Collated Gene Ontology terms

Biological process: enzyme inhibitor activity(2025) protein-containing complex binding(2018, 2025) NADH dehydrogenase (ubiquinone) activity(2003, 2007) oxidoreductase activity(2025) cytochrome-c oxidase activity(2025)

Molecular function: respiratory electron transport chain2025 response to hypoxia2025 negative regulation of mitochondrial electron transport, NADH to ubiquinone2025 cellular response to hypoxia2025 mitochondrial electron transport, cytochrome c to oxygen2024, 2025 proton transmembrane transport2025 negative regulation of reactive oxygen species biosynthetic process2025 mitochondrial electron transport, NADH to ubiquinone2007 cellular respiration2025

Cellular component: respiratory chain complex IV2018, 2024, 2025 mitochondrial inner membrane2013, 2024, 2025 mitochondrion2024, 2025 mitochondrial membrane2025 nucleus2004, 2025 respiratory chain complex I2018, 2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 3/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A803SNF3_ANOCA
Ensembl»
0.0
C15orf48 Chromosome 15 open reading frame 48 Anolis carolinensis
TI:28377 None
   
A0A803TMJ4_ANOCA
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Anolis carolinensis
TI:28377 None
   
F5HMA2_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP013039 AGAP013039-PA (AGAP013039-PB) Anopheles gambiae
TI:7165 None
 
Q5TNR5_ANOGA
EnsemblMetazoa»
0.0
1279745 AGAP003325-PA Anopheles gambiae
TI:7165 None
 
F4P2Z2_BATDJ
euHCVdb»
0.0
BATDEDRAFT_88731 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
A0A3Q1LTU9_BOVIN
Ensembl»
0.0
Cytochrome c oxidase subunit NDUFA4 Bos taurus
TI:9913 None
   
A0A3Q1M6L2_BOVIN
Ensembl»
0.0
Cytochrome c oxidase subunit NDUFA4 Bos taurus
TI:9913 None
   
A5PK67_BOVIN
Ensembl»
0.0
C10H15orf48 Chromosome 10 C15orf48
homolog (MGC165862 protein)		 Bos taurus
TI:9913 None
 
CX4L2_BOVIN
Ensembl»
0.0
COXFA4L2 Cytochrome c oxidase hypoxia associated subunit FA4L2 (NADH
dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2)		 Bos taurus
TI:9913 None
 
CXFA4_BOVIN
Ensembl»
0.0
COXFA4 Cytochrome c oxidase subunit FA4 (Complex I-MLRQ) (CI-MLRQ)
(Cytochrome c oxidase subunit NDUFA4) (NADH-ubiquinone oxidoreductase MLRQ subunit)		 Bos taurus
TI:9913 None
 
A0A9J7K688_BRAFL
euHCVdb»
0.0
LOC118403799 Cytochrome c oxidase
subunit NDUFA4-like isoform X1		 Branchiostoma floridae
TI:7739 None 		     
A0A9J7MIJ4_BRAFL
neXtProt»
0.0
LOC118410893 Normal mucosa of esophagus-specific
gene 1 protein-like isoform X1		 Branchiostoma floridae
TI:7739 None 		     
A0A8I3MZU1_CANLF
Ensembl»
0.0
LOC100682956 Cytochrome c oxidase subunit NDUFA4 Canis lupus
TI:9612 None
   
A0A8I3NDE5_CANLF
Ensembl»
0.0
Uncharacterized protein Canis lupus
TI:9612 None
   
A0A8I3P6P5_CANLF
Ensembl»
0.0
Cytochrome c oxidase subunit NDUFA4 Canis lupus
TI:9612 None
   
A0A8I3P9C2_CANLF
Ensembl»
0.0
Cytochrome c oxidase subunit NDUFA4 Canis lupus
TI:9612 None
   
A0A8I3PWS0_CANLF
Ensembl»
0.0
LOC100688724 Cytochrome c oxidase subunit NDUFA4 Canis lupus
TI:9612 None
   
A0A8I3QAR5_CANLF
Ensembl»
0.0
C30H15orf48 Normal mucosa of esophagus specific 1 Canis lupus
TI:9612 None
   
A0A8I3RXX3_CANLF
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Canis lupus
TI:9612 None
   
H2XRC1_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
 
Q5KPW0_CRYD1
TubercuList»
0.0
CNA01370 Expressed protein Cryptococcus deneoformans
TI:40410 None
 
A0A0R4IT01_DANRE
ZFIN»
0.0
ndufa4l2a NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
subunit 4-like 2 (NDUFA4 mitochondrial complex-associated-like 2a)		 Danio rerio
TI:7955 None
 
CXFA4_DANRE
ZFIN»
0.0
coxfa4 Cytochrome c oxidase subunit FA4
(Cytochrome c oxidase subunit NDUFA4)		 Danio rerio
TI:7955 None
 
F1RE72_DANRE
ZFIN»
0.0
zgc:153317 Normal mucosa of esophagus-specific
gene 1 protein (Zgc:153317)		 Danio rerio
TI:7955 None
 
Q7ZTT8_DANRE
ZFIN»
0.0
ndufa4a Cytochrome c oxidase subunit NDUFA4 Danio rerio
TI:7955 None
 
E9GUJ4_DAPPU
neXtProt»
0.0
DAPPUDRAFT_231182 Uncharacterized protein Daphnia pulex
TI:6669 None
 
E9I2A8_DAPPU
neXtProt»
0.0
DAPPUDRAFT_93873 Uncharacterized protein Daphnia pulex
TI:6669 None
 
Q8SYJ2_DROME
FlyBase»
2.6
ND-MLRQ GEO09626p1 (NADH dehydrogenase (Ubiquinone) MLRQ subunit, isoform A) (NADH dehydrogenase (Ubiquinone)
MLRQ subunit, isoform B) (NADH dehydrogenase (Ubiquinone) MLRQ subunit, isoform C) (RE56733p)		 Drosophila melanogaster
TI:7227 None
 
A0A3Q2I3V2_HORSE
Ensembl»
0.0
Cytochrome c oxidase subunit NDUFA4 Equus caballus
TI:9796 None
   
A0A5F5PV33_HORSE
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Equus caballus
TI:9796 None
   
A0A9R1SP88_HORSE
Ensembl»
0.0
Chromosome 1 C15orf48 homolog Equus caballus
TI:9796 None
   
F6ZIP2_HORSE
Ensembl»
0.0
NDUFA4 Cytochrome c oxidase subunit NDUFA4 Equus caballus
TI:9796 None
   
A0ABI7YR25_FELCA
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Felis catus
TI:9685 None 		     
A0ABI8A3M2_FELCA
Ensembl»
0.0
C15orf48 NMES1 Felis catus
TI:9685 None 		     
A0A8V0YYX0_CHICK
Ensembl»
0.0
C10H15ORF48 Chromosome 10 open reading frame, human C15orf48 Gallus gallus
TI:9031 None
   
R4GGZ2_CHICK
Ensembl»
0.0
NDUFA4 Cytochrome c oxidase subunit NDUFA4 Gallus gallus
TI:9031 None
   
A0A2I2Y4S3_GORGO
Ensembl»
0.0
NDUFA4 mitochondrial complex associated Gorilla gorilla
TI:9593 None
 
A0A2I2YAQ2_GORGO
Ensembl»
0.0
NDUFA4 mitochondrial complex associated like 2 Gorilla gorilla
TI:9593 None
 
CXFA4_GORGO
Ensembl»
0.0
COXFA4 Cytochrome c oxidase subunit FA4
(Cytochrome c oxidase subunit NDUFA4)		 Gorilla gorilla
TI:9593 None
 
G3R413_GORGO
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Gorilla gorilla
TI:9593 None
 
G3SAQ1_GORGO
Ensembl»
0.0
C16H15orf48 Chromosome 15 open reading frame 48 Gorilla gorilla
TI:9593 None
 
T1G2U1_HELRO
EnsemblMetazoa»
0.0
20215389 Uncharacterized protein Helobdella robusta
TI:6412 None
 
CX4L2_HUMAN
Ensembl»
3.2
COXFA4L2 Cytochrome c oxidase hypoxia associated subunit FA4L2 (NADH dehydrogenase [ubiquinone] 1
alpha subcomplex subunit 4-like 2) (NADH-ubiquinone oxidoreductase MLRQ subunit homolog) (NUOMS)		 Homo sapiens
TI:9606 None
 
CX4L3_HUMAN
Ensembl»
0.0
COXFA4L3 Cytochrome c oxidase associated subunit FA4L3 (Modulator of cytochrome C oxidase during
inflammation protein) (MOCCI) (Normal mucosa of esophagus-specific gene 1 protein) (NMES1) (Protein FOAP-11)		 Homo sapiens
TI:9606 None
 
CXFA4_HUMAN
Ensembl»
4.1
COXFA4 Cytochrome c oxidase subunit FA4 (Complex I-MLRQ) (CI-MLRQ)
(Cytochrome c oxidase subunit NDUFA4) (NADH-ubiquinone oxidoreductase MLRQ subunit)		 Homo sapiens
TI:9606 None
 
B7P1B1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW000951 NADH dehydrogenase (EC 1.6.5.3) Ixodes scapularis
TI:6945 None
 
W5MFY1_LEPOC
Ensembl»
0.0
NDUFA4 mitochondrial complex associated like 2 Lepisosteus oculatus
TI:7918 None
 
W5N162_LEPOC
Ensembl»
0.0
Cytochrome c oxidase subunit NDUFA4 Lepisosteus oculatus
TI:7918 None
 
W5N696_LEPOC
Ensembl»
0.0
Chromosome 15 open reading frame 48 Lepisosteus oculatus
TI:7918 None
 
A0A1D5RBT1_MACMU
Ensembl»
0.0
Chromosome 15 open reading frame 48 Macaca mulatta
TI:9544 None
   
CXFA4_MACMU
Ensembl»
0.0
COXFA4 Cytochrome c oxidase subunit FA4
(Cytochrome c oxidase subunit NDUFA4)		 Macaca mulatta
TI:9544 None
 
F7H7R8_MACMU
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Macaca mulatta
TI:9544 None
   
A0A5F8HB01_MONDO
Ensembl»
0.0
LOC130456287 Normal mucosa of
esophagus-specific gene 1 protein		 Monodelphis domestica
TI:13616 None
   
F6Q640_MONDO
Ensembl»
0.0
Uncharacterized protein Monodelphis domestica
TI:13616 None
   
F6QIU8_MONDO
Ensembl»
0.0
NDUFA4 Cytochrome c oxidase subunit NDUFA4 Monodelphis domestica
TI:13616 None
   
K7DYW7_MONDO
Ensembl»
0.0
C1H15orf48 Normal mucosa of
esophagus-specific gene 1 protein		 Monodelphis domestica
TI:13616 None
   
CX4L2_MOUSE
Ensembl»
1.6
Coxfa4l2 Cytochrome c oxidase hypoxia associated subunit FA4L2 (NADH
dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2)		 Mus musculus
TI:10090 None
 
CX4L3_MOUSE
Ensembl»
0.0
Coxfa4l3 Cytochrome c oxidase associated subunit FA4L3
(Normal mucosa of esophagus-specific gene 1 protein)		 Mus musculus
TI:10090 None
 
CXFA4_MOUSE
Ensembl»
0.0
Coxfa4 Cytochrome c oxidase subunit FA4
(Cytochrome c oxidase subunit NDUFA4)		 Mus musculus
TI:10090 None
 
A7RHJ0_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g197216 NADH dehydrogenase [ubiquinone] 1
alpha subcomplex subunit 4		 Nematostella vectensis
TI:45351 None
 
A0A6I8NBA5_ORNAN
Ensembl»
0.0
NDUFA4 Cytochrome c oxidase subunit NDUFA4 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NG90_ORNAN
Ensembl»
0.0
LOC114806569 Normal mucosa of esophagus specific 1 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NQT7_ORNAN
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NY36_ORNAN
Ensembl»
0.0
Normal mucosa of esophagus specific 1 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3HIB8_ORYLA
Ensembl»
0.0
NDUFA4 Cytochrome c oxidase subunit NDUFA4 Oryzias latipes
TI:8090 None
   
A0A3B3HUS5_ORYLA
Ensembl»
0.0
C15orf48 Chromosome 15 open reading frame 48 Oryzias latipes
TI:8090 None
   
H2LB63_ORYLA
Ensembl»
0.0
LOC101155111 Cytochrome c oxidase subunit NDUFA4 Oryzias latipes
TI:8090 None
   
H2LFK5_ORYLA
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Oryzias latipes
TI:8090 None
   
H2LLR2_ORYLA
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Oryzias latipes
TI:8090 None
   
A0A2I3RK84_PANTR
Ensembl»
0.0
NDUFA4 Pan troglodytes
TI:9598 None
 
A0A2I3TUR6_PANTR
Ensembl»
0.0
NDUFA4 Pan troglodytes
TI:9598 None
 
A0A2J8KWA5_PANTR
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Pan troglodytes
TI:9598 None
 
CXFA4_PANTR
Ensembl»
0.0
COXFA4 Cytochrome c oxidase subunit FA4
(Cytochrome c oxidase subunit NDUFA4)		 Pan troglodytes
TI:9598 None
 
H2Q9D3_PANTR
Ensembl»
0.0
C15H15orf48 Chromosome 15 C15orf48 homolog (Chromosome
15 open reading frame 48)		 Pan troglodytes
TI:9598 None
 
E3K185_PUCGT
TubercuList»
0.0
PGTG_04016 Uncharacterized protein Puccinia graminis
TI:5297 None
 
E3KSH8_PUCGT
TubercuList»
0.0
PGTG_12848 Uncharacterized protein Puccinia graminis
TI:5297 None
 
A6IDY9_RAT
RGD»
0.5
Ndufa4 Cytochrome c oxidase subunit NDUFA4 Rattus norvegicus
TI:10116 None
 
CX4L3_RAT
RGD»
0.0
Coxfa4l3 Cytochrome c oxidase associated subunit FA4L3
(Normal mucosa of esophagus-specific gene 1 protein)		 Rattus norvegicus
TI:10116 None
 
D3ZXX8_RAT
RGD»
2.5
Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 Rattus norvegicus
TI:10116 None
   
A0A7M7MXX7_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None 		     
F1SL75_PIG
Ensembl»
0.0
NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 Sus scrofa
TI:9823 None
   
F1SN46_PIG
Ensembl»
0.0
C1H15orf48 Chromosome 1 C15orf48 homolog Sus scrofa
TI:9823 None
   
I3LJI1_PIG
Ensembl»
0.0
NDUFA4 Cytochrome c oxidase subunit NDUFA4 Sus scrofa
TI:9823 None
 
D6WAC4_TRICA
neXtProt»
0.0
GLEAN_01140 Uncharacterized protein Tribolium castaneum
TI:7070 None
 
D6WJL9_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_14044 NADH dehydrogenase [ubiquinone] 1
alpha subcomplex subunit 4-like Protein		 Tribolium castaneum
TI:7070 None
 
A4IHM5_XENTR
Xenbase»
0.0
ndufa4 Cytochrome c oxidase subunit NDUFA4 Xenopus tropicalis
TI:8364 None
 
Q641S0_XENLA
Xenbase»
0.0
ndufa4.S Cytochrome c oxidase subunit NDUFA4 Xenopus laevis
TI:8355 None
 
Q6GQ91_XENLA
Xenbase»
0.0
ndufa4.L Cytochrome c oxidase subunit NDUFA4 Xenopus laevis
TI:8355 None