Biological process: calcium ion binding⁽²⁰²⁵⁾ Wnt-protein binding^{(2010, 2016, 2025)} Wnt receptor activity^{(2007, 2010, 2016, 2018, 2024, 2025)} growth factor activity^{(2010, 2023, 2025)} coreceptor activity^{(2021, 2023, 2025)} toxin transmembrane transporter activity^{(2010, 2025)} collagen binding^{(2003, 2010, 2014, 2025)} epidermal growth factor receptor binding^{(2005, 2007, 2009, 2016, 2025)} receptor ligand activity^{(2021, 2022, 2023, 2025)} transmembrane receptor protein tyrosine kinase activator activity^{(2009, 2021, 2025)}
± 26 laminin binding^{2014, 2025} guanyl-nucleotide exchange factor activity^{2018, 2025} signaling receptor binding^{2010, 2025} protein serine/threonine kinase inhibitor activity²⁰²⁵ protein homodimerization activity^{2010, 2025} low-density lipoprotein particle receptor activity^{2006, 2025} kinase inhibitor activity^{2010, 2025} identical protein binding²⁰²⁵ frizzled binding^{2011, 2025} proteoglycan binding^{2014, 2025} laminin-1 binding^{2010, 2025} extracellular matrix binding^{2008, 2025} extracellular matrix structural constituent^{2010, 2018, 2019, 2020, 2025} serine-type endopeptidase activity²⁰²⁵ serine-type peptidase activity²⁰²⁵ peptidase activity²⁰²⁵ hydrolase activity²⁰²⁵ apolipoprotein binding^{2020, 2021} cargo receptor activity^{2021, 2024} protein kinase activity²⁰²⁵ peroxidase activity²⁰²⁵ oxidoreductase activity²⁰²⁵ nucleotide binding²⁰²⁵ iodide peroxidase activity²⁰²⁵ extracellular ligand-gated monoatomic ion channel activity²⁰²⁵ ATP binding²⁰²⁵

Molecular function: endocytosis²⁰²⁵ canonical Wnt signaling pathway^{2010, 2016, 2018, 2019, 2021, 2023, 2025} positive regulation of cell population proliferation^{2007, 2010, 2011, 2016, 2023, 2025} cell-matrix adhesion^{2002, 2008, 2020, 2025} Wnt signaling pathway^{2010, 2015, 2022, 2025} positive regulation of transcription by RNA polymerase II^{2024, 2025} positive regulation of MAPK cascade^{2021, 2023, 2024, 2025} epidermal growth factor receptor signaling pathway^{2007, 2021, 2022, 2023, 2025} cell adhesion^{2003, 2025} positive regulation of DNA-templated transcription^{2010, 2011, 2025}
± 209 nervous system development²⁰²⁵ tissue development²⁰²⁵ positive regulation of mitotic nuclear division^{2007, 2010, 2025} system development²⁰²⁵ dopaminergic neuron differentiation^{2010, 2016, 2025} vesicle-mediated transport²⁰²⁵ regulation of apoptotic process^{2010, 2025} transmembrane transport²⁰²⁵ positive regulation of cell cycle^{2010, 2025} midbrain development^{2010, 2025} Norrin signaling pathway^{2019, 2025} chordate embryonic development²⁰²⁵ anatomical structure formation involved in morphogenesis²⁰²⁵ retinal blood vessel morphogenesis^{2011, 2016, 2025} regulation of receptor signaling pathway via JAK-STAT^{2011, 2025} ERBB2-EGFR signaling pathway^{2021, 2022, 2025} retina morphogenesis in camera-type eye^{2009, 2010, 2025} positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction^{2020, 2025} positive regulation of mesenchymal cell proliferation^{2010, 2025} regulation of protein localization to cell surface^{2010, 2025} regulation of calcium ion import^{2010, 2025} positive regulation of receptor internalization^{2016, 2025} positive regulation of protein localization to early endosome^{2018, 2025} positive regulation of phosphorylation^{2007, 2025} positive regulation of hyaluronan biosynthetic process^{2012, 2025} positive regulation of gene expression^{2017, 2025} positive regulation of epithelial tube formation^{2020, 2025} positive regulation of endothelial cell proliferation^{2020, 2025} positive regulation of endothelial cell migration^{2020, 2025} positive regulation of cell migration^{2017, 2025} positive regulation of canonical Wnt signaling pathway^{2010, 2025} negative regulation of secretion^{2008, 2025} bone development^{2010, 2025} animal organ development²⁰²⁵ angiogenesis^{2007, 2025} ERK1 and ERK2 cascade^{2011, 2025} regulation of blood pressure^{2010, 2025} protein localization to plasma membrane^{2015, 2025} positive regulation of fat cell differentiation^{2010, 2025} neural crest formation^{2011, 2025} neural crest cell differentiation^{2010, 2025} negative regulation of smooth muscle cell apoptotic process^{2010, 2025} negative regulation of osteoblast differentiation^{2010, 2025} glucose catabolic process^{2010, 2025} cholesterol homeostasis^{2010, 2025} cellular response to cholesterol^{2010, 2025} bone morphogenesis^{2010, 2025} bone marrow development^{2010, 2025} adipose tissue development^{2010, 2025} regulation of transport²⁰²⁵ regulation of primary metabolic process²⁰²⁵ positive regulation of ubiquitin-dependent protein catabolic process^{2011, 2025} positive regulation of macromolecule metabolic process²⁰²⁵ negative regulation of cholesterol efflux^{2011, 2025} positive regulation of osteoblast differentiation^{2018, 2025} basement membrane organization^{2014, 2016, 2018, 2025} anatomical structure morphogenesis²⁰²⁵ extracellular matrix-cell signaling^{2010, 2025} small molecule metabolic process²⁰²⁵ regulation of osteoblast differentiation²⁰²⁵ positive regulation of cell differentiation²⁰²⁵ extracellular matrix organization^{2008, 2025} retina vasculature morphogenesis in camera-type eye^{2010, 2021, 2025} proteolysis²⁰²⁵ embryonic digit morphogenesis^{2004, 2010, 2025} bone remodeling^{2010, 2019, 2025} animal organ morphogenesis²⁰²⁵ gastrulation with mouth forming second^{2004, 2025} establishment of blood-retinal barrier^{2022, 2025} establishment of blood-brain barrier^{2022, 2025} cell migration involved in gastrulation^{2004, 2025} branching involved in mammary gland duct morphogenesis^{2010, 2025} response to peptide hormone^{2008, 2010, 2025} positive regulation of DNA binding²⁰¹¹ limb morphogenesis²⁰¹⁰ epithelial cell differentiation²⁰²⁵ cell-cell adhesion^{2010, 2022, 2025} anterior/posterior pattern specification²⁰²⁰ ventral cord development^{2018, 2025} positive regulation of anterior/posterior axon guidance^{2018, 2025} mammary gland duct morphogenesis²⁰¹⁰ synaptic transmission, cholinergic^{2010, 2025} synapse organization^{2010, 2025} spermatogenesis²⁰²⁵ regulation of basement membrane organization^{2019, 2024} regulation of DNA-templated transcription^{2010, 2025} receptor-mediated endocytosis²⁰²³ protein localization to synapse^{2010, 2025} post-anal tail morphogenesis²⁰¹² positive regulation of peptidyl-threonine phosphorylation^{2011, 2025} positive regulation of cytosolic calcium ion concentration^{2010, 2025} phagocytosis²⁰²¹ oogenesis²⁰²⁵ neuron migration^{2010, 2025} neural tube closure²⁰¹⁰ interneuron axon guidance^{2016, 2025} embryonic hindlimb morphogenesis²⁰¹⁰ embryonic forelimb morphogenesis^{2005, 2010} chemical synaptic transmission^{2010, 2025} cell differentiation²⁰²⁵ amyloid-beta clearance by transcytosis²⁰²¹ amyloid-beta clearance by cellular catabolic process²⁰²¹ vasculature development²⁰¹⁰ trachea cartilage morphogenesis²⁰¹⁰ thalamus development²⁰¹⁰ somitogenesis²⁰¹⁰ somatic stem cell population maintenance²⁰¹⁰ skeletal system morphogenesis²⁰¹⁰ signal transduction²⁰²⁵ roof of mouth development²⁰¹⁰ retina vasculature development in camera-type eye²⁰²² response to folic acid²⁰¹⁰ regulation of protein transport²⁰¹¹ regulation of peptidyl-tyrosine phosphorylation²⁰⁰³ regulation of insulin secretion involved in cellular response to glucose stimulus²⁰¹⁰ regulation of cell population proliferation²⁰¹⁰ regulation of cell development²⁰¹⁰ receptor-mediated endocytosis involved in cholesterol transport²⁰¹⁰ primitive streak formation²⁰¹⁰ positive regulation of skeletal muscle acetylcholine-gated channel clustering²⁰¹⁵ positive regulation of protein tyrosine kinase activity²⁰¹⁶ positive regulation of peptidyl-tyrosine phosphorylation²⁰¹⁵ positive regulation of osteoblast proliferation²⁰¹⁰ positive regulation of ossification²⁰¹⁰ positive regulation of neuron projection development²⁰¹⁷ positive regulation of muscle cell differentiation²⁰²⁴ positive regulation of integrin-mediated signaling pathway²⁰²⁴ positive regulation of fibroblast proliferation^{2015, 2025} positive regulation of cerebellar granule cell precursor proliferation²⁰⁰⁶ positive regulation of cell adhesion²⁰²⁴ positive regulation of bone resorption²⁰¹⁰ positive regulation of apoptotic process²⁰¹⁰ positive regulation of ERK1 and ERK2 cascade^{2018, 2025} positive regulation of DNA biosynthetic process^{2015, 2025} pericardium morphogenesis²⁰¹⁰ peptidyl-tyrosine phosphorylation²⁰⁰⁴ osteoblast development²⁰¹⁰ odontogenesis of dentin-containing tooth²⁰¹⁰ neural tube development²⁰¹⁰ negative regulation of non-canonical Wnt signaling pathway²⁰¹⁰ negative regulation of fat cell differentiation²⁰¹⁰ negative regulation of epithelial cell proliferation²⁰¹⁰ midbrain-hindbrain boundary development²⁰¹⁰ mesodermal cell migration²⁰²⁵ mammary placode formation²⁰¹⁰ mammary gland alveolus development²⁰⁰⁹ liver development²⁰¹⁴ heart looping²⁰¹⁰ generation of neurons²⁰¹⁰ gene expression²⁰²² formation of radial glial scaffolds²⁰¹⁰ forebrain radial glial cell differentiation²⁰¹⁰ forebrain generation of neurons²⁰¹⁰ forebrain development²⁰⁰⁵ face morphogenesis²⁰¹⁰ external genitalia morphogenesis²⁰¹⁰ embryonic retina morphogenesis in camera-type eye²⁰¹⁰ embryonic pattern specification²⁰¹⁰ embryonic limb morphogenesis²⁰¹⁰ embryonic camera-type eye morphogenesis²⁰¹⁰ dorsal/ventral axis specification²⁰²⁰ convergent extension²⁰¹⁰ cholesterol metabolic process²⁰¹⁰ cerebral cortex development²⁰¹⁰ cerebral cortex cell migration²⁰¹⁰ cerebellum morphogenesis²⁰¹⁰ cell-cell signaling²⁰¹⁰ cartilage development^{2014, 2023} branching morphogenesis of an epithelial tube²⁰⁰⁵ blood vessel morphogenesis²⁰²² axis elongation involved in somitogenesis²⁰¹⁰ axis elongation²⁰¹⁰ apoptotic process involved in blood vessel morphogenesis²⁰¹³ anatomical structure regression²⁰¹⁰ amino acid transport²⁰²² triglyceride homeostasis²⁰¹⁸ synaptic assembly at neuromuscular junction²⁰²⁵ sensory perception of sound²⁰¹⁸ segment polarity determination²⁰¹⁷ regulation of multicellular organismal process²⁰²⁵ regulation of compound eye pigmentation²⁰⁰⁷ regulation of bone resorption²⁰²³ regulation of bone mineralization²⁰²³ regulation of Wnt signaling pathway²⁰²³ presynaptic active zone organization²⁰²⁵ posterior lateral line neuromast hair cell development²⁰¹⁸ positive regulation of circadian sleep/wake cycle, sleep²⁰¹⁸ positive regulation of cell-substrate adhesion²⁰⁰⁸ otolith morphogenesis²⁰¹⁸ neural crest cell migration²⁰¹⁶ monoatomic ion transport²⁰²⁵ monoatomic ion transmembrane transport²⁰²⁵ midbrain dopaminergic neuron differentiation²⁰¹⁶ long-term memory²⁰¹³ leg disc pattern formation²⁰¹⁷ kidney development²⁰¹⁵ intracellular signal transduction²⁰⁰⁵ imaginal disc-derived wing margin morphogenesis²⁰¹⁷ homophilic cell adhesion via plasma membrane adhesion molecules²⁰²⁵ glomerular basement membrane development²⁰¹² fin regeneration²⁰²³ embryonic viscerocranium morphogenesis²⁰¹⁶ compound eye morphogenesis²⁰⁰⁶ cellular oxidant detoxification²⁰²⁵ cell elongation involved in imaginal disc-derived wing morphogenesis²⁰¹⁷ bone mineralization²⁰²³ blood circulation²⁰¹⁴ basement membrane assembly involved in embryonic body morphogenesis²⁰¹⁹ anterior lateral line neuromast hair cell development²⁰¹⁸

Cellular component: plasma membrane^{2003, 2008, 2010, 2016, 2021, 2023, 2024, 2025} basement membrane^{2000, 2002, 2003, 2008, 2010, 2011, 2012, 2014, 2017, 2019, 2020, 2024, 2025} membrane^{2012, 2025} cell periphery^{2012, 2025} endoplasmic reticulum²⁰²⁵ extracellular space^{2014, 2015, 2020, 2022, 2025} extracellular region^{2008, 2012, 2013, 2014, 2025} extracellular matrix^{2006, 2018, 2025} early endosome^{2007, 2010, 2013, 2025} Wnt-Frizzled-LRP5/6 complex^{2015, 2016, 2021, 2025}
± 21 membrane raft²⁰²⁵ extracellular exosome^{2014, 2025} cell surface^{2010, 2011, 2025} Wnt signalosome^{2015, 2016, 2021, 2025} receptor complex^{2011, 2025} cytoplasmic vesicle^{2014, 2025} caveola^{2010, 2025} Golgi apparatus^{2013, 2025} synapse²⁰²⁵ neuronal cell body^{2008, 2025} basal part of cell^{2010, 2025} synaptic membrane²⁰¹⁷ presynaptic periactive zone²⁰²⁵ presynaptic membrane²⁰²⁵ platelet alpha granule lumen²⁰¹³ mitochondrion²⁰⁰⁷ lysosomal membrane²⁰¹³ late endosome²⁰⁰⁷ early endosome membrane²⁰¹⁴ clathrin-coated endocytic vesicle membrane²⁰¹⁹ axon terminus²⁰¹⁷