Collated Gene Ontology terms

Biological process: oxidoreductase activity, acting on CH-OH group of donors(2024) 2-hydroxyglutarate dehydrogenase activity(2006, 2017, 2018, 2022, 2024) oxidoreductase activity(2024) malate dehydrogenase (quinone) activity(2007, 2014, 2019, 2024) flavin adenine dinucleotide binding(2008, 2014, 2024) sarcosine oxidase activity(2019, 2024) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(2024) (S)-2-hydroxyglutarate dehydrogenase activity(2024) (S)-2-hydroxy-acid oxidase activity(2015, 2024) nucleotide binding(2024)
aminobutyraldehyde dehydrogenase activity2024 L-amino-acid oxidase activity2024 FAD binding2017

Molecular function: tricarboxylic acid cycle2024 small molecule metabolic process2021, 2024 L-lysine catabolic process2024 tetrahydrofolate metabolic process2024 sarcosine catabolic process2019 pyruvate metabolic process2007 protein import into mitochondrial matrix2021 lysine catabolic process2018 2-oxoglutarate metabolic process2024

Cellular component: mitochondrion2006, 2009, 2018, 2023, 2024 cytoplasm2010, 2017, 2023 membrane2006, 2024 plasma membrane2010, 2014, 2024 mitochondrial inner membrane2006, 2013 kinetoplast2018 extracellular region2024 cytosol2014 cytoplasmic side of plasma membrane2014

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 9/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 1/8 
Bacteria: 18/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

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Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
LHGD_ECOLI
EnsemblBacteria»
2.9
lhgD L-2-hydroxyglutarate dehydrogenase (L2HG dehydrogenase)
(EC 1.1.5.13) (L2HG:quinone oxidoreductase)		 Escherichia coli
TI:562 None
 
L2HDH_HUMAN
Ensembl»
3.8
L2HGDH L-2-hydroxyglutarate dehydrogenase, mitochondrial
(EC 1.1.99.2) (Duranin)		 Homo sapiens
TI:9606 None
 
L2HDH_MOUSE
Ensembl»
1.5
L2hgdh L-2-hydroxyglutarate dehydrogenase, mitochondrial
(EC 1.1.99.2) (Duranin)		 Mus musculus
TI:10090 None
 
MQO_ECOLI
EnsemblBacteria»
1.6
mqo Malate:quinone oxidoreductase (EC 1.1.5.4)
(MQO) (Malate dehydrogenase [quinone])		 Escherichia coli
TI:562 None
 
Q9VJ28_DROME
FlyBase»
1.0
L2HGDH FI05204p (L-2-hydroxyglutarate dehydrogenase, isoform A) (L-2-hydroxyglutarate dehydrogenase, isoform
B) (L-2-hydroxyglutarate dehydrogenase, isoform C (EC 1.1.3.15, EC 1.1.99.2))		 Drosophila melanogaster
TI:7227 None
 
D3ZVS2_RAT
RGD»
1.5
L2hgdh L-2-hydroxyglutarate dehydrogenase Rattus norvegicus
TI:10116 None
   
L2HDH_ARATH
TAIR»
2.4
L2HGDH L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Arabidopsis thaliana
TI:3702 None
 
L2HDH_CAEEL
WormBase»
0.5
Y45G12B.3 L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Caenorhabditis elegans
TI:6239 None
 
L2HDH_DICDI
dictyBase»
0.5
l2hgdh L-2-hydroxyglutarate dehydrogenase,
mitochondrial (EC 1.1.99.2)		 Dictyostelium discoideum
TI:44689 None
 
B8A6D3_DANRE
ZFIN»
0.5
si:ch211-67f24.10 L-2-hydroxyglutarate dehydrogenase (L-2-hydroxyglutarate
dehydrogenase, mitochondrial (EC 1.1.99.2))		 Danio rerio
TI:7955 None
 
A0A8V0ZGL8_CHICK
Ensembl»
0.0
L2HGDH L-2-hydroxyglutarate dehydrogenase Gallus gallus
TI:9031 None