Biological process: RNA polymerase II cis-regulatory region sequence-specific DNA binding^{(2012, 2014, 2016, 2018, 2019, 2020, 2021, 2022, 2025)} DNA-binding transcription factor activity^{(2000, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2013, 2014, 2015, 2017, 2020, 2025)} DNA-binding transcription factor activity, RNA polymerase II-specific^{(2007, 2009, 2011, 2012, 2016, 2017, 2019, 2021, 2023, 2025)} sequence-specific DNA binding^{(2005, 2006, 2007, 2008, 2009, 2010, 2011, 2013, 2015, 2016, 2017, 2018, 2025)} DNA binding^{(2003, 2005, 2006, 2007, 2009, 2010, 2015, 2025)} sequence-specific double-stranded DNA binding^{(2020, 2025)} transcription cis-regulatory region binding^{(2010, 2011, 2017, 2020, 2025)} DNA-binding transcription activator activity, RNA polymerase II-specific^{(2011, 2013, 2014, 2015, 2018, 2019, 2020, 2022, 2024, 2025)} protein domain specific binding^{(2009, 2025)} RNA polymerase II transcription regulatory region sequence-specific DNA binding^{(2012, 2013, 2014, 2015, 2017, 2018, 2025)}
± 20 DNA-binding transcription repressor activity, RNA polymerase II-specific^{2012, 2016, 2024, 2025} promoter-specific chromatin binding^{2017, 2025} DNA binding, bending^{2006, 2010, 2014, 2025} chromatin binding^{2015, 2019, 2025} DNA-binding transcription activator activity^{2020, 2025} RNA polymerase II-specific DNA-binding transcription factor binding^{2021, 2025} cysteine-type endopeptidase regulator activity involved in apoptotic process^{2006, 2025} chromatin DNA binding^{2006, 2025} identical protein binding²⁰²⁵ DNA-binding transcription factor binding^{2021, 2025} ubiquitin conjugating enzyme binding^{2009, 2025} double-stranded DNA binding^{2005, 2007, 2018, 2025} transcription corepressor activity^{2012, 2025} nuclear estrogen receptor binding^{2009, 2025} nucleic acid binding^{2022, 2025} SMAD binding^{2009, 2025} kinase binding^{2011, 2025} structural constituent of cuticle²⁰²⁵ mitochondrial transcription factor activity²⁰²¹ RNA polymerase II general transcription initiation factor activity²⁰¹⁹

Molecular function: cell differentiation^{2006, 2009, 2019, 2025} regulation of transcription by RNA polymerase II^{2008, 2010, 2012, 2013, 2015, 2016, 2025} regulation of DNA-templated transcription^{2002, 2003, 2005, 2006, 2008, 2009, 2014, 2025} anatomical structure morphogenesis^{2006, 2008, 2025} DNA-templated transcription^{2001, 2009, 2025} positive regulation of transcription by RNA polymerase II^{2005, 2006, 2007, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2021, 2022, 2024, 2025} positive regulation of DNA-templated transcription^{2006, 2010, 2011, 2025} animal organ development²⁰²⁵ negative regulation of transcription by RNA polymerase II^{2005, 2006, 2008, 2009, 2011, 2012, 2013, 2016, 2017, 2024, 2025} negative regulation of DNA-templated transcription^{2005, 2006, 2007, 2009, 2010, 2011, 2013, 2025}
± 345 tissue development²⁰²⁵ system development²⁰²⁵ somitogenesis^{2009, 2010, 2015, 2025} heart development^{2006, 2007, 2011, 2018, 2025} positive regulation of apoptotic process^{2006, 2013, 2017, 2025} negative regulation of epithelial to mesenchymal transition^{2011, 2025} positive regulation of gene expression^{2010, 2015, 2017, 2025} mammillary body development^{2010, 2014, 2025} floor plate development^{2010, 2012, 2025} ovarian follicle development^{2006, 2007, 2015, 2025} eye development^{2000, 2006, 2017, 2025} visual learning^{2010, 2025} telencephalon cell migration^{2010, 2025} nervous system development^{2004, 2006, 2025} negative regulation of neuron apoptotic process^{2010, 2025} midbrain development^{2010, 2025} mammillothalamic axonal tract development^{2010, 2025} lens development in camera-type eye^{2006, 2015, 2017, 2025} inferior colliculus development^{2010, 2025} hypothalamus cell migration^{2010, 2025} cell migration in diencephalon^{2010, 2025} axon target recognition^{2010, 2025} dopaminergic neuron differentiation^{2011, 2014, 2015, 2016, 2025} chromatin organization²⁰²⁵ blood vessel development^{2007, 2009, 2011, 2025} thymus development^{2011, 2023, 2025} regulation of cell cycle^{2013, 2015, 2025} positive regulation of lens epithelial cell proliferation^{2015, 2025} odontogenesis of dentin-containing tooth^{2006, 2023, 2025} mesoderm formation^{2006, 2007, 2025} insulin receptor signaling pathway^{2006, 2019, 2025} cell migration^{2006, 2008, 2015, 2017, 2025} thyroid gland development^{2006, 2011, 2025} response to hormone^{2006, 2025} negative regulation of cold-induced thermogenesis^{2018, 2025} lymphangiogenesis^{2006, 2025} cell population proliferation^{2006, 2015, 2017, 2025} apoptotic DNA fragmentation^{2006, 2025} negative regulation of apoptotic process^{2006, 2015, 2025} extraocular skeletal muscle development^{2006, 2025} roof of mouth development^{2020, 2025} response to estradiol^{2010, 2025} positive regulation of vascular wound healing^{2011, 2025} positive regulation of mitotic cell cycle^{2010, 2025} positive regulation of intracellular estrogen receptor signaling pathway^{2010, 2025} positive regulation of endothelial cell migration^{2011, 2025} positive regulation of cell migration involved in sprouting angiogenesis^{2011, 2025} positive regulation of cell adhesion mediated by integrin^{2011, 2025} pharyngeal system development^{2023, 2025} mammary gland lobule development^{2010, 2025} mRNA transcription by RNA polymerase II^{2017, 2025} lactation^{2010, 2025} hard palate development^{2007, 2025} epithelial cell differentiation involved in mammary gland alveolus development^{2010, 2025} endocrine pancreas development^{2011, 2014, 2025} cranial skeletal system development^{2016, 2025} chemokine-mediated signaling pathway^{2017, 2025} cellular response to chemokine^{2017, 2025} urogenital system development^{2010, 2025} thalamus development^{2010, 2025} spinal cord development^{2010, 2025} soft palate development^{2007, 2025} regulation of blood coagulation^{2010, 2025} positive regulation of epithelial to mesenchymal transition^{2017, 2025} paraxial mesoderm formation^{2006, 2017, 2025} negative regulation of mitotic cell cycle^{2006, 2025} negative regulation of lens fiber cell differentiation^{2015, 2018, 2025} epidermal cell fate specification^{2007, 2009, 2014, 2018, 2023} chromatin remodeling^{2010, 2025} chordate pharynx development^{2023, 2025} cellular response to epidermal growth factor stimulus^{2017, 2025} trabecular meshwork development^{2015, 2025} spermatogenesis^{2010, 2025} positive regulation of keratinocyte differentiation^{2017, 2025} iris morphogenesis^{2015, 2025} cornea development in camera-type eye^{2015, 2025} ciliary body morphogenesis^{2015, 2025} vascular endothelial growth factor signaling pathway^{2015, 2025} positive regulation of kidney development^{2010, 2025} positive regulation of hematopoietic stem cell differentiation^{2015, 2025} positive regulation of hematopoietic progenitor cell differentiation^{2015, 2025} positive regulation of BMP signaling pathway^{2010, 2025} negative regulation of lymphangiogenesis^{2015, 2025} negative regulation of angiogenesis^{2015, 2025} metanephric capsule specification^{2010, 2025} metanephric capsule development^{2010, 2025} mesenchymal cell development^{2015, 2025} maintenance of lens transparency^{2015, 2025} glomerular epithelium development^{2017, 2025} endochondral ossification^{2017, 2025} dichotomous subdivision of terminal units involved in ureteric bud branching^{2010, 2025} cerebellum development^{2017, 2025} camera-type eye development^{2006, 2007, 2009, 2011, 2014} mesoderm development^{2006, 2009} pattern specification involved in metanephros development^{2010, 2025} nephrogenic mesenchyme development^{2010, 2025} metanephric nephron development^{2010, 2025} luteinizing hormone secretion^{2013, 2025} in utero embryonic development^{2005, 2006, 2010} canonical Wnt signaling pathway^{2022, 2025} Notch signaling pathway^{2006, 2015} neural crest cell migration^{2006, 2014, 2015, 2023} neural crest cell development^{2007, 2012, 2013, 2015} kidney development^{2006, 2017} positive regulation of neuron differentiation²⁰⁰⁸ embryonic eye morphogenesis^{2006, 2007, 2025} ectoderm development²⁰⁰⁶ ureteric bud development^{2006, 2017} transcription by RNA polymerase II^{2000, 2011, 2025} skeletal system development²⁰⁰⁶ otic placode development²⁰²³ neuron fate specification²⁰⁰⁸ hair follicle morphogenesis^{2004, 2008} glucose homeostasis^{2006, 2025} dorsal/ventral neural tube patterning²⁰²⁰ brain development^{2004, 2006, 2007} ventricular cardiac muscle tissue morphogenesis²⁰⁰⁷ vasculature development^{2009, 2011} vascular endothelial growth factor receptor signaling pathway²⁰⁰⁷ regulation of organ growth²⁰⁰⁷ regulation of gene expression²⁰⁰⁸ regulation of bone mineralization²⁰²³ primitive streak formation²⁰¹¹ positive regulation of smoothened signaling pathway²⁰¹³ positive regulation of gastrulation²⁰¹¹ positive regulation of embryonic development²⁰¹¹ parathyroid gland development²⁰²³ ossification^{2003, 2006} negative regulation of gene expression^{2011, 2022, 2025} negative regulation of apoptotic process involved in outflow tract morphogenesis²⁰¹³ maintenance of animal organ identity²⁰¹⁷ lymph vessel development²⁰⁰⁷ lung epithelial cell differentiation²⁰¹⁰ lung development²⁰⁰⁵ intracellular glucose homeostasis^{2002, 2010} heart morphogenesis²⁰⁰⁷ hair follicle development²⁰²³ granulosa cell differentiation^{2006, 2007} female somatic sex determination^{2006, 2007} epithelial tube branching involved in lung morphogenesis²⁰¹⁰ embryonic viscerocranium morphogenesis^{2006, 2010, 2015} embryonic heart tube development²⁰⁰⁷ embryo development ending in birth or egg hatching^{2006, 2015, 2018, 2025} determination of heart left/right asymmetry²⁰²² determination of adult lifespan^{2015, 2016, 2019, 2025} connective tissue development²⁰¹³ collagen fibril organization²⁰⁰⁶ cell fate specification^{2011, 2014} cell development^{2005, 2014} cell adhesion^{2009, 2018} cartilage development^{2006, 2007, 2019} cardiac muscle cell proliferation²⁰⁰⁷ blood vessel remodeling^{2006, 2007} blood vessel diameter maintenance²⁰¹⁹ axial mesoderm morphogenesis²⁰¹² artery morphogenesis²⁰⁰⁶ anatomical structure formation involved in morphogenesis²⁰¹³ adult locomotory behavior^{2011, 2014} thyroid hormone generation^{2006, 2008} somite rostral/caudal axis specification²⁰¹¹ regulation of steroid metabolic process²⁰¹³ regulation of lipid metabolic process²⁰¹³ regulation of insulin secretion involved in cellular response to glucose stimulus²⁰¹¹ pronephros development²⁰⁰⁹ positive regulation of neurogenesis²⁰⁰⁶ neural plate development²⁰⁰⁶ neural crest cell fate commitment²⁰⁰⁶ negative regulation of neurogenesis²⁰⁰⁶ midbrain-hindbrain boundary development²⁰²⁴ forebrain development²⁰⁰⁶ embryonic organ morphogenesis^{2006, 2008} dorsal/ventral pattern formation^{2006, 2020} determination of ventral identity²⁰⁰⁶ determination of left/right symmetry²⁰²² cellular response to insulin stimulus²⁰²⁵ cell differentiation in hindbrain²⁰⁰⁸ vulval development²⁰⁰⁷ visceral mesoderm-endoderm interaction involved in midgut development^{2002, 2009} vascular associated smooth muscle cell differentiation²⁰²⁰ uterus development²⁰¹⁵ tube morphogenesis²⁰⁰⁸ trophectodermal cell differentiation²⁰⁰⁵ single fertilization²⁰¹⁵ signal transduction involved in regulation of gene expression²⁰¹¹ short-term memory^{2015, 2025} secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development²⁰⁰⁹ response to interleukin-6²⁰¹⁰ respiratory basal cell differentiation²⁰¹⁵ regulation of vascular permeability²⁰¹³ regulation of platelet-derived growth factor receptor-alpha signaling pathway²⁰¹⁵ regulation of mesodermal cell fate specification^{2021, 2025} regulation of Wnt signaling pathway^{2002, 2009} proteoglycan biosynthetic process^{2002, 2009} prostate gland stromal morphogenesis²⁰⁰⁹ prostate gland epithelium morphogenesis²⁰⁰⁹ positive regulation of transcription by RNA polymerase III²⁰¹⁰ positive regulation of multicellular organism growth²⁰⁰⁶ positive regulation of luteinizing hormone secretion²⁰¹⁵ positive regulation of hydrogen peroxide-mediated programmed cell death^{2022, 2025} positive regulation of hepatocyte differentiation^{2009, 2025} positive regulation of follicle-stimulating hormone secretion²⁰¹⁵ positive regulation of epithelial cell proliferation²⁰⁰⁵ positive regulation of core promoter binding²⁰¹⁷ positive regulation of cell-cell adhesion mediated by cadherin²⁰¹¹ positive regulation of DNA binding²⁰¹⁷ podocyte differentiation²⁰¹⁰ podocyte development²⁰¹⁵ pigment cell differentiation^{2006, 2011} pattern specification process²⁰⁰⁸ paraxial mesodermal cell fate commitment²⁰⁰⁶ otic vesicle formation²⁰⁰⁷ otic placode formation^{2011, 2014} oocyte growth²⁰²⁵ neuromuscular process controlling balance²⁰⁰⁶ nematode pharynx development²⁰²⁴ nematode male tail tip morphogenesis^{2004, 2025} negative regulation of neuron differentiation²⁰⁰⁸ negative regulation of mesodermal cell fate determination²⁰⁰⁶ negative regulation of endodermal cell fate specification²⁰⁰⁶ negative regulation of cell population proliferation^{2009, 2025} negative regulation of cell migration²⁰⁰⁶ morphogenesis of an epithelium²⁰²⁵ metanephros development²⁰⁰⁶ mesenchymal-epithelial cell signaling²⁰⁰⁹ mesenchymal cell differentiation²⁰⁰⁶ male gonad development^{2012, 2025} male germ-line sex determination^{2012, 2025} maintenance of protein location^{2007, 2025} lung morphogenesis²⁰¹⁵ learning^{2015, 2025} lacrimal gland development²⁰⁰⁷ ionocyte differentiation²⁰²⁰ inner ear morphogenesis²⁰⁰⁵ hormone metabolic process²⁰⁰⁶ hematopoietic stem cell homeostasis²⁰²⁰ gonad development^{2015, 2025} glycosaminoglycan metabolic process²⁰⁰⁶ glucose mediated signaling pathway²⁰²³ glomerular mesangial cell development²⁰¹⁰ glomerular endothelium development²⁰¹⁰ germ cell migration²⁰⁰⁶ gene expression²⁰²² fourth ventricle development²⁰²⁴ female gonad development²⁰¹⁵ epithelial cell maturation involved in prostate gland development²⁰⁰⁹ endoderm development²⁰⁰⁸ embryonic skeletal system morphogenesis²⁰⁰⁶ embryonic retina morphogenesis in camera-type eye²⁰¹⁹ embryonic placenta development²⁰⁰⁵ embryonic cranial skeleton morphogenesis²⁰⁰⁶ ectoderm formation²⁰⁰⁸ determination of pancreatic left/right asymmetry²⁰²² determination of liver left/right asymmetry²⁰²² cerebellum vasculature development²⁰¹⁵ cellular response to starvation²⁰⁰² cellular response to leukemia inhibitory factor²⁰¹⁷ cellular response to cadmium ion²⁰²⁰ branching involved in ureteric bud morphogenesis²⁰⁰⁹ branching involved in blood vessel morphogenesis²⁰⁰⁵ axon regeneration^{2015, 2025} axon guidance²⁰⁰⁵ axon extension involved in axon guidance^{2007, 2025} aorta development²⁰¹⁶ anterior/posterior pattern specification²⁰²⁰ angiogenesis²⁰²⁵ alveolar secondary septum development²⁰¹⁵ ventral midline development²⁰⁰⁵ sympathetic nervous system development²⁰⁰⁶ spindle pole body organization²⁰¹³ specification of segmental identity, head²⁰⁰⁷ skeletal muscle organ development²⁰²⁰ salivary gland morphogenesis²⁰⁰⁶ salivary gland development²⁰¹¹ response to xenobiotic stimulus²⁰¹⁰ response to thyroid hormone²⁰¹⁷ response to nutrient levels²⁰⁰⁹ response to insulin²⁰⁰⁹ response to human chorionic gonadotropin²⁰²² response to endoplasmic reticulum stress²⁰²¹ response to caloric restriction²⁰¹⁶ regulation of mitochondrial transcription²⁰²¹ regulation of fibroblast growth factor receptor signaling pathway²⁰¹⁵ regulation of cartilage development²⁰²³ regulation of bone development²⁰²³ regulation of Notch signaling pathway²⁰¹⁵ proteasomal protein catabolic process²⁰²¹ pronephric glomerulus development²⁰¹² positive regulation of translation²⁰⁰⁹ positive regulation of miRNA transcription²⁰²² positive regulation of macroautophagy²⁰¹² positive regulation of integrin activation²⁰¹¹ podocyte cell fate commitment²⁰¹² peripheral nervous system development²⁰⁰⁶ pectoral fin morphogenesis²⁰⁰⁷ pectoral fin development²⁰¹⁷ otic vesicle morphogenesis²⁰¹⁴ otic vesicle development²⁰¹⁵ oligodendrocyte cell fate commitment²⁰⁰⁶ neuron development²⁰¹⁵ neurogenesis²⁰⁰⁶ neuroendocrine cell differentiation²⁰¹⁴ neural tube formation²⁰¹⁸ neural plate anterior/posterior regionalization²⁰⁰⁶ nematode larval development²⁰⁰⁶ negative regulation of retinoic acid receptor signaling pathway²⁰¹⁵ negative regulation of programmed cell death²⁰¹⁰ negative regulation of multicellular organism growth²⁰¹¹ negative regulation of cell growth²⁰¹¹ multicellular organismal-level water homeostasis²⁰¹¹ motor neuron axon guidance²⁰¹⁷ mitochondrion organization²⁰¹³ mitochondrial transcription²⁰²⁵ melanocyte differentiation²⁰⁰⁸ lens morphogenesis in camera-type eye²⁰⁰⁸ lateral line nerve glial cell development²⁰⁰⁶ lateral line ganglion development²⁰¹⁴ iridophore differentiation²⁰⁰⁶ hatching gland development²⁰¹² growth plate cartilage chondrocyte proliferation²⁰¹⁰ epidermal cell differentiation²⁰⁰⁷ enteric nervous system development²⁰⁰⁶ endoderm formation²⁰⁰⁶ embryonic morphogenesis²⁰⁰⁹ ectodermal placode formation²⁰¹¹ ectodermal placode development²⁰¹⁶ division septum assembly²⁰²⁵ defense response to other organism²⁰²¹ cranial ganglion development²⁰¹⁴ closure of optic fissure²⁰¹¹ chordate embryonic development²⁰⁰⁵ central nervous system myelin formation²⁰⁰⁶ cement gland development²⁰¹⁸ cellular response to oxidative stress²⁰¹³ cell fate specification involved in pattern specification²⁰⁰⁹ cell division²⁰²⁵ cartilage morphogenesis²⁰²³ cartilage development involved in endochondral bone morphogenesis²⁰¹¹ axis elongation²⁰¹⁸ autophagic cell death²⁰²⁴ anterior/posterior axis specification²⁰⁰⁶ adrenal gland development²⁰¹² Peyer's patch morphogenesis²⁰¹⁰ Malpighian tubule morphogenesis²⁰¹¹ ERAD pathway²⁰²¹ DNA endoreduplication²⁰¹¹

Cellular component: nucleus^{2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2020, 2021, 2022, 2023, 2024, 2025} nucleoplasm^{2013, 2016, 2021, 2022, 2024, 2025} chromatin^{2012, 2015, 2019, 2020, 2025} transcription regulator complex^{2000, 2001, 2016, 2025} nucleolus^{2024, 2025} nuclear body^{2024, 2025} fibrillar center^{2024, 2025} heterochromatin^{2006, 2025} microvillus^{2013, 2025} cytoplasm^{2013, 2022, 2025}
± 6 cytosol^{2006, 2025} mitochondrion²⁰²¹ cell junction²⁰²⁵ actin cytoskeleton²⁰²⁵ M/G1 phase-specific MADS box-forkhead transcription factor complex²⁰¹² Flemming body²⁰²⁵