Collated Gene Ontology terms

Biological process: RNA ligase (GTP) activity(2024) metal ion binding(2024) ligase activity(2024) GTP binding(2024) RNA ligase (ATP) activity(2014, 2018, 2024) vinculin binding(2008, 2024) microtubule motor activity(2024) microtubule binding(2024) endonuclease activity(2024) cytoskeletal motor activity(2024)
RNA ligase activity2011 RNA binding2014 DNA binding2024 ATP binding2024

Molecular function: tRNA splicing, via endonucleolytic cleavage and ligation2011, 2014, 2022, 2024 tRNA processing2021, 2024 RNA processing2024 placenta development2012, 2024 in utero embryonic development2012, 2024 RNA repair2024 vulval development2019 response to bacterium2020 response to antibiotic2019 positive regulation of tRNA processing2016
microtubule-based movement2024 intron homing2024 intein-mediated protein splicing2024 germ cell development2019

Cellular component: tRNA-splicing ligase complex2011, 2014, 2015, 2018, 2022, 2024 nucleus2014, 2015, 2022, 2023, 2024 cytoplasm2012, 2014, 2015, 2022, 2024 nucleoplasm2015, 2023, 2024 intracellular membrane-bounded organelle2023, 2024 cytosol2023, 2024 nuclear envelope2020, 2024 endoplasmic reticulum membrane2020, 2024 peptidoglycan-based cell wall2012 microtubule2024
extracellular region2010 cytoskeleton2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 4/39 
Archea: 8/8 
Bacteria: 8/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
G1KQE8_ANOCA
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Anolis carolinensis
TI:28377 None
   
RTCB_ANOGA
EnsemblMetazoa»
0.0
AGAP008147 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Anopheles gambiae
TI:7165 None
 
O66450_AQUAE
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Aquifex aeolicus
TI:63363 None
 
RTCB_BOVIN
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Bos taurus
TI:9913 None
 
A0A9J7L5T2_BRAFL
CTD»
0.0
LOC118415876 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Branchiostoma floridae
TI:7739 None
   
RTCB_BRAFL
CTD»
0.0
BRAFLDRAFT_216547 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Branchiostoma floridae
TI:7739 None
 
A8Y1R5_CAEBR
WormBase»
0.0
rtcb-1 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Caenorhabditis briggsae
TI:6238 None
 
RTCB_CAEEL
WormBase»
2.9
rtcb-1 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Caenorhabditis elegans
TI:6239 None
 
A0A8I3N8Q9_CANLF
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Canis lupus
TI:9612 None
   
A0A8I3PDZ7_CANLF
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Canis lupus
TI:9612 None
   
A0A2K3D806_CHLRE
EnsemblPlants»
0.0
CHLRE_11g467766v5 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Chlamydomonas reinhardtii
TI:3055 None
 
F6YQL6_CIOIN
Ensembl»
0.0
LOC100176177 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Ciona intestinalis
TI:7719 None
 
RTCB_DANRE
ZFIN»
1.5
rtcb RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Danio rerio
TI:7955 None
 
E9HNI6_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_302483 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Daphnia pulex
TI:6669 None
 
B8DYS7_DICTD
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Dictyoglomus turgidum
TI:513050 None
 
F1A5K8_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_90903 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Dictyostelium purpureum
TI:5786 None
 
RTCB_DICDI
dictyBase»
1.0
DDB_G0278481 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Dictyostelium discoideum
TI:44689 None
 
RTCB_DROME
FlyBase»
2.1
RtcB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Drosophila melanogaster
TI:7227 None
 
RTCB1_ENTH1
VEuPathDB»
0.0
EHI_169260 RNA-splicing ligase RtcB homolog 1 (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase 1)		 Entamoeba histolytica
TI:5759 None
 
RTCB2_ENTH1
VEuPathDB»
0.0
EHI_184560 RNA-splicing ligase RtcB homolog 2 (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase 2)		 Entamoeba histolytica
TI:5759 None
 
F6WLX9_HORSE
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Equus caballus
TI:9796 None
   
M3XE87_FELCA
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Felis catus
TI:9685 None
 
F1NYI3_CHICK
Ensembl»
0.5
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Gallus gallus
TI:9031 None
   
Q74CI9_GEOSL
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Geobacter sulfurreducens
TI:35554 None
 
G3R6Z5_GORGO
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Gorilla gorilla
TI:9593 None
 
Q9HPV7_HALSA
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Halobacterium salinarum
TI:2242 None
 
T1FM25_HELRO
EnsemblMetazoa»
0.0
20209874 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Helobdella robusta
TI:6412 None
 
RTCB_HUMAN
Ensembl»
4.8
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Homo sapiens
TI:9606 None
 
B7PR26_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW005780 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Ixodes scapularis
TI:6945 None
 
B7Q1D5_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW024552 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Ixodes scapularis
TI:6945 None
 
B1L6S4_KORCO
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Korarchaeum cryptofilum
TI:498846 None
 
W5NIE6_LEPOC
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Lepisosteus oculatus
TI:7918 None
 
F7HFI7_MACMU
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Macaca mulatta
TI:9544 None
 
A0A2R6X620_MARPO
EnsemblPlants»
0.0
MARPO_0034s0109 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Marchantia polymorpha
TI:3197 None
 
RTCB_METJA
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid
ligase) [Cleaved into: Mja hyp2 intein (EC 3.1.-.-)]		 Methanocaldococcus jannaschii
TI:2190 None
 
Q8TU09_METAC
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Methanosarcina acetivorans
TI:2214 None
 
F7BCY1_MONDO
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Monodelphis domestica
TI:13616 None
   
RTCB_MONBE
EnsemblProtists»
0.0
24995 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Monosiga brevicollis
TI:81824 None
 
RTCB_MOUSE
Ensembl»
2.6
Rtcb RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy
nucleic acid ligase) (Focal adhesion-associated protein) (FAAP)		 Mus musculus
TI:10090 None
 
RTCB_MYCTU
TubercuList»
0.0
rtcB RNA-splicing ligase RtcB (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Mycobacterium tuberculosis
TI:1773 None
 
A7TAI1_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g9434 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Nematostella vectensis
TI:45351 None
 
RTCB_NEMVE
EnsemblMetazoa»
0.0
v1g198406 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Nematostella vectensis
TI:45351 None
 
A9A3T7_NITMS
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Nitrosopumilus maritimus
TI:338192 None
 
F6X5L9_ORNAN
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Ornithorhynchus anatinus
TI:9258 None
   
H2N0L9_ORYLA
Ensembl»
0.0
rtcb RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Oryzias latipes
TI:8090 None
   
H2QLJ4_PANTR
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Pan troglodytes
TI:9598 None
 
A9SFZ7_PHYPA
EnsemblPlants»
0.0
PHYPA_004291 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Physcomitrium patens
TI:3218 None
 
RTCB_PLAF7
EnsemblProtists»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Plasmodium falciparum
TI:5833 None
 
Q9HT99_PSEAE
EnsemblBacteria»
0.0
PA5471 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Pseudomonas aeruginosa
TI:287 None
 
RTCB_PYRAE
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic
acid ligase) (Archaeal 3'-phosphate RNA splicing ligase)		 Pyrobaculum aerophilum
TI:13773 None
 
A0A8I5YBA4_RAT
RGD»
0.0
Rtcb-ps1 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Rattus norvegicus
TI:10116 None
   
RTCB_RAT
RGD»
4.0
Rtcb RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase) (p55)		 Rattus norvegicus
TI:10116 None
 
Q7ULP9_RHOBA
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Rhodopirellula baltica
TI:265606 None
 
Q7URB3_RHOBA
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Rhodopirellula baltica
TI:265606 None
 
Q97ZF2_SACS2
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Saccharolobus solfataricus
TI:2287 None
 
D8SNU5_SELML
EnsemblPlants»
0.0
SELMODRAFT_2909 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Selaginella moellendorffii
TI:88036 None
 
D8SS91_SELML
EnsemblPlants»
0.0
SELMODRAFT_2870 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Selaginella moellendorffii
TI:88036 None
 
A0A7M7MZ40_STRPU
EnsemblMetazoa»
0.0
RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Strongylocentrotus purpuratus
TI:7668 None
   
F2Z5V0_PIG
Ensembl»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Sus scrofa
TI:9823 None
 
RTCB_PIG
CTD»
0.0
RTCB RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Sus scrofa
TI:9823 None
 
RTCB_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_41953 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Thalassiosira pseudonana
TI:35128 None
 
RTCB_THEKO
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Thermococcus kodakarensis
TI:311400 None
 
B5YH51_THEYD
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Thermodesulfovibrio yellowstonii
TI:28262 None
 
Q9X178_THEMA
EnsemblBacteria»
0.0
rtcB tRNA-splicing ligase RtcB (EC 6.5.1.-) Thermotoga maritima
TI:2336 None
 
D6X2M2_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_10635 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Tribolium castaneum
TI:7070 None
 
A2DG81_TRIV3
VEuPathDB»
0.0
TVAG_164040 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Trichomonas vaginalis
TI:5722 None
 
A2DG82_TRIV3
VEuPathDB»
0.0
TVAG_164050 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Trichomonas vaginalis
TI:5722 None
 
A2EGQ0_TRIV3
VEuPathDB»
0.0
TVAG_302250 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Trichomonas vaginalis
TI:5722 None
 
A2FD12_TRIV3
VEuPathDB»
0.0
TVAG_218190 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Trichomonas vaginalis
TI:5722 None
 
A2FSC4_TRIV3
VEuPathDB»
0.0
TVAG_386070 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Trichomonas vaginalis
TI:5722 None
 
A2G6F6_TRIV3
VEuPathDB»
0.0
TVAG_285740 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Trichomonas vaginalis
TI:5722 None
 
A2G6F7_TRIV3
VEuPathDB»
0.0
TVAG_285750 3'-phosphate/5'-hydroxy nucleic acid
ligase (EC 6.5.1.8)		 Trichomonas vaginalis
TI:5722 None
 
RTCB_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_18395 RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Trichoplax adhaerens
TI:10228 None
 
A0A1L8GQR4_XENLA
Xenbase»
0.0
rtcb.S RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Xenopus laevis
TI:8355 None
   
A0A8J1IYZ0_XENTR
Xenbase»
0.0
LOC100494536 Kinesin-like protein Xenopus tropicalis
TI:8364 None
   
Q05AW6_XENLA
Xenbase»
0.0
rtcb.L RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Xenopus laevis
TI:8355 None
 
RTCB_XENTR
Xenbase»
0.0
rtcb RNA-splicing ligase RtcB homolog (EC
6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)		 Xenopus tropicalis
TI:8364 None