Biological process: heparin binding⁽²⁰²⁴⁾ transition metal ion binding⁽²⁰²⁴⁾ serine-type endopeptidase inhibitor activity^{(2005, 2021, 2024)} metal ion binding⁽²⁰²⁴⁾ identical protein binding^{(2019, 2024)} signaling receptor activator activity^{(2018, 2023, 2024)} signaling receptor binding^{(2009, 2018, 2023, 2024)} alpha-2C adrenergic receptor binding^{(2010, 2021, 2024)} alpha-2B adrenergic receptor binding^{(2010, 2021, 2024)} alpha-2A adrenergic receptor binding^{(2010, 2021, 2024)}
± 28 receptor ligand activity^{2021, 2024} protein serine/threonine kinase binding²⁰²⁴ protein domain specific binding²⁰²⁴ enzyme binding^{2020, 2024} RNA polymerase II cis-regulatory region sequence-specific DNA binding^{2019, 2024} PTB domain binding^{2010, 2024} protein kinase binding²⁰²⁴ DNA binding^{2001, 2009, 2024} low-density lipoprotein particle receptor binding²⁰¹⁷ heparan sulfate proteoglycan binding²⁰¹⁷ frizzled binding²⁰¹⁷ apolipoprotein binding²⁰¹⁷ protein-folding chaperone binding²⁰¹⁸ protein homodimerization activity²⁰²³ protein heterodimerization activity²⁰²³ peptidase activator activity²⁰⁰⁵ integrin binding²⁰¹⁷ insulin receptor binding²⁰¹⁷ heparan sulfate binding²⁰¹⁷ growth factor receptor binding²⁰¹¹ ephrin receptor binding²⁰¹⁷ chromatin binding²⁰²⁰ chemoattractant activity²⁰¹⁷ amylin binding²⁰¹⁷ acetylcholine receptor binding²⁰¹² acetylcholine receptor activator activity²⁰¹⁷ RAGE receptor binding²⁰¹⁸ G protein-coupled receptor binding²⁰¹⁹

Molecular function: axonogenesis^{2005, 2009, 2012, 2021, 2024} central nervous system development^{2013, 2021, 2024} extracellular matrix organization^{2009, 2020, 2021, 2024} regulation of translation^{2006, 2009, 2024} forebrain development^{2005, 2020, 2021, 2024} negative regulation of peptidase activity²⁰²⁴ cytoplasmic polyadenylation^{2006, 2024} endocytosis^{2007, 2009, 2024} intracellular copper ion homeostasis^{2005, 2009, 2024} neuron projection development^{2005, 2009, 2012, 2017, 2024}
± 159 mating behavior^{2005, 2009, 2024} locomotory behavior^{2005, 2009, 2024} cognition^{2018, 2024} dendrite development^{2005, 2009, 2024} axo-dendritic transport^{2005, 2009, 2011, 2024} apoptotic process²⁰²⁴ visual learning^{2005, 2009, 2024} regulation of synapse structure or activity^{2005, 2009, 2024} regulation of multicellular organism growth^{2005, 2009, 2024} positive regulation of mitotic cell cycle^{2005, 2009, 2024} positive regulation of ERK1 and ERK2 cascade^{2017, 2024} neuron remodeling^{2005, 2009, 2024} ionotropic glutamate receptor signaling pathway^{2007, 2009, 2024} collateral sprouting in absence of injury^{2005, 2009, 2024} axon midline choice point recognition^{2005, 2009, 2024} adult locomotory behavior^{2005, 2009, 2024} regulation of gene expression^{2011, 2019, 2023, 2024} positive regulation of transcription by RNA polymerase II^{2008, 2017, 2024} positive regulation of protein metabolic process^{2017, 2023, 2024} positive regulation of gene expression^{2017, 2019, 2023, 2024} cholesterol metabolic process^{2012, 2024} Notch signaling pathway²⁰²⁴ suckling behavior^{2005, 2024} positive regulation of NIK/NF-kappaB signaling^{2018, 2020, 2023, 2024} neuromuscular process controlling balance^{2005, 2024} negative regulation of gene expression^{2017, 2019, 2023, 2024} learning or memory^{2015, 2017, 2022, 2023, 2024} cellular response to norepinephrine stimulus^{2011, 2015, 2024} synapse organization^{2008, 2023, 2024} regulation of presynapse assembly²⁰²⁴ positive regulation of tumor necrosis factor production^{2018, 2020, 2024} neuron differentiation^{2010, 2024} negative regulation of neuron differentiation^{2010, 2024} negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway^{2017, 2024} microglial cell activation^{2019, 2024} cellular response to amyloid-beta^{2017, 2023, 2024} astrocyte activation^{2017, 2019, 2024} amyloid fibril formation^{2016, 2022, 2024} synaptic assembly at neuromuscular junction^{2005, 2024} smooth endoplasmic reticulum calcium ion homeostasis^{2005, 2024} response to oxidative stress^{2012, 2024} regulation of spontaneous synaptic transmission^{2023, 2024} regulation of long-term neuronal synaptic plasticity^{2023, 2024} positive regulation of protein phosphorylation^{2017, 2024} positive regulation of long-term synaptic potentiation^{2017, 2024} positive regulation of interleukin-6 production^{2018, 2024} positive regulation of interleukin-1 beta production^{2018, 2024} positive regulation of inflammatory response^{2020, 2024} positive regulation of glycolytic process^{2019, 2024} positive regulation of chemokine production^{2018, 2024} positive regulation of calcium-mediated signaling^{2023, 2024} positive regulation of amyloid fibril formation^{2023, 2024} positive regulation of T cell migration^{2023, 2024} positive regulation of JNK cascade^{2023, 2024} positive regulation of G2/M transition of mitotic cell cycle^{2013, 2024} neuron projection maintenance^{2017, 2024} neuron cellular homeostasis^{2005, 2024} neuron apoptotic process^{2012, 2024} negative regulation of presynapse assembly²⁰²⁴ negative regulation of long-term synaptic potentiation^{2023, 2024} negative regulation of cell population proliferation^{2017, 2024} modulation of excitatory postsynaptic potential^{2017, 2024} mitotic cell cycle^{2005, 2024} microglia development^{2020, 2024} learning^{2022, 2024} gene expression²⁰²⁴ astrocyte activation involved in immune response^{2017, 2024} G2/M transition of mitotic cell cycle^{2013, 2024} regulation of peptidyl-tyrosine phosphorylation^{2017, 2024} positive regulation of peptidyl-threonine phosphorylation^{2023, 2024} positive regulation of peptidyl-serine phosphorylation^{2023, 2024} cell adhesion²⁰²⁴ positive regulation of neuron apoptotic process^{2018, 2023} positive regulation of endothelin production²⁰¹⁸ positive regulation of apoptotic process^{2017, 2019} positive regulation of MAPK cascade^{2017, 2021, 2024} nervous system development^{2003, 2024} innate immune response²⁰¹⁵ convergent extension²⁰¹⁰ antimicrobial humoral immune response mediated by antimicrobial peptide²⁰¹⁷ G protein-coupled receptor signaling pathway^{2001, 2017} vasculature development²⁰¹⁴ response to yeast²⁰¹⁵ response to interleukin-1²⁰¹⁹ regulation of response to calcium ion²⁰¹⁷ regulation of non-motile cilium assembly²⁰²³ regulation of amyloid-beta clearance²⁰²⁰ protein trimerization²⁰²³ protein tetramerization²⁰²³ positive regulation of monocyte chemotaxis²⁰¹⁷ positive regulation of membrane protein ectodomain proteolysis²⁰¹⁷ nematode larval development^{2007, 2024} negative regulation of blood circulation²⁰¹⁸ midbrain development²⁰⁰⁵ memory^{2017, 2022} long-term memory^{2011, 2015} ecdysis, collagen and cuticulin-based cuticle^{2007, 2024} defense response to Gram-positive bacterium²⁰¹⁵ defense response to Gram-negative bacterium²⁰¹⁵ cell differentiation²⁰²⁴ calcium-mediated signaling²⁰¹⁷ body morphogenesis^{2007, 2024} antifungal humoral response²⁰¹⁵ antibacterial humoral response²⁰¹⁵ adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway^{2017, 2024} short-term memory²⁰¹⁵ response to lead ion²⁰¹⁸ response to electrical stimulus²⁰¹⁵ response to axon injury²⁰⁰⁶ response to auditory stimulus²⁰¹⁷ regulation of transcription by RNA polymerase II²⁰²⁰ regulation of toll-like receptor signaling pathway²⁰²³ regulation of neurotransmitter uptake²⁰²⁴ regulation of neuron differentiation²⁰¹⁷ regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway²⁰²³ regulation of dendritic spine maintenance²⁰²³ regulation of cell-cell adhesion²⁰²² regulation of calcium ion transmembrane transport via high voltage-gated calcium channel²⁰¹⁷ regulation of amyloid fibril formation²⁰¹⁷ regulation of Wnt signaling pathway²⁰²³ regulation of Notch signaling pathway²⁰¹⁷ protein homooligomerization²⁰²³ positive regulation of type II interferon production²⁰¹⁹ positive regulation of superoxide anion generation²⁰¹⁷ positive regulation of response to endoplasmic reticulum stress²⁰¹⁷ positive regulation of protein kinase B signaling²⁰²³ positive regulation of protein import²⁰²³ positive regulation of peptidyl-tyrosine phosphorylation²⁰¹⁷ positive regulation of nitric oxide biosynthetic process²⁰²³ positive regulation of neuron differentiation²⁰²¹ positive regulation of extrinsic apoptotic signaling pathway²⁰²³ positive regulation of excitatory postsynaptic potential²⁰¹⁷ positive regulation of cell activation²⁰¹⁷ positive regulation of amyloid precursor protein catabolic process²⁰²⁴ positive regulation of Toll signaling pathway²⁰²⁴ positive regulation of G protein-coupled receptor signaling pathway²⁰¹⁷ positive regulation of G protein-coupled receptor internalization²⁰¹⁷ positive chemotaxis²⁰²⁴ phospholipase D-activating G protein-coupled receptor signaling pathway²⁰²⁴ peripheral nervous system development²⁰⁰⁷ neuron projection morphogenesis²⁰⁰⁶ negative regulation of transcription by RNA polymerase II²⁰¹⁷ negative regulation of protein localization to nucleus²⁰¹⁷ negative regulation of miRNA transcription²⁰²¹ negative regulation of canonical Wnt signaling pathway²⁰¹⁷ mushroom body development²⁰¹⁵ low-density lipoprotein particle mediated signaling²⁰²⁴ long-term synaptic potentiation²⁰¹⁷ lipoprotein metabolic process²⁰¹⁷ chemical synaptic transmission²⁰¹⁷ cellular response to nerve growth factor stimulus²⁰¹⁵ cellular response to manganese ion²⁰¹⁸ cellular response to copper ion²⁰¹⁸ cellular response to cAMP²⁰¹⁵ axon extension²⁰¹⁵ associative learning²⁰¹⁷ animal organ morphogenesis²⁰⁰³ adenylate cyclase-activating G protein-coupled receptor signaling pathway²⁰²⁴ NMDA selective glutamate receptor signaling pathway²⁰²⁴

Cellular component: membrane^{2001, 2003, 2004, 2009, 2012, 2014, 2017, 2024} plasma membrane^{2006, 2010, 2012, 2015, 2017, 2019, 2021, 2023, 2024} Golgi apparatus^{2004, 2006, 2009, 2013, 2021, 2023, 2024} endomembrane system²⁰²⁴ early endosome^{2018, 2021, 2024} cell surface^{2014, 2017, 2018, 2023, 2024} nucleus^{2001, 2018, 2024} membrane raft^{2014, 2023, 2024} Golgi-associated vesicle^{2018, 2024} cytoplasm^{2005, 2009, 2010, 2017, 2019, 2024}
± 65 perinuclear region of cytoplasm^{2005, 2010, 2013, 2024} endoplasmic reticulum^{2021, 2024} neuron projection^{2006, 2010, 2017, 2021, 2024} extracellular region^{2006, 2017, 2024} growth cone^{2015, 2024} endosome^{2014, 2024} axon^{2009, 2014, 2019, 2024} recycling endosome^{2018, 2024} perikaryon²⁰²⁴ clathrin-coated pit²⁰²⁴ cell projection²⁰²⁴ extracellular space^{2014, 2015, 2017, 2021, 2024} cytoplasmic vesicle^{2005, 2009, 2024} synaptic vesicle^{2014, 2018, 2024} receptor complex^{2013, 2024} presynaptic active zone²⁰²⁴ synapse^{2009, 2024} spindle midzone^{2005, 2024} smooth endoplasmic reticulum²⁰²⁴ nucleoplasm^{2023, 2024} nuclear envelope lumen^{2014, 2024} neuromuscular junction^{2005, 2024} intracellular vesicle²⁰²⁴ dendritic spine^{2009, 2024} dendritic shaft^{2009, 2024} dendrite²⁰²⁴ ciliary rootlet^{2006, 2024} cell-cell junction^{2014, 2024} apical part of cell^{2005, 2024} COPII-coated ER to Golgi transport vesicle^{2013, 2024} neuronal cell body^{2010, 2019, 2021, 2024} amyloid-beta complex^{2017, 2018, 2019} spine apparatus²⁰²⁴ vesicle²⁰²⁴ protein-containing complex²⁰¹⁷ lysosome²⁰¹⁷ lipoprotein particle²⁰¹⁷ intermediate-density lipoprotein particle^{2017, 2023} high-density lipoprotein particle^{2017, 2023} extracellular exosome²⁰¹³ endosome to plasma membrane transport vesicle²⁰¹⁷ endoplasmic reticulum lumen²⁰¹⁷ dendrite membrane²⁰¹⁷ very-low-density lipoprotein particle²⁰²³ trans-Golgi network membrane²⁰¹³ terminal bouton²⁰¹⁸ synaptic membrane²⁰¹⁷ presynapse²⁰¹⁷ postsynapse²⁰¹⁷ platelet alpha granule membrane²⁰¹⁵ platelet alpha granule lumen²⁰¹³ neuronal dense core vesicle²⁰²⁴ mitochondrion²⁰¹⁸ mitochondrial inner membrane²⁰²³ main axon²⁰¹⁵ low-density lipoprotein particle²⁰²³ growth cone lamellipodium²⁰¹⁵ growth cone filopodium²⁰¹⁵ external side of plasma membrane²⁰²³ endosome lumen²⁰¹⁸ cytosol²⁰²³ cell body²⁰¹⁷ basement membrane²⁰⁰³ astrocyte projection²⁰¹⁵ Golgi lumen²⁰¹⁶