Cluster UKP09843
- GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1
Standard knownness: 2.9; Custom knownness: None; Num. species: 44; Orthology database: Panther19.0; Protein members: 50
Collated Gene Ontology terms
Biological process:
guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity(2010, 2019, 2025)
metal ion binding(2025)
hydrolase activity(2025)
transferase activity(2025)
nucleic acid binding(2025)
Molecular function: response to starvation2010 guanosine tetraphosphate catabolic process2010
Cellular component:
Phylogenetic distribution
| Chordates: | 21/21 |  |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 3/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 0/1 | |
| Cnidaria: | 0/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 3/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 3/3 | |
| Excavates: | 0/4 | |
| Harosa: | 0/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 0/39 | |
| Archea: | 0/8 | |
| Bacteria: | 7/35 |
Click here to switch to the previous version of the database.
Proteins
| UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
H9GMV1_ANOCA Ensembl» |
|
|
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Anolis carolinensis TI:28377 None |
|
|
|||||||
|
Q7Q7N0_ANOGA EnsemblMetazoa» |
|
|
1275936 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Anopheles gambiae TI:7165 None |
|
|
|
|||||
|
Q7QKR1_ANOGA EnsemblMetazoa» |
|
|
AgaP_AGAP012646 | AGAP012646-PA |
Anopheles gambiae TI:7165 None |
|
|
|
|||||
|
F4P465_BATDJ euHCVdb» |
|
|
BATDEDRAFT_89127 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Batrachochytrium dendrobatidis TI:109871 None |
|
|
|
|||||
|
F1MR07_BOVIN Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Bos taurus TI:9913 None |
|
|
||||||
|
Q89UG1_BRADU EnsemblBacteria» |
|
|
blr1456 | Blr1456 protein |
Bradyrhizobium diazoefficiens TI:1355477 None |
|
|
|
|||||
|
A0A9J7KW34_BRAFL euHCVdb» |
|
|
LOC118412510 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Branchiostoma floridae TI:7739 None |
|
|
||||||
|
A8XW96_CAEBR WormBase» |
|
|
CBG19806 CBG_19806 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Caenorhabditis briggsae TI:6238 None |
|
|
|
|||||
|
O18307_CAEEL WormBase» |
|
|
CELE_ZK909.3 ZK909.3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Caenorhabditis elegans TI:6239 None |
|
|
|
|||||
|
A0A8I3MRZ7_CANLF Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Canis lupus TI:9612 None |
|
|
||||||
|
A9WHG6_CHLAA EnsemblBacteria» |
|
|
Caur_3093 | Metal-dependent phosphohydrolase HD sub domain |
Chloroflexus aurantiacus TI:1108 None |
|
|
|
|||||
|
F6QJB5_CIOIN Ensembl» |
|
|
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Ciona intestinalis TI:7719 None |
|
|
|
||||||
|
Q5KID5_CRYD1 TubercuList» |
|
|
CND03360 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Cryptococcus deneoformans TI:40410 None |
|
|
|
|||||
|
MESH1_DANRE ZFIN» |
|
|
hddc3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase) |
Danio rerio TI:7955 None |
|
|
|
|||||
|
E9H8N5_DAPPU euHCVdb» |
|
|
DAPPUDRAFT_308647 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Daphnia pulex TI:6669 None |
|
|
|
|||||
|
F0ZTB3_DICPU TubercuList» |
|
|
DICPUDRAFT_155188 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Dictyostelium purpureum TI:5786 None |
|
|
|
|||||
|
Q54KN3_DICDI dictyBase» |
|
|
spoT | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Dictyostelium discoideum TI:44689 None |
|
|
|
|||||
|
MESH1_DROME FlyBase» |
|
|
Mesh1 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Mesh1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase) |
Drosophila melanogaster TI:7227 None |
|
|
|
|||||
|
C4M411_ENTH1 TubercuList» |
|
|
EHI_195060 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Entamoeba histolytica TI:5759 None |
|
|
|
|||||
|
A0A3Q2HGK9_HORSE Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Equus caballus TI:9796 None |
|
|||||||
|
A0ABI7YD22_FELCA Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Felis catus TI:9685 None |
|
|||||||
|
A0A8V0X4C9_CHICK Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Gallus gallus TI:9031 None |
|
|
||||||
|
Q7NIR7_GLOVI EnsemblBacteria» |
|
|
gll2115 | Gll2115 protein |
Gloeobacter violaceus TI:33072 None |
|
|
|
|||||
|
A0A2I2YAG5_GORGO Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Gorilla gorilla TI:9593 None |
|
|
|
|||||
|
T1EMJ6_HELRO EnsemblMetazoa» |
|
|
20197796 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Helobdella robusta TI:6412 None |
|
|
|
|||||
|
MESH1_HUMAN Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase) |
Homo sapiens TI:9606 None |
|
|
|
|||||
|
B7Q0D7_IXOSC EnsemblMetazoa» |
|
|
8034036 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Ixodes scapularis TI:6945 None |
|
|
|
|||||
|
W5N9W8_LEPOC Ensembl» |
|
|
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Lepisosteus oculatus TI:7918 None |
|
|
|
||||||
|
Q8Y8T2_LISMO EnsemblBacteria» |
|
|
lmo0812 | Lmo0812 protein |
Listeria monocytogenes TI:1639 None |
|
|
|
|||||
|
G7MVZ1_MACMU Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Macaca mulatta TI:9544 None |
|
|
||||||
|
A9UYV8_MONBE euHCVdb» |
|
|
MONBRDRAFT_25258 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Monosiga brevicollis TI:81824 None |
|
|
|
|||||
|
MESH1_MOUSE Ensembl» |
|
|
Hddc3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase) |
Mus musculus TI:10090 None |
|
|
|
|||||
|
A0A6I8NEF5_ORNAN Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Ornithorhynchus anatinus TI:9258 None |
|
|
||||||
|
A0A3B3HJN8_ORYLA Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Oryzias latipes TI:8090 None |
|
|
||||||
|
K7BTU9_PANTR Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Pan troglodytes TI:9598 None |
|
|
|
|||||
|
A0A2A6BM82_PRIPA EnsemblMetazoa» |
|
|
WBGene00103413 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Pristionchus pacificus TI:54126 None |
|
|
||||||
|
A0A454XQT1_PRIPA EnsemblMetazoa» |
|
|
WBGene00094801 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Pristionchus pacificus TI:54126 None |
|
|
||||||
|
A0A454XUZ0_PRIPA EnsemblMetazoa» |
|
|
WBGene00272635 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Pristionchus pacificus TI:54126 None |
|
|
||||||
|
Q9I686_PSEAE PharmGKB» |
|
|
PA0431 | Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase |
Pseudomonas aeruginosa TI:287 None |
|
|
|
|||||
|
A0A8I5ZQC5_RAT RGD» |
|
|
Hddc3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Rattus norvegicus TI:10116 None |
|
|||||||
|
A0A7M7RDN5_STRPU EnsemblMetazoa» |
|
|
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Strongylocentrotus purpuratus TI:7668 None |
|
|
|||||||
|
F1RMH8_PIG Ensembl» |
|
|
HDDC3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Sus scrofa TI:9823 None |
|
|
||||||
|
P72810_SYNY3 EnsemblBacteria» |
|
|
sll1660 | Sll1660 protein |
Synechocystis sp. TI:1148 None |
|
|
|
|||||
|
Q6ZEC1_SYNY3 EnsemblBacteria» |
|
|
sll7077 | Sll7077 protein |
Synechocystis sp. TI:1148 None |
|
|
|
|||||
|
D6WD98_TRICA euHCVdb» |
|
|
AUGUSTUS-3.0.2_00063 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Tribolium castaneum TI:7070 None |
|
|
|
|||||
|
Q8PBN2_XANCP EnsemblBacteria» |
|
|
XCC1087 | HD/PDEase domain-containing protein |
Xanthomonas campestris TI:339 None |
|
|
|
|||||
|
A0A8J1KRV3_XENLA Xenbase» |
|
|
LOC108717406 | Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase MESH1 |
Xenopus laevis TI:8355 None |
|
|
||||||
|
A0A8J1M4K3_XENLA euHCVdb» |
|
|
LOC121399405 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Xenopus laevis TI:8355 None |
|
|
||||||
|
A0A8J1M4L3_XENLA euHCVdb» |
|
|
LOC108703681 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) |
Xenopus laevis TI:8355 None |
|
|
||||||
|
MESH1_XENTR Xenbase» |
|
|
hddc3 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase) |
Xenopus tropicalis TI:8364 None |
|
|
|
|||||
