Collated Gene Ontology terms

Biological process: enzyme inhibitor activity(2025) protein-containing complex binding(2018, 2025) NADH dehydrogenase (ubiquinone) activity(2003, 2007) oxidoreductase activity(2025) cytochrome-c oxidase activity(2025)

Molecular function: respiratory electron transport chain2025 response to hypoxia2025 negative regulation of mitochondrial electron transport, NADH to ubiquinone2025 cellular response to hypoxia2025 mitochondrial electron transport, cytochrome c to oxygen2024, 2025 proton transmembrane transport2025 negative regulation of reactive oxygen species biosynthetic process2025 mitochondrial electron transport, NADH to ubiquinone2007 cellular respiration2025

Cellular component: respiratory chain complex IV2018, 2024, 2025 mitochondrial inner membrane2013, 2024, 2025 mitochondrion2024, 2025 mitochondrial membrane2025 nucleus2004, 2025 respiratory chain complex I2018, 2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 3/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
CXFA4_HUMAN
Ensembl»
4.1
COXFA4 Cytochrome c oxidase subunit FA4 (Complex I-MLRQ) (CI-MLRQ)
(Cytochrome c oxidase subunit NDUFA4) (NADH-ubiquinone oxidoreductase MLRQ subunit)		 Homo sapiens
TI:9606 None
 
A6IDY9_RAT
RGD»
0.5
Ndufa4 Cytochrome c oxidase subunit NDUFA4 Rattus norvegicus
TI:10116 None
 
D3ZXX8_RAT
RGD»
2.5
Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 Rattus norvegicus
TI:10116 None
   
CX4L2_HUMAN
Ensembl»
3.2
COXFA4L2 Cytochrome c oxidase hypoxia associated subunit FA4L2 (NADH dehydrogenase [ubiquinone] 1
alpha subcomplex subunit 4-like 2) (NADH-ubiquinone oxidoreductase MLRQ subunit homolog) (NUOMS)		 Homo sapiens
TI:9606 None
 
CX4L2_MOUSE
Ensembl»
1.6
Coxfa4l2 Cytochrome c oxidase hypoxia associated subunit FA4L2 (NADH
dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2)		 Mus musculus
TI:10090 None
 
Q8SYJ2_DROME
FlyBase»
2.6
ND-MLRQ GEO09626p1 (NADH dehydrogenase (Ubiquinone) MLRQ subunit, isoform A) (NADH dehydrogenase (Ubiquinone)
MLRQ subunit, isoform B) (NADH dehydrogenase (Ubiquinone) MLRQ subunit, isoform C) (RE56733p)		 Drosophila melanogaster
TI:7227 None
 
CXFA4_MOUSE
Ensembl»
0.0
Coxfa4 Cytochrome c oxidase subunit FA4
(Cytochrome c oxidase subunit NDUFA4)		 Mus musculus
TI:10090 None
 
R4GGZ2_CHICK
Ensembl»
0.0
NDUFA4 Cytochrome c oxidase subunit NDUFA4 Gallus gallus
TI:9031 None
   
CX4L3_HUMAN
Ensembl»
0.0
COXFA4L3 Cytochrome c oxidase associated subunit FA4L3 (Modulator of cytochrome C oxidase during
inflammation protein) (MOCCI) (Normal mucosa of esophagus-specific gene 1 protein) (NMES1) (Protein FOAP-11)		 Homo sapiens
TI:9606 None
 
CX4L3_MOUSE
Ensembl»
0.0
Coxfa4l3 Cytochrome c oxidase associated subunit FA4L3
(Normal mucosa of esophagus-specific gene 1 protein)		 Mus musculus
TI:10090 None
 
CXFA4_DANRE
ZFIN»
0.0
coxfa4 Cytochrome c oxidase subunit FA4
(Cytochrome c oxidase subunit NDUFA4)		 Danio rerio
TI:7955 None
 
CX4L3_RAT
RGD»
0.0
Coxfa4l3 Cytochrome c oxidase associated subunit FA4L3
(Normal mucosa of esophagus-specific gene 1 protein)		 Rattus norvegicus
TI:10116 None
 
Q7ZTT8_DANRE
ZFIN»
0.0
ndufa4a Cytochrome c oxidase subunit NDUFA4 Danio rerio
TI:7955 None
 
A0A8V0YYX0_CHICK
Ensembl»
0.0
C10H15ORF48 Chromosome 10 open reading frame, human C15orf48 Gallus gallus
TI:9031 None
   
A0A0R4IT01_DANRE
ZFIN»
0.0
ndufa4l2a NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
subunit 4-like 2 (NDUFA4 mitochondrial complex-associated-like 2a)		 Danio rerio
TI:7955 None
 
F1RE72_DANRE
ZFIN»
0.0
zgc:153317 Normal mucosa of esophagus-specific
gene 1 protein (Zgc:153317)		 Danio rerio
TI:7955 None