Collated Gene Ontology terms

Biological process: molecular adaptor activity(2022, 2025) chromatin binding(2012, 2015, 2025) RNA polymerase inhibitor activity(2025) translation elongation factor activity(2025) zinc ion binding(2020, 2025) transcription coactivator activity(2022) nucleic acid binding(2025) cysteine-type deubiquitinase activity(2025) chromatin DNA binding(2017) acyltransferase activity, transferring groups other than amino-acyl groups(2025)
SNARE binding2020 RNA-DNA hybrid ribonuclease activity2025 RNA polymerase II cis-regulatory region sequence-specific DNA binding2017 RNA binding2004

Molecular function: negative regulation of transcription elongation by RNA polymerase II2012, 2024, 2025 transcription pausing by RNA polymerase II2025 translational elongation2025 positive regulation of transcription by RNA polymerase II2015, 2022, 2025 DNA-templated transcription2025 positive regulation of protein modification process2015, 2025 fungal-type cell wall organization2019, 2022 regulation of granulocyte differentiation2023 regulation of gene expression2025 protein transport2025
protein deubiquitination2025 positive regulation of Notch signaling pathway2025 negative regulation of transcription by RNA polymerase II2018 intracellular protein transport2025 endoplasmic reticulum to Golgi vesicle-mediated transport2025 cell wall organization2025 COPII-coated vesicle cargo loading2020

Cellular component: NELF complex2011, 2012, 2025 nucleus2011, 2024, 2025 nucleoplasm2013, 2024, 2025 nuclear body2024, 2025 fungal-type cell wall2013, 2022, 2025 COPII vesicle coat2024, 2025 transcription repressor complex2004 side of membrane2025 membrane2025 mediator complex2022
extracellular region2013 endoplasmic reticulum exit site2020 cytosol2025 chromosome2025 cell periphery2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 2/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
NELFA_MOUSE
Ensembl»
6.1
Nelfa Negative elongation factor A (NELF-A)
(Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2)		 Mus musculus
TI:10090 None
 
F7FPZ3_RAT
RGD»
5.9
Nelfa Negative elongation factor complex member A Rattus norvegicus
TI:10116 None
   
NELFA_HUMAN
Ensembl»
5.0
NELFA Negative elongation factor A (NELF-A)
(Wolf-Hirschhorn syndrome candidate 2 protein)		 Homo sapiens
TI:9606 None
 
A0A8V0Z4C5_CHICK
Ensembl»
1.0
NELFA Negative elongation factor complex member A Gallus gallus
TI:9031 None
   
NELFA_DROME
FlyBase»
2.8
Nelf-A Negative elongation factor A Drosophila melanogaster
TI:7227 None
 
HPF1_YEAST
SGD»
1.3
HPF1 Haze protective factor 1 Saccharomyces cerevisiae
TI:4932 None
 
A0AB32TSV4_DANRE
ZFIN»
0.8
nelfa Negative elongation factor A isoform X1 Danio rerio
TI:7955 None
   
Y5465_DICDI
dictyBase»
1.0
DDB_G0283357 Uncharacterized protein DDB_G0283357 Dictyostelium discoideum
TI:44689 None
 
Q75JP0_DICDI
dictyBase»
0.0
DDB_G0272480 Uncharacterized protein Dictyostelium discoideum
TI:44689 None