Collated Gene Ontology terms

Biological process: protein-macromolecule adaptor activity(2025) identical protein binding(2025) transmembrane signaling receptor activity(2006) structural constituent of ribosome(2025) protein phosphatase regulator activity(2025) enzyme-substrate adaptor activity(2025)

Molecular function: snRNA 3'-end processing2012, 2017, 2025 RNA polymerase II transcription initiation surveillance2025 protein localization to chromatin2025 snRNA processing2006, 2012, 2025 regulation of transcription elongation by RNA polymerase II2025 transcription elongation by RNA polymerase II2025 transcription by RNA polymerase II2025

Cellular component: integrator complex2006, 2012, 2024, 2025 nucleus2017, 2024, 2025 INTAC complex2025 nucleoplasm2015, 2024, 2025 chromatin2025 centrosome2024, 2025 chromosome2025 protein-containing complex2025 nuclear body2025 actin cytoskeleton2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 3/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A803SXM0_ANOCA
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Anolis carolinensis
TI:28377 None 		     
A0A1S4GA71_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
F4P4S7_BATDJ
neXtProt»
0.0
BATDEDRAFT_25329 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
E1BF57_BOVIN
Ensembl»
0.0
INTS6 Integrator complex subunit 6 Bos taurus
TI:9913 None
   
E1BG98_BOVIN
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Bos taurus
TI:9913 None
   
A0A9J7M182_BRAFL
euHCVdb»
0.0
LOC118427294 Integrator complex subunit 6-B-like isoform X3 Branchiostoma floridae
TI:7739 None
   
A8XW43_CAEBR
WormBase»
0.0
ints-6 Protein CBR-DIC-1 Caenorhabditis briggsae
TI:6238 None
 
B7WN63_CAEEL
WormBase»
1.0
ints-6 VWFA domain-containing protein Caenorhabditis elegans
TI:6239 None
 
A0A8I3PDQ3_CANLF
Ensembl»
0.0
INTS6 Integrator complex subunit 6 Canis lupus
TI:9612 None 		     
A0A8I3PYI7_CANLF
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Canis lupus
TI:9612 None 		     
F6UQJ9_CIOIN
Ensembl»
0.0
VWFA domain-containing protein Ciona intestinalis
TI:7719 None
   
B0UYL7_DANRE
ZFIN»
0.0
ints6 Integrator complex subunit 6 Danio rerio
TI:7955 None 		 
 
INT6_DANRE
ZFIN»
2.5
ints6l Integrator complex subunit 6 (Int6) Danio rerio
TI:7955 None
 
E9H4B7_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_188894 VWFA domain-containing protein Daphnia pulex
TI:6669 None
 
E9HNW3_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_331956 VWFA domain-containing protein Daphnia pulex
TI:6669 None
 
F0ZP56_DICPU
TubercuList»
0.0
DICPUDRAFT_79965 VWFA domain-containing protein Dictyostelium purpureum
TI:5786 None
 
INT6_DICDI
dictyBase»
1.5
ints6 Integrator complex subunit 6 homolog Dictyostelium discoideum
TI:44689 None
 
INT6_DROME
FlyBase»
4.7
IntS6 Integrator complex subunit 6 Drosophila melanogaster
TI:7227 None
 
A0A3Q2GXB7_HORSE
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Equus caballus
TI:9796 None
   
A0A9L0RUU2_HORSE
Ensembl»
0.0
INTS6/SAGE1/DDX26B/CT45 C-terminal
domain-containing protein		 Equus caballus
TI:9796 None 		     
A0A9L0S9Z7_HORSE
Ensembl»
0.0
INTS6 Integrator complex subunit 6 Equus caballus
TI:9796 None 		     
A0ABI7WL41_FELCA
Ensembl»
0.0
INTS6L VWFA domain-containing protein Felis catus
TI:9685 None 		     
A0ABI8A8B1_FELCA
Ensembl»
0.0
VWFA domain-containing protein Felis catus
TI:9685 None 		     
A0A1D5PZU0_CHICK
Ensembl»
1.0
INTS6 Integrator complex subunit 6 Gallus gallus
TI:9031 None
   
A0A8V0YUZ8_CHICK
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Gallus gallus
TI:9031 None 		     
A0A2I2YRA5_GORGO
Ensembl»
0.0
INTS6 Integrator complex subunit 6 Gorilla gorilla
TI:9593 None 		 
 
A0A2I2YZG2_GORGO
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Gorilla gorilla
TI:9593 None
 
A0A2I2ZER5_GORGO
Ensembl»
0.0
INTS6/SAGE1/DDX26B/CT45 C-terminal
domain-containing protein		 Gorilla gorilla
TI:9593 None 		 
 
G3RSJ3_GORGO
Ensembl»
0.0
SAGE1 Sarcoma antigen 1 Gorilla gorilla
TI:9593 None
 
T1G9D0_HELRO
EnsemblMetazoa»
0.0
20217677 VWFA domain-containing protein Helobdella robusta
TI:6412 None
 
CT451_HUMAN
Ensembl»
0.0
CT45A1 Cancer/testis antigen family 45 member A1
(Cancer/testis antigen 45-1) (Cancer/testis antigen 45A1)		 Homo sapiens
TI:9606 None
 
CT452_HUMAN
Ensembl»
0.0
CT45A2 Cancer/testis antigen family 45 member A2
(Cancer/testis antigen 45-2) (Cancer/testis antigen 45A2)		 Homo sapiens
TI:9606 None 		 
 
CT453_HUMAN
Ensembl»
0.0
CT45A3 Cancer/testis antigen family 45 member A3 (Cancer/testis antigen 45-3) (Cancer/testis antigen 45-4)
(Cancer/testis antigen 45A3) (Cancer/testis antigen 45A4) (Cancer/testis antigen family 45 member A4)		 Homo sapiens
TI:9606 None
 
CT455_HUMAN
Ensembl»
0.0
CT45A5 Cancer/testis antigen family 45 member A5
(Cancer/testis antigen 45-5) (Cancer/testis antigen 45A5)		 Homo sapiens
TI:9606 None
 
CT456_HUMAN
Ensembl»
0.0
CT45A6 Cancer/testis antigen family 45 member A6
(Cancer/testis antigen 45-6) (Cancer/testis antigen 45A6)		 Homo sapiens
TI:9606 None 		 
 
CT457_HUMAN
Ensembl»
0.0
CT45A7 Cancer/testis antigen family 45
member A7 (Cancer/testis antigen 45A7)		 Homo sapiens
TI:9606 None 		 
 
CT458_HUMAN
Ensembl»
0.0
CT45A8 Cancer/testis antigen family 45
member A8 (Cancer/testis antigen 45A8)		 Homo sapiens
TI:9606 None 		 
 
CT459_HUMAN
Ensembl»
0.0
CT45A9 Cancer/testis antigen family 45
member A9 (Cancer/testis antigen 45A9)		 Homo sapiens
TI:9606 None 		 
 
CT45A_HUMAN
Ensembl»
0.8
CT45A10 Cancer/testis antigen family 45
member A10 (Cancer/testis antigen 45A10)		 Homo sapiens
TI:9606 None
 
INT6L_HUMAN
Ensembl»
1.0
INTS6L Integrator complex subunit
6-like (Protein DDX26B)		 Homo sapiens
TI:9606 None
 
INT6_HUMAN
Ensembl»
7.1
INTS6 Integrator complex subunit 6 (Int6) (DBI-1)
(Protein deleted in cancer 1) (DICE1)		 Homo sapiens
TI:9606 None
 
SAGE1_HUMAN
Ensembl»
1.0
SAGE1 Sarcoma antigen 1
(Cancer/testis antigen 14) (CT14)		 Homo sapiens
TI:9606 None
 
SGE2P_HUMAN
AG»
1.0
SAGE2P Putative SAGE1-like protein
(Sarcoma antigen 2 pseudogene)		 Homo sapiens
TI:9606 None
 
B7PMU6_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW006144 Dice1/dead/H box polypeptide, putative Ixodes scapularis
TI:6945 None 		 
 
B7PMU7_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW006145 Dice1/dead/H box polypeptide, putative Ixodes scapularis
TI:6945 None 		 
 
W5MWA0_LEPOC
Ensembl»
0.0
Integrator complex subunit 6 Lepisosteus oculatus
TI:7918 None
 
W5ND73_LEPOC
Ensembl»
0.0
Integrator complex subunit 6 like Lepisosteus oculatus
TI:7918 None
 
A0A1D5RBU0_MACMU
Ensembl»
0.0
INTS6L Integrator complex subunit
6 like (Protein DDX26B)		 Macaca mulatta
TI:9544 None
 
A0A5F8A8S4_MACMU
Ensembl»
0.0
LOC100424368 INTS6/SAGE1/DDX26B/CT45 C-terminal
domain-containing protein		 Macaca mulatta
TI:9544 None 		     
A0A5F8APL1_MACMU
Ensembl»
0.0
SAGE1 Sarcoma antigen 1 Macaca mulatta
TI:9544 None
   
H9FSW0_MACMU
Ensembl»
0.0
INTS6 Integrator complex subunit 6 Macaca mulatta
TI:9544 None
 
A0A2R6WBS1_MARPO
neXtProt»
0.0
MARPO_0113s0025 Uncharacterized protein Marchantia polymorpha
TI:3197 None
 
F7CES1_MONDO
Ensembl»
0.0
SAGE1 Integrator complex subunit 6-like Monodelphis domestica
TI:13616 None
   
F7D4H4_MONDO
Ensembl»
0.0
INTS6 Integrator complex subunit 6 Monodelphis domestica
TI:13616 None
   
A9VC93_MONBE
neXtProt»
0.0
MONBRDRAFT_34519 Integrator complex subunit
6-like beta-barrel domain-containing protein		 Monosiga brevicollis
TI:81824 None
 
INT6L_MOUSE
Ensembl»
1.0
Ints6l Integrator complex subunit
6-like (Protein DDX26B)		 Mus musculus
TI:10090 None
 
INT6_MOUSE
Ensembl»
6.5
Ints6 Integrator complex subunit 6 (Int6) (DBI-1) Mus musculus
TI:10090 None
 
Q3UJ22_MOUSE
Ensembl»
0.5
Ct45a Cancer/testis antigen 45
(Gene model 648, (NCBI))		 Mus musculus
TI:10090 None
 
A7SQG0_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g10278 VWFA domain-containing protein Nematostella vectensis
TI:45351 None
 
A7T2D0_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g221320 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
A7T2D1_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g221321 VWFA domain-containing protein Nematostella vectensis
TI:45351 None
 
A7T2D2_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g142986 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
F6W6J4_ORNAN
Ensembl»
0.0
INTS6 Integrator complex subunit 6 Ornithorhynchus anatinus
TI:9258 None
   
F7ATY0_ORNAN
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3I535_ORYLA
Ensembl»
0.0
ints6 Integrator complex subunit 6 Oryzias latipes
TI:8090 None
   
H2M2A2_ORYLA
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Oryzias latipes
TI:8090 None
   
A0A2I3SHG7_PANTR
Ensembl»
0.0
Uncharacterized protein Pan troglodytes
TI:9598 None
 
A0A2I3T186_PANTR
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Pan troglodytes
TI:9598 None
 
A0A2I3T3H5_PANTR
Ensembl»
0.0
CT45A10 Cancer/testis antigen family 45 member A10 Pan troglodytes
TI:9598 None
 
A0A2J8JPD9_PANTR
Ensembl»
0.0
SAGE1 Sarcoma antigen 1 Pan troglodytes
TI:9598 None
 
K7BLZ3_PANTR
Ensembl»
0.0
INTS6 Integrator complex subunit 6 Pan troglodytes
TI:9598 None
 
A0BSU6_PARTE
euHCVdb»
0.0
GSPATT00031845001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None
 
A0CGF3_PARTE
euHCVdb»
0.0
GSPATT00007310001 Ku domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0DBQ5_PARTE
euHCVdb»
0.0
GSPATT00015369001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None
 
A0A7I4A0M0_PHYPA
EnsemblPlants»
0.0
LOC112287883 VWFA domain-containing protein Physcomitrium patens
TI:3218 None
 
H3GMW4_PHYRM
EnsemblProtists»
0.0
VWFA domain-containing protein Phytophthora ramorum
TI:164328 None
 
A0A2A6CEN7_PRIPA
EnsemblMetazoa»
0.0
WBGene00276738 39S ribosomal protein L51, mitochondrial Pristionchus pacificus
TI:54126 None
   
A0A8I6AP01_RAT
RGD»
3.5
Ints6 Integrator complex subunit 6 Rattus norvegicus
TI:10116 None
   
M0RC48_RAT
RGD»
0.0
Ints6l Integrator complex subunit 6 like Rattus norvegicus
TI:10116 None
   
M0RCK4_RAT
RGD»
0.0
Ct45a9 Cancer/testis antigen family 45 member A9 Rattus norvegicus
TI:10116 None 		     
D8RFT8_SELML
euHCVdb»
0.0
SELMODRAFT_121744 SELMODRAFT_92379 VWFA domain-containing protein Selaginella moellendorffii
TI:88036 None 		 
 
A0A7M7HH41_STRPU
EnsemblMetazoa»
0.0
VWFA domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7NJY7_STRPU
EnsemblMetazoa»
0.0
VWFA domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A287BAH6_PIG
Ensembl»
0.0
INTS6 Integrator complex subunit 6 Sus scrofa
TI:9823 None
   
K7GS71_PIG
Ensembl»
0.0
INTS6L Integrator complex subunit 6 like Sus scrofa
TI:9823 None
   
B8BVH4_THAPS
neXtProt»
0.0
THAPSDRAFT_2838 WW domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
D2A291_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_07684 Integrator complex subunit 6-A-like Protein Tribolium castaneum
TI:7070 None
 
B3S5H0_TRIAD
CTD»
0.0
TRIADDRAFT_59612 VWFA domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A1L8F7Y8_XENLA
Xenbase»
0.0
ints6l.L Integrator complex subunit 6-like Xenopus laevis
TI:8355 None
   
A0A6I8SUM6_XENTR
Xenbase»
0.0
ints6 Integrator complex subunit 6 Xenopus tropicalis
TI:8364 None
   
A0A8J1LNE4_XENLA
CTD»
0.0
LOC108700181 Integrator complex subunit 6-like Xenopus laevis
TI:8355 None
   
A0ABD8D528_XENLA
Xenbase»
0.0
ints6.S Integrator complex subunit 6-B Xenopus laevis
TI:8355 None
   
A0ABD8DDZ9_XENLA
CTD»
0.0
ints6.L Integrator complex subunit 6-A Xenopus laevis
TI:8355 None
   
B1WAU4_XENTR
Xenbase»
0.0
ints6l Integrator complex subunit 6 like isoform
X1 (Integrator complex subunit 6-like) (LOC548952 protein)		 Xenopus tropicalis
TI:8364 None
 
INT6A_XENLA
Xenbase»
0.0
ints6-a Integrator complex subunit 6-A (Int6-A) Xenopus laevis
TI:8355 None
 
INT6B_XENLA
Xenbase»
0.0
ints6-b Integrator complex subunit 6-B (Int6-B) Xenopus laevis
TI:8355 None