Collated Gene Ontology terms

Biological process: molecular adaptor activity(2022, 2025) chromatin binding(2012, 2015, 2025) RNA polymerase inhibitor activity(2025) translation elongation factor activity(2025) zinc ion binding(2020, 2025) transcription coactivator activity(2022) nucleic acid binding(2025) cysteine-type deubiquitinase activity(2025) chromatin DNA binding(2017) acyltransferase activity, transferring groups other than amino-acyl groups(2025)
SNARE binding2020 RNA-DNA hybrid ribonuclease activity2025 RNA polymerase II cis-regulatory region sequence-specific DNA binding2017 RNA binding2004

Molecular function: negative regulation of transcription elongation by RNA polymerase II2012, 2024, 2025 transcription pausing by RNA polymerase II2025 translational elongation2025 positive regulation of transcription by RNA polymerase II2015, 2022, 2025 DNA-templated transcription2025 positive regulation of protein modification process2015, 2025 fungal-type cell wall organization2019, 2022 regulation of granulocyte differentiation2023 regulation of gene expression2025 protein transport2025
protein deubiquitination2025 positive regulation of Notch signaling pathway2025 negative regulation of transcription by RNA polymerase II2018 intracellular protein transport2025 endoplasmic reticulum to Golgi vesicle-mediated transport2025 cell wall organization2025 COPII-coated vesicle cargo loading2020

Cellular component: NELF complex2011, 2012, 2025 nucleus2011, 2024, 2025 nucleoplasm2013, 2024, 2025 nuclear body2024, 2025 fungal-type cell wall2013, 2022, 2025 COPII vesicle coat2024, 2025 transcription repressor complex2004 side of membrane2025 membrane2025 mediator complex2022
extracellular region2013 endoplasmic reticulum exit site2020 cytosol2025 chromosome2025 cell periphery2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 2/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
H9GD69_ANOCA
Ensembl»
0.0
NELFA Negative elongation factor complex member A Anolis carolinensis
TI:28377 None
   
A0A0E4G9G7_ANOGA
EnsemblMetazoa»
0.0
Protein regulator of cytokinesis 1 Anopheles gambiae
TI:7165 None 		 
 
A0A453YSQ0_ANOGA
EnsemblMetazoa»
0.0
USP domain-containing protein Anopheles gambiae
TI:7165 None
 
A7UR29_ANOGA
EnsemblMetazoa»
0.0
5667720 AGAP002290-PA Anopheles gambiae
TI:7165 None
 
A6QQS5_BOVIN
Ensembl»
0.0
NELFA Negative elongation factor complex
member A (WHSC2 protein)		 Bos taurus
TI:9913 None
 
A0A9J7HXQ7_BRAFL
neXtProt»
0.0
LOC118409435 Negative elongation factor A-like Branchiostoma floridae
TI:7739 None
   
M4DXV4_BRACM
EnsemblPlants»
0.0
CCHC-type domain-containing protein Brassica campestris
TI:3711 None
   
A0A8I3NYG9_CANLF
Ensembl»
0.0
NELFA Negative elongation factor complex member A Canis lupus
TI:9612 None
   
A0A2K3CPC5_CHLRE
euHCVdb»
0.0
CHLRE_17g707551v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3CR61_CHLRE
euHCVdb»
0.0
CHLRE_17g733600v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3CX12_CHLRE
neXtProt»
0.0
CHLRE_14g608200v5 HTH OST-type domain-containing protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3CZF0_CHLRE
euHCVdb»
0.0
CHLRE_13g566500v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3D5W4_CHLRE
euHCVdb»
0.0
CHLRE_12g555001v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3DBE7_CHLRE
euHCVdb»
0.0
CHLRE_10g454350v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3DLR1_CHLRE
euHCVdb»
0.0
CHLRE_07g357500v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3DS81_CHLRE
euHCVdb»
0.0
CHLRE_05g245101v5 BTB domain-containing protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3DSU9_CHLRE
euHCVdb»
0.0
CHLRE_05g236850v5 N-acetyltransferase domain-containing protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3DSV1_CHLRE
euHCVdb»
0.0
CHLRE_05g236878v5 N-acetyltransferase domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3DVH7_CHLRE
euHCVdb»
0.0
CHLRE_03g146567v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3DX41_CHLRE
euHCVdb»
0.0
CHLRE_03g171424v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3DYQ8_CHLRE
euHCVdb»
0.0
CHLRE_03g197450v5 JmjC domain-containing protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
A0A2K3DZ80_CHLRE
euHCVdb»
0.0
CHLRE_03g203351v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None 		 
 
F6SKY6_CIOIN
Ensembl»
0.0
HDAg domain-containing protein Ciona intestinalis
TI:7719 None
 
A0AB32TSV4_DANRE
ZFIN»
0.8
nelfa Negative elongation factor A isoform X1 Danio rerio
TI:7955 None
   
E9HUC3_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_304407 HDAg domain-containing protein Daphnia pulex
TI:6669 None
 
Q75JP0_DICDI
dictyBase»
0.0
DDB_G0272480 Uncharacterized protein Dictyostelium discoideum
TI:44689 None 		 
 
Y5465_DICDI
dictyBase»
1.0
DDB_G0283357 Uncharacterized protein DDB_G0283357 Dictyostelium discoideum
TI:44689 None
 
NELFA_DROME
FlyBase»
2.8
Nelf-A Negative elongation factor A Drosophila melanogaster
TI:7227 None
 
A0A9L0R166_HORSE
Ensembl»
0.0
NELFA Negative elongation factor complex member A Equus caballus
TI:9796 None 		     
A0ABI7Z7Q6_FELCA
Ensembl»
0.0
NELFA HDAg domain-containing protein Felis catus
TI:9685 None 		     
A0A8V0Z4C5_CHICK
Ensembl»
1.0
NELFA Negative elongation factor complex member A Gallus gallus
TI:9031 None
   
G3RE48_GORGO
Ensembl»
0.0
NELFA Negative elongation factor complex member A Gorilla gorilla
TI:9593 None
 
T1EQE7_HELRO
EnsemblMetazoa»
0.0
20198797 Uncharacterized protein Helobdella robusta
TI:6412 None 		 
 
T1F8I3_HELRO
EnsemblMetazoa»
0.0
20205132 Uncharacterized protein Helobdella robusta
TI:6412 None
 
T1FTV1_HELRO
EnsemblMetazoa»
0.0
20212248 Uncharacterized protein Helobdella robusta
TI:6412 None 		 
 
T1FUR1_HELRO
EnsemblMetazoa»
0.0
20212557 HDAg domain-containing protein Helobdella robusta
TI:6412 None
 
T1FVC1_HELRO
EnsemblMetazoa»
0.0
20212767 Uncharacterized protein Helobdella robusta
TI:6412 None
 
NELFA_HUMAN
Ensembl»
5.0
NELFA Negative elongation factor A (NELF-A)
(Wolf-Hirschhorn syndrome candidate 2 protein)		 Homo sapiens
TI:9606 None
 
B7PKJ4_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW018991 Negative elongation factor A, putative Ixodes scapularis
TI:6945 None
 
W5M2E1_LEPOC
Ensembl»
0.0
Negative elongation factor complex member A Lepisosteus oculatus
TI:7918 None
 
H9FZF2_MACMU
Ensembl»
0.0
NELFA Negative elongation factor A (Negative
elongation factor complex member A)		 Macaca mulatta
TI:9544 None
 
F6VE42_MONDO
Ensembl»
0.0
NELFA Negative elongation factor complex member A Monodelphis domestica
TI:13616 None
   
NELFA_MOUSE
Ensembl»
6.1
Nelfa Negative elongation factor A (NELF-A)
(Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2)		 Mus musculus
TI:10090 None
 
A7RTN1_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g201984 Negative elongation factor A Nematostella vectensis
TI:45351 None 		 
 
A7T0K3_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g140527 HDAg domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A7T0K4_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g140529 HDAg domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
A0A6I8P9P6_ORNAN
Ensembl»
0.0
NELFA Negative elongation factor complex member A Ornithorhynchus anatinus
TI:9258 None
   
H2LTZ4_ORYLA
Ensembl»
0.0
NELFA Negative elongation factor complex member A Oryzias latipes
TI:8090 None
   
H2QP42_PANTR
Ensembl»
0.0
NELFA Negative elongation factor complex member
A (Wolf-Hirschhorn syndrome candidate 2)		 Pan troglodytes
TI:9598 None
 
A0BD19_PARTE
neXtProt»
0.0
GSPATT00004530001 LamG-like jellyroll
fold domain-containing protein		 Paramecium tetraurelia
TI:5888 None
 
A0C943_PARTE
euHCVdb»
0.0
GSPATT00006616001 Jacalin-type lectin domain-containing protein Paramecium tetraurelia
TI:5888 None 		 
 
A0CDR0_PARTE
euHCVdb»
0.0
GSPATT00007139001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0CEJ7_PARTE
euHCVdb»
0.0
GSPATT00037652001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0CTL6_PARTE
euHCVdb»
0.0
GSPATT00010367001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0CY68_PARTE
euHCVdb»
0.0
GSPATT00039073001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0D468_PARTE
euHCVdb»
0.0
GSPATT00013301001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0DDS9_PARTE
euHCVdb»
0.0
GSPATT00016037001 LamG-like jellyroll
fold domain-containing protein		 Paramecium tetraurelia
TI:5888 None 		 
 
A0DG62_PARTE
euHCVdb»
0.0
GSPATT00002157001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0DPT7_PARTE
euHCVdb»
0.0
GSPATT00019236001 LamG-like jellyroll
fold domain-containing protein		 Paramecium tetraurelia
TI:5888 None 		 
 
A0DZS5_PARTE
neXtProt»
0.0
GSPATT00021710001 Nucleoporin Paramecium tetraurelia
TI:5888 None 		 
 
A0E372_PARTE
euHCVdb»
0.0
GSPATT00022912001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0E4K0_PARTE
neXtProt»
0.0
GSPATT00023392001 Nucleoporin Paramecium tetraurelia
TI:5888 None 		 
 
A0E8P1_PARTE
euHCVdb»
0.0
GSPATT00024387001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None 		 
 
A0EGP1_PARTE
euHCVdb»
0.0
GSPATT00026806001 LamG-like jellyroll
fold domain-containing protein		 Paramecium tetraurelia
TI:5888 None 		 
 
F7FPZ3_RAT
RGD»
5.9
Nelfa Negative elongation factor complex member A Rattus norvegicus
TI:10116 None
   
HPF1_YEAST
SGD»
1.3
HPF1 Haze protective factor 1 Saccharomyces cerevisiae
TI:4932 None
 
A0A7M7SYS6_STRPU
EnsemblMetazoa»
0.0
HDAg domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A5G2QT16_PIG
Ensembl»
0.0
NELFA Negative elongation factor complex member A Sus scrofa
TI:9823 None 		     
B8C308_THAPS
euHCVdb»
0.0
THAPSDRAFT_22764 Uncharacterized protein Thalassiosira pseudonana
TI:35128 None
 
D6X2R9_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_12492 Negative elongation factor A-like Protein Tribolium castaneum
TI:7070 None
 
B3SB33_TRIAD
CTD»
0.0
TRIADDRAFT_61475 HDAg domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A1L8HKQ3_XENLA
Xenbase»
0.0
nelfa.S Negative elongation factor A Xenopus laevis
TI:8355 None
   
A0A1L8HT19_XENLA
Xenbase»
0.0
nelfa.L Negative elongation factor A Xenopus laevis
TI:8355 None
   
F6Y7E5_XENTR
Xenbase»
0.0
nelfa Negative elongation factor A (Negative
elongation factor complex member A)		 Xenopus tropicalis
TI:8364 None