Collated Gene Ontology terms

Biological process: ATP binding(2024) sulfurtransferase activity(2011, 2020, 2024) tRNA binding(2024) transferase activity(2024) tRNA-5-taurinomethyluridine 2-sulfurtransferase(2015, 2023, 2024) tRNA-specific 2-thiouridylase activity(2017, 2024) methyltransferase activity(2024) CCA tRNA nucleotidyltransferase activity(2024) tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity(2014, 2024) hydrolase activity(2024)

Molecular function: tRNA wobble position uridine thiolation2011, 2014, 2017, 2024 tRNA processing2024 tRNA modification2023, 2024 methylation2024 mitochondrial tRNA wobble position uridine thiolation2004, 2015, 2024 translation2021 mitochondrial tRNA thio-modification2020 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 RNA processing2014

Cellular component: mitochondrion2004, 2005, 2007, 2009, 2013, 2014, 2018, 2023, 2024 cytoplasm2014, 2024 sulfurtransferase complex2014 mitochondrial matrix2015 membrane2024 cytosol2014

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 8/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 4/39 
Archea: 2/8 
Bacteria: 35/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
G1KH08_ANOCA
Ensembl»
0.0
trmu Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Anolis carolinensis
TI:28377 None
   
A0A1S4H7Z4_ANOGA
EnsemblMetazoa»
0.0
tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Anopheles gambiae
TI:7165 None
 
MNMA_AQUAE
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Aquifex aeolicus
TI:63363 None
 
O67046_AQUAE
EnsemblBacteria»
0.0
aq_898 Thil AANH domain-containing protein Aquifex aeolicus
TI:63363 None
 
Q757U9_ASHGO
EnsemblFungi»
0.0
AGOS_AEL087C tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Ashbya gossypii
TI:33169 None
 
MNMA_BACCR
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Bacillus cereus
TI:1396 None
 
MNMA_BACSU
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Bacillus subtilis
TI:1423 None
 
MNMA2_BACTN
EnsemblBacteria»
0.0
mnmA2 tRNA-specific 2-thiouridylase MnmA
2 (EC 2.8.1.13)		 Bacteroides thetaiotaomicron
TI:818 None
 
MNMA3_BACTN
EnsemblBacteria»
0.0
mnmA3 tRNA-specific 2-thiouridylase MnmA
3 (EC 2.8.1.13)		 Bacteroides thetaiotaomicron
TI:818 None
 
F1N2P9_BOVIN
Ensembl»
0.0
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Bos taurus
TI:9913 None
   
MNMA_BRADU
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Bradyrhizobium diazoefficiens
TI:1355477 None
 
A0A9J7MRX8_BRAFL
CTD»
0.0
LOC118415883 Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Branchiostoma floridae
TI:7739 None
   
A8X0Z8_CAEBR
WormBase»
0.0
mttu-1 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Caenorhabditis briggsae
TI:6238 None
 
MTU1_CAEEL
WormBase»
0.5
mttu-1 Probable mitochondrial tRNA-specific
2-thiouridylase 1 (EC 2.8.1.14)		 Caenorhabditis elegans
TI:6239 None
 
A0A1D8PFW8_CANAL
EnsemblFungi»
0.0
CAALFM_C114330WA orf19.7245 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Candida albicans
TI:5476 None
 
A0A8I3NPQ1_CANLF
Ensembl»
0.0
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Canis lupus
TI:9612 None
   
MNMA_CHLTR
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Chlamydia trachomatis
TI:813 None
 
MNMA_CHLAA
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Chloroflexus aurantiacus
TI:1108 None
 
H2XX92_CIOIN
Ensembl»
0.0
Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Ciona intestinalis
TI:7719 None
 
A5HY25_CLOBH
Ensembl»
0.0
CBO0129 Thil AANH domain-containing protein Clostridium botulinum
TI:1491 None
 
MNMA1_CLOBH
Ensembl»
0.0
mnmA1 tRNA-specific 2-thiouridylase MnmA
1 (EC 2.8.1.13)		 Clostridium botulinum
TI:1491 None
 
MNMA2_CLOBH
Ensembl»
0.0
mnmA2 tRNA-specific 2-thiouridylase MnmA
2 (EC 2.8.1.13)		 Clostridium botulinum
TI:1491 None
 
MNMA_COXBU
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Coxiella burnetii
TI:777 None
 
Q5K850_CRYNJ
EnsemblFungi»
0.0
CNM00110 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Cryptococcus neoformans
TI:5207 None
 
MTU1_DANRE
ZFIN»
1.3
trmu Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Danio rerio
TI:7955 None
 
E9HGG5_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_202999 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Daphnia pulex
TI:6669 None
 
MNMA_DEIRA
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Deinococcus radiodurans
TI:1299 None
 
B8DZP1_DICTD
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Dictyoglomus turgidum
TI:513050 None
 
B8E133_DICTD
EnsemblBacteria»
0.0
Dtur_1496 Thil AANH domain-containing protein Dictyoglomus turgidum
TI:513050 None
 
F0ZQQ3_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_154197 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Dictyostelium purpureum
TI:5786 None
 
MTU1_DICDI
dictyBase»
0.5
trmu Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Dictyostelium discoideum
TI:44689 None
 
MTU1_DROME
FlyBase»
1.0
CG3021 Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Drosophila melanogaster
TI:7227 None
 
MNMA_ECOLI
EnsemblBacteria»
3.5
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Escherichia coli
TI:562 None
 
A0A5F5Y6N5_FELCA
Ensembl»
0.0
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Felis catus
TI:9685 None
 
MNMA1_FUSNN
EnsemblBacteria»
0.0
mnmA1 tRNA-specific 2-thiouridylase MnmA
1 (EC 2.8.1.13)		 Fusobacterium nucleatum
TI:851 None
 
MNMA2_FUSNN
EnsemblBacteria»
0.0
mnmA2 tRNA-specific 2-thiouridylase MnmA
2 (EC 2.8.1.13)		 Fusobacterium nucleatum
TI:851 None
 
Q8R5Y0_FUSNN
EnsemblBacteria»
0.0
FN0563 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
(EC 2.1.1.61)		 Fusobacterium nucleatum
TI:851 None
 
MTU1_CHICK
Ensembl»
0.5
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Gallus gallus
TI:9031 None
 
MNMA_GEOSL
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Geobacter sulfurreducens
TI:35554 None
 
Q74G18_GEOSL
EnsemblBacteria»
0.0
GSU0434 Thiamin biosynthesis protein ThiI-related adenine
nucleotide alpha hydrolase superfamily protein		 Geobacter sulfurreducens
TI:35554 None
 
MNMA_GLOVI
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Gloeobacter violaceus
TI:33072 None
 
G3QD90_GORGO
Ensembl»
0.0
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Gorilla gorilla
TI:9593 None
 
MNMA_HAEIN
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Haemophilus influenzae
TI:727 None
 
MNMA_HELPY
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Helicobacter pylori
TI:210 None
 
O24858_HELPY
EnsemblBacteria»
0.0
HP_0013 ATP-binding protein Helicobacter pylori
TI:210 None
 
T1FYP5_HELRO
EnsemblMetazoa»
0.0
20213943 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Helobdella robusta
TI:6412 None
 
MTU1_HUMAN
Ensembl»
0.5
TRMU Mitochondrial tRNA-specific 2-thiouridylase 1
(EC 2.8.1.14) (MTO2 homolog)		 Homo sapiens
TI:9606 None
 
B7P8A5_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW016722 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Ixodes scapularis
TI:6945 None
 
B7PXE7_IXOSC
EnsemblMetazoa»
0.0
8032777 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Ixodes scapularis
TI:6945 None
 
A0A1Y1I5K8_KLENI
EnsemblPlants»
0.0
KFL_002540070 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Klebsormidium nitens
TI:105231 None
 
Q4QIT1_LEIMA
EnsemblProtists»
0.0
LMJF_07_0130 Putative tRNA-methyl transferase (EC 2.1.1.61) Leishmania major
TI:5664 None
 
W5NGP1_LEPOC
Ensembl»
0.0
Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Lepisosteus oculatus
TI:7918 None
 
MNMA_LEPIN
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Leptospira interrogans
TI:173 None
 
MNMA_LISMO
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Listeria monocytogenes
TI:1639 None
 
A0A5F7ZJC9_MACMU
Ensembl»
0.0
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Macaca mulatta
TI:9544 None
   
A0A2R6XL64_MARPO
EnsemblPlants»
0.0
MARPO_0010s0199 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Marchantia polymorpha
TI:3197 None
 
Q8TJR3_METAC
EnsemblBacteria»
0.0
MA_3716 Uncharacterized protein Methanosarcina acetivorans
TI:2214 None
 
Q8TRY2_METAC
EnsemblBacteria»
0.0
MA_1029 Uncharacterized protein Methanosarcina acetivorans
TI:2214 None
 
F7DWM5_MONDO
Ensembl»
0.0
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Monodelphis domestica
TI:13616 None
   
A9V8Y1_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_11336 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Monosiga brevicollis
TI:81824 None
 
MTU1_MOUSE
Ensembl»
0.0
Trmu Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Mus musculus
TI:10090 None
 
MNMA_MYCTU
TubercuList»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Mycobacterium tuberculosis
TI:1773 None
 
MNMA_MYCGE
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Mycoplasma genitalium
TI:2097 None
 
MNMA_NEIMB
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Neisseria meningitidis
TI:487 None
 
A9A2U4_NITMS
EnsemblBacteria»
0.0
Nmar_1725 tRNA
(5-methylaminomethyl-2-thiouridylate)-methyltransferase		 Nitrosopumilus maritimus
TI:338192 None
 
A0A6I8P282_ORNAN
Ensembl»
0.0
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Ornithorhynchus anatinus
TI:9258 None
   
H2MXP7_ORYLA
Ensembl»
0.0
trmu Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Oryzias latipes
TI:8090 None
   
K7D7E3_PANTR
Ensembl»
0.0
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Pan troglodytes
TI:9598 None
 
A0A2K1KMH0_PHYPA
EnsemblPlants»
0.0
PHYPA_005859 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Physcomitrium patens
TI:3218 None
 
H3G702_PHYRM
EnsemblProtists»
0.0
tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Phytophthora ramorum
TI:164328 None
 
H3H8S5_PHYRM
EnsemblProtists»
0.0
tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Phytophthora ramorum
TI:164328 None
 
A0A8R1YT62_PRIPA
EnsemblMetazoa»
0.0
WBGene00277002 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Pristionchus pacificus
TI:54126 None
   
MNMA_PSEAE
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Pseudomonas aeruginosa
TI:287 None
 
MTU1_RAT
RGD»
0.5
Trmu Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Rattus norvegicus
TI:10116 None
 
MNMA_RHOBA
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Rhodopirellula baltica
TI:265606 None
 
B9TC14_RICCO
EnsemblBacteria»
0.0
RCOM_0436960 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Ricinus communis
TI:3988 None
 
MTU1_YEAST
SGD»
3.9
SLM3 Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (Mitochondrial translation
optimization protein 2) (Synthetic lethal with MSS4 3)		 Saccharomyces cerevisiae
TI:4932 None
 
MNMA_SALTY
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Salmonella typhimurium
TI:28901 None
 
B6JVF0_SCHJY
EnsemblFungi»
0.0
SJAG_00358 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Schizosaccharomyces japonicus
TI:4897 None
 
MTU1_SCHPO
PomBase»
2.1
SPAC23H4.04 Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Schizosaccharomyces pombe
TI:4896 None
 
MNMA_SHEON
EnsemblPlants»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Shewanella oneidensis
TI:70863 None
 
MNMA_STAA8
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Staphylococcus aureus
TI:1280 None
 
MNMA_STRR6
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Streptococcus pneumoniae
TI:1313 None
 
MNMA_STRCO
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Streptomyces coelicolor
TI:1902 None
 
A0A7M7MZR2_STRPU
EnsemblMetazoa»
0.0
tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7N002_STRPU
EnsemblMetazoa»
0.0
tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Strongylocentrotus purpuratus
TI:7668 None
   
F1SM74_PIG
Ensembl»
0.0
TRMU Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Sus scrofa
TI:9823 None
 
MNMA_SYNY3
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Synechocystis sp.
TI:1148 None
 
B8LDI7_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_269988 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Thalassiosira pseudonana
TI:35128 None
 
B5YGH6_THEYD
EnsemblBacteria»
0.0
trmU1 tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Thermodesulfovibrio yellowstonii
TI:28262 None
 
B5YHJ9_THEYD
EnsemblBacteria»
0.0
THEYE_A1794 Conserved protein Thermodesulfovibrio yellowstonii
TI:28262 None
 
MNMA_THEMA
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Thermotoga maritima
TI:2336 None
 
D6WSD8_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_30543 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Tribolium castaneum
TI:7070 None
 
B3RIL6_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_20051 tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Trichoplax adhaerens
TI:10228 None
 
B3SFC3_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_9863 tRNA 2-thiouridine(34) synthase MnmA Trichoplax adhaerens
TI:10228 None 		 
 
B3SFT2_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_63064 tRNA 2-thiouridine(34) synthase MnmA Trichoplax adhaerens
TI:10228 None
 
Q581Z9_TRYB2
VEuPathDB»
0.0
Tb08.26N11.230 tRNA-methyl transferase, putative (EC 2.1.1.61) Trypanosoma brucei
TI:5691 None
 
MNMA_VIBCH
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Vibrio cholerae
TI:666 None
 
MNMA_XANCP
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Xanthomonas campestris
TI:339 None
 
A0A6I8QH09_XENTR
Xenbase»
0.0
trmu Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Xenopus tropicalis
TI:8364 None
   
A0A8J0UIY5_XENLA
CTD»
0.0
trmu.L Mitochondrial tRNA-specific 2-thiouridylase
1 (EC 2.8.1.14)		 Xenopus laevis
TI:8355 None
   
Q6C0F9_YARLI
EnsemblFungi»
0.0
YALI0_F25069g tRNA-5-taurinomethyluridine 2-sulfurtransferase
(EC 2.8.1.14)		 Yarrowia lipolytica
TI:4952 None
 
MNMA_YERPE
EnsemblBacteria»
0.0
mnmA tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) Yersinia pestis
TI:632 None