Collated Gene Ontology terms

Biological process: ubiquitin protein ligase activity(2014, 2019, 2022, 2023, 2024) transferase activity(2024) metal ion binding(2024) ubiquitin-protein transferase activity(2011, 2024) zinc ion binding(2014) phosphatidylinositol-3-phosphate binding(2024)

Molecular function: proteasome-mediated ubiquitin-dependent protein catabolic process2011, 2022, 2023, 2024 protein K48-linked ubiquitination2011, 2022, 2024 protein ubiquitination2024 positive regulation of toll-like receptor 4 signaling pathway2023, 2024 autophagosome-lysosome fusion2024 cytoskeleton organization2011

Cellular component: membrane2014, 2022, 2024 cytoplasm2014, 2023, 2024 lysosome2024 intracellular membrane-bounded organelle2022, 2023, 2024 endosome2010, 2024 plasma membrane2014, 2023, 2024 protein-containing complex2018, 2024 cytoplasmic vesicle membrane2014, 2024 nucleoplasm2023, 2024 fibrillar center2023, 2024
cytosol2014, 2016, 2024 synapse2024 synaptic vesicle membrane2024 presynaptic membrane2024 lysosomal membrane2024 endosome membrane2024 cell projection2024 bounding membrane of organelle2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
G1KBA2_ANOCA
Ensembl»
0.0
ZNRF2 Zinc and ring finger 2 Anolis carolinensis
TI:28377 None
   
H9GBV3_ANOCA
Ensembl»
0.0
ZNRF1 Zinc and ring finger 1 Anolis carolinensis
TI:28377 None
   
Q7PG08_ANOGA
EnsemblMetazoa»
0.0
1271904 AGAP000354-PA (AGAP000354-PB) Anopheles gambiae
TI:7165 None
 
A5PKM1_BOVIN
Ensembl»
0.0
ZNRF2 ZNRF2 protein (Zinc and ring finger 2) Bos taurus
TI:9913 None
 
ZNRF1_BOVIN
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Bos taurus
TI:9913 None
 
A0A9J7LDE7_BRAFL
CTD»
0.0
LOC118418534 E3 ubiquitin-protein ligase
znrf2-like isoform X1		 Branchiostoma floridae
TI:7739 None
   
A8WWH0_CAEBR
WormBase»
0.0
CBG04230 CBG_04230 Protein CBG04230 Caenorhabditis briggsae
TI:6238 None
 
Q9N4I6_CAEEL
WormBase»
1.5
CELE_Y71F9AL.10 Y71F9AL.10 RING-type domain-containing protein Caenorhabditis elegans
TI:6239 None
 
A0A8I3PPH4_CANLF
Ensembl»
0.0
ZNRF1 Zinc and ring finger 1 Canis lupus
TI:9612 None
   
A0A8I3S3X6_CANLF
Ensembl»
0.0
ZNRF2 Zinc and ring finger 2 Canis lupus
TI:9612 None
   
F6YWJ3_CIOIN
Ensembl»
0.0
LOC100181970 E3 ubiquitin-protein ligase ZNRF2 Ciona intestinalis
TI:7719 None
 
A7E2J2_DANRE
ZFIN»
1.5
znrf2a Uncharacterized protein
LOC100124611 (Zgc:171663 protein)		 Danio rerio
TI:7955 None
 
Q6PFI9_DANRE
ZFIN»
1.5
wu:fb37d03 Uncharacterized protein LOC406256 (Zgc:66427) Danio rerio
TI:7955 None
 
ZNRF1_DANRE
ZFIN»
3.0
znrf1 E3 ubiquitin-protein ligase znrf1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase znrf1) (Zinc/RING finger protein 1)		 Danio rerio
TI:7955 None
 
ZNRF2_DANRE
ZFIN»
1.5
znrf2 E3 ubiquitin-protein ligase znrf2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase znrf2) (Zinc/RING finger protein 2)		 Danio rerio
TI:7955 None
 
E9FQL9_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_309722 RING-type domain-containing protein Daphnia pulex
TI:6669 None
 
F0ZDS1_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_97086 RING-type domain-containing protein Dictyostelium purpureum
TI:5786 None
 
Q75JS0_DICDI
dictyBase»
1.5
DDB_G0272202 C2H2-type zinc finger-containing protein Dictyostelium discoideum
TI:44689 None
 
Q9W3V3_DROME
FlyBase»
3.8
Dmel\CG14435 Uncharacterized protein, isoform A
(Uncharacterized protein, isoform C)		 Drosophila melanogaster
TI:7227 None
 
A0A3Q2L678_HORSE
Ensembl»
0.0
ZNRF1 Zinc and ring finger 1 Equus caballus
TI:9796 None
   
M3WGH7_FELCA
Ensembl»
0.0
ZNRF1 Zinc and ring finger 1 Felis catus
TI:9685 None
 
M3X456_FELCA
Ensembl»
0.0
ZNRF2 Zinc and ring finger 2 Felis catus
TI:9685 None
 
A0A8V0YYC5_CHICK
Ensembl»
0.0
ZNRF2 Zinc and ring finger 2 Gallus gallus
TI:9031 None
   
A0A8V0ZW26_CHICK
Ensembl»
0.0
ZNRF1 Zinc and ring finger 1 Gallus gallus
TI:9031 None
   
A0A2I2Z4M7_GORGO
Ensembl»
0.0
RING-type domain-containing protein Gorilla gorilla
TI:9593 None
 
G3S9D0_GORGO
Ensembl»
0.0
RING-type domain-containing protein Gorilla gorilla
TI:9593 None
 
T1FXU1_HELRO
EnsemblMetazoa»
0.0
20213639 RING-type domain-containing protein Helobdella robusta
TI:6412 None
 
T1G5C4_HELRO
EnsemblMetazoa»
0.0
20216271 RING-type domain-containing protein Helobdella robusta
TI:6412 None
 
ZNRF1_HUMAN
Ensembl»
4.6
ZNRF1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Homo sapiens
TI:9606 None
 
ZNRF2_HUMAN
Ensembl»
3.3
ZNRF2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger
protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Homo sapiens
TI:9606 None
 
B7PES1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW003698 RING-type domain-containing protein Ixodes scapularis
TI:6945 None
 
W5LXN3_LEPOC
Ensembl»
0.0
RING-type domain-containing protein Lepisosteus oculatus
TI:7918 None
   
W5M1D8_LEPOC
Ensembl»
0.0
Zinc and ring finger 2 Lepisosteus oculatus
TI:7918 None
 
W5M6D2_LEPOC
Ensembl»
0.0
Zinc and ring finger 1 Lepisosteus oculatus
TI:7918 None
 
A0A5F8AHL7_MACMU
Ensembl»
0.0
ZNRF2 Zinc and ring finger 2 Macaca mulatta
TI:9544 None
   
H9ET01_MACMU
Ensembl»
0.0
ZNRF1 E3 ubiquitin-protein ligase ZNRF1
(Zinc and ring finger 1)		 Macaca mulatta
TI:9544 None
 
A0A5F8H040_MONDO
Ensembl»
0.0
ZNRF1 Zinc and ring finger 1 Monodelphis domestica
TI:13616 None
   
F6T6N6_MONDO
Ensembl»
0.0
ZNRF2 Zinc and ring finger 2 Monodelphis domestica
TI:13616 None
   
ZNRF1_MOUSE
Ensembl»
4.6
Znrf1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283
protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Mus musculus
TI:10090 None
 
ZNRF2_MOUSE
Ensembl»
0.5
Znrf2 E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)		 Mus musculus
TI:10090 None
 
A7S6Y6_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g107023 RING-type domain-containing protein Nematostella vectensis
TI:45351 None
 
A0A6I8NG25_ORNAN
Ensembl»
0.0
ZNRF1 Zinc and ring finger 1 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8PHW0_ORNAN
Ensembl»
0.0
ZNRF2 Zinc and ring finger 2 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3HN40_ORYLA
Ensembl»
0.0
Zinc and ring finger 2a Oryzias latipes
TI:8090 None
   
A0A3B3IL97_ORYLA
Ensembl»
0.0
LOC101171690 E3 ubiquitin-protein ligase znrf2 Oryzias latipes
TI:8090 None
   
H2LCZ4_ORYLA
Ensembl»
0.0
LOC101166334 E3 ubiquitin-protein ligase znrf1 Oryzias latipes
TI:8090 None
   
H2MY66_ORYLA
Ensembl»
0.0
znrf1 Zinc and ring finger 1 Oryzias latipes
TI:8090 None
   
H2QUD0_PANTR
Ensembl»
0.0
ZNRF2 Zinc and ring finger 2 Pan troglodytes
TI:9598 None
 
K7DSF0_PANTR
Ensembl»
0.0
ZNRF1 Zinc and ring finger 1 Pan troglodytes
TI:9598 None
 
A0A2A6BNJ7_PRIPA
EnsemblMetazoa»
0.0
WBGene00096296 RING-type domain-containing protein Pristionchus pacificus
TI:54126 None
 
A0A8I6AGK9_RAT
RGD»
4.5
Znrf1 Zinc and ring finger 1 Rattus norvegicus
TI:10116 None
   
M0RBD9_RAT
RGD»
2.5
Znrf2 Zinc and ring finger 2 Rattus norvegicus
TI:10116 None
   
A7EG02_SCLS1
EnsemblFungi»
0.0
SS1G_04243 RING-type domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
A0A7M7LIP0_STRPU
EnsemblMetazoa»
0.0
RING-type domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A287B011_PIG
Ensembl»
0.0
ZNRF2 Zinc and ring finger 2 Sus scrofa
TI:9823 None
   
A0A287B6X8_PIG
Ensembl»
0.0
ZNRF1 Zinc and ring finger 1 Sus scrofa
TI:9823 None
   
A0A139WLL0_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_34580 E3 ubiquitin-protein ligase ZNRF1-like protein Tribolium castaneum
TI:7070 None
 
B3RV22_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_23613 RING-type domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A1L8FRL8_XENLA
Xenbase»
0.0
znrf2.S RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus laevis
TI:8355 None
   
A0A1L8FWD8_XENLA
Xenbase»
0.0
znrf2.L RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus laevis
TI:8355 None
   
A0A1L8GLD9_XENLA
Xenbase»
0.0
znrf1.L E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Xenopus laevis
TI:8355 None
   
A0A803K7F0_XENTR
Xenbase»
0.0
znrf2 E3 ubiquitin-protein ligase ZNRF2 (Zinc and
ring finger 2, E3 ubiquitin protein ligase)		 Xenopus tropicalis
TI:8364 None
   
ZNRF1_XENLA
Xenbase»
0.0
znrf1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Xenopus laevis
TI:8355 None
 
ZNRF1_XENTR
Xenbase»
0.0
znrf1 E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (RING-type
E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)		 Xenopus tropicalis
TI:8364 None
 
Q6C8Z8_YARLI
EnsemblFungi»
0.0
YALI0_D15510g YALI0D15510p Yarrowia lipolytica
TI:4952 None