulatory
subunit 2 (PPP4R2-related protein)		 Drosophila melanogaster
TI:7227 None
 
PP4R2_MOUSE
AG»
4.3
Ppp4r2 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Mus musculus
TI:10090 None
 
PP4R2_YEAST
SGD»
2.7
PSY4 Serine/threonine-protein phosphatase 4
regulatory subunit 2 (PP4R2)		 Saccharomyces cerevisiae
TI:4932 None
 
B4FJ98_MAIZE
EnsemblPlants»
0.0
LOC100216692 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Zea mays
TI:4577 None
 
P4R2B_DANRE
ZFIN»
0.5
ppp4r2b Serine/threonine-protein phosphatase 4
regulatory subunit 2-B		 Danio rerio
TI:7955 None
 
Q8VY58_ARATH
TAIR»
0.5
PP4R2L Serine/threonine-protein phosphatase 4
regulatory subunit-like protein		 Arabidopsis thaliana
TI:3702 None
 
B7QHD7_IXOSC
EnsemblMetazoa»
0.0
8041280 Serine/threonine protein phosphatase
4 regulatory subunit, putative		 Ixodes scapularis
TI:6945 None
 
C6TEN3_SOYBN
EnsemblPlants»
0.0
LOC100803269 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Glycine max
TI:3847 None
 
F2DFE5_HORVV
EnsemblPlants»
0.0
LOC123407290 Predicted protein Hordeum vulgare
TI:4513 None
 
G3RUZ3_GORGO
Ensembl»
0.0
Protein phosphatase 4 regulatory subunit 2 Gorilla gorilla
TI:9593 None
 
G7JRR4_MEDTR
EnsemblPlants»
0.0
11441662 PPP4R2 protein Medicago truncatula
TI:3880 None
 
I1LP88_SOYBN
EnsemblPlants»
0.0
LOC100527622 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Glycine max
TI:3847 None
 
K3XYI3_SETIT
EnsemblPlants»
0.0
LOC101763919 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Setaria italica
TI:4555 None
 
M5X1Z4_PRUPE
neXtProt»
0.0
PRUPE_2G324400 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Prunus persica
TI:3760 None
 
P4R2A_DANRE
ZFIN»
0.5
ppp4r2a Serine/threonine-protein phosphatase 4
regulatory subunit 2-A		 Danio rerio
TI:7955 None
 
PP4R2_XENTR
Xenbase»
0.0
ppp4r2 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Xenopus tropicalis
TI:8364 None
 
Q5ZA33_ORYSJ
neXtProt»
0.0
Os06g0300700 Os06g0300700 protein (cDNA
clone:J023091P20, full insert sequence)		 Oryza sativa
TI:4530 None
 
T1FW15_HELRO
EnsemblMetazoa»
0.0
20213011 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Helobdella robusta
TI:6412 None
 
A0A022RZ85_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a012785mg Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Erythranthe guttata
TI:4155 None
 
A0A061FUH5_THECC
neXtProt»
0.0
TCM_011942 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Theobroma cacao
TI:3641 None
 
A0A067E5W0_CITSI
euHCVdb»
0.0
CISIN_1g025581mg Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Citrus sinensis
TI:2711 None
 
A0A0A0L0H6_CUCSA
euHCVdb»
0.0
Csa_4G092950 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Cucumis sativus
TI:3659 None
 
A0A0K9PIG7_ZOSMR
neXtProt»
0.0
ZOSMA_24G00530 Serine/threonine protein phosphatase
4 regulatory subunit		 Zostera marina
TI:29655 None
 
A0A1U8G8T9_CAPAN
neXtProt»
0.0
T459_09077 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Capsicum annuum
TI:4072 None
 
A0A1Y1ILN0_KLENI
euHCVdb»
0.0
KFL_007200010 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Klebsormidium nitens
TI:105231 None
 
A0A251RMQ9_HELAN
euHCVdb»
0.0
HannXRQ_Chr17g0541681 Protein phosphatase 4 core regulatory subunit R2 Helianthus annuus
TI:4232 None
 
A0A2C9VGV8_MANES
euHCVdb»
0.0
MANES_08G163800v8 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Manihot esculenta
TI:3983 None
 
A0A2I2ZNR1_GORGO
Ensembl»
0.0
Protein phosphatase 4 regulatory subunit 2 Gorilla gorilla
TI:9593 None
 
A0A2I3RNR9_PANTR
Ensembl»
0.0
Uncharacterized protein Pan troglodytes
TI:9598 None
 
A0A2I3S976_PANTR
Ensembl»
0.0
Uncharacterized protein Pan troglodytes
TI:9598 None
 
A0A2I3T5D4_PANTR
Ensembl»
0.0
PPP4R2 Pan troglodytes
TI:9598 None
 
A0A2K1IU53_PHYPA
EnsemblPlants»
0.0
PHYPA_024755 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Physcomitrium patens
TI:3218 None
 
A0A2K1WQ04_POPTR
euHCVdb»
0.0
POPTR_019G052400 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Populus trichocarpa
TI:3694 None
 
A0A2K3DC35_CHLRE
euHCVdb»
0.0
CHLRE_10g463700v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6WJG2_MARPO
euHCVdb»
0.0
MARPO_0084s0069 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Marchantia polymorpha
TI:3197 None
 
A0A7U2FCM4_PHANO
TubercuList»
0.0
JI435_113490 Uncharacterized protein Phaeosphaeria nodorum
TI:13684 None
 
A0A804K4V7_MUSAM
EnsemblPlants»
0.0
GSMUA_343430.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A9K3GSN9_HELAN
euHCVdb»
0.0
HanXRQr2_Chr17g0790301 Protein phosphatase 4 core regulatory subunit R2 Helianthus annuus
TI:4232 None
 
A0A9K3IHB8_HELAN
euHCVdb»
0.0
HanXRQr2_Chr08g0358521 Uncharacterized protein Helianthus annuus
TI:4232 None
 
A0A9R1XNJ2_LACSA
euHCVdb»
0.0
LSAT_V11C300116530 Protein phosphatase 4 core regulatory subunit R2 Lactuca sativa
TI:4236 None
 
A0CKJ1_PARTE
euHCVdb»
0.0
GSPATT00001022001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None
 
A0CNN1_PARTE
euHCVdb»
0.0
GSPATT00008840001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None
 
A7ELW8_SCLS1
TubercuList»
0.0
SS1G_06315 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None
 
A7RKE9_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g198399 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Nematostella vectensis
TI:45351 None
 
A7USV1_ANOGA
EnsemblMetazoa»
0.0
5667476 AGAP002501-PA Anopheles gambiae
TI:7165 None
 
A8XGC5_CAEBR
WormBase»
0.0
ppfr-2 Protein CBR-PPFR-2 Caenorhabditis briggsae
TI:6238 None
 
A9UZZ8_MONBE
euHCVdb»
0.0
MONBRDRAFT_37161 Uncharacterized protein Monosiga brevicollis
TI:81824 None
 
B3RUT7_TRIAD
CTD»
0.0
TRIADDRAFT_55408 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Trichoplax adhaerens
TI:10228 None
 
B9S1Z4_RICCO
euHCVdb»
0.0
RCOM_1324450 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Ricinus communis
TI:3988 None
 
C5Z943_SORBI
neXtProt»
0.0
SORBI_3010G125200 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Sorghum bicolor
TI:4558 None
 
C8V450_EMENI
TubercuList»
0.0
ANIA_03625 Protein phosphatase 4 core regulatory subunit R2 Emericella nidulans
TI:162425 None
 
D2A1H4_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_08382 Uncharacterized protein Tribolium castaneum
TI:7070 None
 
D8RVA6_SELML
neXtProt»
0.0
SELMODRAFT_442684 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
D8S208_SELML
euHCVdb»
0.0
SELMODRAFT_417373 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
E3KVG1_PUCGT
TubercuList»
0.0
PGTG_14340 Uncharacterized protein Puccinia graminis
TI:5297 None
 
E9HKA7_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_229122 EOG090X0BWU Daphnia pulex
TI:6669 None
 
F1A4Z0_DICPU
TubercuList»
0.0
DICPUDRAFT_85184 PPP4R2 Dictyostelium purpureum
TI:5786 None
 
F4NU38_BATDJ
euHCVdb»
0.0
BATDEDRAFT_21609 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
F6HEG4_VITVI
neXtProt»
0.0
VIT_16s0039g02270 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Vitis vinifera
TI:29760 None
 
F6XG24_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
 
H3GKP3_PHYRM
EnsemblProtists»
0.0
Uncharacterized protein Phytophthora ramorum
TI:164328 None
 
I1GYW6_BRADI
EnsemblPlants»
0.0
LOC100821792 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Brachypodium distachyon
TI:15368 None
 
P4R2A_XENLA
Xenbase»
0.0
ppp4r2-a Serine/threonine-protein phosphatase 4
regulatory subunit 2-A		 Xenopus laevis
TI:8355 None
 
P4R2B_XENLA
Xenbase»
0.0
ppp4r2-b Serine/threonine-protein phosphatase 4
regulatory subunit 2-B		 Xenopus laevis
TI:8355 None
 
P91198_CAEEL
WormBase»
0.5
ppfr-2 Protein Phosphatase Four Regulatory subunit Caenorhabditis elegans
TI:6239 None
 
PP4R2_CHICK
CTD»
0.5
PPP4R2 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Gallus gallus
TI:9031 None
 
PP4R2_DICDI
dictyBase»
0.5
ppp4r2 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Dictyostelium discoideum
TI:44689 None
 
PP4R2_EREGS
EnsemblFungi»
0.0
PSY4 Serine/threonine-protein phosphatase 4
regulatory subunit 2 (PP4R2)		 Eremothecium gossypii
TI:33169 None
 
Q4WQF2_ASPFU
TubercuList»
0.0
AFUA_4G12610 Protein phosphatase 4 core regulatory subunit R2 Aspergillus fumigatus
TI:746128 None
 
Q5AK01_CANAL
CGD»
0.0
PSY4 Uncharacterized protein Candida albicans
TI:5476 None
 
Q5KLR6_CRYD1
TubercuList»
0.0
CNB04320 Uncharacterized protein Cryptococcus deneoformans
TI:40410 None
 
Q6C9T9_YARLI
TubercuList»
0.0
YALI0_D08419g YALI0D08419p Yarrowia lipolytica
TI:4952 None
 
Q7SCV4_NEUCR
TubercuList»
0.0
NCU00900 Protein phosphatase 4 core regulatory subunit R2 Neurospora crassa
TI:5141 None
 
W1PQ62_AMBTC
neXtProt»
0.0
AMTR_s00162p00053350 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Amborella trichopoda
TI:13333 None
 
W5MUV0_LEPOC
Ensembl»
0.0
Protein phosphatase 4, regulatory subunit 2b Lepisosteus oculatus
TI:7918 None
 
W8CC72_ORNAN
Ensembl»
0.0
PPP4R2Y PPP4R2Y Ornithorhynchus anatinus
TI:9258 None
 
A0A1D5Q6P1_MACMU
Ensembl»
0.0
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Macaca mulatta
TI:9544 None
   
A0A1S3XVE2_TOBAC
euHCVdb»
0.0
LOC107769224 Serine/threonine-protein phosphatase 4 regulatory subunit 2-A
isoform X1 (Uncharacterized protein LOC107769224 isoform X1)		 Nicotiana tabacum
TI:4097 None
   
A0A1S3YI33_TOBAC
neXtProt»
0.0
LOC107776329 Serine/threonine-protein phosphatase 4 regulatory subunit 2
isoform X1 (Uncharacterized protein LOC107776329 isoform X1)		 Nicotiana tabacum
TI:4097 None
   
A0A1U7YZG1_NELNU
euHCVdb»
0.0
LOC104587609 Serine/threonine-protein phosphatase 4 regulatory
subunit 2 isoform X3		 Nelumbo nucifera
TI:4432 None
   
A0A1U8P7G3_GOSHI
euHCVdb»
0.0
LOC107955772 Serine/threonine-protein phosphatase 4 regulatory
subunit 2 isoform X1		 Gossypium hirsutum
TI:3635 None
   
A0A287AZP4_PIG
Ensembl»
0.0
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Sus scrofa
TI:9823 None
   
A0A2I3RUE7_PANTR
Ensembl»
0.0
Uncharacterized protein Pan troglodytes
TI:9598 None
   
A0A2I3SHS4_PANTR
Ensembl»
0.0
PPP4R2 Pan troglodytes
TI:9598 None
   
A0A2I4FB53_JUGRE
euHCVdb»
0.0
LOC108997175 Serine/threonine-protein phosphatase 4 regulatory
subunit 2-like isoform X1		 Juglans regia
TI:51240 None
   
A0A2I4H0L8_JUGRE
neXtProt»
0.0
LOC109012476 Serine/threonine-protein phosphatase 4
regulatory subunit 2-A-like		 Juglans regia
TI:51240 None
   
A0A3B3IHW3_ORYLA
Ensembl»
0.0
LOC101162291 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Oryzias latipes
TI:8090 None
   
A0A3B6RGZ0_WHEAT
EnsemblPlants»
0.0
Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Triticum aestivum
TI:4565 None
   
A0A3B6SGX8_WHEAT
EnsemblPlants»
0.0
LOC123164664 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Triticum aestivum
TI:4565 None
   
A0A3B6THE1_WHEAT
EnsemblPlants»
0.0
Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Triticum aestivum
TI:4565 None
   
A0A3Q7FIB9_SOLLC
EnsemblPlants»
0.0
LOC101262493 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Solanum lycopersicum
TI:4081 None
   
A0A6I8P151_ORNAN
Ensembl»
0.0
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7RB35_STRPU
EnsemblMetazoa»
0.0
Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3N1L3_CANLF
Ensembl»
0.0
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Canis lupus
TI:9612 None
   
A0A8J1N1G0_XENLA
CTD»
0.0
ppp4r2.S Serine/threonine-protein phosphatase 4 regulatory
subunit 2-B isoform X1		 Xenopus laevis
TI:8355 None
   
A0A8V0ZE92_CHICK
Ensembl»
0.5
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Gallus gallus
TI:9031 None
   
A0A9J7L577_BRAFL
euHCVdb»
0.0
LOC118415304 Serine/threonine-protein phosphatase 4 regulatory
subunit 2-B-like isoform X1		 Branchiostoma floridae
TI:7739 None
   
A0A9R0JIC9_SPIOL
neXtProt»
0.0
LOC110805765 Uncharacterized protein isoform X1 Spinacia oleracea
TI:3562 None
   
A0ABI7W377_FELCA
Ensembl»
0.0
PPP4R2 Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Felis catus
TI:9685 None
   
A0ABM3AFR0_GOSHI
euHCVdb»
0.0
LOC107954829 Uncharacterized protein isoform X1 Gossypium hirsutum
TI:3635 None
   
D4A8H5_RAT
RGD»
3.0
Ppp4r2 Protein phosphatase 4, regulatory subunit 2 Rattus norvegicus
TI:10116 None
   
F1N3Z8_BOVIN
Ensembl»
0.0
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Bos taurus
TI:9913 None
   
F7D7V5_HORSE
Ensembl»
0.0
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Equus caballus
TI:9796 None
   
F7G9R3_MONDO
Ensembl»
0.0
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Monodelphis domestica
TI:13616 None
   
G1KQF0_ANOCA
Ensembl»
0.0
PPP4R2 Protein phosphatase 4 regulatory subunit 2 Anolis carolinensis
TI:28377 None
   
H2M5R0_ORYLA
Ensembl»
0.0
ppp4r2b Protein phosphatase 4, regulatory subunit 2b Oryzias latipes
TI:8090 None
   
M1AGG8_SOLTU
EnsemblPlants»
0.0
Uncharacterized protein Solanum tuberosum
TI:4113 None
   
M4CQ94_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None
   
M4E492_BRACM
EnsemblPlants»
0.0
Serine/threonine-protein phosphatase 4
regulatory subunit 2		 Brassica campestris
TI:3711 None