Collated Gene Ontology terms

Biological process: protein dimerization activity(2025) DNA binding(2025)

Molecular function: vacuolar proton-transporting V-type ATPase complex assembly2013, 2025 lysosomal lumen acidification2025 regulation of lysosome organization2025 regulation of autophagy2025 positive regulation of innate immune response2013 defense response to Gram-negative bacterium2013 IRE1-mediated unfolded protein response2018 DNA-templated transcription2025

Cellular component: endoplasmic reticulum membrane2013, 2018, 2025 cytoplasmic vesicle2025 endoplasmic reticulum-Golgi intermediate compartment membrane2025 ER to Golgi transport vesicle membrane2025 lysosome2010, 2025 chloroplast2018 plasma membrane2012 nucleus2025 endoplasmic reticulum2018

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 3/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 11/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A022Q6I0_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a018121mg Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Erythranthe guttata
TI:4155 None
 
A0A022QJV2_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a016833mg Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Erythranthe guttata
TI:4155 None
 
A0A061EMI6_THECC
euHCVdb»
0.0
TCM_021017 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Theobroma cacao
TI:3641 None
 
A0A067GC58_CITSI
euHCVdb»
0.0
CISIN_1g034046mg Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Citrus sinensis
TI:2711 None
 
A0A072U7J3_MEDTR
EnsemblPlants»
0.0
25495602 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Medicago truncatula
TI:3880 None
 
A0A078FLT5_BRANA
euHCVdb»
0.0
BnaC04g42230D Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Brassica napus
TI:3708 None
 
A0A078G1C3_BRANA
euHCVdb»
0.0
BnaA04g18160D Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Brassica napus
TI:3708 None
 
A0A078HXK5_BRANA
euHCVdb»
0.0
BnaA05g11220D Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Brassica napus
TI:3708 None
 
A0A0A0KPB7_CUCSA
euHCVdb»
0.0
Csa_6G526400 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Cucumis sativus
TI:3659 None
 
A0A0K9PMC2_ZOSMR
euHCVdb»
0.0
ZOSMA_1G01910 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Zostera marina
TI:29655 None
 
A0A139WB65_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_34875 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Tribolium castaneum
TI:7070 None
 
A0A1D5TVU8_WHEAT
EnsemblPlants»
0.0
LOC123054314 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Triticum aestivum
TI:4565 None
   
A0A1D8PIG8_CANAL
CGD»
0.0
CAALFM_C209290WA orf19.4090.1 Uncharacterized protein Candida albicans
TI:5476 None
 
A0A1S4DQT5_TOBAC
euHCVdb»
0.0
LOC107832453 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Nicotiana tabacum
TI:4097 None
   
A0A1U8A6T5_NELNU
euHCVdb»
0.0
LOC104599734 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Nelumbo nucifera
TI:4432 None
   
A0A1U8E863_CAPAN
euHCVdb»
0.0
T459_22808 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Capsicum annuum
TI:4072 None
 
A0A1U8LRD7_GOSHI
euHCVdb»
0.0
LOC107929138 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Gossypium hirsutum
TI:3635 None
   
A0A1U8LSJ4_GOSHI
euHCVdb»
0.0
LOC107930404 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Gossypium hirsutum
TI:3635 None
   
A0A1Y1IID7_KLENI
euHCVdb»
0.0
KFL_006560090 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Klebsormidium nitens
TI:105231 None
 
A0A251SDD8_HELAN
euHCVdb»
0.0
HannXRQ_Chr14g0428301 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Helianthus annuus
TI:4232 None
 
A0A251UKJ0_HELAN
euHCVdb»
0.0
HannXRQ_Chr06g0184021 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Helianthus annuus
TI:4232 None
 
A0A2C9VZ34_MANES
euHCVdb»
0.0
MANES_05G190800v8 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Manihot esculenta
TI:3983 None
 
A0A2C9WHT1_MANES
euHCVdb»
0.0
MANES_01G042100v8 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Manihot esculenta
TI:3983 None
 
A0A2I2YBK4_GORGO
Ensembl»
0.0
VMA21 Uncharacterized protein Gorilla gorilla
TI:9593 None
 
A0A2K3D389_CHLRE
euHCVdb»
0.0
CHLRE_12g500600v5 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6WF27_MARPO
euHCVdb»
0.0
MARPO_0098s0021 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Marchantia polymorpha
TI:3197 None
 
A0A3B3HK43_ORYLA
Ensembl»
0.0
VMA21 Vacuolar ATPase assembly factor VMA21 Oryzias latipes
TI:8090 None
   
A0A3B6B438_WHEAT
EnsemblPlants»
0.0
LOC123190198 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Triticum aestivum
TI:4565 None
   
A0A3B6IW48_WHEAT
EnsemblPlants»
0.0
LOC123092966 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Triticum aestivum
TI:4565 None
   
A0A3B6JLM1_WHEAT
EnsemblPlants»
0.0
Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Triticum aestivum
TI:4565 None
   
A0A3Q2IB77_HORSE
Ensembl»
0.0
Vacuolar ATPase assembly
integral membrane protein VMA21		 Equus caballus
TI:9796 None
   
A0A3Q2KLP6_HORSE
Ensembl»
0.0
Vacuolar ATPase assembly
integral membrane protein vma21		 Equus caballus
TI:9796 None
   
A0A3Q7IY64_SOLLC
EnsemblPlants»
0.0
LOC101245915 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Solanum lycopersicum
TI:4081 None
   
A0A5F7ZTS8_MACMU
Ensembl»
0.0
VMA21 Vacuolar ATPase assembly factor VMA21 Macaca mulatta
TI:9544 None
   
A0A5F8G6B9_MONDO
Ensembl»
0.0
Uncharacterized protein Monodelphis domestica
TI:13616 None
   
A0A5F8GZE0_MONDO
Ensembl»
0.0
Uncharacterized protein Monodelphis domestica
TI:13616 None
   
A0A5F8HG12_MONDO
Ensembl»
0.0
VMA21 Vacuolar ATPase assembly factor VMA21 Monodelphis domestica
TI:13616 None
   
A0A6I8NHD8_ORNAN
Ensembl»
0.0
VMA21 Vacuolar ATPase assembly factor VMA21 Ornithorhynchus anatinus
TI:9258 None
   
A0A6P9EN15_JUGRE
euHCVdb»
0.0
LOC109012689 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Juglans regia
TI:51240 None
   
A0A7M7HL11_STRPU
EnsemblMetazoa»
0.0
Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7U2F8F7_PHANO
TubercuList»
0.0
JI435_043880 ATPase assembly protein VMA21 Phaeosphaeria nodorum
TI:13684 None
 
A0A804HZ69_MUSAM
EnsemblPlants»
0.0
Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Musa acuminata
TI:4641 None
   
A0A804JIT7_MUSAM
EnsemblPlants»
0.0
GSMUA_167360.1 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Musa acuminata
TI:4641 None
 
A0A8I3PIV3_CANLF
Ensembl»
0.0
VMA21 Vacuolar ATPase assembly factor VMA21 Canis lupus
TI:9612 None
   
A0A8I6Y8R7_HORVV
EnsemblPlants»
0.0
LOC123449308 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Hordeum vulgare
TI:4513 None
   
A0A8I7BBV8_HORVV
EnsemblPlants»
0.0
LOC123406114 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Hordeum vulgare
TI:4513 None
   
A0A9J7LFX7_BRAFL
neXtProt»
0.0
LOC118419449 Vacuolar ATPase assembly integral
membrane protein VMA21-like isoform X1		 Branchiostoma floridae
TI:7739 None
   
A0A9K3H5J9_HELAN
euHCVdb»
0.0
HanXRQr2_Chr14g0621421 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Helianthus annuus
TI:4232 None
 
A0A9K3NLD1_HELAN
euHCVdb»
0.0
HanXRQr2_Chr06g0277551 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Helianthus annuus
TI:4232 None
 
A0A9L0S6M2_HORSE
Ensembl»
0.0
VMA21 Vacuolar ATPase assembly factor VMA21 Equus caballus
TI:9796 None
   
A0A9R0K7D9_SPIOL
euHCVdb»
0.0
LOC110800337 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Spinacia oleracea
TI:3562 None
   
A0A9R1XRY2_LACSA
euHCVdb»
0.0
LSAT_V11C200052620 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Lactuca sativa
TI:4236 None
 
A0ABK0M0Q3_RAT
Ensembl»
0.0
Uncharacterized protein Rattus norvegicus
TI:10116 None
   
A0ABM3RRA3_SPIOL
euHCVdb»
0.0
LOC130471849 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Spinacia oleracea
TI:3562 None
   
A8XSY5_CAEBR
WormBase»
0.0
CBG18066 CBG_18066 Protein CBG18066 Caenorhabditis briggsae
TI:6238 None
 
A9TZT5_PHYPA
EnsemblPlants»
0.0
LOC112289799 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Physcomitrium patens
TI:3218 None
 
B6JZB0_SCHJY
TubercuList»
0.0
vma21 Vacuolar H-ATPase assembly protein Vma21 Schizosaccharomyces japonicus
TI:4897 None
 
B6TA44_MAIZE
EnsemblPlants»
0.0
LOC100276400 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Zea mays
TI:4577 None
 
B6TFU9_MAIZE
EnsemblPlants»
0.0
LOC100278829 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Zea mays
TI:4577 None
 
B8C293_THAPS
neXtProt»
0.0
THAPSDRAFT_5204 Vacuolar ATPase assembly
integral membrane protein VMA21		 Thalassiosira pseudonana
TI:35128 None
 
B9MUL9_POPTR
euHCVdb»
0.0
POPTR_001G160500 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Populus trichocarpa
TI:3694 None
 
C5YFP4_SORBI
euHCVdb»
0.0
SORBI_3006G212100 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Sorghum bicolor
TI:4558 None
 
C5Z7U8_SORBI
euHCVdb»
0.0
SORBI_3010G229600 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Sorghum bicolor
TI:4558 None
 
D8SU27_SELML
euHCVdb»
0.0
SELMODRAFT_49779 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Selaginella moellendorffii
TI:88036 None
 
E3K0X6_PUCGT
TubercuList»
0.0
PGTG_03907 Uncharacterized protein Puccinia graminis
TI:5297 None
 
F1S2E1_PIG
Ensembl»
0.0
VMA21 Vacuolar ATPase assembly factor VMA21 Sus scrofa
TI:9823 None
   
F2ED67_HORVV
EnsemblPlants»
0.0
Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Hordeum vulgare
TI:4513 None
 
F5HLX6_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP013364 AGAP013364-PA Anopheles gambiae
TI:7165 None
 
F5HM04_ANOGA
EnsemblMetazoa»
0.0
11175770 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Anopheles gambiae
TI:7165 None
 
F6HFT6_VITVI
euHCVdb»
0.0
VIT_01s0011g01270 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Vitis vinifera
TI:29760 None
 
H2QZ82_PANTR
Ensembl»
0.0
VMA21 VMA21 vacuolar H+-ATPase homolog
(Vacuolar ATPase assembly factor VMA21)		 Pan troglodytes
TI:9598 None
 
H3GCF1_PHYRM
EnsemblProtists»
0.0
Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Phytophthora ramorum
TI:164328 None
 
H9GJS3_ANOCA
Ensembl»
0.0
VMA21 Vacuolar ATPase assembly factor VMA21 Anolis carolinensis
TI:28377 None
   
I1H820_BRADI
EnsemblPlants»
0.0
BRADI_1g69860v3 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Brachypodium distachyon
TI:15368 None
 
I1J1R0_BRADI
EnsemblPlants»
0.0
LOC100836518 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Brachypodium distachyon
TI:15368 None
 
I1M025_SOYBN
EnsemblPlants»
0.0
LOC100527876 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Glycine max
TI:3847 None
 
I1N5U1_SOYBN
EnsemblPlants»
0.0
LOC100500114 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Glycine max
TI:3847 None
 
K4A371_SETIT
EnsemblPlants»
0.0
LOC101759537 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Setaria italica
TI:4555 None
 
M1AQZ4_SOLTU
EnsemblPlants»
0.0
Uncharacterized protein Solanum tuberosum
TI:4113 None
   
M4CN59_BRACM
EnsemblPlants»
0.0
Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Brassica campestris
TI:3711 None
   
M4DYX2_BRACM
EnsemblPlants»
0.0
BRARA_D01894 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Brassica campestris
TI:3711 None
 
M4E263_BRACM
EnsemblPlants»
0.0
Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Brassica campestris
TI:3711 None
   
M5WID5_PRUPE
euHCVdb»
0.0
PRUPE_4G117300 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Prunus persica
TI:3760 None
 
Q0JA73_ORYSJ
euHCVdb»
0.0
Os04g0612900 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Oryza sativa
TI:4530 None
 
T1G4C1_HELRO
EnsemblMetazoa»
0.0
20215919 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Helobdella robusta
TI:6412 None
 
VMA21_ASPFU
EnsemblFungi»
0.0
vma21 Vacuolar ATPase assembly
integral membrane protein vma21		 Aspergillus fumigatus
TI:746128 None
 
VMA21_BOVIN
Ensembl»
0.0
VMA21 Vacuolar ATPase assembly
integral membrane protein VMA21		 Bos taurus
TI:9913 None
 
VMA21_CRYD1
EnsemblFungi»
0.0
VMA21 Vacuolar ATPase assembly
integral membrane protein VMA21		 Cryptococcus deneoformans
TI:40410 None
 
VMA21_EMENI
EnsemblFungi»
0.0
vma21 Vacuolar ATPase assembly
integral membrane protein vma21		 Emericella nidulans
TI:162425 None
 
VMA21_NEUCR
EnsemblFungi»
0.0
vma-21 Vacuolar ATPase assembly
integral membrane protein vma-21		 Neurospora crassa
TI:5141 None
 
VMA21_SCLS1
TubercuList»
0.0
vma21 Vacuolar ATPase assembly
integral membrane protein vma21		 Sclerotinia sclerotiorum
TI:5180 None
 
VMA21_XENLA
Xenbase»
0.0
vma21 Vacuolar ATPase assembly
integral membrane protein vma21		 Xenopus laevis
TI:8355 None
 
VMA21_XENTR
Xenbase»
0.0
vma21 Vacuolar ATPase assembly
integral membrane protein vma21		 Xenopus tropicalis
TI:8364 None
 
W1P799_AMBTC
euHCVdb»
0.0
AMTR_s00078p00104250 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Amborella trichopoda
TI:13333 None
 
W5NBZ8_LEPOC
Ensembl»
0.0
Vacuolar ATPase assembly factor VMA21 Lepisosteus oculatus
TI:7918 None
 
D3ZM03_RAT
RGD»
0.5
Vma21 Vacuolar ATPase assembly factor VMA21 Rattus norvegicus
TI:10116 None
   
Q55BH7_DICDI
dictyBase»
0.5
DDB_G0271358 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q58G56_ARATH
TAIR»
0.5
At1g05780 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Arabidopsis thaliana
TI:3702 None
 
Q9SIN7_ARATH
TAIR»
0.5
At2g31710 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Arabidopsis thaliana
TI:3702 None
 
VMA21_CAEEL
WormBase»
0.5
R07E5.19 Vacuolar ATPase assembly integral
membrane protein VMA21 homolog		 Caenorhabditis elegans
TI:6239 None
 
VMA21_CHICK
Ensembl»
0.5
VMA21 Vacuolar ATPase assembly
integral membrane protein VMA21		 Gallus gallus
TI:9031 None
 
VMA21_SCHPO
PomBase»
0.5
vma21 Vacuolar ATPase assembly
integral membrane protein vma21		 Schizosaccharomyces pombe
TI:4896 None
 
Q21821_CAEEL
WormBase»
1.0
CELE_R07E5.7 R07E5.7 Uncharacterized protein Caenorhabditis elegans
TI:6239 None
 
VMA21_YEAST
SGD»
1.3
VMA21 Vacuolar ATPase assembly
integral membrane protein VMA21		 Saccharomyces cerevisiae
TI:4932 None
 
Q9VDZ5_DROME
FlyBase»
1.5
CG5558 GH27195p Drosophila melanogaster
TI:7227 None
 
VMA21_MOUSE
Ensembl»
1.5
Vma21 Vacuolar ATPase assembly
integral membrane protein Vma21		 Mus musculus
TI:10090 None
 
VMA21_DANRE
ZFIN»
2.1
vma21 Vacuolar ATPase assembly
integral membrane protein vma21		 Danio rerio
TI:7955 None
 
VMA21_HUMAN
Ensembl»
2.1
VMA21 Vacuolar ATPase assembly integral membrane protein
VMA21 (Myopathy with excessive autophagy protein)		 Homo sapiens
TI:9606 None