Biological process: Wnt-protein binding^{(2010, 2016, 2022, 2024)} Wnt receptor activity^{(2007, 2010, 2016, 2018, 2022, 2024)} calcium ion binding⁽²⁰²⁴⁾ coreceptor activity^{(2021, 2023, 2024)} growth factor activity^{(2010, 2023, 2024)} protein homodimerization activity^{(2010, 2011, 2024)} transmembrane receptor protein tyrosine kinase activator activity^{(2009, 2021, 2023, 2024)} receptor ligand activity^{(2021, 2023, 2024)} low-density lipoprotein particle receptor activity^{(2006, 2021, 2024)} toxin transmembrane transporter activity^{(2010, 2024)}
± 25 epidermal growth factor receptor binding^{2005, 2007, 2009, 2016, 2024} receptor tyrosine kinase binding^{2011, 2013, 2015, 2024} collagen binding^{2010, 2014, 2024} signaling receptor binding^{2010, 2024} kinase inhibitor activity^{2010, 2024} identical protein binding²⁰²⁴ guanyl-nucleotide exchange factor activity^{2018, 2024} frizzled binding^{2011, 2024} proteoglycan binding^{2014, 2024} laminin binding^{2014, 2024} laminin-1 binding^{2010, 2024} extracellular matrix binding^{2008, 2024} serine-type endopeptidase activity²⁰²⁴ extracellular matrix structural constituent^{2010, 2018, 2019, 2024} apolipoprotein binding^{2013, 2020, 2021, 2024} serine-type peptidase activity²⁰²⁴ scaffold protein binding^{2013, 2024} lipoprotein particle binding²⁰²³ cargo receptor activity²⁰²¹ protein kinase activity²⁰²⁴ peroxidase activity²⁰²⁴ iodide peroxidase activity²⁰²⁴ extracellular ligand-gated monoatomic ion channel activity²⁰²⁴ G protein-coupled receptor activity²⁰²⁴ ATP binding²⁰²⁴

Molecular function: canonical Wnt signaling pathway^{2010, 2011, 2016, 2018, 2019, 2021, 2023, 2024} endocytosis²⁰²⁴ Wnt signaling pathway^{2015, 2019, 2022, 2024} positive regulation of cell population proliferation^{2007, 2010, 2011, 2016, 2023, 2024} positive regulation of DNA-templated transcription^{2010, 2011, 2024} positive regulation of MAPK cascade^{2021, 2023, 2024} cell-matrix adhesion^{2002, 2024} epidermal growth factor receptor signaling pathway^{2007, 2022, 2023, 2024} cell adhesion²⁰²⁴ positive regulation of transcription by RNA polymerase II^{2011, 2024}
± 239 positive regulation of DNA-binding transcription factor activity^{2010, 2011, 2024} embryonic digit morphogenesis^{2004, 2006, 2010, 2024} positive regulation of mitotic nuclear division^{2007, 2010, 2024} nervous system development²⁰²⁴ negative regulation of protein serine/threonine kinase activity^{2010, 2024} positive regulation of peptidyl-tyrosine phosphorylation^{2015, 2024} negative regulation of canonical Wnt signaling pathway^{2015, 2021, 2024} bone remodeling^{2010, 2019, 2024} anterior/posterior pattern specification^{2020, 2024} Norrin signaling pathway^{2019, 2024} retinal blood vessel morphogenesis^{2011, 2016, 2024} retina vasculature morphogenesis in camera-type eye^{2010, 2021, 2024} regulation of receptor signaling pathway via JAK-STAT^{2011, 2024} limb morphogenesis^{2010, 2024} gastrulation with mouth forming second^{2004, 2024} cholesterol homeostasis^{2010, 2021, 2024} branching involved in mammary gland duct morphogenesis^{2010, 2024} retina morphogenesis in camera-type eye^{2009, 2010, 2024} positive regulation of mesenchymal cell proliferation^{2010, 2024} mesodermal cell migration^{2004, 2024} mammary gland duct morphogenesis^{2010, 2024} establishment of blood-retinal barrier^{2022, 2024} establishment of blood-brain barrier^{2022, 2024} cell-cell adhesion^{2010, 2022, 2024} cell migration involved in gastrulation^{2004, 2024} bone morphogenesis^{2010, 2024} ERBB2-EGFR signaling pathway^{2021, 2024} regulation of insulin secretion involved in cellular response to glucose stimulus^{2010, 2024} positive regulation of skeletal muscle acetylcholine-gated channel clustering^{2015, 2023, 2024} positive regulation of osteoblast differentiation^{2018, 2024} osteoblast development^{2010, 2024} bone marrow development^{2010, 2024} adipose tissue development^{2010, 2024} vasculature development^{2010, 2024} somatic stem cell population maintenance^{2010, 2024} retina vasculature development in camera-type eye^{2022, 2024} regulation of blood pressure^{2010, 2024} regulation of apoptotic process^{2010, 2024} positive regulation of protein kinase B signaling^{2020, 2024} positive regulation of osteoblast proliferation^{2010, 2024} positive regulation of fat cell differentiation^{2010, 2024} osteoblast proliferation^{2010, 2024} negative regulation of osteoblast differentiation^{2010, 2024} glucose catabolic process^{2010, 2024} gene expression^{2022, 2024} extracellular matrix-cell signaling^{2010, 2024} cholesterol metabolic process^{2010, 2024} cell-cell signaling involved in mammary gland development^{2010, 2024} bone development^{2010, 2024} blood vessel morphogenesis^{2022, 2024} apoptotic process involved in blood vessel morphogenesis^{2013, 2024} anatomical structure regression^{2010, 2024} amino acid transport^{2022, 2024} transmembrane transport²⁰²⁴ synaptic assembly at neuromuscular junction^{2007, 2013, 2024} synapse organization^{2010, 2013, 2023, 2024} regulation of protein localization to cell surface^{2010, 2024} regulation of calcium ion import^{2010, 2024} protein localization to plasma membrane^{2015, 2024} positive regulation of receptor internalization^{2016, 2024} positive regulation of protein localization to early endosome^{2018, 2024} positive regulation of phosphorylation^{2007, 2024} positive regulation of hyaluronan biosynthetic process^{2012, 2024} positive regulation of gene expression^{2017, 2024} positive regulation of epithelial tube formation^{2020, 2024} positive regulation of endothelial cell proliferation^{2020, 2024} positive regulation of endothelial cell migration^{2020, 2024} positive regulation of cell migration^{2017, 2024} positive regulation of cell cycle^{2010, 2024} positive regulation of canonical Wnt signaling pathway^{2010, 2024} odontogenesis of dentin-containing tooth^{2007, 2010, 2024} neural crest formation^{2011, 2024} neural crest cell differentiation^{2010, 2024} negative regulation of smooth muscle cell apoptotic process^{2010, 2024} negative regulation of secretion^{2008, 2024} kidney development^{2007, 2013, 2015, 2024} enzyme-linked receptor protein signaling pathway^{2023, 2024} embryonic limb morphogenesis^{2007, 2010, 2024} cellular response to cholesterol^{2010, 2024} angiogenesis^{2007, 2024} amyloid-beta clearance by cellular catabolic process^{2018, 2021, 2024} ERK1 and ERK2 cascade^{2011, 2024} skeletal muscle acetylcholine-gated channel clustering^{2013, 2024} regulation of postsynapse assembly²⁰²⁴ presynaptic membrane assembly^{2013, 2024} postsynaptic membrane assembly^{2013, 2024} positive regulation of ubiquitin-dependent protein catabolic process^{2011, 2024} positive regulation of presynaptic membrane organization^{2013, 2024} positive regulation of peptidyl-threonine phosphorylation^{2011, 2024} positive regulation of epithelial cell proliferation^{2005, 2024} positive regulation of cerebellar granule cell precursor proliferation^{2006, 2024} negative regulation of cholesterol efflux^{2011, 2024} negative regulation of axonogenesis^{2013, 2024} mammary gland alveolus development^{2009, 2024} epithelial cell proliferation^{2005, 2024} cerebellar granule cell precursor proliferation^{2006, 2024} cell population proliferation^{2005, 2024} branching morphogenesis of an epithelial tube^{2005, 2024} receptor clustering^{2007, 2024} proximal/distal pattern formation^{2020, 2024} protein localization^{2007, 2024} positive regulation of cell-substrate adhesion^{2008, 2024} positive regulation of Rac protein signal transduction^{2023, 2024} negative regulation of ossification^{2011, 2024} limb development^{2013, 2024} hair follicle development^{2007, 2024} glomerular basement membrane development^{2012, 2024} extracellular matrix organization^{2008, 2024} dorsal/ventral pattern formation^{2020, 2024} regulation of protein phosphorylation^{2011, 2024} proteolysis²⁰²⁴ generation of neurons^{2010, 2023} animal organ development²⁰²⁴ spermatogenesis²⁰²⁴ receptor-mediated endocytosis involved in cholesterol transport^{2010, 2021, 2024} positive regulation of DNA binding²⁰¹¹ oogenesis²⁰²⁴ vesicle-mediated transport²⁰²⁴ response to peptide hormone^{2008, 2010, 2024} ventral cord development^{2018, 2024} positive regulation of anterior/posterior axon guidance^{2018, 2024} liver development^{2014, 2024} chemical synaptic transmission^{2010, 2024} cell differentiation²⁰²⁴ cartilage development^{2014, 2023, 2024} Wnt signaling pathway involved in somitogenesis^{2010, 2024} synaptic transmission, cholinergic^{2010, 2024} sensory perception of sound^{2018, 2024} regulation of bone resorption^{2023, 2024} regulation of bone mineralization^{2023, 2024} regulation of basement membrane organization^{2017, 2019} regulation of Wnt signaling pathway^{2023, 2024} protein localization to synapse^{2010, 2024} posterior lateral line neuromast hair cell development^{2018, 2024} post-anal tail morphogenesis²⁰¹² otolith morphogenesis^{2018, 2024} neuron migration^{2010, 2024} neural tube closure²⁰¹⁰ neural crest cell migration^{2016, 2024} interneuron axon guidance^{2016, 2024} fin regeneration^{2023, 2024} embryonic viscerocranium morphogenesis^{2016, 2024} embryonic hindlimb morphogenesis^{2005, 2010} embryonic forelimb morphogenesis²⁰¹⁰ dopaminergic neuron differentiation^{2010, 2016} dendrite morphogenesis^{2013, 2024} bone mineralization^{2023, 2024} anterior lateral line neuromast hair cell development^{2018, 2024} Wnt signaling pathway involved in forebrain neuroblast division²⁰¹⁰ ventricular septum morphogenesis²⁰²³ trachea cartilage morphogenesis²⁰¹⁰ thalamus development²⁰¹⁰ stem cell proliferation²⁰¹⁰ somitogenesis²⁰¹⁰ skeletal system morphogenesis²⁰¹⁰ roof of mouth development²⁰¹⁰ response to folic acid²⁰¹⁰ regulation of protein transport²⁰¹¹ regulation of epithelial cell proliferation²⁰¹⁰ regulation of cell development²⁰¹⁰ regulation of anatomical structure morphogenesis²⁰¹⁰ regulation of DNA-templated transcription^{2010, 2024} receptor-mediated endocytosis²⁰²³ primitive streak formation²⁰¹⁰ positive regulation of stem cell proliferation²⁰¹⁰ positive regulation of ossification²⁰¹⁰ positive regulation of neuron projection development²⁰¹⁷ positive regulation of muscle cell differentiation²⁰¹⁷ positive regulation of integrin-mediated signaling pathway²⁰¹⁷ positive regulation of cytosolic calcium ion concentration^{2010, 2024} positive regulation of cell adhesion²⁰¹⁷ positive regulation of bone resorption²⁰¹⁰ positive regulation of apoptotic process²⁰¹⁰ phagocytosis²⁰²¹ pericardium morphogenesis²⁰²³ outflow tract morphogenesis²⁰¹⁰ neural tube development²⁰¹⁰ negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis²⁰¹⁰ negative regulation of planar cell polarity pathway involved in pericardium morphogenesis²⁰¹⁰ negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis²⁰¹⁰ negative regulation of planar cell polarity pathway involved in neural tube closure²⁰¹⁰ negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis²⁰¹⁰ negative regulation of non-canonical Wnt signaling pathway²⁰¹⁰ negative regulation of fat cell differentiation²⁰¹⁰ negative regulation of epithelial cell proliferation²⁰¹⁰ negative regulation of developmental process²⁰¹⁰ midbrain-hindbrain boundary development²⁰¹⁰ midbrain development²⁰¹⁰ mesenchymal cell proliferation²⁰¹⁰ mammary placode formation²⁰¹⁰ heart looping²⁰¹⁰ formation of radial glial scaffolds²⁰¹⁰ forebrain radial glial cell differentiation²⁰¹⁰ forebrain generation of neurons²⁰¹⁰ forebrain development²⁰⁰⁵ fat cell differentiation²⁰¹⁰ face morphogenesis²⁰¹⁰ external genitalia morphogenesis²⁰¹⁰ embryonic retina morphogenesis in camera-type eye²⁰¹⁰ embryonic pattern specification²⁰¹⁰ embryonic camera-type eye morphogenesis²⁰¹⁰ dorsal/ventral axis specification²⁰²⁰ convergent extension²⁰¹⁰ cerebral cortex development²⁰¹⁰ cerebral cortex cell migration²⁰¹⁰ cerebellum morphogenesis²⁰¹⁰ cardiac muscle tissue morphogenesis²⁰¹⁰ basement membrane organization^{2014, 2018} axis elongation involved in somitogenesis²⁰¹⁰ axis elongation²⁰¹⁰ amyloid-beta clearance by transcytosis²⁰²¹ triglyceride homeostasis²⁰¹⁸ signal transduction²⁰²⁴ segment polarity determination²⁰¹⁷ regulation of compound eye pigmentation²⁰⁰⁷ protein phosphorylation²⁰²⁴ presynaptic active zone organization²⁰¹⁷ positive regulation of fibroblast proliferation²⁰¹⁵ positive regulation of circadian sleep/wake cycle, sleep²⁰¹⁸ positive regulation of ERK1 and ERK2 cascade²⁰¹⁸ positive regulation of DNA biosynthetic process²⁰¹⁵ neuromuscular synaptic transmission²⁰⁰⁸ morphogenesis of an epithelium²⁰¹⁰ monoatomic ion transport²⁰²⁴ monoatomic ion transmembrane transport²⁰²⁴ midbrain dopaminergic neuron differentiation²⁰¹⁶ long-term memory²⁰¹³ leg disc pattern formation²⁰¹⁷ intracellular signal transduction²⁰⁰⁵ imaginal disc-derived wing margin morphogenesis²⁰¹⁷ homophilic cell adhesion via plasma membrane adhesion molecules²⁰²⁴ establishment of synaptic specificity at neuromuscular junction²⁰¹⁶ compound eye morphogenesis²⁰⁰⁶ cellular oxidant detoxification²⁰²⁴ cell elongation involved in imaginal disc-derived wing morphogenesis²⁰¹⁷ blood circulation²⁰¹⁴ basement membrane assembly involved in embryonic body morphogenesis²⁰¹⁹ axon regeneration²⁰¹⁹ G protein-coupled receptor signaling pathway²⁰²⁴

Cellular component: plasma membrane^{2003, 2006, 2007, 2008, 2010, 2012, 2016, 2017, 2021, 2023, 2024} membrane^{2012, 2024} basement membrane^{2000, 2006, 2010, 2011, 2012, 2014, 2017, 2019, 2024} extracellular region^{2008, 2013, 2014, 2024} cell surface^{2010, 2013, 2024} extracellular space^{2014, 2015, 2020, 2022, 2024} synapse²⁰²⁴ early endosome^{2007, 2010, 2013, 2023, 2024} Wnt-Frizzled-LRP5/6 complex^{2015, 2016, 2021, 2024} Wnt signalosome^{2015, 2016, 2021, 2024}
± 25 extracellular exosome^{2014, 2024} receptor complex^{2011, 2024} neuromuscular junction^{2013, 2024} cytoplasmic vesicle^{2010, 2014, 2024} caveola^{2010, 2024} Golgi apparatus^{2013, 2024} extracellular matrix^{2006, 2024} cell periphery^{2012, 2024} neuronal cell body^{2008, 2013, 2024} synaptic membrane^{2013, 2017, 2024} endoplasmic reticulum²⁰²⁴ postsynaptic density^{2013, 2024} plasma membrane raft^{2018, 2024} dendrite^{2013, 2024} collagen-containing extracellular matrix²⁰¹⁸ basal part of cell^{2010, 2024} protein complex involved in cell-matrix adhesion²⁰¹⁷ membrane raft²⁰²⁴ platelet alpha granule lumen²⁰¹³ mitochondrion²⁰⁰⁷ lysosomal membrane²⁰¹³ late endosome²⁰⁰⁷ early endosome membrane²⁰¹⁴ clathrin-coated endocytic vesicle membrane²⁰¹⁹ axon terminus²⁰¹⁷