Biological process: growth factor activity^{(2002, 2003, 2004, 2005, 2008, 2012, 2014, 2017, 2022, 2024)} chemoattractant activity^{(2010, 2012, 2013, 2017, 2018, 2023, 2024)} vascular endothelial growth factor receptor binding^{(2004, 2005, 2011, 2012, 2017, 2022, 2024)} vascular endothelial growth factor receptor 3 binding^{(2005, 2007, 2017, 2018, 2024)} heparin binding^{(2004, 2008, 2012, 2014, 2017, 2024)} receptor ligand activity^{(2012, 2017, 2023, 2024)} identical protein binding^{(2005, 2006, 2019, 2024)} vascular endothelial growth factor receptor 1 binding^{(2008, 2010, 2012, 2014, 2017, 2024)} vascular endothelial growth factor receptor 2 binding^{(2007, 2008, 2012, 2014, 2017, 2020, 2024)} cytokine activity^{(2008, 2012, 2017, 2024)}
± 9 platelet-derived growth factor receptor binding^{2003, 2008, 2012, 2017, 2024} fibronectin binding^{2008, 2012, 2017, 2024} transmembrane receptor protein tyrosine kinase activator activity^{2023, 2024} protein homodimerization activity²⁰⁰⁸ extracellular matrix binding^{2008, 2014} signaling receptor binding²⁰¹⁴ protein-containing complex binding²⁰⁰⁵ neuropilin binding²⁰¹⁴ growth factor binding²⁰¹⁵

Molecular function: vascular endothelial growth factor receptor signaling pathway^{2004, 2005, 2007, 2008, 2012, 2014, 2017, 2020, 2022, 2023, 2024} positive regulation of angiogenesis^{2005, 2007, 2010, 2012, 2013, 2014, 2017, 2020, 2024} induction of positive chemotaxis^{2004, 2010, 2017, 2024} positive regulation of mast cell chemotaxis^{2010, 2017, 2024} positive regulation of endothelial cell proliferation^{2007, 2008, 2010, 2012, 2013, 2014, 2022, 2023, 2024} response to hypoxia^{2006, 2007, 2009, 2012, 2017, 2023, 2024} vascular endothelial growth factor signaling pathway^{2015, 2020, 2023, 2024} sprouting angiogenesis^{2012, 2013, 2014, 2018, 2019, 2020, 2024} positive chemotaxis^{2012, 2013, 2014, 2023, 2024} positive regulation of cell division²⁰²⁴
± 216 positive regulation of cell population proliferation^{2003, 2005, 2006, 2007, 2008, 2009, 2012, 2016, 2017, 2024} angiogenesis^{2005, 2006, 2009, 2010, 2012, 2014, 2016, 2017, 2023, 2024} cell differentiation²⁰²⁴ signal transduction^{2003, 2024} positive regulation of lymphangiogenesis^{2012, 2014, 2024} positive regulation of cell migration^{2008, 2016, 2024} dopaminergic neuron differentiation^{2011, 2012, 2015, 2024} cell population proliferation^{2006, 2008, 2024} positive regulation of protein phosphorylation^{2013, 2024} positive regulation of peptidyl-tyrosine phosphorylation^{2010, 2012, 2013, 2014, 2024} positive regulation of blood vessel endothelial cell migration^{2006, 2020, 2023, 2024} positive regulation of protein-containing complex assembly^{2012, 2013, 2024} positive regulation of focal adhesion assembly^{2012, 2024} positive regulation of endothelial cell migration^{2010, 2012, 2013, 2017, 2020, 2024} negative regulation of apoptotic process^{2004, 2010, 2012, 2017, 2023, 2024} cellular response to hypoxia^{2010, 2012, 2017, 2023, 2024} positive regulation of transcription by RNA polymerase II^{2006, 2017, 2023, 2024} positive regulation of cell migration involved in sprouting angiogenesis^{2012, 2017, 2018, 2020, 2024} lymphangiogenesis^{2012, 2014, 2022, 2024} blood vessel morphogenesis^{2006, 2007, 2012, 2014, 2024} blood vessel development^{2005, 2006, 2013, 2016, 2024} tube formation^{2013, 2024} motor neuron migration^{2017, 2024} branching involved in blood vessel morphogenesis^{2007, 2011, 2013, 2023, 2024} regulation of cell shape^{2008, 2012, 2017, 2024} positive regulation of vascular permeability^{2006, 2007, 2010, 2014, 2019, 2024} positive regulation of receptor internalization^{2012, 2014, 2017, 2024} positive regulation of positive chemotaxis^{2008, 2012, 2017, 2024} positive regulation of neuroblast proliferation^{2006, 2011, 2012, 2024} positive regulation of cell adhesion^{2011, 2012, 2017, 2024} positive regulation of MAPK cascade²⁰²⁴ monocyte differentiation^{2011, 2012, 2017, 2024} macrophage differentiation^{2011, 2012, 2017, 2024} endothelial cell chemotaxis²⁰²⁴ cell migration involved in sprouting angiogenesis^{2012, 2014, 2017, 2024} positive regulation of epithelial cell proliferation^{2005, 2006, 2012, 2024} positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway^{2012, 2017, 2024} phospholipase C-activating G protein-coupled receptor signaling pathway²⁰²⁴ negative regulation of gene expression^{2010, 2016, 2019, 2021, 2024} positive regulation of mesenchymal stem cell proliferation^{2016, 2024} positive regulation of glial cell proliferation^{2006, 2024} negative regulation of osteoblast differentiation^{2016, 2024} morphogenesis of embryonic epithelium^{2004, 2024} glial cell proliferation^{2006, 2024} cellular response to leukemia inhibitory factor^{2017, 2024} animal organ morphogenesis^{2006, 2024} vasculature development^{2009, 2010, 2015, 2024} retinal ganglion cell axon guidance^{2023, 2024} response to bacterium^{2018, 2024} positive regulation of protein kinase activity^{2016, 2024} positive regulation of cold-induced thermogenesis^{2018, 2024} positive regulation of axon extension involved in axon guidance^{2013, 2023, 2024} lung development^{2007, 2012, 2024} fibroblast proliferation^{2011, 2024} commissural neuron axon guidance^{2013, 2023, 2024} cellular response to vascular endothelial growth factor stimulus^{2015, 2023, 2024} artery morphogenesis^{2009, 2010, 2012, 2024} surfactant homeostasis^{2007, 2012, 2024} regulation of nitric oxide mediated signal transduction^{2018, 2024} primitive erythrocyte differentiation^{2008, 2012, 2024} post-embryonic camera-type eye development^{2009, 2012, 2024} positive regulation of sprouting angiogenesis^{2018, 2024} positive regulation of branching involved in ureteric bud morphogenesis^{2010, 2012, 2024} positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis^{2018, 2020, 2024} ovarian follicle development^{2007, 2012, 2024} mesoderm development^{2004, 2012, 2024} mammary gland alveolus development^{2009, 2012, 2024} lung vasculature development^{2014, 2024} lactation^{2009, 2012, 2024} kidney development^{2009, 2012, 2024} in utero embryonic development^{2009, 2012, 2024} heart morphogenesis^{2009, 2012, 2024} eye photoreceptor cell development^{2006, 2012, 2024} epithelial cell proliferation^{2005, 2013, 2024} epithelial cell differentiation^{2006, 2012, 2024} cell migration^{2005, 2024} cardiac muscle cell development^{2009, 2012, 2024} camera-type eye morphogenesis^{2006, 2012, 2024} vasodilation^{2021, 2024} vascular wound healing^{2020, 2024} vascular endothelial growth factor receptor-2 signaling pathway^{2021, 2024} regulation of hematopoietic progenitor cell differentiation^{2014, 2024} regulation of growth^{2018, 2024} regulation of endothelial cell differentiation^{2014, 2024} positive regulation of vascular endothelial growth factor signaling pathway^{2023, 2024} positive regulation of trophoblast cell migration^{2020, 2024} positive regulation of p38MAPK cascade^{2012, 2024} positive regulation of osteoblast differentiation^{2016, 2024} positive regulation of gene expression^{2012, 2021, 2024} positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway^{2023, 2024} positive regulation of endothelial cell chemotaxis^{2023, 2024} neuroblast proliferation^{2011, 2024} negative regulation of transcription by RNA polymerase II^{2012, 2024} negative regulation of fat cell differentiation^{2016, 2024} negative regulation of establishment of endothelial barrier^{2019, 2024} negative regulation of epithelial to mesenchymal transition^{2017, 2024} negative regulation of cell-cell adhesion mediated by cadherin^{2019, 2024} negative regulation of cell-cell adhesion^{2014, 2024} negative regulation of blood-brain barrier permeability^{2019, 2024} negative regulation of adherens junction organization^{2019, 2024} homeostasis of number of cells within a tissue^{2016, 2024} epithelial cell maturation^{2007, 2024} endothelial cell proliferation^{2021, 2024} endothelial cell migration^{2014, 2024} cellular stress response to acid chemical^{2018, 2024} cell-cell adhesion^{2014, 2024} bone trabecula morphogenesis^{2016, 2024} bone trabecula formation^{2016, 2024} apoptotic process^{2004, 2024} negative regulation of cysteine-type endopeptidase activity involved in apoptotic process^{2012, 2024} protein O-linked glycosylation^{2009, 2024} heart development^{2010, 2024} coronary vasculature development^{2010, 2024} cardiac muscle contraction^{2010, 2024} positive regulation of protein kinase B signaling^{2006, 2010, 2020, 2023} lymph vessel development^{2020, 2024} lymph vessel morphogenesis^{2012, 2017, 2024} response to xenobiotic stimulus^{2007, 2009, 2024} venous endothelial cell migration involved in lymph vessel development^{2014, 2024} regulation of vascular endothelial growth factor receptor signaling pathway^{2009, 2024} positive regulation of ERK1 and ERK2 cascade^{2010, 2014, 2023} motor neuron axon guidance^{2006, 2015, 2024} VEGF-activated neuropilin signaling pathway²⁰²³ venous blood vessel morphogenesis^{2013, 2024} vasculogenesis^{2004, 2005, 2010} regulation of vascular endothelial growth factor signaling pathway^{2015, 2024} regulation of blood pressure²⁰²³ positive regulation of protein secretion^{2006, 2024} outflow tract morphogenesis²⁰¹² nervous system development^{2004, 2005} negative regulation of blood pressure^{2009, 2024} glycogen metabolic process²⁰²³ endoderm development^{2004, 2024} coronary vein morphogenesis²⁰¹² coronary artery morphogenesis²⁰¹² cardiac vascular smooth muscle cell development²⁰¹² cardiac muscle tissue regeneration^{2022, 2024} regulation of morphogenesis of a branching structure²⁰⁰⁹ positive regulation of vascular wound healing²⁰¹⁰ positive regulation of DNA biosynthetic process²⁰¹⁸ placenta development²⁰²³ neuron development^{2013, 2016} negative regulation of neuron apoptotic process^{2010, 2013} hemopoiesis^{2004, 2010} gene expression²⁰²³ female pregnancy^{2007, 2014} branching involved in ureteric bud morphogenesis²⁰⁰³ blood circulation^{2007, 2024} venous blood vessel development²⁰¹⁹ tissue remodeling²⁰²³ thyroid gland development²⁰⁰⁶ substrate-dependent cell migration²⁰⁰³ stem cell proliferation²⁰⁰⁷ response to vitamin A²⁰¹³ response to progesterone²⁰¹³ response to oxygen levels²⁰¹⁴ response to interleukin-1²⁰⁰⁹ response to glucose²⁰¹⁶ response to folic acid²⁰¹³ response to estradiol²⁰¹³ response to dexamethasone²⁰¹⁴ regulation of vasculature development²⁰¹⁴ regulation of transcription by RNA polymerase II²⁰¹² regulation of heart contraction²⁰⁰⁵ regulation of angiogenesis²⁰⁰⁵ regulation of angioblast cell migration involved in selective angioblast sprouting²⁰¹⁰ pronephros development²⁰⁰⁶ positive regulation of vascular endothelial growth factor receptor signaling pathway²⁰¹⁰ positive regulation of stem cell proliferation²⁰⁰⁷ positive regulation of smooth muscle cell proliferation²⁰⁰⁶ positive regulation of signal transduction²⁰⁰⁵ positive regulation of receptor signaling pathway via STAT²⁰²⁴ positive regulation of protein localization to early endosome²⁰¹⁴ positive regulation of protein kinase C signaling²⁰¹² positive regulation of protein autophosphorylation²⁰¹² positive regulation of mesenchymal cell proliferation²⁰⁰⁷ positive regulation of leukocyte migration²⁰⁰⁸ positive regulation of interleukin-6 production²⁰⁰⁹ positive regulation of epithelial tube formation²⁰²⁰ positive regulation of cell-matrix adhesion²⁰¹³ positive regulation of I-kappaB kinase/NF-kappaB signaling²⁰²³ phosphorylation²⁰⁰⁸ neuron apoptotic process²⁰¹³ negative regulation of programmed cell death²⁰⁰⁸ negative regulation of miRNA transcription²⁰²³ negative regulation of extrinsic apoptotic signaling pathway²⁰¹³ negative regulation of epithelial cell proliferation²⁰¹³ negative regulation of bone resorption²⁰⁰⁶ mesenchymal cell proliferation²⁰⁰⁷ mRNA stabilization²⁰⁰⁶ lung alveolus development²⁰⁰⁶ epicardial cell to mesenchymal cell transition²⁰¹⁰ endocardial progenitor cell migration to the midline involved in heart field formation²⁰¹² dorsal aorta development²⁰¹⁹ cerebellum vasculature development²⁰¹⁶ central nervous system vasculogenesis²⁰¹⁹ cellular response to xenobiotic stimulus²⁰¹³ cellular response to wortmannin²⁰²² cellular response to mechanical stimulus²⁰²¹ cellular response to hormone stimulus²⁰⁰⁷ cellular response to fibroblast growth factor stimulus²⁰¹³ cellular response to estrogen stimulus²⁰²² cellular response to dexamethasone stimulus²⁰¹³ cell-cell signaling²⁰⁰³ cell maturation²⁰¹² cell chemotaxis²⁰¹³ cardioblast migration to the midline involved in heart rudiment formation²⁰¹⁹ branching morphogenesis of an epithelial tube²⁰⁰⁷ blood vessel remodeling²⁰⁰⁶ blood vessel maturation²⁰⁰⁷ blood vessel endothelial cell proliferation involved in sprouting angiogenesis²⁰⁰⁶ basophil chemotaxis²⁰¹⁰ animal organ regeneration²⁰⁰⁵ angiogenesis involved in coronary vascular morphogenesis²⁰¹⁴ angioblast cell migration from lateral mesoderm to midline²⁰¹⁰ T-helper 1 type immune response²⁰⁰⁶

Cellular component: extracellular space^{2003, 2007, 2008, 2010, 2012, 2014, 2015, 2016, 2017, 2018, 2024} membrane²⁰²⁴ extracellular region^{2004, 2008, 2009, 2010, 2011, 2013, 2014, 2024} cytoplasm^{2012, 2016, 2017, 2024} secretory granule^{2012, 2017, 2024} cell surface^{2008, 2012, 2017, 2024} nucleus^{2016, 2024} adherens junction^{2019, 2024} VEGF-A complex^{2023, 2024} platelet alpha granule lumen^{2013, 2024}
± 6 endoplasmic reticulum²⁰²⁴ Golgi apparatus²⁰²⁴ vesicle²⁰⁰⁸ plasma membrane²⁰²⁴ extracellular matrix²⁰⁰⁴ basement membrane²⁰⁰⁶