Collated Gene Ontology terms

Biological process: proline-tRNA ligase activity(2005, 2007, 2016, 2017, 2019, 2024) aminoacyl-tRNA ligase activity(2024) ATP binding(2024) aminoacyl-tRNA editing activity(2024) nucleotide binding(2024) catalytic activity, acting on a tRNA(2024) transferase activity(2024) RNA binding(2014, 2024) structural constituent of ribosome(2001) proton transmembrane transporter activity(2024)
identical protein binding2024 Ala-tRNA(Pro) hydrolase activity2010

Molecular function: prolyl-tRNA aminoacylation2005, 2016, 2017, 2021, 2024 translation2001, 2024 aminoacyl-tRNA metabolism involved in translational fidelity2021, 2024 tRNA aminoacylation for protein translation2024 mitochondrial translation2009, 2020 proton transmembrane transport2024 proton motive force-driven ATP synthesis2024 mitochondrial genome maintenance2001

Cellular component: mitochondrion2009, 2016, 2018, 2020, 2023, 2024 cytoplasm2024 cytosol2008, 2014, 2017 mitochondrial large ribosomal subunit2001, 2016, 2018, 2020, 2024 ribosome2024 mitochondrial matrix2018, 2024 mitochondrial inner membrane2014, 2020 ribonucleoprotein complex2024 proton-transporting ATP synthase complex, coupling factor F(o)2024 plasma membrane2010
peptidoglycan-based cell wall2010 mitochondrial ribosome2002

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 11/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 30/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
G1KQH6_ANOCA
Ensembl»
0.0
MRPL39 Mitochondrial ribosomal protein L39 Anolis carolinensis
TI:28377 None
   
Q7QAP8_ANOGA
EnsemblMetazoa»
0.0
1274253 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Anopheles gambiae
TI:7165 None
 
Q7QE50_ANOGA
EnsemblMetazoa»
0.0
1272552 AGAP010644-PA Anopheles gambiae
TI:7165 None
 
SYP_AQUAE
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Aquifex aeolicus
TI:63363 None
 
Q75BN8_ASHGO
EnsemblFungi»
0.0
AGOS_ACR233W proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Ashbya gossypii
TI:33169 None
 
Q4WT30_ASPFU
EnsemblFungi»
0.0
AFUA_1G10750 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Aspergillus fumigatus
TI:746128 None
 
SYP1_BACCR
EnsemblBacteria»
0.0
proS1 Proline--tRNA ligase 1 (EC 6.1.1.15)
(Prolyl-tRNA synthetase 1) (ProRS 1)		 Bacillus cereus
TI:1396 None
 
SYP_BACSU
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Bacillus subtilis
TI:1423 None
 
SYP_BRADU
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Bradyrhizobium diazoefficiens
TI:1355477 None
 
A0A9J7KQ28_BRAFL
CTD»
0.0
LOC118410481 39S ribosomal protein L39, mitochondrial-like Branchiostoma floridae
TI:7739 None
   
A0A9J7MCJ8_BRAFL
CTD»
0.0
LOC118431603 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Branchiostoma floridae
TI:7739 None
   
C3ZWE4_BRAFL
CTD»
0.0
LOC118410480 39S ribosomal protein L39, mitochondrial-like Branchiostoma floridae
TI:7739 None
 
A8WJ18_CAEBR
CTD»
0.0
CBG23664 CBG_23664 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Caenorhabditis briggsae
TI:6238 None
 
A8WJ19_CAEBR
WormBase»
0.0
pars-2 Protein CBR-PARS-2 Caenorhabditis briggsae
TI:6238 None
 
O45869_CAEEL
WormBase»
1.0
pars-2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Caenorhabditis elegans
TI:6239 None
 
A0A1D8PRZ3_CANAL
EnsemblFungi»
0.0
PRS proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Candida albicans
TI:5476 None
 
A0A8I3NNI4_CANLF
Ensembl»
0.0
PARS2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Canis lupus
TI:9612 None
   
A0A8I3NUK2_CANLF
Ensembl»
0.0
MRPL39 Uncharacterized protein Canis lupus
TI:9612 None
   
SYP_CHLTR
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Chlamydia trachomatis
TI:813 None
 
A9WD42_CHLAA
EnsemblBacteria»
0.0
Caur_1792 Proline--tRNA ligase (EC 6.1.1.15) Chloroflexus aurantiacus
TI:1108 None
 
F6SNK4_CIOIN
Ensembl»
0.0
TGS domain-containing protein Ciona intestinalis
TI:7719 None
   
F6YLQ9_CIOIN
Ensembl»
0.0
proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Ciona intestinalis
TI:7719 None
   
A5I7N0_CLOBH
Ensembl»
0.0
proS2 Prolyl-tRNA synthetase (EC 6.1.1.15) Clostridium botulinum
TI:1491 None
 
SYP_COXBU
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Coxiella burnetii
TI:777 None
 
Q6P0C4_DANRE
ZFIN»
1.0
fc83e06 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Danio rerio
TI:7955 None
 
Q7T3F9_DANRE
ZFIN»
0.0
fa13h09 39S ribosomal protein L39, mitochondrial
(Mitochondrial ribosomal protein L39) (Mrpl39 protein)		 Danio rerio
TI:7955 None
 
E9GAP4_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_127919 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Daphnia pulex
TI:6669 None
 
F0Z9C0_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_74994 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Dictyostelium purpureum
TI:5786 None
 
Q75JK9_DICDI
dictyBase»
2.0
mproS proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Dictyostelium discoideum
TI:44689 None
 
Q9VZY9_DROME
FlyBase»
2.8
ProRS-m proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Drosophila melanogaster
TI:7227 None
 
C8VSU1_EMENI
EnsemblFungi»
0.0
ANIA_01201 Prolyl-tRNA synthetase
(AFU_orthologue AFUA_1G10750)		 Emericella nidulans
TI:162425 None
 
SYP_ECOLI
EnsemblBacteria»
4.2
proS Proline--tRNA ligase (EC 6.1.1.15) (Global
RNA synthesis factor) (Prolyl-tRNA synthetase) (ProRS)		 Escherichia coli
TI:562 None
 
M3WUL3_FELCA
Ensembl»
0.0
MRPL39 Mitochondrial ribosomal protein L39 Felis catus
TI:9685 None
 
M3WXQ3_FELCA
Ensembl»
0.0
PARS2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Felis catus
TI:9685 None
 
SYP_FUSNN
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Fusobacterium nucleatum
TI:851 None
 
A0A8V0Y7X0_CHICK
Ensembl»
0.0
MRPL39 Mitochondrial ribosomal protein L39 Gallus gallus
TI:9031 None
   
A0A8V0ZXU5_CHICK
Ensembl»
0.0
TTC4 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Gallus gallus
TI:9031 None
   
SYP_GEOSL
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Geobacter sulfurreducens
TI:35554 None
 
SYP_GLOVI
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Gloeobacter violaceus
TI:33072 None
 
G3QRP9_GORGO
Ensembl»
0.0
PARS2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Gorilla gorilla
TI:9593 None
 
G3RRC1_GORGO
Ensembl»
0.0
MRPL39 Mitochondrial ribosomal protein L39 Gorilla gorilla
TI:9593 None
 
SYP_HAEIN
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Haemophilus influenzae
TI:727 None
 
SYP_HELPY
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Helicobacter pylori
TI:210 None
 
T1ETR2_HELRO
EnsemblMetazoa»
0.0
20199962 TGS domain-containing protein Helobdella robusta
TI:6412 None
 
T1G2I7_HELRO
EnsemblMetazoa»
0.0
20215285 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Helobdella robusta
TI:6412 None
 
RM39_HUMAN
Ensembl»
1.1
MRPL39 Large ribosomal subunit protein mL39 (39S ribosomal protein L39,
mitochondrial) (L39mt) (MRP-L39) (39S ribosomal protein L5, mitochondrial) (L5mt) (MRP-L5)		 Homo sapiens
TI:9606 None
 
SYPM_HUMAN
Ensembl»
1.0
PARS2 Probable proline--tRNA ligase, mitochondrial
(EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Homo sapiens
TI:9606 None
 
B7P672_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW016025 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Ixodes scapularis
TI:6945 None
 
B7PEZ0_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW018045 39S ribosomal protein L39, putative
(39S ribosomal protein L39, putative (Fragment))		 Ixodes scapularis
TI:6945 None
 
B7QNP9_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW015137 tRNA synthetases class II, putative (EC
6.1.1.15) (tRNA synthetases class II, putative (Fragment))		 Ixodes scapularis
TI:6945 None
 
W5MQ94_LEPOC
Ensembl»
0.0
proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Lepisosteus oculatus
TI:7918 None
 
W5MXL4_LEPOC
Ensembl»
0.0
Mitochondrial ribosomal protein L39 Lepisosteus oculatus
TI:7918 None
 
SYP_LEPIN
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Leptospira interrogans
TI:173 None
 
SYP_LISMO
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Listeria monocytogenes
TI:1639 None
 
A0A1D5QSM8_MACMU
Ensembl»
0.0
MRPL39 Mitochondrial ribosomal protein L39 Macaca mulatta
TI:9544 None
   
F6YZE4_MACMU
Ensembl»
0.0
PARS2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Macaca mulatta
TI:9544 None
   
F6QZF9_MONDO
Ensembl»
0.0
MRPL39 Mitochondrial ribosomal protein L39 Monodelphis domestica
TI:13616 None
   
A9URY8_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_14603 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Monosiga brevicollis
TI:81824 None
 
RM39_MOUSE
Ensembl»
2.5
Mrpl39 Large ribosomal subunit protein mL39 (39S
ribosomal protein L39, mitochondrial) (L39mt) (MRP-L39)		 Mus musculus
TI:10090 None
 
SYPM_MOUSE
Ensembl»
0.0
Pars2 Probable proline--tRNA ligase, mitochondrial
(EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Mus musculus
TI:10090 None
 
SYP_MYCTU
TubercuList»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Mycobacterium tuberculosis
TI:1773 None
 
SYP_NEIMB
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Neisseria meningitidis
TI:487 None
 
Q7S207_NEUCR
EnsemblFungi»
0.0
NCU09892 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Neurospora crassa
TI:5141 None
 
A0A6I8NFQ1_ORNAN
Ensembl»
0.0
ATP synthase-coupling factor 6, mitochondrial
(ATP synthase peripheral stalk subunit F6)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8PQJ4_ORNAN
Ensembl»
0.0
PARS2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3HC39_ORYLA
Ensembl»
0.0
pars2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Oryzias latipes
TI:8090 None
   
H2LLE7_ORYLA
Ensembl»
0.0
mrpl39 Mitochondrial ribosomal protein L39 Oryzias latipes
TI:8090 None
   
H2PZ38_PANTR
Ensembl»
0.0
PARS2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Pan troglodytes
TI:9598 None
 
K7BUD6_PANTR
Ensembl»
0.0
MRPL39 Mitochondrial ribosomal protein L39 Pan troglodytes
TI:9598 None
 
H3GJ79_PHYRM
EnsemblProtists»
0.0
proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Phytophthora ramorum
TI:164328 None
 
Q8I2Q5_PLAF7
EnsemblProtists»
0.0
PF3D7_0925300 Proline--tRNA ligase, putative (EC 6.1.1.15) Plasmodium falciparum
TI:5833 None
 
A0A2A6BSI9_PRIPA
EnsemblMetazoa»
0.0
WBGene00097299 Pars-2 Pristionchus pacificus
TI:54126 None
 
A0A2A6BWK2_PRIPA
EnsemblMetazoa»
0.0
WBGene00118432 Pinin_SDK_memA domain-containing protein Pristionchus pacificus
TI:54126 None
 
SYP_PSEAE
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Pseudomonas aeruginosa
TI:287 None
 
M0R6J0_RAT
RGD»
0.0
Mrpl39 Mitochondrial ribosomal protein L39 Rattus norvegicus
TI:10116 None
   
SYPM_RAT
RGD»
1.0
Pars2 Probable proline--tRNA ligase, mitochondrial
(EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Rattus norvegicus
TI:10116 None
 
SYPM_YEAST
SGD»
1.5
AIM10 Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Altered inheritance
rate of mitochondria protein 10) (Prolyl-tRNA synthetase) (ProRS)		 Saccharomyces cerevisiae
TI:4932 None
 
SYP_SALTY
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Salmonella typhimurium
TI:28901 None
 
B6K1X3_SCHJY
EnsemblFungi»
0.0
SJAG_02236 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Schizosaccharomyces japonicus
TI:4897 None
 
SYPM_SCHPO
PomBase»
1.6
SPBC24C6.03 Probable proline--tRNA ligase, mitochondrial
(EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Schizosaccharomyces pombe
TI:4896 None
 
A7F9V3_SCLS1
EnsemblFungi»
0.0
SS1G_14384 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None
 
SYP_SHEON
EnsemblPlants»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Shewanella oneidensis
TI:70863 None
 
SYP_STAA8
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Staphylococcus aureus
TI:1280 None
 
SYP_STRR6
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Streptococcus pneumoniae
TI:1313 None
 
SYP_STRCO
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Streptomyces coelicolor
TI:1902 None
 
A0A7M7HC36_STRPU
EnsemblMetazoa»
0.0
TGS domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7PHG5_STRPU
EnsemblMetazoa»
0.0
proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A287BDI0_PIG
Ensembl»
0.0
PARS2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Sus scrofa
TI:9823 None
   
A0A287BI43_PIG
Ensembl»
0.0
MRPL39 Mitochondrial ribosomal protein L39 Sus scrofa
TI:9823 None
   
SYP_SYNY3
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Synechocystis sp.
TI:1148 None
 
SYP_THEYD
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Thermodesulfovibrio yellowstonii
TI:28262 None
 
SYP_THEMA
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Thermotoga maritima
TI:2336 None
 
D6WC57_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_01328 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Tribolium castaneum
TI:7070 None
 
B3S0Y8_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_58133 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Trichoplax adhaerens
TI:10228 None
 
B3SFE8_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_9363 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Trichoplax adhaerens
TI:10228 None
 
SYP_VIBCH
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Vibrio cholerae
TI:666 None
 
SYP_XANCP
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Xanthomonas campestris
TI:339 None
 
A0A1L8HCS5_XENLA
Xenbase»
0.0
mrpl39.L 39S ribosomal protein L39, mitochondrial Xenopus laevis
TI:8355 None
   
B0BMR0_XENTR
Xenbase»
0.0
pars2 proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Xenopus tropicalis
TI:8364 None
 
Q5M7P1_XENTR
Xenbase»
0.0
mrpl39 39S ribosomal protein L39,
mitochondrial (Mitochondrial ribosomal protein L39)		 Xenopus tropicalis
TI:8364 None
 
Q7ZXS4_XENLA
Xenbase»
0.0
pars2.L proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Xenopus laevis
TI:8355 None
 
Q6C8Z3_YARLI
EnsemblFungi»
0.0
YALI0_D15620g proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase)		 Yarrowia lipolytica
TI:4952 None
 
SYP_YERPE
EnsemblBacteria»
0.0
proS Proline--tRNA ligase (EC
6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)		 Yersinia pestis
TI:632 None