Unknome v3

Cluster UKP09730
RNA POLYMERASE II-ASSOCIATED PROTEIN 3
Standard knownness: 7.0; Custom knownness: None; Num. species: 50; Orthology database: Panther19.0; Protein members: 66

Collated Gene Ontology terms

Biological process: zinc ion binding⁽²⁰²⁵⁾ protein-folding chaperone binding⁽²⁰¹³⁾ metal ion binding⁽²⁰²⁵⁾ molecular adaptor activity⁽²⁰¹⁸⁾ Hsp90 protein binding^{(2015, 2023)} clathrin binding⁽²⁰²⁴⁾ Hsp70 protein binding⁽²⁰¹⁵⁾

Molecular function: protein folding²⁰¹³ protein stabilization^{2024, 2025} post-translational protein targeting to endoplasmic reticulum membrane²⁰¹⁸ box C/D snoRNP assembly^{2013, 2024} regulation of locomotor rhythm²⁰¹⁵ protein-containing complex assembly²⁰²⁴ post-transcriptional regulation of gene expression²⁰¹⁶ negative regulation of motor neuron apoptotic process²⁰¹⁵ meiotic cell cycle²⁰²⁵ clathrin-dependent endocytosis²⁰²⁴
clathrin coat disassembly²⁰²³

Cellular component: R2TP complex^{2013, 2016, 2025} cytosol^{2009, 2024, 2025} cytoplasm^{2015, 2018, 2024, 2025} nucleus^{2009, 2018, 2025} protein folding chaperone complex²⁰²⁵ mitochondrion^{2014, 2018, 2025} membrane²⁰²⁰ TRC complex²⁰¹⁸ RPAP3/R2TP/prefoldin-like complex²⁰²⁵ vesicle²⁰²⁴
phagocytic vesicle²⁰⁰⁶ mitotic spindle pole body²⁰⁰⁹ cilium²⁰²⁵ ciliary tip²⁰²⁵ ciliary basal body²⁰²⁵ cell division site²⁰⁰⁹ acrosomal vesicle²⁰²⁵

Phylogenetic distribution

Chordates:	21/21
Echinoderms:	0/0
Hemichordates:	1/1
Annelids:	0/1
Molluscs:	0/0
Bryozoans:	0/0
Platyhelminthes:	0/0
Rotifers:	0/0
Nematodes:	2/3
Arthropods:	3/5
Tardigrades:	0/0
Placozoa:	0/1
Cnidaria:	1/1
Porifera:	0/0
Choanoflagellates+:	8/1
Dikarya:	0/14
Fungi (other):	0/1
Protozoa:	3/3
Excavates:	4/4
Harosa:	3/4
Hacrobia:	0/0
Plants:	4/39
Archea:	0/8
Bacteria:	0/35

Cluster UKP09730

Collated Gene Ontology terms

Phylogenetic distribution

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Knownness history

Proteins