Unknome v3

Cluster UKP09847
GLYCOSYL HYDROLASE-RELATED
Standard knownness: 5.8; Custom knownness: None; Num. species: 45; Orthology database: Panther19.0; Protein members: 62

Collated Gene Ontology terms

Biological process: catalytic activity⁽²⁰²⁴⁾ hydrolase activity, hydrolyzing O-glycosyl compounds^{(2021, 2024)} protein-glucosylgalactosylhydroxylysine glucosidase activity^{(2017, 2019, 2020, 2024)} alpha,alpha-trehalase activity^{(2009, 2014, 2020, 2021, 2024)} carbohydrate binding⁽²⁰²⁴⁾ hydrolase activity, acting on glycosyl bonds⁽²⁰²⁴⁾ transferase activity⁽²⁰²⁴⁾ kojibiose phosphorylase activity^{(2018, 2024)} glycosyltransferase activity⁽²⁰²⁴⁾ maltose phosphorylase activity⁽²⁰²⁴⁾
trehalose-phosphatase activity²⁰¹⁰ phosphatase activity²⁰²⁴ hydrolase activity²⁰²⁴

Molecular function: carbohydrate metabolic process^{2017, 2020, 2024} trehalose catabolic process^{2009, 2013, 2014, 2019, 2024} trehalose transport^{2020, 2024} carbon utilization^{2020, 2024} trehalose biosynthetic process²⁰²⁴ proteolysis²⁰²¹ maltose catabolic process²⁰²⁴ glycoside metabolic process²⁰¹⁴

Cellular component: cytosol^{2019, 2023, 2024} fungal-type cell wall^{2013, 2014, 2019, 2024} membrane^{2020, 2024} extracellular region^{2010, 2012, 2024} cytoplasm²⁰¹⁷ fungal-type vacuole lumen^{2020, 2024} fungal-type vacuole^{2013, 2024} cell wall-bounded periplasmic space^{2013, 2024} cell periphery^{2020, 2024} plasma membrane²⁰¹⁰
vacuole²⁰²⁴ vacuolar lumen²⁰²⁴ spore wall²⁰⁰⁹ periplasmic space²⁰²⁴ peptidoglycan-based cell wall²⁰¹⁰ extracellular vesicle²⁰¹⁹

Phylogenetic distribution

Chordates:	19/21
Echinoderms:	0/0
Hemichordates:	1/1
Annelids:	1/1
Molluscs:	0/0
Bryozoans:	0/0
Platyhelminthes:	0/0
Rotifers:	0/0
Nematodes:	0/3
Arthropods:	3/5
Tardigrades:	0/0
Placozoa:	0/1
Cnidaria:	1/1
Porifera:	0/0
Choanoflagellates+:	9/1
Dikarya:	0/14
Fungi (other):	0/1
Protozoa:	2/3
Excavates:	2/4
Harosa:	0/4
Hacrobia:	0/0
Plants:	0/39
Archea:	0/8
Bacteria:	7/35

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Protein sequences (FASTA format)

Knownness history

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Proteins

UniProt ID
Organism DB»

Standard knownness

clustom knownness

Species [Key only]

Protein domain links

K7CGS7_PANTR
Ensembl»

0.0

ATHL1

ATH1, acid trehalase-like
1 (Protein-glucosylgalactosylhydroxylysine glucosidase)

Pan troglodytes
TI:9598 None

TREA_EMENI
VEuPathDB»

0.0

treA

Acid trehalase (EC
3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)

Emericella nidulans
TI:162425 None

T1FLT2_HELRO
EnsemblMetazoa»

0.0

20209781

C2 NT-type domain-containing protein

Helobdella robusta
TI:6412 None

ATC1_CANAL
EnsemblFungi»

0.0

ATC1

Cell wall acid trehalase ATC1
(EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)

Candida albicans
TI:5476 None

A7EMV4_SCLS1
EnsemblFungi»

0.0

SS1G_06653

Glycoside hydrolase family
65 N-terminal domain-containing protein

Sclerotinia sclerotiorum
TI:5180 None

A0A1S4GYK4_ANOGA
EnsemblMetazoa»

0.0

Glycoside hydrolase family 65
central catalytic domain-containing protein

Anopheles gambiae
TI:7165 None

A0A1S4GYL2_ANOGA
EnsemblMetazoa»

0.0

Glycoside hydrolase family 65
central catalytic domain-containing protein

Anopheles gambiae
TI:7165 None

A0A1S4HDS5_ANOGA
EnsemblMetazoa»

0.0

Glycoside hydrolase family 65
central catalytic domain-containing protein

Anopheles gambiae
TI:7165 None

A0A7M7G1B8_STRPU
EnsemblMetazoa»

0.0

Glycoside hydrolase family 65
central catalytic domain-containing protein

Strongylocentrotus purpuratus
TI:7668 None

A7EIP9_SCLS1
EnsemblFungi»

0.0

SS1G_05192

Glycoside hydrolase family 65
central catalytic domain-containing protein

Sclerotinia sclerotiorum
TI:5180 None

A7S9D0_NEMVE
EnsemblMetazoa»

0.0

NEMVEDRAFT_v1g21500

Glycoside hydrolase family 65
central catalytic domain-containing protein

Nematostella vectensis
TI:45351 None

A7SAZ0_NEMVE
EnsemblMetazoa»

0.0

NEMVEDRAFT_v1g31786

Glycoside hydrolase family 65
central catalytic domain-containing protein

Nematostella vectensis
TI:45351 None

A7SIA7_NEMVE
EnsemblMetazoa»

0.0

NEMVEDRAFT_v1g245466

Glycoside hydrolase family 65
central catalytic domain-containing protein

Nematostella vectensis
TI:45351 None

A7SIA8_NEMVE
EnsemblMetazoa»

0.0

NEMVEDRAFT_v1g119418

Glycoside hydrolase family 65
central catalytic domain-containing protein

Nematostella vectensis
TI:45351 None

A9UQ61_MONBE
EnsemblProtists»

0.0

MONBRDRAFT_22300

Glycoside hydrolase family 65
central catalytic domain-containing protein

Monosiga brevicollis
TI:81824 None

A9UXV0_MONBE
EnsemblProtists»

0.0

MONBRDRAFT_16873

Glycoside hydrolase family 65
central catalytic domain-containing protein

Monosiga brevicollis
TI:81824 None

E9GXQ6_DAPPU
EnsemblMetazoa»

0.0

DAPPUDRAFT_55687

Glycoside hydrolase family 65
central catalytic domain-containing protein

Daphnia pulex
TI:6669 None

F0ZLA6_DICPU
EnsemblProtists»

0.0

DICPUDRAFT_97948

Glycoside hydrolase family 65
central catalytic domain-containing protein

Dictyostelium purpureum
TI:5786 None

H2Y3R2_CIOIN
Ensembl»

0.0

Glycoside hydrolase family 65
central catalytic domain-containing protein

Ciona intestinalis
TI:7719 None

K7EGJ9_ORNAN
Ensembl»

0.0

PGGHG

Glycoside hydrolase family 65
central catalytic domain-containing protein

Ornithorhynchus anatinus
TI:9258 None

T1ES14_HELRO
EnsemblMetazoa»

0.0

20199364

Glycoside hydrolase family 65
central catalytic domain-containing protein

Helobdella robusta
TI:6412 None

T1FUU3_HELRO
EnsemblMetazoa»

0.0

20212589

Glycoside hydrolase family 65
central catalytic domain-containing protein

Helobdella robusta
TI:6412 None

T1G2R9_HELRO
EnsemblMetazoa»

0.0

20215367

Glycoside hydrolase family 65
central catalytic domain-containing protein

Helobdella robusta
TI:6412 None

Q9RJM8_STRCO
EnsemblBacteria»

0.0

SCO0616

Glycoside hydrolase family 65 protein

Streptomyces coelicolor
TI:1902 None

Q4Q2X6_LEIMA
EnsemblProtists»

0.0

LMJF_34_2240

Glycosyl hydrolase

Leishmania major
TI:5664 None

Q584E6_TRYB2
VEuPathDB»

0.0

Tb04.1H19.760

Glycosyl hydrolase

Trypanosoma brucei
TI:5691 None

Q383L2_TRYB2
VEuPathDB»

0.0

Tb11.01.2440

Glycosyl hydrolase, putative

Trypanosoma brucei
TI:5691 None

Q9L2I8_STRCO
EnsemblBacteria»

0.0

SCF42.31c

Glycosyl transferase

Streptomyces coelicolor
TI:1902 None

A9WEH2_CHLAA
EnsemblBacteria»

0.0

Caur_2019

Kojibiose phosphorylase (EC 2.4.1.230)

Chloroflexus aurantiacus
TI:1108 None

KOJP_ECOLI
EnsemblBacteria»

1.8

ycjT

Kojibiose phosphorylase (EC 2.4.1.230)

Escherichia coli
TI:562 None

Q8Y5E3_LISMO
EnsemblBacteria»

0.0

lmo2121

Lmo2121 protein

Listeria monocytogenes
TI:1639 None

Q8Y3K2_LISMO
EnsemblBacteria»

0.0

lmo2833

Lmo2833 protein

Listeria monocytogenes
TI:1639 None

Q9VKD9_DROME
FlyBase»

1.5

Dmel\CG16965

MIP16835p1

Drosophila melanogaster
TI:7227 None

MALPY_BACSU
EnsemblBacteria»

0.0

mdxK

Maltose phosphorylase (EC 2.4.1.8)

Bacillus subtilis
TI:1423 None

Q9K109_NEIMB
EnsemblBacteria»

0.0

mapA

Maltose phosphorylase (EC 2.4.1.8)

Neisseria meningitidis
TI:487 None

ATH1_YEAST
SGD»

5.8

ATH1

Periplasmic acid trehalase ATH1
(EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)

Saccharomyces cerevisiae
TI:4932 None

A0A1D5Q064_MACMU
Ensembl»

0.0

PGGHG

Protein-glucosylgalactosylhydroxylysine
glucosidase

Macaca mulatta
TI:9544 None

A0A2I2YY42_GORGO
Ensembl»

0.0

PGGHG

Protein-glucosylgalactosylhydroxylysine
glucosidase

Gorilla gorilla
TI:9593 None

A0A3Q2KSQ3_HORSE
Ensembl»

0.0

PGGHG

Protein-glucosylgalactosylhydroxylysine
glucosidase

Equus caballus
TI:9796 None

A0A6I8RPX9_XENTR
Xenbase»

0.0

pgghg

Protein-glucosylgalactosylhydroxylysine
glucosidase

Xenopus tropicalis
TI:8364 None

A0A8I3Q443_CANLF
Ensembl»

0.0

PGGHG

Protein-glucosylgalactosylhydroxylysine
glucosidase

Canis lupus
TI:9612 None

A0A8V0ZG57_CHICK
Ensembl»

0.0

PGGHG

Protein-glucosylgalactosylhydroxylysine
glucosidase

Gallus gallus
TI:9031 None

A0A9J7LQD3_BRAFL
CTD»

0.0

LOC118422669

Protein-glucosylgalactosylhydroxylysine
glucosidase-like

Branchiostoma floridae
TI:7739 None

A0A9J7M222_BRAFL
CTD»

0.0

LOC118427572

Protein-glucosylgalactosylhydroxylysine
glucosidase-like

Branchiostoma floridae
TI:7739 None

D3ZY02_RAT
RGD»

2.0

Pgghg

Protein-glucosylgalactosylhydroxylysine
glucosidase

Rattus norvegicus
TI:10116 None

F1RGC7_PIG
Ensembl»

0.0

PGGHG

Protein-glucosylgalactosylhydroxylysine
glucosidase

Sus scrofa
TI:9823 None

G1KTZ6_ANOCA
Ensembl»

0.0

PGGHG

Protein-glucosylgalactosylhydroxylysine
glucosidase

Anolis carolinensis
TI:28377 None

H2LP20_ORYLA
Ensembl»

0.0

pgghg

Protein-glucosylgalactosylhydroxylysine
glucosidase

Oryzias latipes
TI:8090 None

M3WJN8_FELCA
Ensembl»

0.0

PGGHG

Protein-glucosylgalactosylhydroxylysine
glucosidase

Felis catus
TI:9685 None

A0A310TM71_XENLA
Xenbase»

0.0

pgghg.L

Protein-glucosylgalactosylhydroxylysine glucosidase
isoform X1

Xenopus laevis
TI:8355 None

PGGHG_CHICK
CTD»

2.6

PGGHG

Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107)
(Acid trehalase-like protein 1)

Gallus gallus
TI:9031 None

PGGHG_DANRE
ZFIN»

1.0

pgghg

Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107)
(Acid trehalase-like protein 1)

Danio rerio
TI:7955 None

PGGHG_DICDI
dictyBase»

1.0

pgghg

Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107)
(Acid trehalase-like protein 1)

Dictyostelium discoideum
TI:44689 None

PGGHG_HUMAN
Ensembl»

2.6

PGGHG

Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107)
(Acid trehalase-like protein 1)

Homo sapiens
TI:9606 None

PGGHG_MOUSE
Ensembl»

0.0

Pgghg

Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107)
(Acid trehalase-like protein 1)

Mus musculus
TI:10090 None

Q4Q0N8_LEIMA
EnsemblProtists»

0.0

LMJF_36_5240

Putative glycosyl hydrolase (EC 3.2.1.28)

Leishmania major
TI:5664 None

Y2006_MYCTU
TubercuList»

0.0

Rv2006

Uncharacterized glycosyl hydrolase
Rv2006 (EC 3.2.1.-)

Mycobacterium tuberculosis
TI:1773 None

Y3401_MYCTU
TubercuList»

0.0

Rv3401

Uncharacterized glycosyl hydrolase
Rv3401 (EC 3.2.1.-)

Mycobacterium tuberculosis
TI:1773 None

Q6C6P1_YARLI
EnsemblFungi»

0.0

YALI0_E07744g

YALI0E07744p

Yarrowia lipolytica
TI:4952 None

E3KTV6_PUCGT
EnsemblFungi»

0.0

PGTG_13445

alpha,alpha-trehalase (EC 3.2.1.28)

Puccinia graminis
TI:5297 None

Q4WFG4_ASPFU
EnsemblFungi»

0.0

AFUA_3G02280

alpha,alpha-trehalase (EC 3.2.1.28)

Aspergillus fumigatus
TI:746128 None

Q751H7_ASHGO
EnsemblFungi»

0.0

AGOS_AGL271W

alpha,alpha-trehalase (EC 3.2.1.28)

Ashbya gossypii
TI:33169 None