Collated Gene Ontology terms

Biological process: glutaminyl-peptide cyclotransferase activity(2010, 2011, 2012, 2020, 2024) zinc ion binding(2011, 2020, 2022, 2024) acyltransferase activity(2024) metal ion binding(2024) peptidase activity(2024) aminopeptidase activity(2024) RNA binding(2024)

Molecular function: proteolysis2024 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase2011, 2012, 2020 sexual reproduction2012 protein modification process2003 defense response to Gram-negative bacterium2008

Cellular component: extracellular region2010, 2016, 2024 membrane2014, 2024 Golgi apparatus2012, 2023, 2024 mitochondrion2010, 2014, 2024 Golgi membrane2024 tertiary granule lumen2016 specific granule lumen2016 ficolin-1-rich granule lumen2016 extracellular space2012 extracellular exosome2014
endoplasmic reticulum2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 11/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 3/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
G1K927_ANOCA
Ensembl»
0.0
QPCT Glutaminyl-peptide cyclotransferase (EC
2.3.2.5) (Glutaminyl cyclase)		 Anolis carolinensis
TI:28377 None
   
H9G7W2_ANOCA
Ensembl»
0.0
Glutaminyl-peptide cyclotransferase (EC
2.3.2.5) (Glutaminyl cyclase)		 Anolis carolinensis
TI:28377 None
   
A0A1S4GSP0_ANOGA
EnsemblMetazoa»
0.0
glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Anopheles gambiae
TI:7165 None
 
A0A1S4H2J7_ANOGA
EnsemblMetazoa»
0.0
glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Anopheles gambiae
TI:7165 None
 
O67732_AQUAE
EnsemblBacteria»
0.0
aq_1891 Peptidase M28 domain-containing protein Aquifex aeolicus
TI:63363 None
 
Q756R5_ASHGO
EnsemblFungi»
0.0
AGOS_AER189W Peptide hydrolase (EC 3.4.-.-) Ashbya gossypii
TI:33169 None
 
Q4WP74_ASPFU
EnsemblFungi»
0.0
AFUA_4G08280 Peptide hydrolase (EC 3.4.-.-) Aspergillus fumigatus
TI:746128 None
 
Q8A4P9_BACTN
EnsemblBacteria»
0.0
BT_2548 Leucine aminopeptidase Bacteroides thetaiotaomicron
TI:818 None
 
F4NUG9_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_2945 Peptide hydrolase (EC 3.4.-.-) Batrachochytrium dendrobatidis
TI:109871 None
 
QPCTL_BOVIN
Ensembl»
0.0
QPCTL Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5)
(Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC)		 Bos taurus
TI:9913 None
 
QPCT_BOVIN
CTD»
0.0
QPCT Glutaminyl-peptide cyclotransferase (EC 2.3.2.5)
(Glutaminyl cyclase) (QC) (Glutaminyl-tRNA cyclotransferase)		 Bos taurus
TI:9913 None
 
A0A9J7L379_BRAFL
CTD»
0.0
LOC118414679 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Branchiostoma floridae
TI:7739 None
   
A8X8J5_CAEBR
WormBase»
0.0
CBG09655 CBG_09655 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Caenorhabditis briggsae
TI:6238 None
 
G5EBT9_CAEEL
WormBase»
1.0
CELE_H27A22.1 H27A22.1 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Caenorhabditis elegans
TI:6239 None
 
A0A8I3MXW9_CANLF
Ensembl»
0.0
QPCTL glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Canis lupus
TI:9612 None
   
A0A8I3PHH6_CANLF
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Canis lupus
TI:9612 None
   
F6XS17_CIOIN
Ensembl»
0.0
LOC100175874 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Ciona intestinalis
TI:7719 None
   
Q5KD06_CRYNJ
EnsemblFungi»
0.0
CNH02870 Peptide hydrolase (EC 3.4.-.-) Cryptococcus neoformans
TI:5207 None
 
A0A8M3AK24_DANRE
CTD»
1.0
qpct glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Danio rerio
TI:7955 None
   
E9QEV8_DANRE
ZFIN»
1.0
qpctlb glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Danio rerio
TI:7955 None
 
Q1LWV0_DANRE
ZFIN»
1.0
fb71g05 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Danio rerio
TI:7955 None
 
E9G781_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_314716 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Daphnia pulex
TI:6669 None
 
F0Z989_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_26772 Peptidase M28 domain-containing protein Dictyostelium purpureum
TI:5786 None
 
QPCT_DICDI
dictyBase»
2.5
qpct Glutaminyl-peptide cyclotransferase (EC 2.3.2.5)
(Glutaminyl cyclase) (QC) (Glutaminyl-tRNA cyclotransferase)		 Dictyostelium discoideum
TI:44689 None
 
Q8I936_DROME
FlyBase»
1.0
CG10487 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Drosophila melanogaster
TI:7227 None
 
Q9VTH7_DROME
FlyBase»
2.3
Dmel\CG6168 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Drosophila melanogaster
TI:7227 None
 
QPCT1_DROME
FlyBase»
1.8
QC Glutaminyl-peptide cyclotransferase (EC
2.3.2.5) (Glutaminyl cyclase)		 Drosophila melanogaster
TI:7227 None
 
QPCT2_DROME
FlyBase»
1.8
isoQC Glutaminyl-peptide cyclotransferase (EC
2.3.2.5) (Iso glutaminyl cyclase)		 Drosophila melanogaster
TI:7227 None
 
Q5BCM4_EMENI
EnsemblFungi»
0.0
ANIA_01706 Peptide hydrolase (EC 3.4.-.-) Emericella nidulans
TI:162425 None
 
F6W773_HORSE
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Equus caballus
TI:9796 None
   
M3WH13_FELCA
Ensembl»
0.0
QPCTL glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Felis catus
TI:9685 None
 
M3WST2_FELCA
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Felis catus
TI:9685 None
 
A0A8V0XX04_CHICK
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Gallus gallus
TI:9031 None
   
G3QZV3_GORGO
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Gorilla gorilla
TI:9593 None
 
G3RR07_GORGO
Ensembl»
0.0
QPCTL glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Gorilla gorilla
TI:9593 None
 
T1FV27_HELRO
EnsemblMetazoa»
0.0
20212673 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Helobdella robusta
TI:6412 None
 
QPCTL_HUMAN
Ensembl»
3.4
QPCTL Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5)
(Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC)		 Homo sapiens
TI:9606 None
 
QPCT_HUMAN
Ensembl»
4.3
QPCT Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase)
(QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC)		 Homo sapiens
TI:9606 None
 
B7PPW1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW006370 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Ixodes scapularis
TI:6945 None
 
QPCT_IXOSC
EnsemblMetazoa»
0.0
Qptc Glutaminyl-peptide cyclotransferase (EC 2.3.2.5)
(Glutaminyl cyclase) (QC) (Glutaminyl-tRNA cyclotransferase)		 Ixodes scapularis
TI:6945 None
 
Q4QJA7_LEIMA
EnsemblProtists»
0.0
LMJF_05_0950 Putative glutaminyl cyclase (EC 2.3.2.5) Leishmania major
TI:5664 None
 
W5NCA8_LEPOC
Ensembl»
0.0
glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Lepisosteus oculatus
TI:7918 None
 
A0A5F7ZYW8_MACMU
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Macaca mulatta
TI:9544 None
   
F7E1J2_MACMU
Ensembl»
0.0
QPCTL glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Macaca mulatta
TI:9544 None
   
F7DZS6_MONDO
Ensembl»
0.0
QPCTL glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Monodelphis domestica
TI:13616 None
   
F7F2N3_MONDO
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Monodelphis domestica
TI:13616 None
   
A9V297_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_9158 Peptidase M28 domain-containing protein Monosiga brevicollis
TI:81824 None
 
QPCTL_MOUSE
Ensembl»
2.0
Qpctl Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5)
(Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC)		 Mus musculus
TI:10090 None
 
QPCT_MOUSE
AG»
1.5
Qpct Glutaminyl-peptide cyclotransferase (EC 2.3.2.5)
(Glutaminyl cyclase) (QC) (Glutaminyl-tRNA cyclotransferase)		 Mus musculus
TI:10090 None
 
A7SRT3_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g12286 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Nematostella vectensis
TI:45351 None
 
A7UW85_NEUCR
EnsemblFungi»
0.0
NCU11249 Peptide hydrolase (EC 3.4.-.-) Neurospora crassa
TI:5141 None
 
Q7S0R5_NEUCR
EnsemblFungi»
0.0
NCU09018 Peptide hydrolase (EC 3.4.-.-) Neurospora crassa
TI:5141 None
 
A0A6I8N2Z9_ORNAN
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NDR8_ORNAN
Ensembl»
0.0
glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Ornithorhynchus anatinus
TI:9258 None
   
F6PST1_ORNAN
Ensembl»
0.0
glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Ornithorhynchus anatinus
TI:9258 None
   
H2LQX6_ORYLA
Ensembl»
0.0
qpctl glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Oryzias latipes
TI:8090 None
   
H2MSK2_ORYLA
Ensembl»
0.0
LOC101160122 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Oryzias latipes
TI:8090 None
   
H2QHR8_PANTR
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Pan troglodytes
TI:9598 None
 
K7AI89_PANTR
Ensembl»
0.0
QPCTL glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Pan troglodytes
TI:9598 None
 
A0A2A6C6U2_PRIPA
EnsemblMetazoa»
0.0
WBGene00107694 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Pristionchus pacificus
TI:54126 None
 
E3JR74_PUCGT
EnsemblFungi»
0.0
PGTG_00696 Peptide hydrolase (EC 3.4.-.-) Puccinia graminis
TI:5297 None
 
B5DFI7_RAT
RGD»
2.0
Qpctl glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Rattus norvegicus
TI:10116 None
   
D4AC85_RAT
RGD»
2.0
Qpct glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Rattus norvegicus
TI:10116 None
   
Q7UHT1_RHOBA
EnsemblBacteria»
0.0
RB13002 Peptidase M28 domain-containing protein Rhodopirellula baltica
TI:265606 None
 
YFI8_YEAST
SGD»
1.6
YFR018C Uncharacterized protein YFR018C Saccharomyces cerevisiae
TI:4932 None
 
A7EGW1_SCLS1
EnsemblFungi»
0.0
SS1G_04553 Peptide hydrolase (EC 3.4.-.-) Sclerotinia sclerotiorum
TI:5180 None
 
A0A286ZMY2_PIG
Ensembl»
0.0
QPCTL glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Sus scrofa
TI:9823 None
 
A0A4X1T2C1_PIG
Ensembl»
0.0
QPCT glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Sus scrofa
TI:9823 None
   
A0A139WCP3_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_34176 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Tribolium castaneum
TI:7070 None
 
B3RJS8_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_20276 glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Trichoplax adhaerens
TI:10228 None
 
Q57XR4_TRYB2
VEuPathDB»
0.0
Tb07.21H15.500 Glutaminyl cyclase, putative (EC 2.3.2.5) Trypanosoma brucei
TI:5691 None
 
A0A1L8F825_XENLA
Xenbase»
0.0
qpctl.L glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Xenopus laevis
TI:8355 None
   
A0A6I8QDP8_XENTR
Xenbase»
0.0
qpctl glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Xenopus tropicalis
TI:8364 None
   
Q28IZ1_XENTR
Xenbase»
0.0
qpct glutaminyl-peptide cyclotransferase (EC 2.3.2.5) Xenopus tropicalis
TI:8364 None
 
Q66KH1_XENLA
Xenbase»
0.0
qpct.L Glutaminyl-peptide cyclotransferase (EC 2.3.2.5)
(Glutaminyl cyclase) (Glutaminyl-tRNA cyclotransferase)		 Xenopus laevis
TI:8355 None
 
Q6C472_YARLI
EnsemblFungi»
0.0
YALI0_E29205g Peptide hydrolase (EC 3.4.-.-) Yarrowia lipolytica
TI:4952 None