Collated Gene Ontology terms

Biological process: oxidoreductase activity, acting on metal ions(2021, 2022, 2025) oxidoreductase activity(2025) metal ion binding(2025) transmembrane ascorbate ferrireductase activity(2021, 2022) calcium ion binding(2025)

Molecular function: intracellular iron ion homeostasis2021, 2025 immune system process2025 defense response to bacterium2025 innate immune response2025 defense response to protozoan2010, 2025 transmembrane transport2025 negative regulation of immune response2010

Cellular component: membrane2014, 2024, 2025 extracellular region2009, 2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
FRRS1_DROME
FlyBase»
2.9
sdr2 Ferric reductase 1 (EC
1.-.-.-) (stromal cell-derived receptor 2)		 Drosophila melanogaster
TI:7227 None
 
DFP_DROME
FlyBase»
1.6
l(2)34Fc Defense protein l(2)34Fc Drosophila melanogaster
TI:7227 None
 
FRRS1_HUMAN
Ensembl»
2.0
FRRS1 Ferric reductase 1 (EC 1.-.-.-) (Ferric-chelate
reductase 1) (Stromal cell-derived receptor 2) (SDR-2)		 Homo sapiens
TI:9606 None
 
FRRS1_MOUSE
AG»
2.6
Frrs1 Ferric reductase 1 (EC 1.-.-.-) (Ferric-chelate
reductase 1) (Stromal cell-derived receptor 2) (SDR-2)		 Mus musculus
TI:10090 None
 
A0A8I6A2I6_RAT
RGD»
2.0
Frrs1 Ferric-chelate reductase 1
(Stromal cell-derived receptor 2)		 Rattus norvegicus
TI:10116 None
   
A0A2R8QNK3_DANRE
ZFIN»
0.0
si:ch73-196i15.3 Reeler domain-containing
protein precursor (Si:ch73-196i15.3)		 Danio rerio
TI:7955 None
 
FRRS1_DANRE
ZFIN»
0.5
frrs1 Ferric reductase 1 (EC 1.-.-.-) Danio rerio
TI:7955 None
 
A0A8M9P9U0_DANRE
ZFIN»
0.0
LOC108179096 Uncharacterized protein isoform X1 Danio rerio
TI:7955 None
   
A0A8V0ZZD8_CHICK
Ensembl»
1.0
FRRS1 Ferric chelate reductase 1 Gallus gallus
TI:9031 None
   
RELD1_HUMAN
Ensembl»
0.0
REELD1 Reelin domain-containing protein 1 Homo sapiens
TI:9606 None
 
A0A8M1RSC6_DANRE
ZFIN»
0.0
si:ch73-14h1.2 Defense protein 3 Danio rerio
TI:7955 None
   
A0A8V0XSW1_CHICK
Ensembl»
0.0
LOC101749214 Reeler domain containing 1 Gallus gallus
TI:9031 None
   
A0A8V0ZVC7_CHICK
Ensembl»
0.0
LOC424473 Reelin domain-containing protein Gallus gallus
TI:9031 None
   
A0AB32T7Q4_DANRE
ZFIN»
0.0
frrs1a Ferric-chelate reductase 1 Danio rerio
TI:7955 None
   
A2CEY7_DANRE
ZFIN»
0.0
si:dkey-251i10.2 Si:dkey-251i10.2 (Uncharacterized
protein LOC562682 precursor)		 Danio rerio
TI:7955 None
 
A8WHS3_CAEEL
WormBase»
0.0
CELE_F23B12.4 F23B12.4 ShKT domain-containing protein Caenorhabditis elegans
TI:6239 None
 
Q9VAN1_DROME
FlyBase»
0.0
Dmel\CG14515 Reelin domain-containing protein Drosophila melanogaster
TI:7227 None