Collated Gene Ontology terms

Biological process: RNA ligase (GTP) activity(2024, 2025) nucleotide binding(2025) metal ion binding(2025) ligase activity(2025) GTP binding(2025) vinculin binding(2008, 2025) protein guanylyltransferase activity(2025) RNA ligase (ATP) activity(2018, 2025) nuclease activity(2025) hydrolase activity(2025)
endonuclease activity2025 RNA ligase activity2011 RNA binding2014 DNA binding2025

Molecular function: tRNA splicing, via endonucleolytic cleavage and ligation2011, 2014, 2024, 2025 RNA processing2025 tRNA processing2021, 2025 IRE1-mediated unfolded protein response2018, 2025 mRNA splicing, via endonucleolytic cleavage and ligation2025 tRNA exon ligation2025 RNA splicing, via endonucleolytic cleavage and ligation2025 RNA repair2025 placenta development2012 in utero embryonic development2012
vulval development2019 response to bacterium2020 response to antibiotic2019 positive regulation of transporter activity2019 positive regulation of tRNA processing2016 intron homing2025 intein-mediated protein splicing2025 germ cell development2019

Cellular component: tRNA-splicing ligase complex2011, 2014, 2015, 2018, 2025 nucleus2014, 2015, 2025 cytoplasm2012, 2014, 2015, 2025 nucleoplasm2015, 2024, 2025 cytosol2024, 2025 catalytic complex2025 nuclear envelope2020, 2025 endoplasmic reticulum membrane2020, 2025 peptidoglycan-based cell wall2012 extracellular region2010

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 4/39 
Archea: 8/8 
Bacteria: 8/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
F1NYI3_CHICK
Ensembl»
1.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Gallus gallus
TI:9031 None
   
RTCB_CAEEL
WormBase»
5.0
rtcb-1 RNA-splicing ligase rtcb-1 (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Caenorhabditis elegans
TI:6239 None
 
RTCB_DANRE
ZFIN»
2.0
rtcb RNA-splicing ligase RTCB (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic
acid ligase) (RNA 2',3'-cyclic phosphate and 5'-OH ligase)		 Danio rerio
TI:7955 None
 
RTCB_DICDI
dictyBase»
1.5
DDB_G0278481 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Dictyostelium discoideum
TI:44689 None
 
RTCB_DROME
FlyBase»
2.6
RtcB RNA-splicing ligase RtcB (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Drosophila melanogaster
TI:7227 None
 
RTCB_HUMAN
Ensembl»
10.9
RTCB RNA-splicing ligase RTCB (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic
acid ligase) (RNA 2',3'-cyclic phosphate and 5'-OH ligase)		 Homo sapiens
TI:9606 None
 
RTCB_MOUSE
Ensembl»
7.6
Rtcb RNA-splicing ligase RTCB (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)
(Focal adhesion-associated protein) (FAAP) (RNA 2',3'-cyclic phosphate and 5'-OH ligase)		 Mus musculus
TI:10090 None
 
RTCB_RAT
RGD»
7.0
Rtcb RNA-splicing ligase RTCB (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid
ligase) (RNA 2',3'-cyclic phosphate and 5'-OH ligase) (p55)		 Rattus norvegicus
TI:10116 None