Biological process: histone H3K27 methyltransferase activity^{(2009, 2010, 2014, 2015, 2021, 2022, 2023, 2024)} histone methyltransferase activity^{(2003, 2006, 2009, 2011, 2017, 2019, 2024)} methyltransferase activity⁽²⁰²⁴⁾ chromatin binding^{(2003, 2013, 2014, 2019, 2022, 2024)} histone H3K27 trimethyltransferase activity^{(2023, 2024)} nucleosome binding^{(2022, 2024)} promoter-specific chromatin binding^{(2016, 2024)} transcription corepressor activity^{(2018, 2020, 2024)} protein-lysine N-methyltransferase activity^{(2014, 2015, 2020, 2023, 2024)} DNA binding^{(2005, 2018, 2019, 2024)}
± 17 single-stranded RNA binding^{2011, 2024} sequence-specific DNA binding^{2007, 2011, 2019, 2024} histone binding^{2022, 2024} chromatin DNA binding^{2014, 2016, 2020, 2024} RNA binding^{2013, 2020, 2022, 2024} RNA polymerase II core promoter sequence-specific DNA binding^{2017, 2024} transcription corepressor binding^{2020, 2024} ribonucleoprotein complex binding^{2015, 2024} primary miRNA binding^{2016, 2024} molecular condensate scaffold activity^{2022, 2024} lncRNA binding^{2021, 2024} RNA polymerase II cis-regulatory region sequence-specific DNA binding^{2017, 2024} transcription cis-regulatory region binding^{2013, 2024} transcription coregulator activity²⁰²⁰ transcription coactivator activity²⁰²¹ histone H3K9 methyltransferase activity²⁰⁰⁹ histone H3 methyltransferase activity²⁰²⁴

Molecular function: chromatin remodeling^{2018, 2024} heterochromatin formation^{2018, 2021, 2023, 2024} methylation²⁰²⁴ chromatin organization^{2003, 2024} negative regulation of gene expression, epigenetic^{2013, 2016, 2023, 2024} rhythmic process²⁰²⁴ negative regulation of transcription by RNA polymerase II^{2010, 2013, 2014, 2018, 2024} regulation of short-day photoperiodism, flowering^{2018, 2024} negative regulation of DNA-templated transcription^{2004, 2005, 2009, 2011, 2024} facultative heterochromatin formation^{2021, 2022, 2024}
± 85 vernalization response^{2006, 2024} subtelomeric heterochromatin formation^{2018, 2024} response to abscisic acid^{2018, 2024} regulation of leaf senescence^{2018, 2024} callus formation^{2020, 2024} response to tetrachloromethane^{2016, 2024} regulation of transcription by RNA polymerase II^{2006, 2014, 2021, 2024} regulation of circadian rhythm^{2014, 2024} liver regeneration^{2016, 2024} hepatocyte homeostasis^{2016, 2024} regulation of gene expression^{2011, 2016, 2020, 2024} positive regulation of epithelial to mesenchymal transition^{2013, 2024} negative regulation of retinoic acid receptor signaling pathway^{2009, 2024} stem cell differentiation^{2010, 2024} small ncRNA-mediated heterochromatin formation²⁰²⁴ skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration^{2014, 2024} regulation of neurogenesis^{2011, 2024} regulation of gliogenesis^{2011, 2024} regulation of cell population proliferation^{2010, 2024} protein localization to chromatin^{2013, 2024} positive regulation of protein serine/threonine kinase activity^{2013, 2024} positive regulation of cell population proliferation^{2018, 2024} positive regulation of cell migration²⁰²⁴ positive regulation of cell cycle G1/S phase transition^{2018, 2024} positive regulation of MAP kinase activity^{2013, 2024} positive regulation of GTPase activity^{2013, 2024} negative regulation of transcription elongation by RNA polymerase II^{2010, 2024} negative regulation of striated muscle cell differentiation^{2004, 2024} negative regulation of stem cell differentiation^{2010, 2024} negative regulation of keratinocyte differentiation^{2010, 2024} negative regulation of epidermal cell differentiation^{2010, 2024} negative regulation of G1/S transition of mitotic cell cycle^{2013, 2024} keratinocyte differentiation^{2010, 2024} hemopoiesis^{2020, 2024} epidermal cell differentiation^{2010, 2024} cerebellar cortex development^{2011, 2024} cellular response to trichostatin A^{2016, 2024} cellular response to hydrogen peroxide^{2013, 2024} cardiac muscle hypertrophy in response to stress^{2016, 2024} G1/S transition of mitotic cell cycle^{2013, 2024} G1 to G0 transition^{2010, 2024} DNA methylation-dependent heterochromatin formation^{2014, 2024} B cell differentiation^{2020, 2024} regulation of DNA-templated transcription^{2003, 2019, 2024} vegetative to reproductive phase transition of meristem^{2010, 2024} regulation of flower development^{2019, 2024} leaf morphogenesis^{2005, 2024} DNA-mediated transformation^{2008, 2024} hippocampus development^{2014, 2024} regulation of long-day photoperiodism, flowering^{2018, 2024} negative regulation of gene expression^{2013, 2016, 2024} synaptic transmission, GABAergic^{2021, 2024} response to estradiol^{2014, 2024} regulation of kidney development^{2022, 2024} protein modification process^{2013, 2024} positive regulation of dendrite development^{2014, 2024} negative regulation of cytokine production involved in inflammatory response^{2021, 2024} flower development²⁰²⁴ cell differentiation²⁰²⁴ positive regulation of transcription by RNA polymerase II^{2014, 2024} positive regulation of circadian rhythm²⁰²¹ abscisic acid-activated signaling pathway²⁰²⁴ tissue homeostasis²⁰¹⁶ tissue development²⁰²⁰ syncytial blastoderm mitotic cell cycle²⁰⁰⁷ seed morphogenesis²⁰⁰⁹ response to absence of light²⁰⁰⁹ regulation of neuroblast proliferation²⁰¹⁷ regulation of endosperm development²⁰¹⁰ positive regulation of hemopoiesis²⁰²¹ positive regulation of DNA-templated transcription²⁰²⁴ neurogenesis²⁰⁰⁸ immunoglobulin heavy chain V-D-J recombination²⁰¹⁶ heart development²⁰¹⁶ germ-line stem cell division²⁰⁰⁶ germ cell development²⁰⁰⁶ gamete generation²⁰⁰⁶ fin regeneration²⁰¹⁷ epigenetic regulation of gene expression²⁰¹⁴ digestive tract development²⁰¹⁷ circadian rhythm²⁰²¹ axon guidance²⁰⁰⁷ arterial endothelial cell fate commitment²⁰²⁴ anterior/posterior axis specification²⁰²¹ anatomical structure morphogenesis²⁰⁰³

Cellular component: nucleus^{2003, 2004, 2006, 2014, 2018, 2019, 2023, 2024} PcG protein complex^{2011, 2016, 2018, 2024} ESC/E(Z) complex^{2006, 2010, 2012, 2013, 2014, 2020, 2022, 2024} chromatin silencing complex^{2013, 2018, 2020, 2024} nucleoplasm^{2013, 2014, 2023, 2024} chromosome, telomeric region^{2018, 2024} chromatin^{2005, 2014, 2024} pronucleus^{2003, 2024} pericentric heterochromatin^{2021, 2024} chromosome²⁰²⁴
± 6 membrane²⁰²⁴ synapse²⁰²⁴ heterochromatin²⁰²² plasmodesma²⁰²¹ nucleosome²⁰⁰⁶ histone methyltransferase complex²⁰¹⁰