Collated Gene Ontology terms

Biological process: ubiquitin protein ligase activity(2014, 2019, 2023, 2024, 2025) transferase activity(2025) zinc ion binding(2014, 2025) metal ion binding(2025) ubiquitin-protein transferase activity(2011, 2025) phosphatidylinositol-3-phosphate binding(2025)

Molecular function: proteasome-mediated ubiquitin-dependent protein catabolic process2011, 2022, 2023, 2024, 2025 protein K48-linked ubiquitination2011, 2022, 2025 positive regulation of autophagosome-lysosome fusion2024, 2025 protein ubiquitination2022, 2024 positive regulation of toll-like receptor 4 signaling pathway2023, 2025 ubiquitin-dependent protein catabolic process2025 toll-like receptor 4 signaling pathway2025 toll-like receptor 3 signaling pathway2025 regulation of toll-like receptor 4 signaling pathway2025 regulation of toll-like receptor 3 signaling pathway2025
intracellular potassium ion homeostasis2025 cytoskeleton organization2011

Cellular component: membrane2014, 2022, 2025 cytoplasm2014, 2024, 2025 endosome2010, 2025 lysosome2025 plasma membrane2014, 2023, 2025 protein-containing complex2018, 2025 presynaptic membrane2025 cytosol2014, 2016, 2025 cytoplasmic vesicle membrane2014, 2025 synaptic vesicle membrane2025
lysosomal membrane2025 endosome membrane2025 cytoplasmic vesicle2025 nucleoplasm2025 fibrillar center2025 ciliary transition zone2025 ciliary tip2025 bounding membrane of organelle2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 4/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
G3S9D0_GORGO
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Gorilla gorilla
TI:9593 None
 
ZNRF1_HUMAN
Ensembl»
5.4
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Homo sapiens
TI:9606 None
 
K7DSF0_PANTR
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Pan troglodytes
TI:9598 None
 
ZNRF1_MOUSE
Ensembl»
9.1
Znrf1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Mus musculus
TI:10090 None
 
H9ET01_MACMU
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Macaca mulatta
TI:9544 None
 
Q6PFI9_DANRE
ZFIN»
1.5
wu:fb37d03 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Danio rerio
TI:7955 None
 
ZNRF1_XENTR
Xenbase»
0.0
znrf1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Xenopus tropicalis
TI:8364 None
 
A0A2I2Z4M7_GORGO
Ensembl»
0.0
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Gorilla gorilla
TI:9593 None
 
B7PES1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW003698 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Ixodes scapularis
TI:6945 None
 
H2QUD0_PANTR
Ensembl»
0.0
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Pan troglodytes
TI:9598 None
 
Q7PG08_ANOGA
EnsemblMetazoa»
0.0
1271904 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Anopheles gambiae
TI:7165 None
 
Q9W3V3_DROME
FlyBase»
4.6
detr E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Drosophila melanogaster
TI:7227 None
 
T1FXU1_HELRO
EnsemblMetazoa»
0.0
20213639 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Helobdella robusta
TI:6412 None
 
T1G5C4_HELRO
EnsemblMetazoa»
0.0
20216271 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Helobdella robusta
TI:6412 None
 
W5M1D8_LEPOC
Ensembl»
0.0
RING-type E3 ubiquitin transferase (EC 2.3.2.27) Lepisosteus oculatus
TI:7918 None
 
ZNRF1_XENLA
Xenbase»
0.0
znrf1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Xenopus laevis
TI:8355 None
 
ZNRF2_HUMAN
Ensembl»
4.1
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger
protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Homo sapiens
TI:9606 None
 
A0A139WLL0_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_34580 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Tribolium castaneum
TI:7070 None
 
A0A7U2ER59_PHANO
TubercuList»
0.0
JI435_006000 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Phaeosphaeria nodorum
TI:13684 None
 
A0E829_PARTE
neXtProt»
0.0
GSPATT00024174001 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Paramecium tetraurelia
TI:5888 None
 
A5PKM1_BOVIN
Ensembl»
0.0
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Bos taurus
TI:9913 None
 
A7E2J2_DANRE
ZFIN»
1.5
znrf2a E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Danio rerio
TI:7955 None
 
A7EG02_SCLS1
neXtProt»
0.0
SS1G_04243 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Sclerotinia sclerotiorum
TI:5180 None
 
A7S6Y6_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g107023 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Nematostella vectensis
TI:45351 None
 
A8WWH0_CAEBR
WormBase»
0.0
CBG04230 CBG_04230 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Caenorhabditis briggsae
TI:6238 None
 
B3RV22_TRIAD
CTD»
0.0
TRIADDRAFT_23613 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Trichoplax adhaerens
TI:10228 None
 
E9FQL9_DAPPU
neXtProt»
0.0
DAPPUDRAFT_309722 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Daphnia pulex
TI:6669 None
 
F0ZDS1_DICPU
TubercuList»
0.0
DICPUDRAFT_97086 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Dictyostelium purpureum
TI:5786 None
 
F6YWJ3_CIOIN
Ensembl»
0.0
LOC100181970 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Ciona intestinalis
TI:7719 None
 
Q6C8Z8_YARLI
TubercuList»
0.0
YALI0_D15510g RING-type E3 ubiquitin transferase (EC 2.3.2.27) Yarrowia lipolytica
TI:4952 None
 
Q75EW7_EREGS
neXtProt»
0.0
AGOS_AAL039C RING-type E3 ubiquitin transferase (EC 2.3.2.27) Eremothecium gossypii
TI:33169 None
 
Q75JS0_DICDI
dictyBase»
1.5
DDB_G0272202 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Dictyostelium discoideum
TI:44689 None
 
Q9N4I6_CAEEL
WormBase»
1.5
CELE_Y71F9AL.10 Y71F9AL.10 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Caenorhabditis elegans
TI:6239 None
 
W5M6D2_LEPOC
Ensembl»
0.0
E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Lepisosteus oculatus
TI:7918 None
 
ZNRF1_BOVIN
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Bos taurus
TI:9913 None
 
ZNRF1_DANRE
ZFIN»
3.0
znrf1 E3 ubiquitin-protein ligase znrf1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase znrf1) (Zinc/RING finger protein 1)		 Danio rerio
TI:7955 None
 
ZNRF2_DANRE
ZFIN»
1.5
znrf2 E3 ubiquitin-protein ligase znrf2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase znrf2) (Zinc/RING finger protein 2)		 Danio rerio
TI:7955 None
 
ZNRF2_MOUSE
Ensembl»
3.0
Znrf2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Mus musculus
TI:10090 None
 
A0A1L8FRL8_XENLA
Xenbase»
0.0
znrf2.S RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus laevis
TI:8355 None
   
A0A1L8FWD8_XENLA
Xenbase»
0.0
znrf2.L RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus laevis
TI:8355 None
   
A0A1L8GLD9_XENLA
Xenbase»
0.0
znrf1.L E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Xenopus laevis
TI:8355 None
   
A0A287B011_PIG
Ensembl»
0.0
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Sus scrofa
TI:9823 None
   
A0A287B6X8_PIG
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Sus scrofa
TI:9823 None
   
A0A2A6BNJ7_PRIPA
EnsemblMetazoa»
0.0
WBGene00096296 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Pristionchus pacificus
TI:54126 None
   
A0A3B3HN40_ORYLA
Ensembl»
0.0
RING-type E3 ubiquitin transferase (EC 2.3.2.27) Oryzias latipes
TI:8090 None
   
A0A3B3IL97_ORYLA
Ensembl»
0.0
znrf2b RING-type E3 ubiquitin transferase (EC 2.3.2.27) Oryzias latipes
TI:8090 None
   
A0A3Q2L678_HORSE
Ensembl»
0.0
ZNRF1 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Equus caballus
TI:9796 None
   
A0A5F5PGP4_HORSE
Ensembl»
0.0
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Equus caballus
TI:9796 None
   
A0A5F7ZA02_MACMU
Ensembl»
0.0
RING-type E3 ubiquitin transferase (EC 2.3.2.27) Macaca mulatta
TI:9544 None
   
A0A5F8H040_MONDO
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Monodelphis domestica
TI:13616 None
   
A0A6I8NG25_ORNAN
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8PHW0_ORNAN
Ensembl»
0.0
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7LIP0_STRPU
EnsemblMetazoa»
0.0
E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803K7F0_XENTR
Xenbase»
0.0
znrf2 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus tropicalis
TI:8364 None
   
A0A8I3PPH4_CANLF
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Canis lupus
TI:9612 None
   
A0A8I3S3X6_CANLF
Ensembl»
0.0
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Canis lupus
TI:9612 None
   
A0A8I5ZUZ1_RAT
RGD»
1.5
Znrf1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Rattus norvegicus
TI:10116 None
   
A0A8V0YYC5_CHICK
Ensembl»
1.5
ZNRF2 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Gallus gallus
TI:9031 None
   
A0A8V0ZW26_CHICK
Ensembl»
1.5
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Gallus gallus
TI:9031 None
   
A0A9J7LDE7_BRAFL
neXtProt»
0.0
LOC118418534 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Branchiostoma floridae
TI:7739 None
   
A0ABI7W248_FELCA
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Felis catus
TI:9685 None
   
A0ABI7Y6F9_FELCA
Ensembl»
0.0
ZNRF2 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Felis catus
TI:9685 None
   
A0ABK0LSC4_RAT
RGD»
1.0
Znrf2 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Rattus norvegicus
TI:10116 None
   
F6T6N6_MONDO
Ensembl»
0.0
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Monodelphis domestica
TI:13616 None
   
F7E8G6_MACMU
Ensembl»
0.0
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Macaca mulatta
TI:9544 None
   
G1KBA2_ANOCA
Ensembl»
0.0
ZNRF2 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Anolis carolinensis
TI:28377 None
   
H2LCZ4_ORYLA
Ensembl»
0.0
zgc:66427 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Oryzias latipes
TI:8090 None
   
H2MY66_ORYLA
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Oryzias latipes
TI:8090 None
   
H9GBV3_ANOCA
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Anolis carolinensis
TI:28377 None
   
W5LXN3_LEPOC
Ensembl»
0.0
RING-type E3 ubiquitin transferase (EC 2.3.2.27) Lepisosteus oculatus
TI:7918 None