Collated Gene Ontology terms

Biological process: dihydroxy-acid dehydratase activity(2010, 2012, 2013, 2022, 2023, 2025) lyase activity(2025) catalytic activity(2025) metal ion binding(2025) iron-sulfur cluster binding(2025) 2 iron, 2 sulfur cluster binding(2025) hydro-lyase activity(2015, 2025) magnesium ion binding(2025) copper ion binding(2021)

Molecular function: branched-chain amino acid biosynthetic process2010, 2012, 2013, 2015, 2023, 2025 amino acid biosynthetic process2025 isoleucine biosynthetic process2022, 2024, 2025 L-valine biosynthetic process2022, 2024, 2025 L-leucine biosynthetic process2022, 2025 root development2015 response to salt stress2015 pollen development2015 embryo sac development2015 L-isoleucine biosynthetic process2004

Cellular component: chloroplast stroma2021, 2025 mitochondrion2009, 2018, 2025 chloroplast2018, 2021, 2025 plastid2021 plasma membrane2010 mitochondrial matrix2024 cytosol2011

Phylogenetic distribution

Chordates: 0/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 0/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 3/8 
Bacteria: 8/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
ILVD_ARATH
TAIR»
6.4
DHAD Dihydroxy-acid dehydratase, chloroplastic
(AthDHAD) (DAD) (EC 4.2.1.9)		 Arabidopsis thaliana
TI:3702 None
 
ILV3_SCHPO
PomBase»
4.7
SPAC17G8.06c Dihydroxy-acid dehydratase, mitochondrial
(DAD) (EC 4.2.1.9)		 Schizosaccharomyces pombe
TI:4896 None
 
ILV3_YEAST
SGD»
2.6
ILV3 Dihydroxy-acid dehydratase, mitochondrial
(DAD) (EC 4.2.1.9)		 Saccharomyces cerevisiae
TI:4932 None
 
A0A022QV93_ERYGU
neXtProt»
0.0
MIMGU_mgv1a003052mg dihydroxy-acid dehydratase (EC 4.2.1.9) Erythranthe guttata
TI:4155 None
 
A0A061EST7_THECC
neXtProt»
0.0
TCM_020385 dihydroxy-acid dehydratase (EC 4.2.1.9) Theobroma cacao
TI:3641 None
 
A0A067DKU2_CITSI
neXtProt»
0.0
CISIN_1g007192mg dihydroxy-acid dehydratase (EC 4.2.1.9) Citrus sinensis
TI:2711 None
 
A0A078FY76_BRANA
neXtProt»
0.0
BnaA01g23200D dihydroxy-acid dehydratase (EC 4.2.1.9) Brassica napus
TI:3708 None
 
A0A078I644_BRANA
neXtProt»
0.0
BnaC01g30200D dihydroxy-acid dehydratase (EC 4.2.1.9) Brassica napus
TI:3708 None
 
A0A078I8W0_BRANA
neXtProt»
0.0
BnaC09g21470D dihydroxy-acid dehydratase (EC 4.2.1.9) Brassica napus
TI:3708 None
 
A0A0A0L6U0_CUCSA
neXtProt»
0.0
Csa_3G133100 dihydroxy-acid dehydratase (EC 4.2.1.9) Cucumis sativus
TI:3659 None
 
A0A0K9NLI2_ZOSMR
neXtProt»
0.0
ZOSMA_8G00980 dihydroxy-acid dehydratase (EC 4.2.1.9) Zostera marina
TI:29655 None
 
A0A0Q3FJF1_BRADI
EnsemblPlants»
0.0
LOC100829216 dihydroxy-acid dehydratase (EC 4.2.1.9) Brachypodium distachyon
TI:15368 None
 
A0A1S3Z1R6_TOBAC
neXtProt»
0.0
LOC107782074 dihydroxy-acid dehydratase (EC 4.2.1.9) Nicotiana tabacum
TI:4097 None
   
A0A1S3ZK66_TOBAC
neXtProt»
0.0
LOC107787836 dihydroxy-acid dehydratase (EC 4.2.1.9) Nicotiana tabacum
TI:4097 None
   
A0A1U7YWZ9_NELNU
neXtProt»
0.0
LOC104587899 dihydroxy-acid dehydratase (EC 4.2.1.9) Nelumbo nucifera
TI:4432 None
   
A0A1U8IL92_GOSHI
neXtProt»
0.0
LOC107897843 dihydroxy-acid dehydratase (EC 4.2.1.9) Gossypium hirsutum
TI:3635 None
   
A0A1U8JLG1_GOSHI
euHCVdb»
0.0
LOC107908457 Dihydroxy-acid dehydratase, chloroplastic Gossypium hirsutum
TI:3635 None
   
A0A1U8KA91_GOSHI
neXtProt»
0.0
LOC107914890 dihydroxy-acid dehydratase (EC 4.2.1.9) Gossypium hirsutum
TI:3635 None
   
A0A1U8LIG4_GOSHI
neXtProt»
0.0
LOC107927784 dihydroxy-acid dehydratase (EC 4.2.1.9) Gossypium hirsutum
TI:3635 None
   
A0A1U8PCH0_GOSHI
neXtProt»
0.0
LOC107957083 dihydroxy-acid dehydratase (EC 4.2.1.9) Gossypium hirsutum
TI:3635 None
   
A0A1Y1I7Q9_KLENI
neXtProt»
0.0
KFL_002030090 dihydroxy-acid dehydratase (EC 4.2.1.9) Klebsormidium nitens
TI:105231 None
 
A0A251SF80_HELAN
neXtProt»
0.0
HannXRQ_Chr14g0435331 HanXRQr2_Chr14g0634061 dihydroxy-acid dehydratase (EC 4.2.1.9) Helianthus annuus
TI:4232 None
 
A0A251SF95_HELAN
euHCVdb»
0.0
HannXRQ_Chr14g0435341 Putative
dihydroxy-acid/6-phosphogluconate dehydratase		 Helianthus annuus
TI:4232 None
 
A0A251VJT4_HELAN
neXtProt»
0.0
ILVD dihydroxy-acid dehydratase (EC 4.2.1.9) Helianthus annuus
TI:4232 None
 
A0A2C9UE54_MANES
neXtProt»
0.0
MANES_15G050825v8 dihydroxy-acid dehydratase (EC 4.2.1.9) Manihot esculenta
TI:3983 None
 
A0A2G2Y8R7_CAPAN
euHCVdb»
0.0
T459_30555 Dihydroxy-acid/6-phosphogluconate dehydratase
C-terminal domain-containing protein		 Capsicum annuum
TI:4072 None
 
A0A2G2Y8W9_CAPAN
neXtProt»
0.0
T459_30554 Dihydroxy-acid/6-phosphogluconate dehydratase
C-terminal domain-containing protein		 Capsicum annuum
TI:4072 None 		 
 
A0A2G2Y9A0_CAPAN
euHCVdb»
0.0
T459_30556 Dihydroxy-acid dehydratase, chloroplastic Capsicum annuum
TI:4072 None
 
A0A2G2ZK49_CAPAN
neXtProt»
0.0
T459_15320 dihydroxy-acid dehydratase (EC 4.2.1.9) Capsicum annuum
TI:4072 None
 
A0A2I4F622_JUGRE
neXtProt»
0.0
LOC108995890 dihydroxy-acid dehydratase (EC 4.2.1.9) Juglans regia
TI:51240 None
   
A0A2K1JV99_PHYPA
EnsemblPlants»
0.0
LOC112288744 dihydroxy-acid dehydratase (EC 4.2.1.9) Physcomitrium patens
TI:3218 None
 
A0A2R6X0T1_MARPO
neXtProt»
0.0
MARPO_0044s0128 dihydroxy-acid dehydratase (EC 4.2.1.9) Marchantia polymorpha
TI:3197 None
 
A0A3B6RFN1_WHEAT
EnsemblPlants»
0.0
LOC123153596 dihydroxy-acid dehydratase (EC 4.2.1.9) Triticum aestivum
TI:4565 None
   
A0A3B6SGP6_WHEAT
EnsemblPlants»
0.0
LOC123157147 dihydroxy-acid dehydratase (EC 4.2.1.9) Triticum aestivum
TI:4565 None
   
A0A3B6TJJ8_WHEAT
EnsemblPlants»
0.0
LOC123165567 dihydroxy-acid dehydratase (EC 4.2.1.9) Triticum aestivum
TI:4565 None
   
A0A3P6BKW3_BRACM
EnsemblPlants»
0.0
BRAA07T28596Z BRAPAZ1V2_A07P09480.2 dihydroxy-acid dehydratase (EC 4.2.1.9) Brassica campestris
TI:3711 None
 
A0A3Q7GK31_SOLLC
EnsemblPlants»
0.0
LOC101246533 dihydroxy-acid dehydratase (EC 4.2.1.9) Solanum lycopersicum
TI:4081 None
   
A0A3Q7J9S1_SOLLC
EnsemblPlants»
0.0
LOC101264707 dihydroxy-acid dehydratase (EC 4.2.1.9) Solanum lycopersicum
TI:4081 None
   
A0A7U2EQ91_PHANO
TubercuList»
0.0
JI435_300320 Dihydroxy-acid/6-phosphogluconate dehydratase
N-terminal domain-containing protein		 Phaeosphaeria nodorum
TI:13684 None
 
A0A7U2FIZ8_PHANO
TubercuList»
0.0
JI435_128840 dihydroxy-acid dehydratase (EC 4.2.1.9) Phaeosphaeria nodorum
TI:13684 None
 
A0A7U2HWV6_PHANO
TubercuList»
0.0
JI435_005510 dihydroxy-acid dehydratase (EC 4.2.1.9) Phaeosphaeria nodorum
TI:13684 None
 
A0A804ILD1_MUSAM
EnsemblPlants»
0.0
GSMUA_110820.1 dihydroxy-acid dehydratase (EC 4.2.1.9) Musa acuminata
TI:4641 None
 
A0A8I7BEF2_HORVV
EnsemblPlants»
0.0
LOC123407417 dihydroxy-acid dehydratase (EC 4.2.1.9) Hordeum vulgare
TI:4513 None
   
A0A9K3H6R1_HELAN
euHCVdb»
0.0
HanXRQr2_Chr14g0634071 Dihydroxy-acid dehydratase (EC 4.2.1.9) Helianthus annuus
TI:4232 None
 
A0A9R0IHD5_SPIOL
neXtProt»
0.0
LOC110788698 dihydroxy-acid dehydratase (EC 4.2.1.9) Spinacia oleracea
TI:3562 None
   
A0A9R0IIA0_SPIOL
neXtProt»
0.0
LOC110788312 dihydroxy-acid dehydratase (EC 4.2.1.9) Spinacia oleracea
TI:3562 None
   
A0A9R1V6H0_LACSA
neXtProt»
0.0
LSAT_V11C600322200 dihydroxy-acid dehydratase (EC 4.2.1.9) Lactuca sativa
TI:4236 None
 
A0A9R1VHU6_LACSA
neXtProt»
0.0
LSAT_V11C500275970 dihydroxy-acid dehydratase (EC 4.2.1.9) Lactuca sativa
TI:4236 None
 
A0A9R1VQ72_LACSA
euHCVdb»
0.0
LSAT_V11C400219670 Dihydroxy-acid/6-phosphogluconate dehydratase
C-terminal domain-containing protein		 Lactuca sativa
TI:4236 None 		 
 
A0A9R1X837_LACSA
euHCVdb»
0.0
LSAT_V11C500289020 Dihydroxy-acid/6-phosphogluconate dehydratase
C-terminal domain-containing protein		 Lactuca sativa
TI:4236 None
 
A7EU45_SCLS1
TubercuList»
0.0
SS1G_08852 dihydroxy-acid dehydratase (EC 4.2.1.9) Sclerotinia sclerotiorum
TI:5180 None
 
A7EU65_SCLS1
neXtProt»
0.0
SS1G_08872 dihydroxy-acid dehydratase (EC 4.2.1.9) Sclerotinia sclerotiorum
TI:5180 None
 
A7RMM9_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g239399 dihydroxy-acid dehydratase (EC 4.2.1.9) Nematostella vectensis
TI:45351 None
 
A8IX80_CHLRE
neXtProt»
0.0
CHLRE_03g206600v5 dihydroxy-acid dehydratase (EC 4.2.1.9) Chlamydomonas reinhardtii
TI:3055 None
 
A9A271_NITMS
EnsemblBacteria»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Nitrosopumilus maritimus
TI:338192 None
 
A9V147_MONBE
neXtProt»
0.0
MONBRDRAFT_32689 dihydroxy-acid dehydratase (EC 4.2.1.9) Monosiga brevicollis
TI:81824 None
 
B4FWX5_MAIZE
EnsemblPlants»
0.0
LOC100273676 dihydroxy-acid dehydratase (EC 4.2.1.9) Zea mays
TI:4577 None
 
B6K5X3_SCHJY
TubercuList»
0.0
ilv3 dihydroxy-acid dehydratase (EC 4.2.1.9) Schizosaccharomyces japonicus
TI:4897 None
 
B8C011_THAPS
neXtProt»
0.0
DAD1 dihydroxy-acid dehydratase (EC 4.2.1.9) Thalassiosira pseudonana
TI:35128 None
 
B9GMG3_POPTR
neXtProt»
0.0
POPTR_001G051700 dihydroxy-acid dehydratase (EC 4.2.1.9) Populus trichocarpa
TI:3694 None
 
B9H085_POPTR
neXtProt»
0.0
POPTR_003G176600 dihydroxy-acid dehydratase (EC 4.2.1.9) Populus trichocarpa
TI:3694 None
 
B9RWL5_RICCO
neXtProt»
0.0
RCOM_1020720 dihydroxy-acid dehydratase (EC 4.2.1.9) Ricinus communis
TI:3988 None
 
C0P869_MAIZE
EnsemblPlants»
0.0
LOC100384514 dihydroxy-acid dehydratase (EC 4.2.1.9) Zea mays
TI:4577 None
 
C5YN64_SORBI
neXtProt»
0.0
SORBI_3007G167800 dihydroxy-acid dehydratase (EC 4.2.1.9) Sorghum bicolor
TI:4558 None
 
D8QVL8_SELML
neXtProt»
0.0
SELMODRAFT_165632 dihydroxy-acid dehydratase (EC 4.2.1.9) Selaginella moellendorffii
TI:88036 None
 
D8QVM1_SELML
neXtProt»
0.0
SELMODRAFT_79178 dihydroxy-acid dehydratase (EC 4.2.1.9) Selaginella moellendorffii
TI:88036 None
 
D8QVM6_SELML
euHCVdb»
0.0
SELMODRAFT_404530 Dihydroxy-acid/6-phosphogluconate dehydratase
C-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8SAA4_SELML
euHCVdb»
0.0
SELMODRAFT_420018 Dihydroxy-acid/6-phosphogluconate dehydratase
N-terminal domain-containing protein		 Selaginella moellendorffii
TI:88036 None
 
D8SAB2_SELML
euHCVdb»
0.0
SELMODRAFT_420025 Dihydroxy-acid dehydratase Selaginella moellendorffii
TI:88036 None
 
D8SAB4_SELML
neXtProt»
0.0
SELMODRAFT_233520 dihydroxy-acid dehydratase (EC 4.2.1.9) Selaginella moellendorffii
TI:88036 None
 
E3KGZ6_PUCGT
TubercuList»
0.0
PGTG_09284 dihydroxy-acid dehydratase (EC 4.2.1.9) Puccinia graminis
TI:5297 None
 
F6HS67_VITVI
neXtProt»
0.0
VIT_05s0051g00830 dihydroxy-acid dehydratase (EC 4.2.1.9) Vitis vinifera
TI:29760 None
 
G7IRL3_MEDTR
EnsemblPlants»
0.0
11422645 dihydroxy-acid dehydratase (EC 4.2.1.9) Medicago truncatula
TI:3880 None
 
H3G777_PHYRM
EnsemblProtists»
0.0
dihydroxy-acid dehydratase (EC 4.2.1.9) Phytophthora ramorum
TI:164328 None
 
H3GB83_PHYRM
EnsemblProtists»
0.0
dihydroxy-acid dehydratase (EC 4.2.1.9) Phytophthora ramorum
TI:164328 None
 
H3H908_PHYRM
EnsemblProtists»
0.0
Dihydroxy-acid dehydratase Phytophthora ramorum
TI:164328 None
 
I1M137_SOYBN
EnsemblPlants»
0.0
GLYMA_13G207900 dihydroxy-acid dehydratase (EC 4.2.1.9) Glycine max
TI:3847 None
 
ILVC_ASPFU
EnsemblFungi»
0.0
ilvC Dihydroxy-acid dehydratase ilvC, mitochondrial
(DHAD ilvC) (EC 4.2.1.9)		 Aspergillus fumigatus
TI:746128 None
 
ILVD2_BRADU
EnsemblBacteria»
0.0
ilvD2 Dihydroxy-acid dehydratase 2
(DAD 2) (EC 4.2.1.9)		 Bradyrhizobium diazoefficiens
TI:1355477 None
 
ILVD3_BRADU
EnsemblBacteria»
0.0
ilvD3 Dihydroxy-acid dehydratase 3
(DAD 3) (EC 4.2.1.9)		 Bradyrhizobium diazoefficiens
TI:1355477 None
 
ILVD_CHLAA
EnsemblBacteria»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Chloroflexus aurantiacus
TI:1108 None
 
ILVD_GLOVI
EnsemblBacteria»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Gloeobacter violaceus
TI:33072 None
 
ILVD_LEPIN
EnsemblBacteria»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Leptospira interrogans
TI:173 None
 
ILVD_MYCTU
PseudoCAP»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Mycobacterium tuberculosis
TI:1773 None
 
ILVD_PYRAE
EnsemblBacteria»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Pyrobaculum aerophilum
TI:13773 None
 
ILVD_RHOBA
EnsemblBacteria»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Rhodopirellula baltica
TI:265606 None
 
ILVD_SACS2
EnsemblBacteria»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Saccharolobus solfataricus
TI:2287 None
 
ILVD_STRR6
euHCVdb»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Streptococcus pneumoniae
TI:1313 None
 
ILVD_SYNY3
EnsemblBacteria»
0.0
ilvD Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) Synechocystis sp.
TI:1148 None
 
K3YGU0_SETIT
EnsemblPlants»
0.0
LOC101783283 dihydroxy-acid dehydratase (EC 4.2.1.9) Setaria italica
TI:4555 None
 
M1BNJ2_SOLTU
EnsemblPlants»
0.0
LOC102606211 dihydroxy-acid dehydratase (EC 4.2.1.9) Solanum tuberosum
TI:4113 None
   
M1CSJ1_SOLTU
EnsemblPlants»
0.0
Dehydratase family Solanum tuberosum
TI:4113 None
   
M4EHV2_BRACM
EnsemblPlants»
0.0
dihydroxy-acid dehydratase (EC 4.2.1.9) Brassica campestris
TI:3711 None
   
M5XN10_PRUPE
neXtProt»
0.0
PRUPE_1G003100 dihydroxy-acid dehydratase (EC 4.2.1.9) Prunus persica
TI:3760 None
 
Q1K658_NEUCR
TubercuList»
0.0
NCU04579 dihydroxy-acid dehydratase (EC 4.2.1.9) Neurospora crassa
TI:5141 None
 
Q4WK65_ASPFU
neXtProt»
0.0
AFUA_1G03550 dihydroxy-acid dehydratase (EC 4.2.1.9) Aspergillus fumigatus
TI:746128 None
 
Q5AJY2_CANAL
CGD»
0.0
ILV3 dihydroxy-acid dehydratase (EC 4.2.1.9) Candida albicans
TI:5476 None
 
Q5AZD4_EMENI
TubercuList»
0.0
ANIA_06346 dihydroxy-acid dehydratase (EC 4.2.1.9) Emericella nidulans
TI:162425 None
 
Q5B5X2_EMENI
neXtProt»
0.0
ANIA_04058 dihydroxy-acid dehydratase (EC 4.2.1.9) Emericella nidulans
TI:162425 None
 
Q5KCL8_CRYD1
TubercuList»
0.0
CNH01530 dihydroxy-acid dehydratase (EC 4.2.1.9) Cryptococcus deneoformans
TI:40410 None
 
Q6CAY2_YARLI
TubercuList»
0.0
YALI0_C23408g dihydroxy-acid dehydratase (EC 4.2.1.9) Yarrowia lipolytica
TI:4952 None
 
Q6YZH8_ORYSJ
neXtProt»
0.0
Os08g0559600 dihydroxy-acid dehydratase (EC 4.2.1.9) Oryza sativa
TI:4530 None
 
Q75CN6_EREGS
neXtProt»
0.0
AGOS_ACL117W dihydroxy-acid dehydratase (EC 4.2.1.9) Eremothecium gossypii
TI:33169 None
 
Q7SBQ5_NEUCR
TubercuList»
0.0
NCU05683 dihydroxy-acid dehydratase (EC 4.2.1.9) Neurospora crassa
TI:5141 None
 
U5D005_AMBTC
neXtProt»
0.0
AMTR_s00039p00081330 dihydroxy-acid dehydratase (EC 4.2.1.9) Amborella trichopoda
TI:13333 None