Collated Gene Ontology terms

Biological process: hormone activity(2005, 2007, 2009, 2015, 2025) glucagon receptor binding(2007, 2010, 2017, 2025) receptor ligand activity(2022, 2024, 2025) identical protein binding(2025) gastric inhibitory polypeptide receptor binding(2021, 2025) signaling receptor binding(2003)

Molecular function: positive regulation of insulin secretion involved in cellular response to glucose stimulus2011, 2017, 2025 negative regulation of apoptotic process2011, 2020, 2025 adenylate cyclase-modulating G protein-coupled receptor signaling pathway2007, 2017, 2025 glucose homeostasis2020, 2025 response to activity2020, 2025 signal transduction2025 positive regulation of ERK1 and ERK2 cascade2013, 2014, 2025 positive regulation of calcium ion import2011, 2025 cellular response to glucagon stimulus2022, 2025 adenylate cyclase-activating G protein-coupled receptor signaling pathway2022, 2025
regulation of insulin secretion2020, 2025 response to starvation2010, 2017 positive regulation of gluconeogenesis2015, 2019 negative regulation of appetite2009, 2015, 2025 intracellular glucose homeostasis2025 positive regulation of bicellular tight junction assembly2014 negative regulation of execution phase of apoptosis2013 type B pancreatic cell development2015 response to L-arginine2015 regulation of lipid metabolic process2005 regulation of carbohydrate metabolic process2005 positive regulation of insulin secretion2025 positive regulation of adenylate cyclase activity2016 negative regulation of intrinsic apoptotic signaling pathway2013 lipid biosynthetic process2015 lactate biosynthetic process2015 feeding behavior2003 G protein-coupled receptor signaling pathway2019

Cellular component: extracellular space2020, 2022, 2025 extracellular region2009, 2016, 2025 plasma membrane2022, 2025 cytoplasm2015, 2025 secretory granule lumen2012, 2023 endoplasmic reticulum lumen2023

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 0/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 5 10 15 20 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A1L3MY50_ORNAN
Ensembl»
0.0
GCG Glucagon Ornithorhynchus anatinus
TI:9258 None
 
A0A5F8A440_MACMU
Ensembl»
0.0
GCG Glucagon Macaca mulatta
TI:9544 None
   
A0A8I3QXE0_CANLF
Ensembl»
0.0
GCG Glucagon Canis lupus
TI:9612 None
   
F7ABP1_HORSE
Ensembl»
0.0
GCG Glucagon Equus caballus
TI:9796 None
   
F7D9G8_XENTR
Xenbase»
0.0
gcg Glucagon Xenopus tropicalis
TI:8364 None
 
F7F3N7_MONDO
Ensembl»
0.0
GCG Glucagon Monodelphis domestica
TI:13616 None
   
G3QHC4_GORGO
Ensembl»
0.0
GCG Glucagon Gorilla gorilla
TI:9593 None
 
H2LC36_ORYLA
Ensembl»
0.0
GCG Glucagon Oryzias latipes
TI:8090 None
   
H2QIW1_PANTR
Ensembl»
0.0
GCG Glucagon Pan troglodytes
TI:9598 None
 
H9GKR8_ANOCA
Ensembl»
0.0
GCG Glucagon Anolis carolinensis
TI:28377 None
   
A0A3B3HK03_ORYLA
Ensembl»
0.0
Glucagon / GIP / secretin
/ VIP family domain-containing protein		 Oryzias latipes
TI:8090 None
   
A0A803THB8_ANOCA
Ensembl»
0.0
LOC103277774 Glucagon / GIP / secretin
/ VIP family domain-containing protein		 Anolis carolinensis
TI:28377 None
   
A0ABI7ZUX4_FELCA
Ensembl»
0.0
GCG Glucagon / GIP / secretin
/ VIP family domain-containing protein		 Felis catus
TI:9685 None
   
A0A0R4IS85_DANRE
ZFIN»
3.4
gcga Glucagon a Danio rerio
TI:7955 None
 
A0A3B3HVJ8_ORYLA
Ensembl»
0.0
GCG Glucagon b Oryzias latipes
TI:8090 None
   
B0R1C3_DANRE
ZFIN»
1.0
gcgb Glucagon b Danio rerio
TI:7955 None
 
W5MPN6_LEPOC
Ensembl»
0.0
Glucagon b Lepisosteus oculatus
TI:7918 None
 
C0J3M5_CHICK
Ensembl»
2.5
LOC100858942 Glucagon type II Gallus gallus
TI:9031 None
 
GLUC1_XENLA
Xenbase»
0.0
gcg1 Glucagon-1 (Glucagon I) [Cleaved into: Glucagon; Glucagon-like peptide 1A (GLP-1A); Glucagon-like
peptide 1B (GLP-1B); Glucagon-like peptide 1C (GLP-1C); Glucagon-like peptide 2 (GLP-2)]		 Xenopus laevis
TI:8355 None
 
B7ZQU9_XENLA
Xenbase»
0.0
gcg.L Glucagon-1 isoform X1 Xenopus laevis
TI:8355 None
 
GLUC2_XENLA
CTD»
0.0
gcg2 Glucagon-2 (Glucagon II) [Cleaved into: Glucagon; Glucagon-like peptide 1A
(GLP-1A); Glucagon-like peptide 1B (GLP-1B); Glucagon-like peptide 1C (GLP-1C)]		 Xenopus laevis
TI:8355 None
 
A0A8J0UBU4_XENLA
CTD»
0.0
gcg.2.L Pro-glucagon Xenopus laevis
TI:8355 None
   
GLUC_CHICK
Ensembl»
3.3
GCG Pro-glucagon [Cleaved into: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1);
Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Gallus gallus
TI:9031 None
 
GLUC_BOVIN
Ensembl»
0.0
GCG Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Bos taurus
TI:9913 None
 
GLUC_CANLF
CTD»
0.0
GCG Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Canis lupus
TI:9612 None
 
GLUC_MOUSE
Ensembl»
17.4
Gcg Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Mus musculus
TI:10090 None
 
GLUC_PIG
Ensembl»
0.0
GCG Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Sus scrofa
TI:9823 None
 
GLUC_RAT
RGD»
20.5
Gcg Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Rattus norvegicus
TI:10116 None
 
GLUC_HUMAN
Ensembl»
13.3
GCG Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1
(GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]		 Homo sapiens
TI:9606 None