Collated Gene Ontology terms

Biological process: hormone activity(2005, 2007, 2009, 2015, 2017, 2024) glucagon receptor binding(2007, 2010, 2017, 2024) receptor ligand activity(2022, 2023, 2024) identical protein binding(2024) signaling receptor binding(2003) gastric inhibitory polypeptide receptor binding(2021)

Molecular function: protein kinase A signaling2011, 2017, 2024 positive regulation of insulin secretion involved in cellular response to glucose stimulus2011, 2017, 2024 negative regulation of apoptotic process2011, 2020, 2024 regulation of insulin secretion2020, 2024 adenylate cyclase-modulating G protein-coupled receptor signaling pathway2007, 2017, 2024 response to activity2020, 2024 glucose homeostasis2020, 2024 positive regulation of gluconeogenesis2015, 2019, 2024 positive regulation of ERK1 and ERK2 cascade2011, 2013, 2014, 2024 cellular response to glucagon stimulus2022, 2024
positive regulation of calcium ion import2011, 2024 negative regulation of execution phase of apoptosis2013, 2024 gluconeogenesis2019, 2024 adenylate cyclase-activating G protein-coupled receptor signaling pathway2017, 2024 positive regulation of protein kinase activity2011, 2024 positive regulation of peptidyl-threonine phosphorylation2011, 2024 positive regulation of peptidyl-serine phosphorylation2013, 2024 signal transduction2024 response to starvation2010, 2017 negative regulation of intrinsic apoptotic signaling pathway2013 negative regulation of appetite2009, 2015 type B pancreatic cell development2015 response to L-arginine2015 regulation of lipid metabolic process2005 regulation of carbohydrate metabolic process2005 positive regulation of protein binding2013 positive regulation of bicellular tight junction assembly2014 lipid biosynthetic process2015 lactate biosynthetic process2015 feeding behavior2003 G protein-coupled receptor signaling pathway2019

Cellular component: extracellular space2017, 2020, 2022, 2024 extracellular region2009, 2016, 2024 plasma membrane2022, 2024 cytoplasm2011, 2015, 2024 secretory granule lumen2012, 2023 membrane2024 endoplasmic reticulum lumen2023

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 0/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 5 10 15 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A0R4IS85_DANRE
ZFIN»
3.4
gcg Glucagon a (Glucagon isoform 1 precursor) Danio rerio
TI:7955 None
 
B0R1C3_DANRE
ZFIN»
1.0
gcgb Glucagon b (Glucagon precursor) Danio rerio
TI:7955 None
 
C0J3M5_CHICK
Ensembl»
3.0
LOC100858942 Glucagon type II Gallus gallus
TI:9031 None
 
GLUC_CHICK
Ensembl»
3.8
GCG Pro-glucagon [Cleaved into: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1);
Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Gallus gallus
TI:9031 None
 
GLUC_HUMAN
Ensembl»
11.5
GCG Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1
(GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Homo sapiens
TI:9606 None
 
GLUC_MOUSE
Ensembl»
15.2
Gcg Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Mus musculus
TI:10090 None
 
GLUC_RAT
RGD»
20.0
Gcg Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Rattus norvegicus
TI:10116 None