Collated Gene Ontology terms

Biological process: (S)-2-hydroxyglutarate dehydrogenase activity(2006, 2017, 2018, 2025) oxidoreductase activity, acting on CH-OH group of donors(2025) oxidoreductase activity(2025) L-malate dehydrogenase (quinone) activity(2007, 2014, 2019, 2025) flavin adenine dinucleotide binding(2008, 2014, 2025) sarcosine oxidase activity(2019, 2025) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(2025) (S)-2-hydroxyglutarate dehydrogenase (quinone) activity(2025) nucleotide binding(2025) aminobutyraldehyde dehydrogenase (NAD+) activity(2025)
L-amino-acid oxidase activity2025 FAD binding2017

Molecular function: small molecule metabolic process2021, 2025 tricarboxylic acid cycle2025 L-lysine catabolic process2025 tetrahydrofolate metabolic process2025 sarcosine catabolic process2019 pyruvate metabolic process2007 lysine catabolic process2018 2-oxoglutarate metabolic process2025

Cellular component: mitochondrion2006, 2009, 2018, 2024, 2025 plasma membrane2010, 2014, 2025 membrane2006, 2025 mitochondrial inner membrane2006, 2013, 2025 cytoplasm2010, 2025 kinetoplast2018, 2025 cytosol2014 cytoplasmic side of plasma membrane2014

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 10/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 1/8 
Bacteria: 18/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A8V0ZGL8_CHICK
Ensembl»
1.0
L2HGDH L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Gallus gallus
TI:9031 None
   
B8A6D3_DANRE
ZFIN»
1.0
l2hgdh L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Danio rerio
TI:7955 None
 
D3ZVS2_RAT
RGD»
2.0
L2hgdh L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Rattus norvegicus
TI:10116 None
   
L2HDH_ARATH
TAIR»
2.6
L2HGDH L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Arabidopsis thaliana
TI:3702 None
 
L2HDH_CAEEL
WormBase»
1.0
Y45G12B.3 L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Caenorhabditis elegans
TI:6239 None
 
L2HDH_DICDI
dictyBase»
1.0
l2hgdh L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Dictyostelium discoideum
TI:44689 None
 
L2HDH_HUMAN
Ensembl»
4.3
L2HGDH L-2-hydroxyglutarate dehydrogenase, mitochondrial
(EC 1.1.99.2) (Duranin)		 Homo sapiens
TI:9606 None
 
L2HDH_MOUSE
Ensembl»
3.8
L2hgdh L-2-hydroxyglutarate dehydrogenase, mitochondrial
(EC 1.1.99.2) (Duranin)		 Mus musculus
TI:10090 None
 
LHGD_ECOLI
EnsemblBacteria»
3.4
lhgD L-2-hydroxyglutarate dehydrogenase (L2HG dehydrogenase)
(EC 1.1.5.13) (L2HG:quinone oxidoreductase)		 Escherichia coli
TI:562 None
 
MQO_ECOLI
EnsemblBacteria»
1.6
mqo Malate:quinone oxidoreductase (EC 1.1.5.4)
(MQO) (Malate dehydrogenase [quinone])		 Escherichia coli
TI:562 None
 
Q9VJ28_DROME
FlyBase»
2.6
L2HGDH L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Drosophila melanogaster
TI:7227 None