Unknome v3

Cluster UKP06412
GLUCAGON
Standard knownness: 20.5; Custom knownness: None; Num. species: 20; Orthology database: Panther19.0; Protein members: 29

Collated Gene Ontology terms

Biological process: hormone activity^{(2005, 2007, 2009, 2015, 2025)} glucagon receptor binding^{(2007, 2010, 2017, 2025)} receptor ligand activity^{(2022, 2024, 2025)} identical protein binding⁽²⁰²⁵⁾ gastric inhibitory polypeptide receptor binding^{(2021, 2025)} signaling receptor binding⁽²⁰⁰³⁾

Molecular function: positive regulation of insulin secretion involved in cellular response to glucose stimulus^{2011, 2017, 2025} negative regulation of apoptotic process^{2011, 2020, 2025} adenylate cyclase-modulating G protein-coupled receptor signaling pathway^{2007, 2017, 2025} glucose homeostasis^{2020, 2025} response to activity^{2020, 2025} signal transduction²⁰²⁵ positive regulation of ERK1 and ERK2 cascade^{2013, 2014, 2025} positive regulation of calcium ion import^{2011, 2025} cellular response to glucagon stimulus^{2022, 2025} adenylate cyclase-activating G protein-coupled receptor signaling pathway^{2022, 2025}
regulation of insulin secretion^{2020, 2025} response to starvation^{2010, 2017} positive regulation of gluconeogenesis^{2015, 2019} negative regulation of appetite^{2009, 2015, 2025} intracellular glucose homeostasis²⁰²⁵ positive regulation of bicellular tight junction assembly²⁰¹⁴ negative regulation of execution phase of apoptosis²⁰¹³ type B pancreatic cell development²⁰¹⁵ response to L-arginine²⁰¹⁵ regulation of lipid metabolic process²⁰⁰⁵ regulation of carbohydrate metabolic process²⁰⁰⁵ positive regulation of insulin secretion²⁰²⁵ positive regulation of adenylate cyclase activity²⁰¹⁶ negative regulation of intrinsic apoptotic signaling pathway²⁰¹³ lipid biosynthetic process²⁰¹⁵ lactate biosynthetic process²⁰¹⁵ feeding behavior²⁰⁰³ G protein-coupled receptor signaling pathway²⁰¹⁹

Cellular component: extracellular space^{2020, 2022, 2025} extracellular region^{2009, 2016, 2025} plasma membrane^{2022, 2025} cytoplasm^{2015, 2025} secretory granule lumen^{2012, 2023} endoplasmic reticulum lumen²⁰²³

Phylogenetic distribution

Chordates:	20/21
Echinoderms:	0/0
Hemichordates:	0/1
Annelids:	0/1
Molluscs:	0/0
Bryozoans:	0/0
Platyhelminthes:	0/0
Rotifers:	0/0
Nematodes:	0/3
Arthropods:	0/5
Tardigrades:	0/0
Placozoa:	0/1
Cnidaria:	0/1
Porifera:	0/0
Choanoflagellates+:	0/1
Dikarya:	0/14
Fungi (other):	0/1
Protozoa:	0/3
Excavates:	0/4
Harosa:	0/4
Hacrobia:	0/0
Plants:	0/39
Archea:	0/8
Bacteria:	0/35

Find a cluster

Download

Protein sequences (FASTA format)

Knownness history

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»

Species [Show all]

A0A0R4IS85_DANRE
ZFIN»

3.4

gcga

Glucagon a

Danio rerio
TI:7955 None

B0R1C3_DANRE
ZFIN»

1.0

gcgb

Glucagon b

Danio rerio
TI:7955 None

C0J3M5_CHICK
Ensembl»

2.5

LOC100858942

Glucagon type II

Gallus gallus
TI:9031 None

GLUC_CHICK
Ensembl»

3.3

GCG

Pro-glucagon [Cleaved into: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1);
Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]

Gallus gallus
TI:9031 None

GLUC_HUMAN
Ensembl»

13.3

GCG

Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1
(GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]

Homo sapiens
TI:9606 None

GLUC_MOUSE
Ensembl»

17.4

Gcg

Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide
1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]

Mus musculus
TI:10090 None

GLUC_RAT
RGD»

20.5

Gcg