Collated Gene Ontology terms

Biological process: phosphatase activity(2025) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(2025) hydrolase activity(2025) inositol-polyphosphate 5-phosphatase activity(2007, 2008, 2009, 2022, 2024, 2025) SH3 domain binding(2009, 2025) protein-macromolecule adaptor activity(2011, 2024, 2025) SH2 domain binding(2010, 2025) actin binding(2025) phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(2023, 2025) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(2025)
phosphatidylinositol-3,4,5-trisphosphate binding2007, 2025 phosphatidylinositol trisphosphate phosphatase activity2009 inositol-4,5-bisphosphate 5-phosphatase activity2005, 2025 inositol phosphate phosphatase activity2025 PTB domain binding2009 signaling adaptor activity2011 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity2025

Molecular function: immune system process2025 regulation of immune response2020, 2024, 2025 phosphatidylinositol dephosphorylation2025 innate immune response2025 adaptive immune response2025 negative regulation of insulin-like growth factor receptor signaling pathway2009, 2022, 2025 positive regulation of B cell differentiation2004, 2022, 2025 negative regulation of signal transduction2011, 2022, 2025 negative regulation of neutrophil differentiation2011, 2022, 2025 negative regulation of bone resorption2004, 2022, 2025
negative regulation of natural killer cell mediated cytotoxicity2008, 2024, 2025 lipid metabolic process2009, 2025 regulation of signal transduction2025 cellular defense response2025 cell-cell signaling2025 cell adhesion2010, 2025 negative regulation of T cell receptor signaling pathway2020, 2025 natural killer cell activation2024, 2025 endochondral ossification2013, 2025 endocytosis2010, 2025 actin filament organization2010, 2025 positive regulation of natural killer cell mediated cytotoxicity2008, 2013, 2015, 2025 phosphate-containing compound metabolic process2007, 2025 regulation of protein localization2024 regulation of actin filament organization2024 phosphatidylinositol biosynthetic process2012, 2025 organophosphate metabolic process2025 establishment of mitotic spindle orientation2024 apoptotic process2023, 2025 negative regulation of cell population proliferation2009 natural killer cell mediated cytotoxicity2025 ruffle assembly2012 response to insulin2009 regulation of natural killer cell activation2009 post-embryonic development2009 positive regulation of peptidyl-tyrosine phosphorylation2006 positive regulation of natural killer cell mediated immunity2011 positive regulation of lymphocyte differentiation2011 positive regulation of innate immune response2011 positive regulation of erythrocyte differentiation2004 positive regulation of apoptotic process2004 phosphatidylinositol 3-kinase/protein kinase B signal transduction2023 peptidyl-tyrosine phosphorylation2008 negative regulation of platelet-derived growth factor receptor signaling pathway2009, 2025 negative regulation of osteoclast differentiation2004 negative regulation of neutrophil chemotaxis2013 negative regulation of neuron projection development2009, 2025 negative regulation of monocyte differentiation2011 negative regulation of interleukin-6 production2020 negative regulation of insulin receptor signaling pathway2009, 2025 negative regulation of immune response2004 negative regulation of granulocyte differentiation2011 negative regulation of gene expression2009 negative regulation of MAP kinase activity2009, 2025 negative regulation of DNA replication2009, 2025 negative regulation of B cell proliferation2004 negative regulation of B cell activation2011 leukocyte activation involved in immune response2011 intracellular signal transduction2011 inositol trisphosphate metabolic process2007, 2025 immunoglobulin mediated immune response2004 humoral immune response2004 glucose metabolic process2009 gene expression2023 determination of adult lifespan2004 chemotaxis to cAMP2022 ERK1 and ERK2 cascade2023 signal transduction2007 response to xenobiotic stimulus2009 positive regulation of signal transduction2011 notochord morphogenesis2025 negative regulation of fibroblast growth factor receptor signaling pathway2010 T cell receptor signaling pathway2025 BMP signaling pathway2010

Cellular component: cytosol2011, 2015, 2020, 2022, 2023, 2024, 2025 membrane2025 cytoskeleton2025 cytoplasm2001, 2009, 2024, 2025 nuclear speck2019, 2025 lamellipodium2009, 2025 nucleus2019, 2025 filopodium2025 basal plasma membrane2024, 2025 spindle pole2024, 2025
plasma membrane2009, 2025 membrane raft2025 cortical cytoskeleton2010, 2025 actin filament2010, 2025 Golgi apparatus2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 0/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 5 10 15 20 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
SHIP2_RAT
RGD»
21.0
Inppl1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1)
(Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)		 Rattus norvegicus
TI:10116 None
 
SHIP2_MOUSE
Ensembl»
20.4
Inppl1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1)
(Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)		 Mus musculus
TI:10090 None
 
SHIP1_MOUSE
Ensembl»
22.1
Inpp5d Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa)
(SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)		 Mus musculus
TI:10090 None
 
SHIP1_RAT
RGD»
14.8
Inpp5d Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase)
(EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1)		 Rattus norvegicus
TI:10116 None
 
SHIP2_HUMAN
Ensembl»
8.9
INPPL1 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1)
(Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)		 Homo sapiens
TI:9606 None
 
SHIP1_HUMAN
Ensembl»
10.4
INPP5D Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145)
(Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)		 Homo sapiens
TI:9606 None
 
SHP2A_DANRE
ZFIN»
4.7
inppl1a Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1A)
(INPPL1-A) (SH2 domain-containing inositol 5'-phosphatase 2A) (SH2 domain-containing inositol phosphatase 2A) (SHIP-2A)		 Danio rerio
TI:7955 None
 
SHP2B_DANRE
ZFIN»
1.5
inppl1b Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1B)
(INPPL-1B) (SH2 domain-containing inositol 5'-phosphatase 2B) (SH2 domain-containing inositol phosphatase 2B) (SHIP-2B)		 Danio rerio
TI:7955 None
 
SH21A_MOUSE
Ensembl»
4.4
Sh2d1a SH2 domain-containing protein 1A (Signaling lymphocytic activation molecule-associated
protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)		 Mus musculus
TI:10090 None
 
A0A8V0ZTL7_CHICK
Ensembl»
2.5
INPP5D phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
(EC 3.1.3.86)		 Gallus gallus
TI:9031 None
   
SH21A_RAT
RGD»
3.0
Sh2d1a SH2 domain-containing protein 1A Rattus norvegicus
TI:10116 None
 
SH21A_HUMAN
Ensembl»
3.2
SH2D1A SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic
activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)		 Homo sapiens
TI:9606 None
 
A0A8V0X4G9_CHICK
Ensembl»
0.0
INPPL1A phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
(EC 3.1.3.86)		 Gallus gallus
TI:9031 None
   
A0A8V0Z2V5_CHICK
Ensembl»
1.5
INPPL1B phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
(EC 3.1.3.86)		 Gallus gallus
TI:9031 None
   
SH21C_MOUSE
Ensembl»
4.0
Sh2d1b2 SH2 domain-containing protein 1B2
(EAT-2-related transducer) (ERT) (EAT-2B)		 Mus musculus
TI:10090 None
 
Q54W40_DICDI
dictyBase»
2.6
Dd5P1 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
(EC 3.1.3.86)		 Dictyostelium discoideum
TI:44689 None
 
SH21B_MOUSE
AG»
3.6
Sh2d1b SH2 domain-containing protein 1B
(EWS/FLI1-activated transcript 2) (EAT-2)		 Mus musculus
TI:10090 None
 
A0A8M9Q0J1_DANRE
ZFIN»
0.8
inpp5d phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
(EC 3.1.3.86)		 Danio rerio
TI:7955 None
   
E1BV81_CHICK
Ensembl»
0.0
SH2D1A SH2 domain containing 1A Gallus gallus
TI:9031 None
   
SH21B_HUMAN
Ensembl»
2.4
SH2D1B SH2 domain-containing protein 1B
(EWS/FLI1-activated transcript 2) (EAT-2)		 Homo sapiens
TI:9606 None
 
A0A8I6ALR3_RAT
RGD»
2.5
Sh2d1b2 SH2 domain containing 1B2 Rattus norvegicus
TI:10116 None
   
A2BGK3_DANRE
ZFIN»
0.0
sh2d1aa SH2 domain-containing 1A duplicate a Danio rerio
TI:7955 None
 
R4GIG4_CHICK
Ensembl»
0.0
SH2D1B SH2 domain containing 1B Gallus gallus
TI:9031 None
   
E7F0N7_DANRE
ZFIN»
0.0
sh2d1ab SH2 domain-containing 1A duplicate
b (SH2 domain-containing protein 1A)		 Danio rerio
TI:7955 None
 
E7F659_DANRE
ZFIN»
0.0
si:ch73-264p11.1 Si:ch73-264p11.1 (Uncharacterized
protein LOC100000923)		 Danio rerio
TI:7955 None