Biological process: ubiquitin protein ligase activity^{(2014, 2018, 2019, 2020, 2021, 2023, 2024, 2025)} ubiquitin-protein transferase activity^{(2005, 2008, 2010, 2011, 2014, 2016, 2021, 2024, 2025)} zinc ion binding^{(2003, 2006, 2011, 2014, 2016, 2022, 2025)} metal ion binding⁽²⁰²⁵⁾ transferase activity⁽²⁰²⁵⁾ ubiquitin conjugating enzyme binding^{(2008, 2016, 2019, 2025)} nucleic acid binding⁽²⁰²⁵⁾ RNA-DNA hybrid ribonuclease activity⁽²⁰²⁵⁾ catalytic activity⁽²⁰²⁵⁾ ligase activity⁽²⁰²⁵⁾
± 12 ubiquitin binding^{2018, 2025} ubiquitin-like protein transferase activity^{2002, 2004, 2025} nuclear androgen receptor binding^{2010, 2025} ubiquitin protein ligase binding^{2011, 2025} acyltransferase activity²⁰²⁵ catalytic activity, acting on a protein²⁰²⁵ RNA-directed DNA polymerase activity²⁰²⁵ transcription coactivator activity²⁰⁰² structural constituent of ribosome²⁰²⁵ helicase activity²⁰²⁵ NAD+ poly-ADP-ribosyltransferase activity²⁰²⁵ DNA binding²⁰²⁵

Molecular function: protein ubiquitination^{2008, 2011, 2014, 2016, 2019, 2025} ubiquitin-dependent protein catabolic process^{2002, 2005, 2010, 2013, 2014, 2021, 2023, 2024, 2025} regulation of canonical Wnt signaling pathway^{2014, 2023, 2025} DNA-templated transcription²⁰²⁵ protein K6-linked ubiquitination^{2023, 2024, 2025} apoptotic process²⁰²⁵ mitophagy^{2023, 2024, 2025} protein autoubiquitination^{2008, 2011, 2014, 2018, 2025} protein polyubiquitination^{2010, 2014, 2020, 2021, 2025} rescue of stalled ribosome^{2023, 2025}
± 91 protein-RNA covalent cross-linking repair^{2024, 2025} autophagy²⁰²⁵ negative regulation of apoptotic process^{2017, 2025} regulation of androgen receptor signaling pathway^{2010, 2025} regulation of DNA-templated transcription^{2010, 2025} positive regulation of DNA-templated transcription^{2010, 2025} modulation of chemical synaptic transmission²⁰²⁵ protein K63-linked ubiquitination^{2010, 2025} protein K48-linked ubiquitination^{2010, 2025} pattern recognition receptor signaling pathway^{2023, 2025} hematopoietic stem cell proliferation^{2010, 2025} proteasome-mediated ubiquitin-dependent protein catabolic process^{2024, 2025} regulation of anatomical structure morphogenesis²⁰²⁵ positive regulation of catabolic process²⁰²⁵ response to stress²⁰²⁵ negative regulation of intracellular signal transduction²⁰²⁵ regulation of protein catabolic process at postsynapse, modulating synaptic transmission²⁰²⁴ positive regulation of metabolic process²⁰²⁵ response to endoplasmic reticulum stress²⁰²⁵ regulation of secretion by cell²⁰²⁵ regulation of primary metabolic process²⁰²⁵ protein monoubiquitination^{2019, 2020} negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway²⁰²⁵ response to toxic substance^{2008, 2025} response to oxidative stress^{2010, 2013} positive regulation of autophagy of mitochondrion²⁰²⁰ oogenesis^{2013, 2014} negative regulation of mitochondrial fusion^{2013, 2021} negative regulation of engulfment of apoptotic cell^{2014, 2025} negative regulation of cell migration^{2023, 2025} negative regulation of JNK cascade^{2007, 2016} natural killer cell mediated cytotoxicity²⁰¹³ innate immune response^{2014, 2025} immune system process²⁰²⁵ developmental cell growth²⁰¹⁰ determination of adult lifespan^{2008, 2025} defense response to virus²⁰²⁵ defense response²⁰²⁵ cellular response to virus²⁰²⁵ adaptive immune response²⁰²⁵ RNA-templated DNA biosynthetic process²⁰²⁵ type 2 mitophagy²⁰²⁵ translational termination²⁰²⁵ translational elongation²⁰²⁵ translation²⁰²⁵ sporulation resulting in formation of a cellular spore²⁰⁰⁶ spermatogenesis²⁰¹³ sperm mitochondrion organization²⁰²¹ sorocarp stalk cell differentiation²⁰²² signal transduction²⁰⁰² seed maturation²⁰¹⁴ response to temperature stimulus²⁰¹⁰ response to UV-B²⁰¹² regulation of translational termination²⁰¹³ regulation of translation²⁰²⁵ regulation of transcription by RNA polymerase II²⁰⁰² regulation of mitochondrion organization²⁰⁰⁹ regulation of macromolecule metabolic process²⁰²⁵ regulation of jasmonic acid mediated signaling pathway²⁰²⁵ regulation of jasmonic acid biosynthetic process²⁰²⁵ regulation of double fertilization forming a zygote and endosperm²⁰¹⁰ regulation of cytoplasmic translational termination²⁰⁰⁵ regulation of cellular response to oxidative stress²⁰¹² regulation of apoptotic process²⁰¹⁰ positive regulation of protein targeting to mitochondrion²⁰¹⁸ positive regulation of proteasomal protein catabolic process²⁰¹⁹ positive regulation of neuronal action potential²⁰¹⁸ positive regulation of neurogenesis²⁰¹⁴ positive regulation of mitophagy²⁰²¹ positive regulation of mitochondrial fission²⁰²¹ positive regulation of locomotor rhythm²⁰¹⁸ positive regulation of compound eye pigmentation²⁰⁰⁹ neuron cellular homeostasis²⁰¹³ negative regulation of abscisic acid-activated signaling pathway²⁰²¹ mitochondrion organization²⁰¹⁸ mitochondrial fission²⁰¹¹ mitochondrial electron transport, NADH to ubiquinone²⁰⁰⁹ microtubule cytoskeleton organization²⁰⁰¹ larval locomotory behavior²⁰¹⁷ histone catabolic process²⁰¹³ gibberellin mediated signaling pathway²⁰²¹ gibberellic acid mediated signaling pathway²⁰²⁵ exocytosis²⁰²⁵ endoplasmic reticulum organization²⁰¹⁴ cytoplasmic pattern recognition receptor signaling pathway²⁰²⁵ cellular response to hypoxia²⁰¹¹ androgen receptor signaling pathway²⁰⁰² adult locomotory behavior²⁰¹⁴ acquisition of seed longevity²⁰²¹ abscisic acid-activated signaling pathway²⁰²⁵ PKR/eIFalpha signaling²⁰²⁵

Cellular component: cytoplasm^{2002, 2004, 2008, 2010, 2011, 2014, 2016, 2018, 2019, 2025} ubiquitin ligase complex^{2002, 2005, 2008, 2023, 2025} nucleus^{2002, 2004, 2005, 2009, 2010, 2012, 2014, 2018, 2020, 2022, 2025} membrane²⁰²⁵ organelle membrane²⁰²⁵ cytosol^{2009, 2013, 2016, 2019, 2020, 2024, 2025} mitochondrial membrane^{2011, 2020, 2025} Golgi apparatus^{2006, 2020, 2025} nucleoplasm^{2024, 2025} mitochondrion^{2018, 2020, 2024, 2025}
± 33 endoplasmic reticulum^{2018, 2023, 2025} cytolytic granule^{2013, 2017, 2025} plasma membrane^{2021, 2024, 2025} nuclear body^{2016, 2025} endoplasmic reticulum membrane^{2023, 2025} SCF ubiquitin ligase complex^{2016, 2025} Lewy body^{2016, 2025} Cul4A-RING E3 ubiquitin ligase complex^{2016, 2025} Cul3-RING ubiquitin ligase complex^{2016, 2025} Cul2-RING ubiquitin ligase complex^{2016, 2025} cytosolic ribosome^{2023, 2025} Cul5-RING ubiquitin ligase complex^{2016, 2025} mitochondrial outer membrane^{2015, 2025} hippocampal mossy fiber to CA3 synapse²⁰²⁴ glutamatergic synapse²⁰²⁴ centrosome^{2001, 2025} presynapse²⁰²⁵ postsynaptic density²⁰²⁵ neuron projection²⁰²⁵ Cajal body²⁰²⁵ site of double-strand break^{2013, 2025} postsynapse²⁰²⁵ neuronal cell body^{2008, 2025} endosome membrane^{2016, 2025} cytoplasmic vesicle membrane²⁰²⁵ cytoplasmic vesicle²⁰²⁵ vacuolar membrane²⁰²⁵ small ribosomal subunit²⁰²⁵ ribosome²⁰²⁵ ribonucleoprotein complex²⁰²⁵ plant-type vacuole membrane²⁰²¹ other organism cell membrane²⁰²⁵ host cell presynaptic membrane²⁰²⁵