Collated Gene Ontology terms

Biological process: tRNA-intron lyase activity(2013, 2017, 2025) lyase activity(2025) nucleic acid binding(2025) endonuclease activity(2025) hydrolase activity(2025)

Molecular function: tRNA-type intron splice site recognition and cleavage2013, 2017, 2024, 2025 tRNA processing2021, 2025 tRNA splicing, via endonucleolytic cleavage and ligation2025 mRNA processing2025

Cellular component: nucleus2025 tRNA-intron endonuclease complex2003, 2013, 2024, 2025 nucleolus2025 nucleoplasm2015, 2024, 2025 mitochondrial outer membrane2018, 2024, 2025 cytoplasmic side of mitochondrial outer membrane2025 mitochondrion2018 endomembrane system2025

Phylogenetic distribution

Chordates: 18/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 2/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
SEN34_YEAST
SGD»
4.2
SEN34 tRNA-splicing endonuclease subunit SEN34 (EC 4.6.1.16) (Splicing
endonuclease of 34 kDa) (tRNA-intron endonuclease SEN34)		 Saccharomyces cerevisiae
TI:4932 None
 
SEN34_MOUSE
Ensembl»
1.5
Tsen34 tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte
receptor cluster member 5 homolog) (tRNA-intron endonuclease Sen34)		 Mus musculus
TI:10090 None
 
SEN34_HUMAN
Ensembl»
1.8
TSEN34 tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte
receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)		 Homo sapiens
TI:9606 None
 
Q0E8E7_DROME
FlyBase»
1.8
Tsen34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Drosophila melanogaster
TI:7227 None
 
A0A8J0TCF6_XENLA
Xenbase»
0.0
tsen34.L tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Xenopus laevis
TI:8355 None
   
F6Z3Z2_XENTR
Xenbase»
0.0
tsen34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Xenopus tropicalis
TI:8364 None
   
F7EPS7_ORNAN
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Ornithorhynchus anatinus
TI:9258 None
   
F7H3C1_MACMU
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Macaca mulatta
TI:9544 None
 
Q3MHE1_BOVIN
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Bos taurus
TI:9913 None
 
A0A8I3RT24_CANLF
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Canis lupus
TI:9612 None
   
A0A9J7MDQ6_BRAFL
euHCVdb»
0.0
LOC118431731 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Branchiostoma floridae
TI:7739 None
   
A0A9L0RSL3_HORSE
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit SEN34 (EC 4.6.1.16)
(tRNA-intron endonuclease SEN34) (tRNA-splicing endonuclease subunit Sen34)		 Equus caballus
TI:9796 None
   
A0ABK0L8H2_RAT
RGD»
0.5
Tsen34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Rattus norvegicus
TI:10116 None
   
A0NGQ6_ANOGA
EnsemblMetazoa»
0.0
4577804 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Anopheles gambiae
TI:7165 None
 
B6K069_SCHJY
TubercuList»
0.0
sen34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Schizosaccharomyces japonicus
TI:4897 None
 
E3JY13_PUCGT
TubercuList»
0.0
PGTG_02399 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Puccinia graminis
TI:5297 None
 
E9FVZ2_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_191173 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Daphnia pulex
TI:6669 None
 
F0ZRY7_DICPU
TubercuList»
0.0
DICPUDRAFT_36938 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Dictyostelium purpureum
TI:5786 None
 
H9GMZ3_ANOCA
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit SEN34 (EC 4.6.1.16)
(tRNA-intron endonuclease SEN34) (tRNA-splicing endonuclease subunit Sen34)		 Anolis carolinensis
TI:28377 None
   
Q4WV80_ASPFU
TubercuList»
0.0
AFUA_5G11140 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Aspergillus fumigatus
TI:746128 None
 
SEN34_SCHPO
PomBase»
1.0
sen34 Probable tRNA-splicing endonuclease subunit sen34
(EC 4.6.1.16) (tRNA-intron endonuclease sen34)		 Schizosaccharomyces pombe
TI:4896 None
 
W5M1C9_LEPOC
Ensembl»
0.0
tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Lepisosteus oculatus
TI:7918 None
 
A0A2I2YDD3_GORGO
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Gorilla gorilla
TI:9593 None
 
C8VUX2_EMENI
TubercuList»
0.0
ANIA_00190 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Emericella nidulans
TI:162425 None
 
D6WIR4_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_00092 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Tribolium castaneum
TI:7070 None
 
Q59T38_CANAL
CGD»
0.0
CAALFM_C205670CA orf19.14168 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Candida albicans
TI:5476 None
 
A0A287AT72_PIG
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Sus scrofa
TI:9823 None
   
A0A7M7REK9_STRPU
EnsemblMetazoa»
0.0
tRNA-splicing endonuclease subunit SEN34 (EC 4.6.1.16)
(tRNA-intron endonuclease SEN34) (tRNA-splicing endonuclease subunit Sen34)		 Strongylocentrotus purpuratus
TI:7668 None
   
A7ET24_SCLS1
euHCVdb»
0.0
SS1G_08479 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Sclerotinia sclerotiorum
TI:5180 None
 
B7QL54_IXOSC
EnsemblMetazoa»
0.0
8042899 tRNA-intron lyase (EC 4.6.1.16) Ixodes scapularis
TI:6945 None
 
F7F900_MONDO
Ensembl»
0.0
tRNA-splicing endonuclease subunit SEN34 (EC 4.6.1.16)
(tRNA-intron endonuclease SEN34) (tRNA-splicing endonuclease subunit Sen34)		 Monodelphis domestica
TI:13616 None
   
H2R5V1_PANTR
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Pan troglodytes
TI:9598 None
 
Q556W4_DICDI
dictyBase»
1.0
DDB_G0273343 DDB_G0273777 tRNA-splicing endonuclease subunit SEN34 (EC
4.6.1.16) (tRNA-splicing endonuclease subunit Sen34)		 Dictyostelium discoideum
TI:44689 None
 
Q5KKV0_CRYD1
TubercuList»
0.0
CNC01760 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Cryptococcus deneoformans
TI:40410 None
 
Q6C497_YARLI
TubercuList»
0.0
YALI0_E28600g tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Yarrowia lipolytica
TI:4952 None
 
SEN34_EREGS
EnsemblFungi»
0.0
SEN34 tRNA-splicing endonuclease subunit SEN34
(EC 4.6.1.16) (tRNA-intron endonuclease SEN34)		 Eremothecium gossypii
TI:33169 None
 
SEN34_NEUCR
EnsemblFungi»
0.0
tsp-4 Probable tRNA-splicing endonuclease subunit tsp-4 (EC
4.6.1.16) (tRNA-intron endonuclease sen34) (tRNA-splicing protein 2)		 Neurospora crassa
TI:5141 None
 
T1FKE0_HELRO
EnsemblMetazoa»
0.0
20209289 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Helobdella robusta
TI:6412 None
 
A2FT30_TRIV3
TubercuList»
0.0
TVAG_096360 tRNA-intron lyase (EC 4.6.1.16) Trichomonas vaginalis
TI:5722 None
 
A0A1Y1I147_KLENI
neXtProt»
0.0
KFL_001980160 tRNA-intron lyase (EC 4.6.1.16) Klebsormidium nitens
TI:105231 None
 
A0A2K3CYL8_CHLRE
neXtProt»
0.0
CHLRE_14g630500v5 tRNA-intron lyase (EC 4.6.1.16) Chlamydomonas reinhardtii
TI:3055 None
 
A0A7U2F4P3_PHANO
TubercuList»
0.0
JI435_086330 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Phaeosphaeria nodorum
TI:13684 None
 
A0ABI8AN09_FELCA
Ensembl»
0.0
TSEN34 tRNA-splicing endonuclease subunit
Sen34 (EC 4.6.1.16)		 Felis catus
TI:9685 None
   
A7SW35_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g134862 tRNA-splicing endonuclease subunit SEN34 (EC 4.6.1.16)
(tRNA-intron endonuclease SEN34) (tRNA-splicing endonuclease subunit Sen34)		 Nematostella vectensis
TI:45351 None
 
A8XIX1_CAEBR
WormBase»
0.0
tsen-34 tRNA-intron lyase (EC 4.6.1.16) Caenorhabditis briggsae
TI:6238 None
 
A9V454_MONBE
euHCVdb»
0.0
MONBRDRAFT_33205 tRNA-intron lyase (EC
4.6.1.16) (tRNA-intron endonuclease SEN34)		 Monosiga brevicollis
TI:81824 None
 
F4NVZ3_BATDJ
neXtProt»
0.0
BATDEDRAFT_22850 tRNA-intron lyase (EC 4.6.1.16) Batrachochytrium dendrobatidis
TI:109871 None
 
C4LV03_ENTH1
TubercuList»
0.0
EHI_042160 EHI_092410 tRNA-intron lyase (EC 4.6.1.16) Entamoeba histolytica
TI:5759 None
 
Q8MQ07_CAEEL
WormBase»
0.0
tsen-34 tRNA-intron lyase (EC 4.6.1.16) Caenorhabditis elegans
TI:6239 None
 
B3S1J0_TRIAD
CTD»
0.0
TRIADDRAFT_58307 TSEN34 N-terminal domain-containing protein Trichoplax adhaerens
TI:10228 None