Collated Gene Ontology terms

Biological process: hydrolase activity(2011, 2025) carboxylic ester hydrolase activity(2025) prenylcysteine methylesterase activity(2006, 2017, 2025) catalytic activity(2003, 2025) serine hydrolase activity(2008, 2010, 2022, 2025) arylformamidase activity(2020, 2023, 2025) triacylglycerol lipase activity(2010, 2016, 2022, 2023, 2025) short-chain carboxylesterase activity(2010, 2011, 2017) acetylalkylglycerol acetylhydrolase activity(2025) deacetylase activity(2004, 2005, 2025)
serine-type peptidase activity2025 phosphate ion binding2008, 2025 acetylesterase activity2011, 2025 hydrolase activity, acting on glycosyl bonds2025 carboxylesterase activity2025 steryl deacetylase activity2013, 2017 metal ion binding2025 lipase activity2001, 2005, 2011 endo-1,4-beta-xylanase activity2025 zinc ion binding2025 calcium ion binding2025 versiconal hemiacetal acetate esterase activity2025 sterol ester esterase activity2025 protein homodimerization activity2013 phospholipase C activity2010 phosphatidylcholine phospholipase C activity2025 hydrolase activity, acting on ester bonds2025 acylcarnitine hydrolase activity2019

Molecular function: L-tryptophan catabolic process to kynurenine2005, 2017, 2025 L-tryptophan catabolic process2025 lipid metabolic process2025 lipid catabolic process2024, 2025 'de novo' NAD+ biosynthetic process from L-tryptophan2025 positive regulation of triglyceride catabolic process2010, 2017, 2025 ether lipid metabolic process2020, 2025 proteolysis2025 xylan catabolic process2025 xenobiotic metabolic process2008, 2025
sterol metabolic process2013, 2017 sterigmatocystin biosynthetic process2021, 2024 protein dephosphorylation2008 symbiont-mediated perturbation of host innate immune response2023 response to toxic substance2013 response to acidic pH2018 response to abscisic acid2011 positive regulation of cell growth2025 meiotic cell cycle2025 low-density lipoprotein particle clearance2025 glycerolipid catabolic process2011 biological process involved in interaction with host2010 NAD+ biosynthetic process2025

Cellular component: endoplasmic reticulum membrane2005, 2010, 2011, 2015, 2017, 2025 Golgi membrane2011, 2017, 2025 membrane2006, 2008, 2014, 2022, 2025 cytoplasm2009, 2011, 2017, 2025 plasma membrane2010, 2025 cytosol2008, 2009, 2025 nucleus2009, 2025 extracellular region2012, 2018, 2025 endoplasmic reticulum2009, 2014, 2018 phagocytic vesicle2006, 2009
mitochondrion2009, 2025 cell surface2025 lumenal side of endoplasmic reticulum membrane2025 lipid droplet2014 endoplasmic reticulum lumen2013 chloroplast2018 cell periphery2018 capsule2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 3/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 2/8 
Bacteria: 20/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
NCEH1_HUMAN
Ensembl»
2.8
NCEH1 Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol
acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1)		 Homo sapiens
TI:9606 None
 
AAAD_HUMAN
Ensembl»
7.7
AADAC Arylacetamide deacetylase (EC 3.1.1.3) Homo sapiens
TI:9606 None
 
AES_ECOLI
EnsemblBacteria»
3.7
aes Acetyl esterase (EC 3.1.1.-) (EcE) Escherichia coli
TI:562 None
 
ICML1_ARATH
TAIR»
0.5
ICMEL1 Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL1
(EC 3.1.1.n2) (Isoprenylcysteine methylesterase-like protein 1)		 Arabidopsis thaliana
TI:3702 None
 
KFA_MOUSE
Ensembl»
2.2
Afmid Kynurenine formamidase (KFA) (KFase) (EC
3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)		 Mus musculus
TI:10090 None
 
ICME_ARATH
TAIR»
1.3
ICME Isoprenylcysteine alpha-carbonyl methylesterase ICME (EC
3.1.1.n2) (Isoprenylcysteine methylesterase) (Prenylcysteine methylesterase) (AtPCME)		 Arabidopsis thaliana
TI:3702 None
 
ICML2_ARATH
TAIR»
1.3
ICMEL2 Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL2
(EC 3.1.1.n2) (Isoprenylcysteine methylesterase-like protein 2)		 Arabidopsis thaliana
TI:3702 None
 
NCEH1_MOUSE
Ensembl»
4.5
Nceh1 Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl
MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1) (Chlorpyrifos oxon-binding protein) (CPO-BP)		 Mus musculus
TI:10090 None
 
SAY1_YEAST
SGD»
3.2
SAY1 Steryl acetyl hydrolase 1 (EC 3.1.1.-) Saccharomyces cerevisiae
TI:4932 None
 
AAAD_MOUSE
Ensembl»
6.3
Aadac Arylacetamide deacetylase (EC 3.1.1.3) Mus musculus
TI:10090 None
 
ADCL2_HUMAN
Ensembl»
0.0
AADACL2 Arylacetamide deacetylase-like 2 (EC 3.1.1.-) Homo sapiens
TI:9606 None
 
AAAD_RAT
RGD»
4.0
Aadac Arylacetamide deacetylase (EC 3.1.1.3) Rattus norvegicus
TI:10116 None
 
AD4F1_MOUSE
Ensembl»
0.0
Aadacl4fm1 Arylacetamide deacetylase-like 4 family member 1
(EC 3.1.1.-) (AADACL4 family member 1)		 Mus musculus
TI:10090 None
 
ADCL3_HUMAN
Ensembl»
0.0
AADACL3 Arylacetamide deacetylase-like 3 (EC 3.1.1.-) Homo sapiens
TI:9606 None
 
B2RWD2_MOUSE
Ensembl»
0.0
Aadacl2 Arylacetamide deacetylase-like 2 Mus musculus
TI:10090 None
 
KFA_DANRE
ZFIN»
0.5
afmid Kynurenine formamidase (KFA) (KFase) (EC
3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)		 Danio rerio
TI:7955 None
 
KFA_DROME
FlyBase»
1.9
KFase Kynurenine formamidase (KFA) (KFase) (EC
3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)		 Drosophila melanogaster
TI:7227 None
 
KFA_HUMAN
Ensembl»
0.5
AFMID Kynurenine formamidase (KFA) (KFase) (EC
3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)		 Homo sapiens
TI:9606 None
 
NCEH1_RAT
RGD»
3.5
Nceh1 Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol
acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1)		 Rattus norvegicus
TI:10116 None
 
VSH5_DICDI
dictyBase»
0.0
cinB Vegetative-specific protein H5 Dictyostelium discoideum
TI:44689 None
 
A0JME8_DANRE
ZFIN»
0.5
nceh1b.1 Neutral cholesterol ester hydrolase 1 (EC
3.1.1.71) (Acetylalkylglycerol acetylhydrolase) (Arylacetamide deacetylase-like 1)		 Danio rerio
TI:7955 None
 
A5PMM7_DANRE
ZFIN»
0.0
si:dkey-193c22.1 Si:dkey-193c22.1 (Uncharacterized
protein LOC567837)		 Danio rerio
TI:7955 None
 
ADCL3_MOUSE
Ensembl»
0.0
Aadacl3 Arylacetamide deacetylase-like 3 (EC 3.1.1.-) Mus musculus
TI:10090 None
 
ADCL4_HUMAN
Ensembl»
0.0
AADACL4 Arylacetamide deacetylase-like 4 (EC 3.1.1.-) Homo sapiens
TI:9606 None
 
MU180_SCHPO
PomBase»
1.0
mug180 Putative steryl acetyl hydrolase mug81 (EC
3.1.1.-) (Meiotically up-regulated gene 180 protein)		 Schizosaccharomyces pombe
TI:4896 None
 
O62460_CAEEL
WormBase»
0.5
afmd-2 Alpha/beta hydrolase
fold-3 domain-containing protein		 Caenorhabditis elegans
TI:6239 None
 
Q18974_CAEEL
WormBase»
0.5
afmd-1 BD-FAE-like domain-containing protein Caenorhabditis elegans
TI:6239 None
 
Q19839_CAEEL
WormBase»
0.0
trcs-1 Alpha/beta hydrolase
fold-3 domain-containing protein		 Caenorhabditis elegans
TI:6239 None
 
Q54DJ5_DICDI
dictyBase»
0.0
DDB_G0292226 BD-FAE-like domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54FB4_DICDI
dictyBase»
0.0
DDB_G0290975 Alpha/beta hydrolase
fold-3 domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
Q54K46_DICDI
dictyBase»
0.0
DDB_G0287609 Alpha/beta hydrolase
fold-3 domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
Q54L36_DICDI
dictyBase»
0.0
DDB_G0286925 Esterase/lipase/thioesterase
domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
Q54QI3_DICDI
dictyBase»
0.0
DDB_G0283819 FYVE-type domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54R44_DICDI
dictyBase»
0.0
DDB_G0283413 Kynurenine formamidase (KFA) (KFase) (EC
3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)		 Dictyostelium discoideum
TI:44689 None
 
Q6DKF1_DANRE
ZFIN»
0.5
nceh1a Neutral cholesterol ester hydrolase 1 (EC
3.1.1.71) (Acetylalkylglycerol acetylhydrolase) (Arylacetamide deacetylase-like 1)		 Danio rerio
TI:7955 None
 
Q7JMM5_CAEEL
WormBase»
0.0
CELE_T09B9.1 T09B9.1 Alpha/beta hydrolase
fold-3 domain-containing protein		 Caenorhabditis elegans
TI:6239 None
 
Q8BUY2_MOUSE
Ensembl»
0.0
Aadacl2fm1 AADACL2 family member 1 Mus musculus
TI:10090 None
 
Q94187_CAEEL
WormBase»
0.0
CELE_F16F9.4 F16F9.4 Alpha/beta hydrolase
fold-3 domain-containing protein		 Caenorhabditis elegans
TI:6239 None
 
Q9XWL5_CAEEL
WormBase»
0.0
nceh-1 Alpha/beta hydrolase
fold-3 domain-containing protein		 Caenorhabditis elegans
TI:6239 None
 
YE76_SCHPO
PomBase»
0.0
SPAC4A8.06c AB hydrolase superfamily
protein C4A8.06c (EC 3.-.-.-)		 Schizosaccharomyces pombe
TI:4896 None
 
YFZ3_SCHPO
PomBase»
0.0
SPAC1039.03 AB hydrolase superfamily
protein C1039.03 (EC 3.-.-.-)		 Schizosaccharomyces pombe
TI:4896 None
 
YKN2_SCHPO
PomBase»
0.5
SPAPB1A11.02 AB hydrolase superfamily
protein B1A11.02 (EC 3.-.-.-)		 Schizosaccharomyces pombe
TI:4896 None
 
A0A8I5XWI7_RAT
RGD»
0.0
Aadacl4fm3 AADACL4 family member 3 Rattus norvegicus
TI:10116 None
   
A0A8M1NVX1_DANRE
ZFIN»
0.0
aadacl4 Arylacetamide deacetylase-like 4 Danio rerio
TI:7955 None
   
A0A8M1Q1F6_DANRE
ZFIN»
0.5
nceh1b.2 Neutral cholesterol ester hydrolase 1 (EC
3.1.1.71) (Acetylalkylglycerol acetylhydrolase) (Arylacetamide deacetylase-like 1)		 Danio rerio
TI:7955 None
   
A0A8V0X9N3_CHICK
Ensembl»
0.0
AADAC Arylacetamide deacetylase Gallus gallus
TI:9031 None
   
A0A8V0ZA21_CHICK
Ensembl»
0.0
LOC121106479 Alpha/beta hydrolase
fold-3 domain-containing protein		 Gallus gallus
TI:9031 None
   
A0A8V0ZGR1_CHICK
Ensembl»
0.0
AADACL3B Alpha/beta hydrolase
fold-3 domain-containing protein		 Gallus gallus
TI:9031 None
   
A0A8V0ZH30_CHICK
Ensembl»
0.0
Alpha/beta hydrolase
fold-3 domain-containing protein		 Gallus gallus
TI:9031 None
   
A0A8V0ZH66_CHICK
Ensembl»
0.0
AADACL4B Alpha/beta hydrolase
fold-3 domain-containing protein		 Gallus gallus
TI:9031 None
   
A0A8V0ZN92_CHICK
Ensembl»
0.0
AADACL4A Alpha/beta hydrolase
fold-3 domain-containing protein		 Gallus gallus
TI:9031 None
   
A0A8V1AN76_CHICK
Ensembl»
0.5
AFMID Kynurenine formamidase (KFA) (KFase) (EC
3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)		 Gallus gallus
TI:9031 None
   
A0ABK0LSL4_RAT
Ensembl»
0.0
Aadacl2 Arylacetamide deacetylase-like 2 Rattus norvegicus
TI:10116 None
   
A0ACD6B5H8_DANRE
ZFIN»
0.0
aadac Arylacetamide deacetylase isoform X1 Danio rerio
TI:7955 None 		     
A2A752_MOUSE
Ensembl»
0.0
Aadacl4fm2 AADACL4 family member 2 Mus musculus
TI:10090 None
   
B1ASB3_MOUSE
Ensembl»
0.0
Aadacl4fm5 AADACL4 family member 5 Mus musculus
TI:10090 None
   
B1AVU5_MOUSE
Ensembl»
0.0
Aadacl4 Arylacetamide deacetylase like 4 Mus musculus
TI:10090 None
   
B1AVU6_MOUSE
Ensembl»
0.0
Aadacl4fm4 AADACL4 family member 4 Mus musculus
TI:10090 None
   
B1AVU7_MOUSE
Ensembl»
0.0
AAdacl4fm3 AADACL4 family member 3 Mus musculus
TI:10090 None
   
D3ZBA8_RAT
RGD»
0.0
Aadacl4fm1 AADACL4 family member 1 Rattus norvegicus
TI:10116 None
   
D3ZCR8_RAT
RGD»
0.0
Aadacl3 Arylacetamide deacetylase-like 3 Rattus norvegicus
TI:10116 None
   
D3ZTU9_RAT
RGD»
0.0
Aadacl4 Arylacetamide deacetylase-like 4 Rattus norvegicus
TI:10116 None
   
D3ZXW5_RAT
RGD»
0.0
Aadacl2l Arylacetamide deacetylase-like 2 like Rattus norvegicus
TI:10116 None
   
D4A340_RAT
RGD»
0.0
Aadacl4fm3l1 AADACL4 family member 3 like 1 Rattus norvegicus
TI:10116 None
   
D4A8F5_RAT
RGD»
0.0
Aadacl2fm2l1 AADACL2 family member 2 like 1 Rattus norvegicus
TI:10116 None
   
F1LVG7_RAT
RGD»
0.0
Aadacl2fm3 AADACL2 family member 3 like 1 Rattus norvegicus
TI:10116 None
   
F1NF25_CHICK
Ensembl»
0.5
NCEH1 Neutral cholesterol ester hydrolase 1 (EC
3.1.1.71) (Acetylalkylglycerol acetylhydrolase) (Arylacetamide deacetylase-like 1)		 Gallus gallus
TI:9031 None
   
F1P4H5_CHICK
Ensembl»
0.0
AADACL3C Alpha/beta hydrolase
fold-3 domain-containing protein		 Gallus gallus
TI:9031 None
   
M0R509_RAT
RGD»
0.0
Aadacl2fm2 AADACL2 family member 2 Rattus norvegicus
TI:10116 None
   
M0R631_RAT
RGD»
0.0
Aadacl4fm2 AADACL4 family member 2 Rattus norvegicus
TI:10116 None
   
M0RC77_RAT
RGD»
1.0
Afmid Kynurenine formamidase (KFA) (KFase) (EC
3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)		 Rattus norvegicus
TI:10116 None
   
W4VSP6_MOUSE
Ensembl»
0.0
Aadacl2fm2 AADACL2 family member 2 Mus musculus
TI:10090 None