Collated Gene Ontology terms

Biological process: transmembrane transporter activity(2023, 2024, 2025) sphingolipid transporter activity(2019, 2022, 2023, 2025) lysophospholipid:sodium symporter activity(2022, 2025) carboxylic acid transmembrane transporter activity(2024)

Molecular function: transmembrane transport2023, 2024, 2025 lipid transport2019, 2021, 2025 sphingosine-1-phosphate receptor signaling pathway2012, 2013, 2021, 2022, 2025 lysophospholipid transport2022, 2025 phospholipid efflux2022, 2024 regulation of humoral immune response2013, 2022, 2025 sensory perception of sound2022, 2025 regulation of T cell migration2022, 2025 sphingolipid metabolic process2013 regulation of lysosomal lumen pH2022
regulation of eye pigmentation2013 oogenesis2007, 2025 lymphocyte migration2013 lymphocyte homeostasis2013 lymph node development2013 embryonic heart tube morphogenesis2014 cellular senescence2014 cardioblast migration to the midline involved in heart rudiment formation2014 bone development2012 T cell homeostasis2013 B cell homeostasis2013 vasculature development2013 synaptic vesicle endocytosis2007 synaptic assembly at neuromuscular junction2009 sphingolipid biosynthetic process2025 regulation of synaptic assembly at neuromuscular junction2006 regulation of programmed cell death2006 regulation of nurse cell apoptotic process2006 regulation of female receptivity2006 regulation of cartilage development2012 programmed cell death2006 nurse cell apoptotic process2010 negative regulation of BMP signaling pathway2019 lysosome organization2012 locomotion2007 larval central nervous system remodeling2006 glial cell migration2011 glial cell differentiation2011 endosome to lysosome transport2007 endocytosis2007 embryonic viscerocranium morphogenesis2014 double fertilization forming a zygote and endosperm2007 courtship behavior2006 cellular response to starvation2012 cell differentiation2025 carboxylic acid transport2022 carboxylic acid transmembrane transport2025 branching involved in blood vessel morphogenesis2009 autophagy2014 autophagosome maturation2014

Cellular component: membrane2023, 2024, 2025 lysosomal membrane2013, 2025 lysosome2022, 2025 plasma membrane2013, 2017, 2020, 2023, 2024, 2025 endomembrane system2025 mitochondrion2018 late endosome membrane2009, 2025 endosome membrane2025 chloroplast2018 mitochondrial inner membrane2025
vesicle2011 presynapse2025 cytoplasm2018 Golgi medial cisterna2019

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 1/8 
Bacteria: 4/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 5 10 15 Knownness

Click here to switch to the previous version of the database.


Proteins

UniProt ID
Organism DB»
Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
Q9C9R9_ARATH
TAIR»
1.3
UNE2 At1g78130 (Major facilitator superfamily protein)
(Putative transporter; 34935-36578) (Transporter like protein)
Arabidopsis thaliana
TI:3702 None
 
Q9W3W7_DROME
FlyBase»
1.5
Dmel\CG14439 LP14756p (MIP04609p) (Uncharacterized protein, isoform A) (Uncharacterized
protein, isoform B) (Uncharacterized protein, isoform C)
Drosophila melanogaster
TI:7227 None
 
A0A3B1DV80_CAEEL
WormBase»
0.5
spin-4 Major facilitator superfamily
(MFS) profile domain-containing protein
Caenorhabditis elegans
TI:6239 None
 
O01927_CAEEL
WormBase»
0.5
spin-1 Major facilitator superfamily
(MFS) profile domain-containing protein
Caenorhabditis elegans
TI:6239 None
 
Q18545_CAEEL
WormBase»
0.5
spin-2 Major facilitator superfamily
(MFS) profile domain-containing protein
Caenorhabditis elegans
TI:6239 None
 
Q19235_CAEEL
WormBase»
0.5
spin-3 Major facilitator superfamily
(MFS) profile domain-containing protein
Caenorhabditis elegans
TI:6239 None
 
A0A1P8BBK2_ARATH
TAIR»
0.0
At5g10190 Major facilitator superfamily protein Arabidopsis thaliana
TI:3702 None
 
F4IQK9_ARATH
TAIR»
0.5
At2g18590 Major facilitator superfamily protein Arabidopsis thaliana
TI:3702 None
 
O23203_ARATH
TAIR»
0.5
C7A10.570 Major facilitator superfamily protein Arabidopsis thaliana
TI:3702 None
 
SPNS1_ARATH
TAIR»
0.5
At5g65687 Probable sphingolipid transporter
spinster homolog 1
Arabidopsis thaliana
TI:3702 None
 
SPNS2_ARATH
TAIR»
0.5
At5g64500 Probable sphingolipid transporter
spinster homolog 2
Arabidopsis thaliana
TI:3702 None
 
SPNS3_ARATH
TAIR»
0.5
At2g22730 Probable sphingolipid transporter
spinster homolog 3
Arabidopsis thaliana
TI:3702 None
 
SPIN_DROME
FlyBase»
16.3
spin Protein spinster (Protein
benchwarmer) (Protein diphthong)
Drosophila melanogaster
TI:7227 None
 
SPNS3_DANRE
ZFIN»
0.5
spns3 Protein spinster homolog
3 (Spinster-like protein 3)
Danio rerio
TI:7955 None
 
SPNS1_HUMAN
Ensembl»
3.1
SPNS1 Protein spinster homolog 1
(HSpin1) (SPNS1) (Spinster-like protein 1)
Homo sapiens
TI:9606 None
 
SPNS1_MOUSE
Ensembl»
3.9
Spns1 Protein spinster homolog 1 (MSpin1) (Spns1) Mus musculus
TI:10090 None
 
SPNS1_DANRE
ZFIN»
3.7
spns1 Protein spinster homolog 1 (Protein
not really started) (Spinster-like protein) (Spns1)
Danio rerio
TI:7955 None
 
SPNS1_RAT
RGD»
3.5
Spns1 Protein spinster homolog 1 (RSpin1) (Spns1) Rattus norvegicus
TI:10116 None
 
SPNS3_HUMAN
Ensembl»
0.5
SPNS3 Protein spinster homolog 3 Homo sapiens
TI:9606 None
 
SPNS3_MOUSE
Ensembl»
0.5
Spns3 Protein spinster homolog 3 Mus musculus
TI:10090 None
 
D3ZPS4_RAT
RGD»
9.0
Spns2 SPNS lysolipid
transporter 2, sphingosine-1-phosphate
Rattus norvegicus
TI:10116 None
   
A0A8V1AK80_CHICK
Ensembl»
0.5
SPNS3 SPNS lysolipid transporter
3, sphingosine-1-phosphate (putative)
Gallus gallus
TI:9031 None
   
A0A8I5ZPL7_RAT
RGD»
0.5
Spns3 Sphingolipid transporter 3 Rattus norvegicus
TI:10116 None
   
SPNS2_HUMAN
Ensembl»
7.4
SPNS2 Sphingosine-1-phosphate transporter SPNS2
(Protein spinster homolog 2)
Homo sapiens
TI:9606 None
 
SPNS2_DANRE
ZFIN»
11.7
spns2 Sphingosine-1-phosphate transporter SPNS2 (Protein spinster
homolog 2) (Protein two of hearts)
Danio rerio
TI:7955 None
 
SPNS2_MOUSE
Ensembl»
15.0
Spns2 Sphingosine-1-phosphate transporter SPNS2 (Protein spinster
homolog 2) (Spinster homolog 2) (Spns2)
Mus musculus
TI:10090 None
 
A0A8V1ACY4_CHICK
Ensembl»
2.0
SPNS2 Spinster homolog 2 Gallus gallus
TI:9031 None