Collated Gene Ontology terms

Biological process: dolichyl-phosphate-mannose-protein mannosyltransferase activity(2023, 2025) transferase activity(2025) mannosyltransferase activity(2023, 2025) structural constituent of cuticle(2025) glycosyltransferase activity(2025)

Molecular function: protein O-linked glycosylation via mannose2018, 2021, 2025 calcium ion homeostasis2014, 2025

Cellular component: endoplasmic reticulum membrane2014, 2021, 2025 endoplasmic reticulum2010, 2025 membrane2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 1/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 1/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A139WIR8_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_32761 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Tribolium castaneum
TI:7070 None
 
A0A1L8GY90_XENLA
Xenbase»
0.0
tmtc2.L dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Xenopus laevis
TI:8355 None
   
A0A1S4H0X0_ANOGA
EnsemblMetazoa»
0.0
dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Anopheles gambiae
TI:7165 None
 
A0A2A6CDX0_PRIPA
EnsemblMetazoa»
0.0
WBGene00092286 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Pristionchus pacificus
TI:54126 None
   
A0A2I2YJ53_GORGO
Ensembl»
0.0
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Gorilla gorilla
TI:9593 None
 
A0A2I3SV63_PANTR
Ensembl»
0.0
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Pan troglodytes
TI:9598 None
 
A0A3B3HS65_ORYLA
Ensembl»
0.0
TMTC2 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Oryzias latipes
TI:8090 None
   
A0A5G2QN86_PIG
Ensembl»
0.0
TMTC2 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Sus scrofa
TI:9823 None
   
A0A6I8P9M8_ORNAN
Ensembl»
0.0
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7T003_STRPU
EnsemblMetazoa»
0.0
dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3RYI9_CANLF
Ensembl»
0.0
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Canis lupus
TI:9612 None
   
A0A8I6ALM4_RAT
RGD»
1.5
Tmtc2 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Rattus norvegicus
TI:10116 None
   
A0A8M9PQN7_DANRE
CTD»
1.0
tmtc2b dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Danio rerio
TI:7955 None
   
A0A8V0YBS4_CHICK
Ensembl»
0.0
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Gallus gallus
TI:9031 None
   
A0A9J7HQD6_BRAFL
euHCVdb»
0.0
LOC118406545 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Branchiostoma floridae
TI:7739 None
   
A0A9L0RAA6_HORSE
Ensembl»
0.0
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Equus caballus
TI:9796 None
   
A0AAA9SZI4_BOVIN
Ensembl»
0.0
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Bos taurus
TI:9913 None
   
A0ABI7XLJ0_FELCA
Ensembl»
0.0
TMTC2 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Felis catus
TI:9685 None
   
A2F6V5_TRIV3
TubercuList»
0.0
TVAG_015550 TPR Domain containing protein Trichomonas vaginalis
TI:5722 None 		 
 
A4IIJ1_XENTR
Xenbase»
0.0
tmtc2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Xenopus tropicalis
TI:8364 None
 
A7S9A3_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g109754 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Nematostella vectensis
TI:45351 None
 
A8DWB6_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g225954 Alpha-1,3-glucosyltransferase Nematostella vectensis
TI:45351 None 		 
 
A9UT00_MONBE
euHCVdb»
0.0
MONBRDRAFT_23301 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Monosiga brevicollis
TI:81824 None
 
B3DJK1_DANRE
ZFIN»
1.0
tmtc2a dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Danio rerio
TI:7955 None
 
B3RRP9_TRIAD
CTD»
0.0
TRIADDRAFT_22709 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Trichoplax adhaerens
TI:10228 None
 
B7PFA9_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW017985 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Ixodes scapularis
TI:6945 None
 
B7Q9H4_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW021797 Uncharacterized protein Ixodes scapularis
TI:6945 None 		 
 
E9GVA5_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_54951 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Daphnia pulex
TI:6669 None
 
E9GXS9_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_15312 Uncharacterized protein Daphnia pulex
TI:6669 None 		 
 
E9HK77_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_115100 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Daphnia pulex
TI:6669 None
 
E9HMJ6_DAPPU
neXtProt»
0.0
DAPPUDRAFT_262194 DUF1736 domain-containing protein Daphnia pulex
TI:6669 None 		 
 
F6XAQ8_CIOIN
Ensembl»
0.0
dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Ciona intestinalis
TI:7719 None
 
F7A719_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None 		 
 
F7F5F8_MONDO
Ensembl»
0.0
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Monodelphis domestica
TI:13616 None
   
G1KQ79_ANOCA
Ensembl»
0.0
TMTC2 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Anolis carolinensis
TI:28377 None
   
H2MMT6_ORYLA
Ensembl»
0.0
TMTC2 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Oryzias latipes
TI:8090 None
   
H8WH72_CAEBR
CTD»
0.0
CBG23627 CBG_23627 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Caenorhabditis briggsae
TI:6238 None
 
H9FQL1_MACMU
Ensembl»
0.0
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Macaca mulatta
TI:9544 None
 
O16296_CAEEL
WormBase»
1.0
CELE_F32D1.3 F32D1.3 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Caenorhabditis elegans
TI:6239 None
 
Q89UI4_BRADU
EnsemblBacteria»
0.0
blr1433 Blr1433 protein Bradyrhizobium diazoefficiens
TI:1355477 None 		 
 
T1EJ56_HELRO
EnsemblMetazoa»
0.0
20196606 Uncharacterized protein Helobdella robusta
TI:6412 None 		 
 
T1F4G5_HELRO
EnsemblMetazoa»
0.0
20203714 Uncharacterized protein Helobdella robusta
TI:6412 None 		 
 
T1G368_HELRO
EnsemblMetazoa»
0.0
20215516 dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Helobdella robusta
TI:6412 None
 
TMTC1_DROME
FlyBase»
2.9
Tmtc1 Protein O-mannosyl-transferase Tmtc1 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 1) (Transmembrane and tetratricopeptide repeat-containing 1)		 Drosophila melanogaster
TI:7227 None
 
TMTC2_DROME
FlyBase»
2.9
Tmtc2 Protein O-mannosyl-transferase Tmtc2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Drosophila melanogaster
TI:7227 None
 
TMTC2_HUMAN
Ensembl»
3.4
TMTC2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Homo sapiens
TI:9606 None
 
TMTC2_MOUSE
Ensembl»
4.0
Tmtc2 Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Mus musculus
TI:10090 None
 
TMTC2_XENLA
Xenbase»
0.0
tmtc2 Protein O-mannosyl-transferase tmtc2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase
targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)		 Xenopus laevis
TI:8355 None
 
W5NHQ2_LEPOC
Ensembl»
0.0
dolichyl-phosphate-mannose--protein mannosyltransferase
(EC 2.4.1.109)		 Lepisosteus oculatus
TI:7918 None