Collated Gene Ontology terms

Biological process: hormone activity(2005, 2007, 2009, 2015, 2025) glucagon receptor binding(2007, 2010, 2017, 2025) receptor ligand activity(2022, 2024, 2025) identical protein binding(2025) gastric inhibitory polypeptide receptor binding(2021, 2025) signaling receptor binding(2003)

Molecular function: positive regulation of insulin secretion involved in cellular response to glucose stimulus2011, 2017, 2025 negative regulation of apoptotic process2011, 2020, 2025 adenylate cyclase-modulating G protein-coupled receptor signaling pathway2007, 2017, 2025 glucose homeostasis2020, 2025 response to activity2020, 2025 signal transduction2025 positive regulation of ERK1 and ERK2 cascade2013, 2014, 2025 positive regulation of calcium ion import2011, 2025 cellular response to glucagon stimulus2022, 2025 adenylate cyclase-activating G protein-coupled receptor signaling pathway2022, 2025
regulation of insulin secretion2020, 2025 response to starvation2010, 2017 positive regulation of gluconeogenesis2015, 2019 negative regulation of appetite2009, 2015, 2025 intracellular glucose homeostasis2025 positive regulation of bicellular tight junction assembly2014 negative regulation of execution phase of apoptosis2013 type B pancreatic cell development2015 response to L-arginine2015 regulation of lipid metabolic process2005 regulation of carbohydrate metabolic process2005 positive regulation of insulin secretion2025 positive regulation of adenylate cyclase activity2016 negative regulation of intrinsic apoptotic signaling pathway2013 lipid biosynthetic process2015 lactate biosynthetic process2015 feeding behavior2003 G protein-coupled receptor signaling pathway2019

Cellular component: extracellular space2020, 2022, 2025 extracellular region2009, 2016, 2025 plasma membrane2022, 2025 cytoplasm2015, 2025 secretory granule lumen2012, 2023 endoplasmic reticulum lumen2023

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 0/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 5 10 15 20 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
GLUC_HUMAN
Ensembl»
13.3
GCG Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1
(GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Homo sapiens
TI:9606 None
 
GLUC_MOUSE
Ensembl»
17.4
Gcg Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Mus musculus
TI:10090 None
 
GLUC_RAT
RGD»
20.5
Gcg Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Rattus norvegicus
TI:10116 None
 
A0A0R4IS85_DANRE
ZFIN»
3.4
gcga Glucagon a Danio rerio
TI:7955 None
 
GLUC_CHICK
Ensembl»
3.3
GCG Pro-glucagon [Cleaved into: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1);
Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Gallus gallus
TI:9031 None
 
B0R1C3_DANRE
ZFIN»
1.0
gcgb Glucagon b Danio rerio
TI:7955 None
 
C0J3M5_CHICK
Ensembl»
2.5
LOC100858942 Glucagon type II Gallus gallus
TI:9031 None