Collated Gene Ontology terms

Biological process: ubiquitin protein ligase activity(2014, 2019, 2023, 2024, 2025) transferase activity(2025) zinc ion binding(2014, 2025) metal ion binding(2025) ubiquitin-protein transferase activity(2011, 2025) phosphatidylinositol-3-phosphate binding(2025)

Molecular function: proteasome-mediated ubiquitin-dependent protein catabolic process2011, 2022, 2023, 2024, 2025 protein K48-linked ubiquitination2011, 2022, 2025 positive regulation of autophagosome-lysosome fusion2024, 2025 protein ubiquitination2022, 2024 positive regulation of toll-like receptor 4 signaling pathway2023, 2025 ubiquitin-dependent protein catabolic process2025 toll-like receptor 4 signaling pathway2025 toll-like receptor 3 signaling pathway2025 regulation of toll-like receptor 4 signaling pathway2025 regulation of toll-like receptor 3 signaling pathway2025
intracellular potassium ion homeostasis2025 cytoskeleton organization2011

Cellular component: membrane2014, 2022, 2025 cytoplasm2014, 2024, 2025 endosome2010, 2025 lysosome2025 plasma membrane2014, 2023, 2025 protein-containing complex2018, 2025 presynaptic membrane2025 cytosol2014, 2016, 2025 cytoplasmic vesicle membrane2014, 2025 synaptic vesicle membrane2025
lysosomal membrane2025 endosome membrane2025 cytoplasmic vesicle2025 nucleoplasm2025 fibrillar center2025 ciliary transition zone2025 ciliary tip2025 bounding membrane of organelle2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 4/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
Q9N4I6_CAEEL
WormBase»
1.5
CELE_Y71F9AL.10 Y71F9AL.10 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Caenorhabditis elegans
TI:6239 None
 
A7E2J2_DANRE
ZFIN»
1.5
znrf2a E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Danio rerio
TI:7955 None
 
Q6PFI9_DANRE
ZFIN»
1.5
wu:fb37d03 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Danio rerio
TI:7955 None
 
ZNRF1_DANRE
ZFIN»
3.0
znrf1 E3 ubiquitin-protein ligase znrf1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase znrf1) (Zinc/RING finger protein 1)		 Danio rerio
TI:7955 None
 
ZNRF2_DANRE
ZFIN»
1.5
znrf2 E3 ubiquitin-protein ligase znrf2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase znrf2) (Zinc/RING finger protein 2)		 Danio rerio
TI:7955 None
 
Q75JS0_DICDI
dictyBase»
1.5
DDB_G0272202 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Dictyostelium discoideum
TI:44689 None
 
Q9W3V3_DROME
FlyBase»
4.6
detr E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Drosophila melanogaster
TI:7227 None
 
A0A8V0YYC5_CHICK
Ensembl»
1.5
ZNRF2 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Gallus gallus
TI:9031 None
   
A0A8V0ZW26_CHICK
Ensembl»
1.5
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Gallus gallus
TI:9031 None
   
ZNRF1_HUMAN
Ensembl»
5.4
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Homo sapiens
TI:9606 None
 
ZNRF2_HUMAN
Ensembl»
4.1
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger
protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Homo sapiens
TI:9606 None
 
ZNRF1_MOUSE
Ensembl»
9.1
Znrf1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Mus musculus
TI:10090 None
 
ZNRF2_MOUSE
Ensembl»
3.0
Znrf2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Mus musculus
TI:10090 None
 
A0A8I5ZUZ1_RAT
RGD»
1.5
Znrf1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Rattus norvegicus
TI:10116 None
   
A0ABK0LSC4_RAT
RGD»
1.0
Znrf2 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Rattus norvegicus
TI:10116 None