Collated Gene Ontology terms

Biological process: transmembrane monodehydroascorbate reductase activity(2021, 2025) metal ion binding(2025) oxidoreductase activity(2021, 2025) transmembrane ascorbate ferrireductase activity(2021, 2025) heme binding(2018, 2025) ferric-chelate reductase activity(2022, 2025) serine-type endopeptidase activity(2025)

Molecular function: transmembrane transport2025 ascorbate homeostasis2021, 2025 intracellular iron ion homeostasis2022, 2025 iron ion import across plasma membrane2025 sorocarp development2022 proteolysis2025

Cellular component: endoplasmic reticulum membrane2022, 2025 membrane2024, 2025 endoplasmic reticulum2018, 2025 vesicle2018, 2025 cytoplasmic vesicle2025 cytoplasmic vesicle membrane2025 Golgi membrane2022, 2025 phagocytic vesicle membrane2022, 2025 plasma membrane2022, 2025 macropinosome2022, 2025
endolysosome membrane2022, 2025 apical plasma membrane2025 phagocytic cup2025 chloroplast2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 8/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
B561L_ARATH
TAIR»
0.5
At2g30890 Cytochrome b561 domain-containing
protein At2g30890 (Protein b561A.tha12)		 Arabidopsis thaliana
TI:3702 None
 
B561M_ARATH
TAIR»
0.5
At4g18260 Cytochrome b561 domain-containing
protein At4g18260 (Protein b561A.tha13)		 Arabidopsis thaliana
TI:3702 None
 
A9Z1K9_CAEEL
WormBase»
0.0
CELE_M03A1.8 M03A1.8 ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Caenorhabditis elegans
TI:6239 None
 
C56D1_HUMAN
Ensembl»
0.5
CYB561D1 Probable transmembrane reductase CYB561D1 (EC
7.2.1.3) (Cytochrome b561 domain-containing protein 1)		 Homo sapiens
TI:9606 None
 
A0A8V1ACF4_CHICK
Ensembl»
0.0
CYB561D2 ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Gallus gallus
TI:9031 None
   
C56D2_HUMAN
Ensembl»
4.4
CYB561D2 Transmembrane reductase CYB561D2 (EC 7.2.1.3) (Cytochrome b561
domain-containing protein 2) (Putative tumor suppressor protein 101F6)		 Homo sapiens
TI:9606 None
 
A0A0G2K452_RAT
RGD»
0.0
Cyb561d1 ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Rattus norvegicus
TI:10116 None
   
C56D1_MOUSE
Ensembl»
0.5
Cyb561d1 Probable transmembrane reductase CYB561D1 (EC
7.2.1.3) (Cytochrome b561 domain-containing protein 1)		 Mus musculus
TI:10090 None
 
C56D2_MOUSE
Ensembl»
6.4
Cyb561d2 Transmembrane reductase CYB561D2 (EC 7.2.1.3)
(Cytochrome b561 domain-containing protein 2)		 Mus musculus
TI:10090 None
 
C56D2_RAT
RGD»
5.5
Cyb561d2 Transmembrane reductase CYB561D2 (EC 7.2.1.3)
(Cytochrome b561 domain-containing protein 2)		 Rattus norvegicus
TI:10116 None
 
Q9VIU6_DROME
FlyBase»
1.0
Dmel\CG10165 ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Drosophila melanogaster
TI:7227 None
 
Q9VIU0_DROME
FlyBase»
1.0
Dmel\CG10337 ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Drosophila melanogaster
TI:7227 None
 
Q9VIT6_DROME
FlyBase»
2.6
Fire ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Drosophila melanogaster
TI:7227 None
 
Q9VIT5_DROME
FlyBase»
2.6
Fire-like ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Drosophila melanogaster
TI:7227 None
 
Q66HZ6_DANRE
ZFIN»
0.5
cyb561d1 ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Danio rerio
TI:7955 None
 
Q5XJT3_DANRE
ZFIN»
1.5
cyb561d2 ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Danio rerio
TI:7955 None
 
FR1A_DICDI
dictyBase»
1.3
fr1A Ferric-chelate reductase fr1A Dictyostelium discoideum
TI:44689 None
 
FR1B_DICDI
dictyBase»
1.4
fr1B Putative ferric-chelate reductase fr1B Dictyostelium discoideum
TI:44689 None
 
FR1C_DICDI
dictyBase»
2.9
fr1C Ferric-chelate reductase fr1C Dictyostelium discoideum
TI:44689 None
 
Q9W4U9_DROME
FlyBase»
1.0
frag7 ascorbate ferrireductase
(transmembrane) (EC 7.2.1.3)		 Drosophila melanogaster
TI:7227 None