Unknome v3

Cluster UKP09984
TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3
Standard knownness: 4.0; Custom knownness: None; Num. species: 47; Orthology database: Panther19.0; Protein members: 73

Collated Gene Ontology terms

Biological process: translation elongation factor activity⁽²⁰²⁴⁾ ubiquitin-protein transferase activity⁽²⁰¹³⁾ transcription elongation factor activity⁽²⁰²⁰⁾ structural constituent of ribosome⁽²⁰²⁴⁾ oxidoreductase activity⁽²⁰²⁴⁾ double-stranded DNA binding⁽²⁰⁰⁵⁾ alpha-tubulin binding⁽²⁰¹⁹⁾ RNA polymerase II general transcription initiation factor activity⁽²⁰²⁰⁾

Molecular function: transcription elongation by RNA polymerase II^{2004, 2020, 2021, 2024} transcription by RNA polymerase II^{2005, 2024} transcription initiation at RNA polymerase II promoter^{2020, 2021, 2024} translational elongation²⁰²⁴ ubiquitin-dependent protein catabolic process^{2017, 2018} regulation of transcription by RNA polymerase II^{2003, 2005} imaginal disc-derived wing vein specification²⁰¹³ tubulin complex assembly²⁰¹⁹ translation²⁰²⁴ regulation of DNA-templated transcription elongation²⁰⁰⁵
post-chaperonin tubulin folding pathway²⁰¹⁹ nucleotide-excision repair²⁰¹⁷ microtubule cytoskeleton organization²⁰¹⁹ maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)²⁰²¹

Cellular component: elongin complex^{2011, 2013, 2020, 2021, 2024} nucleus^{2011, 2018, 2024} transcription elongation factor complex^{2004, 2024} site of DNA damage²⁰¹⁹ nucleoplasm^{2013, 2016} cytoplasm^{2018, 2019} Cul3-RING ubiquitin ligase complex^{2013, 2017} ribosome²⁰²⁴ extracellular space²⁰¹³ euchromatin²⁰¹¹

Phylogenetic distribution

Chordates:	21/21
Echinoderms:	0/0
Hemichordates:	1/1
Annelids:	1/1
Molluscs:	0/0
Bryozoans:	0/0
Platyhelminthes:	0/0
Rotifers:	0/0
Nematodes:	3/3
Arthropods:	5/5
Tardigrades:	0/0
Placozoa:	1/1
Cnidaria:	1/1
Porifera:	0/0
Choanoflagellates+:	12/1
Dikarya:	0/14
Fungi (other):	0/1
Protozoa:	2/3
Excavates:	0/4
Harosa:	0/4
Hacrobia:	0/0
Plants:	0/39
Archea:	0/8
Bacteria:	0/35

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Protein sequences (FASTA format)

Knownness history

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Proteins

UniProt ID
Organism DB»

Species [Key only]

ELOA1_DROME
FlyBase»

3.9

EloA

Transcription elongation factor B polypeptide 3 (Elongin-A) (RNA
polymerase II transcription factor SIII subunit A) (dEloA)

Drosophila melanogaster
TI:7227 None

ELOA1_YEAST
SGD»

2.8

ELA1

Elongin-A

Saccharomyces cerevisiae
TI:4932 None

ELOA1_RAT
RGD»

3.0

Eloa

Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor
SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3)

Rattus norvegicus
TI:10116 None

ELOA1_HUMAN
Ensembl»

1.7

ELOA

Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor
SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3)

Homo sapiens
TI:9606 None

ELOA1_SCHPO
PomBase»

4.0

pof4

Elongin-A (Protein pof4)

Schizosaccharomyces pombe
TI:4896 None

F0ZZ73_DICPU
EnsemblProtists»

0.0

DICPUDRAFT_157468

CAP-Gly domain-containing protein

Dictyostelium purpureum
TI:5786 None

A0A3Q2HWX6_HORSE
Ensembl»

0.0

LOC111772418

Elongin-A

Equus caballus
TI:9796 None

ELOA2_HUMAN
Ensembl»

1.8

ELOA2

Elongin-A2 (EloA2) (RNA polymerase II transcription factor SIII
subunit A2) (Transcription elongation factor B polypeptide 3B)

Homo sapiens
TI:9606 None

K7CFJ1_PANTR
Ensembl»

0.0

ELOA

Elongin-A

Pan troglodytes
TI:9598 None

B7PRF9_IXOSC
EnsemblMetazoa»

0.0

IscW_ISCW007299

Transcription elongation factor
B polypeptide, putative

Ixodes scapularis
TI:6945 None

D7EK50_TRICA
EnsemblMetazoa»

0.0

AUGUSTUS-3.0.2_01477

Transcription elongation factor
B polypeptide 3-like Protein

Tribolium castaneum
TI:7070 None

E7F7H1_DANRE
ZFIN»

0.0

tceb3l

Elongin A,-like (Transcription elongation
factor B polypeptide 3)

Danio rerio
TI:7955 None

ELOA1_CAEEL
WormBase»

0.8

tceb-3

Transcription elongation factor B polypeptide 3 (Elongin-A)
(RNA polymerase II transcription factor SIII subunit A)

Caenorhabditis elegans
TI:6239 None

ELOA1_MOUSE
Ensembl»

0.0

Eloa

Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor
SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3)

Mus musculus
TI:10090 None

A0A8I3RYL8_CANLF
Ensembl»

0.0

ELOA

Elongin-A

Canis lupus
TI:9612 None

A8XY94_CAEBR
WormBase»

0.0

tceb-3

Protein CBG20634

Caenorhabditis briggsae
TI:6238 None

G3RGB1_GORGO
Ensembl»

0.0

ELOA

Elongin-A

Gorilla gorilla
TI:9593 None

H2RDQ3_PANTR
Ensembl»

0.0

ELOA2

Elongin A2

Pan troglodytes
TI:9598 None

I3LRU2_PIG
Ensembl»

0.0

ELOA

Elongin-A

Sus scrofa
TI:9823 None

A0A1D8PD64_CANAL
EnsemblFungi»

0.0

ELA1

Elongin-A

Candida albicans
TI:5476 None

A0A1L8HFS2_XENLA
Xenbase»

0.0

eloa.L

Elongin-A

Xenopus laevis
TI:8355 None

A0A1S4GKT5_ANOGA
EnsemblMetazoa»

0.0

Uncharacterized protein

Anopheles gambiae
TI:7165 None

A0A2I2V2Y6_FELCA
Ensembl»

0.0

ELOA

Elongin-A

Felis catus
TI:9685 None

A0A2I2Y924_GORGO
Ensembl»

0.0

TFIIS N-terminal domain-containing protein

Gorilla gorilla
TI:9593 None

A0A2I2ZQ92_GORGO
Ensembl»

0.0

TFIIS N-terminal domain-containing protein

Gorilla gorilla
TI:9593 None

A0A454XID0_PRIPA
EnsemblMetazoa»

0.0

WBGene00096566

TFIIS N-terminal domain-containing protein

Pristionchus pacificus
TI:54126 None

A0A5F8GRN2_MONDO
Ensembl»

0.0

TFIIS N-terminal domain-containing protein

Monodelphis domestica
TI:13616 None

A0A6I8PH67_ORNAN
Ensembl»

0.0

Elongin-A

Ornithorhynchus anatinus
TI:9258 None

A0A7M7RIP4_STRPU
EnsemblMetazoa»

0.0

TFIIS N-terminal domain-containing protein

Strongylocentrotus purpuratus
TI:7668 None

A0A8J0U8U1_XENLA
Xenbase»

0.0

eloa.S

Elongin-A isoform X1

Xenopus laevis
TI:8355 None

A0A8J0VBB1_XENLA
Xenbase»

0.0

LOC108716910

Elongin-A isoform X1

Xenopus laevis
TI:8355 None

A0A8V0XDU2_CHICK
Ensembl»

0.0

LOC421892

TFIIS N-terminal domain-containing protein

Gallus gallus
TI:9031 None

A0A9J7KE98_BRAFL
CTD»

0.0

LOC118403989

Elongin-A-like isoform X1

Branchiostoma floridae
TI:7739 None

A7RN30_NEMVE
EnsemblMetazoa»

0.0

NEMVEDRAFT_v1g199556

TFIIS N-terminal domain-containing protein

Nematostella vectensis
TI:45351 None

B3S438_TRIAD
EnsemblMetazoa»

0.0

TRIADDRAFT_58942

TFIIS N-terminal domain-containing protein

Trichoplax adhaerens
TI:10228 None

E9FYD5_DAPPU
EnsemblMetazoa»

0.0

EOG090X0BTZ

Daphnia pulex
TI:6669 None

F6SVR5_XENTR
Ensembl»

0.0

LOC100497894

Elongin-A (Elongin-A isoform X1)

Xenopus tropicalis
TI:8364 None

F6UIM4_CIOIN
Ensembl»

0.0

LOC100182348

Elongin-A

Ciona intestinalis
TI:7719 None

F6UT31_XENTR
Xenbase»

0.0

eloa

Elongin-A

Xenopus tropicalis
TI:8364 None

F6WWB3_ORNAN
Ensembl»

0.0

LOC100088046

TFIIS N-terminal domain-containing protein

Ornithorhynchus anatinus
TI:9258 None

F6ZN30_MONDO
Ensembl»

0.0

TFIIS N-terminal domain-containing protein

Monodelphis domestica
TI:13616 None

F7BQV6_HORSE
Ensembl»

0.0

Elongin-A

Equus caballus
TI:9796 None

F7CT40_MONDO
Ensembl»

0.0

ELOA

Elongin A

Monodelphis domestica
TI:13616 None

F7CTT6_HORSE
Ensembl»

0.0

ELOA

Elongin-A

Equus caballus
TI:9796 None

F7DD64_MACMU
Ensembl»

0.0

ELOA2

Elongin A2

Macaca mulatta
TI:9544 None

F7EJS2_MACMU
Ensembl»

0.0

ELOA

Elongin-A

Macaca mulatta
TI:9544 None

G3QV73_GORGO
Ensembl»

0.0

TFIIS N-terminal domain-containing protein

Gorilla gorilla
TI:9593 None

G3RUP8_GORGO
Ensembl»

0.0

TFIIS N-terminal domain-containing protein

Gorilla gorilla
TI:9593 None

H2LTJ3_ORYLA
Ensembl»

0.0

eloa

Elongin-A

Oryzias latipes
TI:8090 None

H2M1N9_ORYLA
Ensembl»

0.0

LOC101175342

Elongin-A

Oryzias latipes
TI:8090 None

H2R6Q9_PANTR
Ensembl»

0.0

LOC100609028

TFIIS N-terminal domain-containing protein

Pan troglodytes
TI:9598 None

H9G9W4_ANOCA
Ensembl»

0.0

eloa

Elongin-A

Anolis carolinensis
TI:28377 None

Q5ZID8_CHICK
Ensembl»

0.0

TCEB3

Elongin-A

Gallus gallus
TI:9031 None

Q803L4_DANRE
ZFIN»

0.0

fc15a12

Elongin-A

Danio rerio
TI:7955 None

T1FSJ0_HELRO
EnsemblMetazoa»

0.0

20211787

Elongin-A

Helobdella robusta
TI:6412 None

W5LYB6_LEPOC
Ensembl»

0.0

Elongin-A

Lepisosteus oculatus
TI:7918 None

W5NJS7_LEPOC
Ensembl»

0.0

Transcription elongation factor
B polypeptide 3-like

Lepisosteus oculatus
TI:7918 None

A7EX05_SCLS1
VEuPathDB»

0.0

SS1G_09864

Elongin-A

Sclerotinia sclerotiorum
TI:5180 None

A9URJ3_MONBE
EnsemblProtists»

0.0

MONBRDRAFT_31370

Elongin-A

Monosiga brevicollis
TI:81824 None

B6JVX5_SCHJY
EnsemblFungi»

0.0

SJAG_00540

Elongin-A

Schizosaccharomyces japonicus
TI:4897 None

E3KGU7_PUCGT
EnsemblFungi»

0.0

PGTG_08708

Elongin-A

Puccinia graminis
TI:5297 None

ELOA1_ASHGO
EnsemblFungi»

0.0

ELA1

Elongin-A

Ashbya gossypii
TI:33169 None

Q4X201_ASPFU
EnsemblFungi»

0.0

AFUA_2G08170

RNA polymerase II transcription factor
SIII (Elongin) subunit A, putative

Aspergillus fumigatus
TI:746128 None

Q55CM9_DICDI
dictyBase»

0.0

DDB_G0269992

Elongin-A

Dictyostelium discoideum
TI:44689 None

Q5AZV2_EMENI
EnsemblFungi»

0.0

ANIA_06178

RNA polymerase II transcription factor SIII
(Elongin) subunit A, putative (AFU_orthologue AFUA_2G08170)

Emericella nidulans
TI:162425 None

Q5KCI4_CRYNJ
EnsemblFungi»

0.0

CNH01130

Pof4 protein, putative

Cryptococcus neoformans
TI:5207 None

Q6CBQ6_YARLI
EnsemblFungi»

0.0

YALI0_C16500g

YALI0C16500p

Yarrowia lipolytica
TI:4952 None

A7T9W6_NEMVE
EnsemblMetazoa»

0.0

NEMVEDRAFT_v1g224313

TFIIS N-terminal domain-containing protein

Nematostella vectensis
TI:45351 None

A0A8I5ZYM1_RAT
RGD»

0.0

LOC120097453

Elongin-A3 member D-like

Rattus norvegicus
TI:10116 None

A0A8I6A3I1_RAT
RGD»

0.0

LOC120097531

Elongin-A3-like

Rattus norvegicus
TI:10116 None

A0A8I6ADU6_RAT
RGD»

0.0

Eloa-ps1

Uncharacterized protein

Rattus norvegicus
TI:10116 None

A0A8I6AFE6_RAT
RGD»

0.0

EloaA2l1

Elongin-A2-like

Rattus norvegicus
TI:10116 None

A0A8I6AL34_RAT
RGD»

0.0

Eloa-ps3

Uncharacterized protein

Rattus norvegicus
TI:10116 None

Cluster UKP09984

Collated Gene Ontology terms

Phylogenetic distribution

Find a cluster

Download

Knownness history

Proteins